{"id":"https://openalex.org/W2012772141","doi":"https://doi.org/10.1074/jbc.m401374200","title":"Crystal Structures of Staphylococcus aureus Sortase A and Its Substrate Complex","display_name":"Crystal Structures of Staphylococcus aureus Sortase A and Its Substrate Complex","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2012772141","doi":"https://doi.org/10.1074/jbc.m401374200","mag":"2012772141","pmid":"https://pubmed.ncbi.nlm.nih.gov/15117963"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m401374200","doi":"https://doi.org/10.1074/jbc.m401374200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m401374200","pdf_url":"http://www.jbc.org/article/S0021925818361969/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818361969/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113620382","display_name":"Yinong Zong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yinong Zong","raw_affiliation_strings":["Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama, Birmingham, Alabama 35294, USA","Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama, Birmingham, Alabama 35294 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama, Birmingham, Alabama 35294, USA","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]},{"raw_affiliation_string":"Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama, Birmingham, Alabama 35294 and the","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032985390","display_name":"Todd Bice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd W. Bice","raw_affiliation_strings":["Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama, Birmingham, Alabama 35294 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama, Birmingham, Alabama 35294 and the","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072363609","display_name":"Hung Ton\u2010That","orcid":"https://orcid.org/0000-0003-1611-0469","observed_orcids":["https://orcid.org/0000-0003-1611-0469"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung Ton-That","raw_affiliation_strings":["Committee on Microbiology, University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Microbiology, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083683183","display_name":"Olaf Schneewind","orcid":"https://orcid.org/0000-0001-9652-3823","observed_orcids":["https://orcid.org/0000-0001-9652-3823"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olaf Schneewind","raw_affiliation_strings":["Committee on Microbiology, University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Microbiology, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023260744","display_name":"Sthanam V.L. Narayana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sthanam V.L. Narayana","raw_affiliation_strings":["Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama, Birmingham, Alabama 35294 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama, Birmingham, Alabama 35294 and the","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023260744"],"corresponding_institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.9246,"has_fulltext":true,"cited_by_count":276,"citation_normalized_percentile":{"value":0.84677376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"279","issue":"30","first_page":"31383","last_page":"31389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sortase-a","display_name":"sortase A","score":0.8889999985694885},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9459999799728394},{"id":"https://openalex.org/keywords/lpxtg-motif","display_name":"LPXTG motif","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cell-wall-anchoring","display_name":"cell wall anchoring","score":0.5809999704360962},{"id":"https://openalex.org/keywords/active-site-structure","display_name":"active site structure","score":0.6179999709129333},{"id":"https://openalex.org/keywords/substrate-binding-pocket","display_name":"substrate binding pocket","score":0.8519999980926514},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.7139999866485596},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.5910000205039978},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C165175003","wikidata":"https://www.wikidata.org/wiki/Q24738833","display_name":"Sortase","level":4,"score":0.8957775831222534},{"id":"https://openalex.org/C2778839769","wikidata":"https://www.wikidata.org/wiki/Q12856814","display_name":"Sortase A","level":4,"score":0.8853046298027039},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.6384695172309875},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.5965118408203125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5930523872375488},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5820159912109375},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5008931159973145},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4584810733795166},{"id":"https://openalex.org/C65556437","wikidata":"https://www.wikidata.org/wiki/Q766195","display_name":"Protein Data Bank (RCSB PDB)","level":2,"score":0.4383496046066284},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.43700680136680603},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4339934289455414},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3437897562980652},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2650659680366516},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.1208951473236084},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019881","descriptor_name":"Aminoacyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019881","descriptor_name":"Aminoacyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019881","descriptor_name":"Aminoacyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m401374200","doi":"https://doi.org/10.1074/jbc.m401374200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m401374200","pdf_url":"http://www.jbc.org/article/S0021925818361969/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15117963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15117963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m401374200","doi":"https://doi.org/10.1074/jbc.m401374200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m401374200","pdf_url":"http://www.jbc.org/article/S0021925818361969/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3551998385","display_name":"PROMOTE COMMERCIALLY FUNDED RESEARCH AND TECHNLGY DEVELOPMENT IN THE FIELD OF BIOPHYSICAL AND ENG","funder_award_id":"NCC8246","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G6196351111","display_name":"Nonparametric Modeling of Long-term HIV/Cell Dynamics","funder_award_id":"R01AI052765","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8311035521","display_name":"Surface Proteins of Gram-Positive Bacteria","funder_award_id":"R01AI038897","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012772141.pdf","grobid_xml":"https://content.openalex.org/works/W2012772141.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W565471074","https://openalex.org/W991054534","https://openalex.org/W1539796472","https://openalex.org/W1561893393","https://openalex.org/W1726597626","https://openalex.org/W1966070420","https://openalex.org/W1967352806","https://openalex.org/W1969290393","https://openalex.org/W1975000832","https://openalex.org/W1979135961","https://openalex.org/W1988872938","https://openalex.org/W1991306189","https://openalex.org/W1992162955","https://openalex.org/W1993231216","https://openalex.org/W1994105222","https://openalex.org/W1995017064","https://openalex.org/W1995105203","https://openalex.org/W1996028739","https://openalex.org/W1996247731","https://openalex.org/W2003546739","https://openalex.org/W2006683797","https://openalex.org/W2011187496","https://openalex.org/W2015114099","https://openalex.org/W2020083726","https://openalex.org/W2020213381","https://openalex.org/W2020632471","https://openalex.org/W2039597975","https://openalex.org/W2046191483","https://openalex.org/W2062828954","https://openalex.org/W2065129970","https://openalex.org/W2068809677","https://openalex.org/W2070709658","https://openalex.org/W2075753195","https://openalex.org/W2075952240","https://openalex.org/W2084292396","https://openalex.org/W2085921322","https://openalex.org/W2090088862","https://openalex.org/W2092247572","https://openalex.org/W2103880491","https://openalex.org/W2110736523","https://openalex.org/W2122162523","https://openalex.org/W2122873066","https://openalex.org/W2128823898","https://openalex.org/W2139508887","https://openalex.org/W2143118088","https://openalex.org/W2144841919","https://openalex.org/W2146052711","https://openalex.org/W2149181402","https://openalex.org/W2153399124","https://openalex.org/W2154518695","https://openalex.org/W2155436577","https://openalex.org/W2163269267"],"related_works":["https://openalex.org/W2072336070","https://openalex.org/W2006751255","https://openalex.org/W2032526672","https://openalex.org/W1005801511","https://openalex.org/W86335220","https://openalex.org/W2149181402","https://openalex.org/W2075952240","https://openalex.org/W2327882909","https://openalex.org/W1988872938","https://openalex.org/W2070434290"],"abstract_inverted_index":{"The":[0,82,167],"cell":[1,31,79],"wall":[2,32,80],"envelope":[3,33],"of":[4,23,58,66,76,89,103,106,111,114,130,141,192,210,214,233],"staphylococci":[5],"and":[6,54,62,78,86,113,124,137,179,182,199,219,227],"other":[7],"Gram-positive":[8,207,239],"pathogens":[9],"is":[10,172],"coated":[11],"with":[12,17,41,119],"surface":[13,48,235],"proteins":[14,22,49],"that":[15],"interact":[16],"human":[18],"host":[19],"tissues.":[20],"Surface":[21],"Staphylococcus":[24],"aureus":[25,216],"are":[26,145,201],"covalently":[27],"linked":[28],"to":[29],"the":[30,51,55,59,64,73,100,115,126,131,142,153,159,165,175,188,211],"by":[34,149],"a":[35,184,229],"mechanism":[36,88,232],"requiring":[37],"C-terminal":[38,74],"sorting":[39],"signals":[40],"an":[42,67,107],"LPXTG":[43,60,143],"motif.":[44],"Sortase":[45],"(SrtA)":[46],"cleaves":[47],"between":[50,70,174],"threonine":[52,71,138],"(T)":[53,139],"glycine":[56],"(G)":[57],"motif":[61,144],"catalyzes":[63],"formation":[65],"amide":[68],"bond":[69,171],"at":[72,158,183],"end":[75],"polypeptides":[77],"cross-bridges.":[81],"active":[83,108,176,212],"site":[84,109,177],"architecture":[85],"catalytic":[87],"sortase":[90,204,217,220],"A":[91,218],"has":[92],"hitherto":[93],"not":[94],"been":[95],"revealed.":[96],"Here":[97],"we":[98],"present":[99],"crystal":[101],"structures":[102],"native":[104],"SrtA,":[105,112],"mutant":[110,116],"SrtA":[117],"complexed":[118],"its":[120],"substrate":[121,127,225],"LPETG":[122],"peptide":[123,170],"describe":[125],"binding":[128],"pocket":[129],"enzyme.":[132],"Highly":[133],"conserved":[134,202],"proline":[135],"(P)":[136],"residues":[140,181],"held":[146],"in":[147,203,238],"position":[148,161],"hydrophobic":[150],"contacts,":[151],"whereas":[152],"glutamic":[154],"acid":[155],"residue":[156],"(E)":[157],"X":[160],"points":[162],"out":[163],"into":[164,224],"solvent.":[166],"scissile":[168],"T-G":[169],"positioned":[173],"Cys(184)":[178],"Arg(197)":[180],"greater":[185],"distance":[186],"from":[187,206],"imidazolium":[189],"side":[190],"chain":[191],"His(120).":[193],"All":[194],"three":[195],"residues,":[196],"His(120),":[197],"Cys(184),":[198],"Arg(197),":[200],"enzymes":[205],"bacteria.":[208,240],"Comparison":[209],"sites":[213],"S.":[215],"B":[221],"provides":[222],"insight":[223],"specificity":[226],"suggests":[228],"universal":[230],"sortase-catalyzed":[231],"bacterial":[234],"protein":[236],"anchoring":[237]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}