{"id":"https://openalex.org/W2012763758","doi":"https://doi.org/10.1042/bj20140952","title":"Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression","display_name":"Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression","publication_year":2014,"publication_date":"2014-10-23","ids":{"openalex":"https://openalex.org/W2012763758","doi":"https://doi.org/10.1042/bj20140952","mag":"2012763758","pmid":"https://pubmed.ncbi.nlm.nih.gov/25339598","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4772664"},"language":"en","primary_location":{"id":"doi:10.1042/bj20140952","doi":"https://doi.org/10.1042/bj20140952","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20140952","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4772664/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037359600","display_name":"Muayad F. Almahariq","orcid":"https://orcid.org/0000-0001-8138-3389","observed_orcids":["https://orcid.org/0000-0001-8138-3389"]},"institutions":[{"id":"https://openalex.org/I4405281163","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Muayad Almahariq","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, U.S.A","Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, U.S.A","institution_ids":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, U.S.A","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064997314","display_name":"Fang C. Mei","orcid":"https://orcid.org/0000-0002-2589-1036","observed_orcids":["https://orcid.org/0000-0002-2589-1036"]},"institutions":[{"id":"https://openalex.org/I4405281163","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang\u00a0C. Mei","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, U.S.A","institution_ids":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460847","display_name":"Hui Wang","orcid":"https://orcid.org/0000-0002-8706-2217","observed_orcids":["https://orcid.org/0000-0002-8706-2217"]},"institutions":[{"id":"https://openalex.org/I4405281163","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hui Wang","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, U.S.A","institution_ids":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082044049","display_name":"Anthony Cao","orcid":"https://orcid.org/0009-0009-4062-3767","observed_orcids":["https://orcid.org/0009-0009-4062-3767"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony\u00a0T. Cao","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, U.S.A","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087845928","display_name":"Suxia Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suxia Yao","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, U.S.A","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020114169","display_name":"Lynn Soong","orcid":"https://orcid.org/0000-0003-3370-3434","observed_orcids":["https://orcid.org/0000-0003-3370-3434"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn Soong","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, U.S.A","Department of Pathology, University of Texas Medical Branch, Galveston, TX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, U.S.A","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Pathology, University of Texas Medical Branch, Galveston, TX, U.S.A","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046764208","display_name":"Jiaren Sun","orcid":"https://orcid.org/0000-0001-5084-4437","observed_orcids":["https://orcid.org/0000-0001-5084-4437"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaren Sun","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, U.S.A","Department of Pathology, University of Texas Medical Branch, Galveston, TX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, U.S.A","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Pathology, University of Texas Medical Branch, Galveston, TX, U.S.A","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006930837","display_name":"Yingzi Cong","orcid":"https://orcid.org/0000-0003-4167-7395","observed_orcids":["https://orcid.org/0000-0003-4167-7395"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingzi Cong","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, U.S.A","Department of Pathology, University of Texas Medical Branch, Galveston, TX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, U.S.A","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Pathology, University of Texas Medical Branch, Galveston, TX, U.S.A","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100774573","display_name":"Ju Chen","orcid":"https://orcid.org/0000-0001-7674-4776","observed_orcids":["https://orcid.org/0000-0001-7674-4776"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ju Chen","raw_affiliation_strings":["Department of Medicine, University of California, La Jolla, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, La Jolla, CA, U.S.A","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080619609","display_name":"Xiaodong Cheng","orcid":"https://orcid.org/0000-0002-3479-1694","observed_orcids":["https://orcid.org/0000-0002-3479-1694"]},"institutions":[{"id":"https://openalex.org/I4405281163","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaodong Cheng","raw_affiliation_strings":["Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, U.S.A","institution_ids":["https://openalex.org/I4405281163","https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5037359600","https://openalex.org/A5080619609","https://openalex.org/A5100460847"],"corresponding_institution_ids":["https://openalex.org/I4405281163","https://openalex.org/I55302922","https://openalex.org/I919571938"],"apc_list":null,"apc_paid":null,"fwci":2.6089,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.8991371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"465","issue":"2","first_page":"295","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epac1","display_name":"Epac1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/epac","display_name":"Epac","score":0.9419999718666077},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9470000267028809},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8799999952316284},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9729999899864197},{"id":"https://openalex.org/keywords/smad7","display_name":"Smad7","score":0.972000002861023},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/oral-tolerance","display_name":"oral tolerance","score":0.8619999885559082},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.6743728518486023},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.6026577949523926},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5919720530509949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5752755403518677},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5575672388076782},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.5149070024490356},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.5107300281524658},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4876152575016022},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.45271408557891846},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.43626856803894043},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43338093161582947},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4222731292247772},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.40269923210144043},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3969481289386749},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37882035970687866},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.17105385661125183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13338905572891235},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09288781881332397}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051906","descriptor_name":"Smad7 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051906","descriptor_name":"Smad7 Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj20140952","doi":"https://doi.org/10.1042/bj20140952","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20140952","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:25339598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25339598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4772664","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4772664/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt90m3z3ts","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/90m3z3ts","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemical Journal, vol 465, iss 2","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4772664","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4772664/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem J","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1620896901","display_name":null,"funder_award_id":"T32-GM89657-3","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1644961519","display_name":"CaMKII and InsP3-Mediated Signaling in Cardiac Myocytes","funder_award_id":"P01HL080101","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G638645882","display_name":null,"funder_award_id":"T32AI60549-10","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6831578510","display_name":"Epac/cAMP-GEF, A Novel Intracellular cAMP Receptor","funder_award_id":"R01GM066170","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6909879773","display_name":"Training in Pharmacological Sciences","funder_award_id":"T32GM089657","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000891033","display_name":"Biodefense Training Program","funder_award_id":"T32AI060549","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1543612160","https://openalex.org/W1553444759","https://openalex.org/W1577872659","https://openalex.org/W1885709862","https://openalex.org/W1909001376","https://openalex.org/W1930163146","https://openalex.org/W1972321016","https://openalex.org/W1972429412","https://openalex.org/W1972685619","https://openalex.org/W1979353700","https://openalex.org/W1982155401","https://openalex.org/W1986660413","https://openalex.org/W1996683094","https://openalex.org/W2001131198","https://openalex.org/W2001740313","https://openalex.org/W2030819935","https://openalex.org/W2038869692","https://openalex.org/W2045979867","https://openalex.org/W2046709996","https://openalex.org/W2054326230","https://openalex.org/W2056700771","https://openalex.org/W2061434125","https://openalex.org/W2072853625","https://openalex.org/W2078037416","https://openalex.org/W2078881821","https://openalex.org/W2086005876","https://openalex.org/W2086979421","https://openalex.org/W2093070846","https://openalex.org/W2093687979","https://openalex.org/W2094061652","https://openalex.org/W2097995306","https://openalex.org/W2098479780","https://openalex.org/W2098983864","https://openalex.org/W2099887519","https://openalex.org/W2100357356","https://openalex.org/W2105484520","https://openalex.org/W2115970547","https://openalex.org/W2119236548","https://openalex.org/W2121730220","https://openalex.org/W2123833754","https://openalex.org/W2130612262","https://openalex.org/W2130800855","https://openalex.org/W2132411360","https://openalex.org/W2134639722","https://openalex.org/W2135299099","https://openalex.org/W2141267203","https://openalex.org/W2141565645","https://openalex.org/W2152532651","https://openalex.org/W2153389047","https://openalex.org/W2153618088","https://openalex.org/W2154830075","https://openalex.org/W2155355681","https://openalex.org/W2158387009","https://openalex.org/W2161545566","https://openalex.org/W2168985658","https://openalex.org/W2171241069","https://openalex.org/W2414822697"],"related_works":["https://openalex.org/W1979353700","https://openalex.org/W2413172240","https://openalex.org/W1501307290","https://openalex.org/W2123794877","https://openalex.org/W2517285197","https://openalex.org/W1972321016","https://openalex.org/W2967876857","https://openalex.org/W2415052762","https://openalex.org/W2770740503","https://openalex.org/W7100111530"],"abstract_inverted_index":{"The":[0,166],"cAMP":[1],"signalling":[2],"pathway":[3],"plays":[4,138],"an":[5,139,152],"essential":[6],"role":[7,18,141],"in":[8,29,43,121,128,142,161,164,192],"immune":[9,105],"functions.":[10],"In":[11],"the":[12,17,20,61,104,134,156,169],"present":[13,170],"study":[14,171],"we":[15],"examined":[16],"of":[19,41,53,60,69,79,109,114,117,149,168,202],"cAMP/EPAC1":[21],"(exchange":[22],"protein":[23],"directly":[24],"activated":[25],"by":[26,95],"cAMP)":[27],"axis":[28],"regulatory":[30],"T-cell":[31],"(Treg)-mediated":[32],"immunosuppression":[33],"using":[34,151],"genetic":[35],"and":[36,45,67,72,163,178,198],"pharmacological":[37,147],"approaches.":[38],"Genetic":[39],"deletion":[40,108,158],"EPAC1":[42,56,110,137,150,157,174,180],"Tregs":[44,96,189],"effector":[46],"T-cells":[47,83],"(Teffs)":[48],"synergistically":[49],"attenuated":[50],"Treg-mediated":[51,143,176],"suppression":[52],"Teffs.":[54],"Mechanistically,":[55],"inhibition":[57,148],"enhanced":[58],"activation":[59],"transcription":[62,70],"factor":[63,89],"STAT3":[64],"(signal":[65],"transducer":[66],"activator":[68],"3)":[71],"up-regulated":[73],"SMAD7":[74],"expression":[75,78],"while":[76],"down-regulating":[77],"SMAD4.":[80],"Consequently,":[81],"CD4+":[82],"were":[84],"desensitized":[85],"to":[86,97,112],"transforming":[87],"growth":[88],"(TGF)":[90],"\u03b21,":[91],"a":[92,99,122,182,199],"cytokine":[93],"employed":[94],"exert":[98],"broad":[100,185],"inhibitory":[101],"function":[102],"within":[103],"system.":[106],"Furthermore,":[107],"led":[111],"production":[113],"significant":[115],"levels":[116],"ovalbumin":[118],"IgG":[119],"antibodies":[120],"low-dose,":[123],"oral-tolerance":[124],"mouse":[125],"model.":[126],"These":[127],"vivo":[129,162],"observations":[130],"are":[131,190],"consistent":[132],"with":[133,184],"finding":[135],"that":[136,173],"important":[140],"suppression.":[144],"More":[145],"importantly,":[146],"EPAC-specific":[153],"inhibitor":[154],"recapitulates":[155],"phenotype":[159],"both":[160],"vitro.":[165],"results":[167],"show":[172],"boosts":[175],"suppression,":[177],"identifies":[179],"as":[181],"target":[183],"therapeutic":[186],"potential":[187],"because":[188],"involved":[191],"numerous":[193],"pathologies,":[194],"including":[195],"autoimmunity,":[196],"infections":[197],"wide":[200],"range":[201],"cancers.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}