{"id":"https://openalex.org/W201274129","doi":null,"title":"Methicillin-resistant Staphylococcus aureus: a pervasive pathogen highlights the need for new antimicrobial development.","display_name":"Methicillin-resistant Staphylococcus aureus: a pervasive pathogen highlights the need for new antimicrobial development.","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W201274129","mag":"201274129","pmid":"https://pubmed.ncbi.nlm.nih.gov/21165342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002151"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3002151","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002151","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yale J Biol Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002151","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050887272","display_name":"Emily A. Morell","orcid":"https://orcid.org/0000-0002-5608-0367","observed_orcids":["https://orcid.org/0000-0002-5608-0367"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily A Morell","raw_affiliation_strings":["Harvard Medical School/Castle Society, Boston, Massachusetts 02115, USA. emily_morell@hms.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School/Castle Society, Boston, Massachusetts 02115, USA. emily_morell@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026358193","display_name":"Daniel M. Balkin","orcid":"https://orcid.org/0000-0003-1201-9908","observed_orcids":["https://orcid.org/0000-0003-1201-9908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel M Balkin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2712,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.95874072,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"83","issue":"4","first_page":"223","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.7620000243186951},{"id":"https://openalex.org/keywords/community-acquired-infections","display_name":"community-acquired infections","score":0.7979999780654907},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.8970000147819519},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.859000027179718},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8980000019073486},{"id":"https://openalex.org/keywords/secreted-enzymes","display_name":"secreted enzymes","score":0.5540000200271606},{"id":"https://openalex.org/keywords/toxins","display_name":"toxins","score":0.7570000290870667},{"id":"https://openalex.org/keywords/surface-proteins","display_name":"surface proteins","score":0.8759999871253967},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.7289999723434448},{"id":"https://openalex.org/keywords/public-health-burden","display_name":"public health burden","score":0.7839999794960022},{"id":"https://openalex.org/keywords/novel-antibiotic-discovery","display_name":"new antibiotic development","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8370712995529175},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6968880295753479},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5645592212677002},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5569368600845337},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.5459902882575989},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.542121946811676},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.5138993263244629},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.49069392681121826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47186869382858276},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.45333725214004517},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.4330858588218689},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4198874235153198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4129027724266052},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37678658962249756},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32588058710098267},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22877192497253418},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046915","descriptor_name":"Penicillin-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3002151","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002151","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yale J Biol Med","raw_type":"Text"},{"id":"pmid:21165342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21165342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Yale journal of biology and medicine","raw_type":"Journal Article"},{"id":"mag:201274129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21165342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3002151","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002151","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yale J Biol Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W174787682","https://openalex.org/W1533381682","https://openalex.org/W1854886190","https://openalex.org/W1974322322","https://openalex.org/W1975600062","https://openalex.org/W1976780773","https://openalex.org/W1980030331","https://openalex.org/W1990293025","https://openalex.org/W1996317585","https://openalex.org/W2001885083","https://openalex.org/W2014403207","https://openalex.org/W2024764217","https://openalex.org/W2026868331","https://openalex.org/W2027320048","https://openalex.org/W2037541009","https://openalex.org/W2044761912","https://openalex.org/W2045851410","https://openalex.org/W2047380896","https://openalex.org/W2048923085","https://openalex.org/W2067830719","https://openalex.org/W2079988639","https://openalex.org/W2082329713","https://openalex.org/W2092239030","https://openalex.org/W2096066440","https://openalex.org/W2103807926","https://openalex.org/W2105838618","https://openalex.org/W2108223609","https://openalex.org/W2110146923","https://openalex.org/W2111188921","https://openalex.org/W2111610806","https://openalex.org/W2116607488","https://openalex.org/W2118935747","https://openalex.org/W2119629693","https://openalex.org/W2119768770","https://openalex.org/W2121175754","https://openalex.org/W2122689885","https://openalex.org/W2123689798","https://openalex.org/W2126828161","https://openalex.org/W2130436333","https://openalex.org/W2131944185","https://openalex.org/W2137755807","https://openalex.org/W2151150074","https://openalex.org/W2154775956","https://openalex.org/W2155322726","https://openalex.org/W2166425259","https://openalex.org/W2168482920","https://openalex.org/W2170051717","https://openalex.org/W2176472482","https://openalex.org/W2314649741","https://openalex.org/W4245663047","https://openalex.org/W4293253343","https://openalex.org/W4299125473"],"related_works":["https://openalex.org/W2319125903","https://openalex.org/W2783824971","https://openalex.org/W7024580469","https://openalex.org/W2593927309","https://openalex.org/W2908265981","https://openalex.org/W7132426392","https://openalex.org/W29836097","https://openalex.org/W1822917180","https://openalex.org/W2010746820","https://openalex.org/W7099660182"],"abstract_inverted_index":{"Staphylococcus":[0],"aureus":[1,29,49,84],"(S.":[2],"aureus)":[3],"has":[4,30,40,50,86,105,121],"entered":[5],"the":[6,24,36,60,79,103,149],"spotlight":[7],"as":[8,142],"a":[9,43,65,110],"globally":[10],"pervasive":[11],"drug-resistant":[12],"pathogen.":[13],"While":[14],"historically":[15],"associated":[16],"exclusively":[17],"with":[18,124],"hospital-acquired":[19],"infections":[20,85],"in":[21,93,98,102],"immunocompromised":[22],"hosts,":[23],"methicillin-resistant":[25],"form":[26],"of":[27,54,67,81,118,136,139,148],"S.":[28,48,83],"been":[31,106,122],"spreading":[32],"throughout":[33],"communities":[34],"since":[35],"1990s.":[37],"Indeed,":[38],"it":[39],"now":[41],"become":[42],"common":[44],"household":[45],"term:":[46],"MRSA.":[47],"developed":[51],"numerous":[52],"mechanisms":[53],"virulence":[55],"and":[56,72],"strategies":[57],"to":[58,95,127],"evade":[59],"human":[61],"immune":[62],"system,":[63],"including":[64],"host":[66],"surface":[68],"proteins,":[69],"secreted":[70],"enzymes,":[71],"toxins.":[73],"In":[74],"hospital":[75],"intensive":[76],"care":[77],"units,":[78],"proportion":[80],"MRSA-related":[82],"increased":[87],"strikingly":[88],"from":[89],"just":[90],"2":[91],"percent":[92,97],"1974":[94],"64":[96],"2004.":[99],"Its":[100],"presence":[101],"community":[104],"rising":[107],"similarly,":[108],"posing":[109],"significant":[111],"public":[112],"health":[113],"burden.":[114],"The":[115,133],"growing":[116],"incidence":[117],"MRSA":[119,143],"unfortunately":[120],"met":[123],"dwindling":[125],"efforts":[126],"develop":[128],"new,":[129],"more":[130],"effective":[131],"antibiotics.":[132,153],"continued":[134],"emergence":[135],"resistant":[137],"strains":[138],"bacteria":[140],"such":[141],"demands":[144],"an":[145],"urgent":[146],"revival":[147],"search":[150],"for":[151],"new":[152]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}