{"id":"https://openalex.org/W2012709673","doi":"https://doi.org/10.1073/pnas.82.14.4823","title":"Differentiation of normal marrow and HL60 cells induced by antithymocyte globulin.","display_name":"Differentiation of normal marrow and HL60 cells induced by antithymocyte globulin.","publication_year":1985,"publication_date":"1985-07-01","ids":{"openalex":"https://openalex.org/W2012709673","doi":"https://doi.org/10.1073/pnas.82.14.4823","mag":"2012709673","pmid":"https://pubmed.ncbi.nlm.nih.gov/3875092","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/390997"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.82.14.4823","doi":"https://doi.org/10.1073/pnas.82.14.4823","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.82.14.4823","pdf_url":"https://www.pnas.org/content/pnas/82/14/4823.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/82/14/4823.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102969494","display_name":"ROBERT F. HUNTER","orcid":"https://orcid.org/0000-0002-7104-0814","observed_orcids":["https://orcid.org/0000-0002-7104-0814"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R F Hunter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049494353","display_name":"Nelda G. Mold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N G Mold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113624102","display_name":"R. Brian Mitchell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R B Mitchell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032673809","display_name":"Andrew T. Huang","orcid":"https://orcid.org/0000-0002-4000-6963","observed_orcids":["https://orcid.org/0000-0002-4000-6963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A T Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9139,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.85440321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"82","issue":"14","first_page":"4823","last_page":"4827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.16200000047683716,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.06199999898672104,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antithymocyte-globulin","display_name":"antithymocyte globulin","score":1.0},{"id":"https://openalex.org/keywords/acquired-aplastic-anemia","display_name":"acquired aplastic anemia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hematopoietic-differentiation","display_name":"hematopoietic differentiation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.7369999885559082},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/terminal-differentiation","display_name":"terminal differentiation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/myeloid-colony-formation","display_name":"myeloid colony formation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/colony-stimulating-factors","display_name":"colony-stimulating factors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/granulocyte-maturation","display_name":"granulocyte maturation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/differentiation-inducing-agents","display_name":"differentiation-inducing agents","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.725349485874176},{"id":"https://openalex.org/C2778903051","wikidata":"https://www.wikidata.org/wiki/Q5630035","display_name":"HL60","level":3,"score":0.713476836681366},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6351786851882935},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.6182851791381836},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6043168306350708},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.5786488652229309},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5649527907371521},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5595030188560486},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.42920437455177307},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30093854665756226},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2780683636665344},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2767482101917267},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2537539303302765},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13893398642539978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000961","descriptor_name":"Antilymphocyte Serum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.82.14.4823","doi":"https://doi.org/10.1073/pnas.82.14.4823","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.82.14.4823","pdf_url":"https://www.pnas.org/content/pnas/82/14/4823.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:390997","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/390997","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:3875092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3875092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.82.14.4823","doi":"https://doi.org/10.1073/pnas.82.14.4823","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.82.14.4823","pdf_url":"https://www.pnas.org/content/pnas/82/14/4823.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1510122588","display_name":null,"funder_award_id":"CA 09307-06","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2012709673.pdf"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W33772365","https://openalex.org/W43300615","https://openalex.org/W45183960","https://openalex.org/W1562876511","https://openalex.org/W1993411007","https://openalex.org/W1995171456","https://openalex.org/W2001020350","https://openalex.org/W2010566496","https://openalex.org/W2062124441","https://openalex.org/W2085685800","https://openalex.org/W2087235200","https://openalex.org/W2125376694","https://openalex.org/W2141083396","https://openalex.org/W2320441301"],"related_works":["https://openalex.org/W1986450202","https://openalex.org/W1974496004","https://openalex.org/W1968447998","https://openalex.org/W1988106887","https://openalex.org/W2021773826","https://openalex.org/W2397156964","https://openalex.org/W25018531","https://openalex.org/W1970797758","https://openalex.org/W2433156046","https://openalex.org/W2412296197"],"abstract_inverted_index":{"Antithymocyte":[0],"globulin":[1],"(ATG)":[2],"therapy":[3],"is":[4,25,115],"an":[5],"important":[6],"treatment":[7],"alternative":[8],"for":[9,62,223],"patients":[10,142],"with":[11,69,143],"acquired":[12,144],"aplastic":[13,145],"anemia.":[14,146],"The":[15,100,110],"mechanism":[16,135],"by":[17,108],"which":[18],"it":[19],"exerts":[20],"its":[21],"effects":[22],"on":[23,118],"hematopoiesis":[24],"unknown.":[26],"In":[27],"this":[28],"report,":[29],"we":[30],"describe":[31,149],"the":[32,63,119,134,137,150,159,179,185,197,215],"ability":[33,151,186],"of":[34,42,50,76,102,112,121,128,152,178,203,206,214,226],"horse":[35,98],"ATG":[36,70,89,129,153,164],"to":[37,133,154,166,187,220],"induce":[38,155],"growth":[39,64,107],"and":[40,60,65,169,174,191,211],"differentiation":[41,157,205,213],"normal":[43,51,207],"bone":[44,53],"marrow.":[45],"A":[46],"single":[47],"cell":[48,162,217],"suspension":[49],"human":[52],"marrow":[54,208],"was":[55],"cultured":[56],"in":[57,86,92,140,158,196],"methylcellulose":[58],"medium":[59,95],"examined":[61],"maturation":[66],"after":[67],"incubation":[68],"(10":[71],"micrograms/ml).":[72],"After":[73],"3-4":[74],"days":[75],"culture,":[77],"spherical":[78,113],"colonies":[79,114],"containing":[80,88,94],"mature":[81,182],"myeloid":[82,209],"elements":[83,210],"were":[84],"found":[85],"cultures":[87,93],"but":[90],"not":[91,116],"or":[96,123],"preimmunization":[97],"IgG.":[99],"addition":[101],"10%":[103],"colony-stimulating":[104],"factor":[105],"increased":[106],"40%.":[109],"number":[111],"dependent":[117],"presence":[120],"macrophages":[122],"T":[124],"lymphocytes.":[125],"This":[126],"property":[127],"may":[130],"be":[131],"relevant":[132],"behind":[136],"hematologic":[138],"recovery":[139],"some":[141],"We":[147],"also":[148],"terminal":[156,212],"HL60":[160,167,216],"leukemic":[161],"line.":[163],"binds":[165],"cells":[168,180],"at":[170],"concentrations":[171],"between":[172],"10":[173],"100":[175],"micrograms/ml,":[176],"50%":[177],"become":[181],"granulocytes,":[183],"acquire":[184],"reduce":[188],"nitroblue":[189],"tetrazolium,":[190],"lose":[192],"their":[193],"proliferative":[194],"capacity":[195],"clonogenic":[198],"assay.":[199],"These":[200],"new":[201],"observations":[202],"ATG-induced":[204],"line":[218],"point":[219],"different":[221],"avenues":[222],"future":[224],"search":[225],"differentiation-inducing":[227],"agents.":[228]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
