{"id":"https://openalex.org/W2012693944","doi":"https://doi.org/10.1089/vim.1989.2.271","title":"Modulation of Cancer Patients' Immune Responses by Administration of Anti-Idiotypic Antibodies","display_name":"Modulation of Cancer Patients' Immune Responses by Administration of Anti-Idiotypic Antibodies","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2012693944","doi":"https://doi.org/10.1089/vim.1989.2.271","mag":"2012693944","pmid":"https://pubmed.ncbi.nlm.nih.gov/2610826"},"language":"en","primary_location":{"id":"doi:10.1089/vim.1989.2.271","doi":"https://doi.org/10.1089/vim.1989.2.271","is_oa":false,"landing_page_url":"https://doi.org/10.1089/vim.1989.2.271","pdf_url":null,"source":{"id":"https://openalex.org/S203476268","display_name":"Viral Immunology","issn_l":"0882-8245","issn":["0882-8245","1557-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021976445","display_name":"Dorothee Herlyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DOROTHEE HERLYN","raw_affiliation_strings":["Wistar Institute, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028276022","display_name":"Martine A. Wettendorff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARTINE WETTENDORFF","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064972382","display_name":"Dimitrios Iliopoulos","orcid":"https://orcid.org/0000-0003-2780-2372","observed_orcids":["https://orcid.org/0000-0003-2780-2372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DIMITRIOS ILIOPOULOS","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103495962","display_name":"Ekkehard Schmoll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EKKEHARD SCHMOLL","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075426014","display_name":"INGOLF SCHEDEL","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"INGOLF SCHEDEL","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050328478","display_name":"Hilary Koprowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HILARY KOPROWSKI","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1644,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.45367093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":"4","first_page":"271","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.07010000199079514,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-idiotypic-antibodies","display_name":"anti-idiotypic antibodies","score":0.9290000200271606},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7059999704360962},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7310000061988831},{"id":"https://openalex.org/keywords/intradermal-vaccination","display_name":"intradermal vaccination","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.7580000162124634},{"id":"https://openalex.org/keywords/anti-anti-idiotypic-antibodies","display_name":"anti-anti-idiotypic antibodies","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.45500001311302185},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/serum-tumor-markers","display_name":"serum tumor markers","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.662706732749939},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6461484432220459},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.6427944898605347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5762953758239746},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5414112210273743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5010247230529785},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.42750221490859985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3266518712043762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18650203943252563},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C107038049","wikidata":"https://www.wikidata.org/wiki/Q35986","display_name":"Aesthetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/vim.1989.2.271","doi":"https://doi.org/10.1089/vim.1989.2.271","is_oa":false,"landing_page_url":"https://doi.org/10.1089/vim.1989.2.271","pdf_url":null,"source":{"id":"https://openalex.org/S203476268","display_name":"Viral Immunology","issn_l":"0882-8245","issn":["0882-8245","1557-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Immunology","raw_type":"journal-article"},{"id":"pmid:2610826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2610826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1479792841","https://openalex.org/W1511687273","https://openalex.org/W1991852370","https://openalex.org/W2007924699","https://openalex.org/W2024855477","https://openalex.org/W2046907336","https://openalex.org/W2048025181","https://openalex.org/W2078837657","https://openalex.org/W2080724710","https://openalex.org/W2081549751","https://openalex.org/W2085414514"],"related_works":["https://openalex.org/W2024855477","https://openalex.org/W1784906962","https://openalex.org/W2007924699","https://openalex.org/W2409127913","https://openalex.org/W1535765047","https://openalex.org/W2158770355","https://openalex.org/W4232875002","https://openalex.org/W2080837403","https://openalex.org/W2041946632","https://openalex.org/W2049766468"],"abstract_inverted_index":{"Thirty":[0],"patients":[1,56,98,116],"with":[2,62,75,113,125],"Dukes":[3],"stage":[4],"D":[5],"colon":[6,51],"carcinoma":[7,52],"who":[8],"had":[9,18,38,99,106,117,121],"undergone":[10],"operative":[11],"removal":[12],"of":[13,27,30,104,135,154],"the":[14,76,132,152],"primary":[15],"tumor":[16,67,71,81,101],"and":[17,69,73,93],"growing":[19],"hepatic":[20],"metastases":[21],"each":[22],"received":[23,107,122],"four":[24],"intradermal":[25],"injections":[26,111],"0.5-4":[28],"mg":[29],"alum-precipitated":[31],"goat":[32],"anti-idiotypic":[33],"antibodies":[34],"(anti-Id).":[35],"The":[36,83],"anti-Id":[37,110],"been":[39],"produced":[40],"against":[41,160],"murine":[42],"monoclonal":[43],"antibody":[44],"(mAb)":[45],"CO17-1A,":[46,64],"which":[47],"defines":[48],"a":[49,144],"human":[50,158],"associated":[53],"antigen.":[54],"All":[55],"elaborated":[57],"anti-anti-Id":[58],"that":[59],"shared":[60],"idiotopes":[61],"mAb":[63,77],"bound":[65],"to":[66,80,147],"cells":[68],"isolated":[70],"antigen,":[72],"competed":[74],"for":[78],"binding":[79],"cells.":[82],"clinical":[84,133],"response":[85,146],"was":[86],"monitored":[87],"by":[88],"ultrasonography,":[89],"CT,":[90],"radionuclide":[91],"scanning,":[92],"serum":[94],"marker":[95],"assays.":[96],"Six":[97],"partial":[100],"responses;":[102],"five":[103],"these":[105],"additional":[108,123],"booster":[109],"along":[112],"chemotherapy.":[114],"Seven":[115],"stabilized":[118],"tumor;":[119],"six":[120],"anti-Id,":[124,148],"chemotherapy":[126],"also":[127],"in":[128,142,157],"four.":[129],"Conclusions":[130],"about":[131],"role":[134],"such":[136],"immunization":[137],"await":[138],"further":[139],"study,":[140],"but":[141],"demonstrating":[143],"specific":[145],"our":[149],"results":[150],"support":[151],"use":[153],"this":[155],"approach":[156],"immunotherapy":[159],"tumors":[161],"or":[162],"pathogens.":[163]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
