{"id":"https://openalex.org/W2012693715","doi":"https://doi.org/10.1242/jeb.00240","title":"Actin comet tails, endosomes and endosymbionts","display_name":"Actin comet tails, endosomes and endosymbionts","publication_year":2003,"publication_date":"2003-05-20","ids":{"openalex":"https://openalex.org/W2012693715","doi":"https://doi.org/10.1242/jeb.00240","mag":"2012693715","pmid":"https://pubmed.ncbi.nlm.nih.gov/12756279"},"language":"en","primary_location":{"id":"doi:10.1242/jeb.00240","doi":"https://doi.org/10.1242/jeb.00240","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jeb.00240","pdf_url":"https://journals.biologists.com/jeb/article-pdf/206/12/1977/1244555/1977.pdf","source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.biologists.com/jeb/article-pdf/206/12/1977/1244555/1977.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041456639","display_name":"Kammy L. Fehrenbacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kammy Fehrenbacher","raw_affiliation_strings":["These individuals contributed equally to this manuscript","Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"These individuals contributed equally to this manuscript","institution_ids":[]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024618487","display_name":"Thomas M. Huckaba","orcid":"https://orcid.org/0000-0002-6711-9175","observed_orcids":["https://orcid.org/0000-0002-6711-9175"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Huckaba","raw_affiliation_strings":["These individuals contributed equally to this manuscript","Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"These individuals contributed equally to this manuscript","institution_ids":[]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088786470","display_name":"Hyeong\u2010Cheol Yang","orcid":"https://orcid.org/0000-0001-9420-7894","observed_orcids":["https://orcid.org/0000-0001-9420-7894"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyeong-Cheol Yang","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077467093","display_name":"Istvan R. Boldogh","orcid":"https://orcid.org/0000-0002-0088-1130","observed_orcids":["https://orcid.org/0000-0002-0088-1130"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Istvan Boldogh","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034877269","display_name":"Liza A. Pon","orcid":"https://orcid.org/0000-0002-5593-4412","observed_orcids":["https://orcid.org/0000-0002-5593-4412"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Liza Pon","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034877269"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":0.3391,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.32645403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"206","issue":"12","first_page":"1977","last_page":"1984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.1851000040769577,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arp2-3-complex","display_name":"Arp2/3 complex","score":0.9779999852180481},{"id":"https://openalex.org/keywords/actin-comet-tails","display_name":"actin comet tails","score":0.9010000228881836},{"id":"https://openalex.org/keywords/actin-nucleation","display_name":"actin nucleation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/intracellular-motility","display_name":"intracellular motility","score":0.6309999823570251},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.7059999704360962},{"id":"https://openalex.org/keywords/endosymbionts","display_name":"endosymbionts","score":0.968999981880188},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-motility","display_name":"mitochondrial motility","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cell-division","display_name":"cell division","score":0.546999990940094},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.5260000228881836},{"id":"https://openalex.org/keywords/actin-related-proteins","display_name":"actin-related proteins","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7747451663017273},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.6961787939071655},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.6376702785491943},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6128132343292236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6003668308258057},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5301089286804199},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5214906930923462},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.20617997646331787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06162646412849426}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1242/jeb.00240","doi":"https://doi.org/10.1242/jeb.00240","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jeb.00240","pdf_url":"https://journals.biologists.com/jeb/article-pdf/206/12/1977/1244555/1977.pdf","source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},{"id":"pmid:12756279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12756279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental biology","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jexbio:206/12/1977","doi":null,"is_oa":false,"landing_page_url":"http://jeb.biologists.org/cgi/content/short/206/12/1977","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1242/jeb.00240","doi":"https://doi.org/10.1242/jeb.00240","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jeb.00240","pdf_url":"https://journals.biologists.com/jeb/article-pdf/206/12/1977/1244555/1977.pdf","source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1954926414","display_name":null,"funder_award_id":"GM66307","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2331460769","display_name":"Actin Organization and Polarization","funder_award_id":"R01GM066307","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6535423909","display_name":"Mitochondrial Motility and Inheritance","funder_award_id":"R01GM045735","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G969546682","display_name":null,"funder_award_id":"GM-45735","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012693715.pdf","grobid_xml":"https://content.openalex.org/works/W2012693715.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W39079674","https://openalex.org/W216372990","https://openalex.org/W1498435062","https://openalex.org/W1509530066","https://openalex.org/W1519901358","https://openalex.org/W1543768950","https://openalex.org/W1570636004","https://openalex.org/W1593929303","https://openalex.org/W1603724904","https://openalex.org/W1635520329","https://openalex.org/W1960007027","https://openalex.org/W1964083750","https://openalex.org/W1967955638","https://openalex.org/W1972467203","https://openalex.org/W1981265611","https://openalex.org/W1988282769","https://openalex.org/W1994621399","https://openalex.org/W1995773618","https://openalex.org/W1997339395","https://openalex.org/W2004900153","https://openalex.org/W2007586038","https://openalex.org/W2009068509","https://openalex.org/W2010781630","https://openalex.org/W2015799458","https://openalex.org/W2018317768","https://openalex.org/W2027351170","https://openalex.org/W2028642981","https://openalex.org/W2039325880","https://openalex.org/W2041098549","https://openalex.org/W2045923054","https://openalex.org/W2047979211","https://openalex.org/W2058069285","https://openalex.org/W2058924693","https://openalex.org/W2061828721","https://openalex.org/W2062941196","https://openalex.org/W2063713887","https://openalex.org/W2072263383","https://openalex.org/W2073449911","https://openalex.org/W2078822480","https://openalex.org/W2078894888","https://openalex.org/W2079099921","https://openalex.org/W2082119144","https://openalex.org/W2088899830","https://openalex.org/W2095384215","https://openalex.org/W2099573412","https://openalex.org/W2105389175","https://openalex.org/W2105789974","https://openalex.org/W2107625881","https://openalex.org/W2109084265","https://openalex.org/W2110017448","https://openalex.org/W2110640625","https://openalex.org/W2112659088","https://openalex.org/W2113395636","https://openalex.org/W2115607127","https://openalex.org/W2117411464","https://openalex.org/W2118875203","https://openalex.org/W2119529835","https://openalex.org/W2122782850","https://openalex.org/W2123779991","https://openalex.org/W2128302846","https://openalex.org/W2129622055","https://openalex.org/W2140617471","https://openalex.org/W2145631189","https://openalex.org/W2148334175","https://openalex.org/W2151063801","https://openalex.org/W2157815908","https://openalex.org/W2165668665","https://openalex.org/W2166520458","https://openalex.org/W2166581533","https://openalex.org/W2183670135"],"related_works":["https://openalex.org/W2031970687","https://openalex.org/W2109145995","https://openalex.org/W2078822480","https://openalex.org/W2058924693","https://openalex.org/W7096055291","https://openalex.org/W7095112425","https://openalex.org/W2143916476","https://openalex.org/W7098890850","https://openalex.org/W2041098549","https://openalex.org/W1606449940"],"abstract_inverted_index":{"The":[0],"Arp2/3":[1,29,95],"complex":[2,30],"consists":[3],"of":[4,13,23,27,43,61,69,78],"seven":[5],"highly":[6],"conserved":[7],"and":[8,20,36,74,76],"tightly":[9],"associated":[10],"subunits,":[11],"two":[12],"which":[14],"are":[15],"the":[16,24,28,40,92],"actin-related":[17],"proteins":[18],"Arp2":[19],"Arp3.":[21],"One":[22],"best-studied":[25],"functions":[26],"is":[31,47,50],"to":[32],"stimulate":[33],"actin":[34],"nucleation":[35],"force":[37,53],"production":[38,54],"at":[39],"leading":[41],"edge":[42],"motile":[44],"cells.":[45],"What":[46],"now":[48],"clear":[49],"that":[51],"Arp2/3-complex-mediated":[52],"drives":[55],"many":[56],"intracellular":[57,97],"movements,":[58],"including":[59],"movement":[60,77],"bacterial":[62],"pathogens":[63],"in":[64,83,91],"infected":[65],"host":[66],"cells,":[67],"internalization":[68],"extracellular":[70],"materials":[71],"via":[72],"phagocytosis":[73],"endocytosis,":[75],"mitochondria":[79],"during":[80],"cell":[81],"division":[82],"budding":[84],"yeast.":[85],"Here,":[86],"we":[87],"describe":[88],"recent":[89],"advances":[90],"mechanisms":[93],"underlying":[94],"complex-driven":[96],"movement.":[98]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}