{"id":"https://openalex.org/W2012652858","doi":"https://doi.org/10.1016/0162-3109(88)90015-x","title":"Effect of PGE1 treatment on in vitro thymocyte function of normal and autoimmune mice","display_name":"Effect of PGE1 treatment on in vitro thymocyte function of normal and autoimmune mice","publication_year":1988,"publication_date":"1988-09-01","ids":{"openalex":"https://openalex.org/W2012652858","doi":"https://doi.org/10.1016/0162-3109(88)90015-x","mag":"2012652858","pmid":"https://pubmed.ncbi.nlm.nih.gov/2974449"},"language":"en","primary_location":{"id":"doi:10.1016/0162-3109(88)90015-x","doi":"https://doi.org/10.1016/0162-3109(88)90015-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0162-3109(88)90015-x","pdf_url":null,"source":{"id":"https://openalex.org/S131233414","display_name":"Immunopharmacology","issn_l":"0162-3109","issn":["0162-3109","1879-047X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024683498","display_name":"Judith A. Whittum\u2010Hudson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Judith Whittum-Hudson","raw_affiliation_strings":["Department of Pathology, University of Connecticut Health Center, School of Medicine, Farmington 06032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Connecticut Health Center, School of Medicine, Farmington 06032","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037734477","display_name":"Mark C. Ballow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Ballow","raw_affiliation_strings":["Department of Pediatrics, University of Connecticut Health Center, School of Medicine, Farmington, CT 06032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Connecticut Health Center, School of Medicine, Farmington, CT 06032, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064923635","display_name":"Robert B. Zurier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Zurier","raw_affiliation_strings":["The Rheumatology Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rheumatology Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, U.S.A","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024683498"],"corresponding_institution_ids":["https://openalex.org/I75929689"],"apc_list":null,"apc_paid":null,"fwci":1.077,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.76531559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"2","first_page":"71","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e1","display_name":"prostaglandin E1","score":1.0},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9309999942779541},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.7429999709129333},{"id":"https://openalex.org/keywords/mitogenic-response","display_name":"mitogen response","score":0.7129999995231628},{"id":"https://openalex.org/keywords/peanut-lectin","display_name":"peanut lectin","score":0.7609999775886536},{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.6140000224113464},{"id":"https://openalex.org/keywords/immune-complex-nephritis","display_name":"immune complex nephritis","score":0.656000018119812},{"id":"https://openalex.org/keywords/thymocyte-depletion","display_name":"thymocyte depletion","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.731977105140686},{"id":"https://openalex.org/C2778954852","wikidata":"https://www.wikidata.org/wiki/Q7799635","display_name":"Thymocyte","level":4,"score":0.6941192150115967},{"id":"https://openalex.org/C2779837120","wikidata":"https://www.wikidata.org/wiki/Q579348","display_name":"Prostaglandin E1","level":2,"score":0.5687201619148254},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5409063100814819},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5194118022918701},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5094252228736877},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.508438766002655},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5019495487213135},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48966720700263977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4820912182331085},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.39584165811538696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.198894202709198},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.12827634811401367},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.06881946325302124},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0162-3109(88)90015-x","doi":"https://doi.org/10.1016/0162-3109(88)90015-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0162-3109(88)90015-x","pdf_url":null,"source":{"id":"https://openalex.org/S131233414","display_name":"Immunopharmacology","issn_l":"0162-3109","issn":["0162-3109","1879-047X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:2974449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2974449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.4300000071525574}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1440612553","display_name":null,"funder_award_id":"AI-09649","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1545826940","display_name":null,"funder_award_id":"AI 07080","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6548813772","display_name":null,"funder_award_id":"AI-14743","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1495692618","https://openalex.org/W1527848737","https://openalex.org/W1537795442","https://openalex.org/W1554817242","https://openalex.org/W1556919365","https://openalex.org/W1558223645","https://openalex.org/W1590696067","https://openalex.org/W1603669210","https://openalex.org/W1619215150","https://openalex.org/W1987059501","https://openalex.org/W1999789083","https://openalex.org/W2004842826","https://openalex.org/W2006091217","https://openalex.org/W2013482261","https://openalex.org/W2019001444","https://openalex.org/W2019639204","https://openalex.org/W2030500189","https://openalex.org/W2036409079","https://openalex.org/W2040060814","https://openalex.org/W2045312135","https://openalex.org/W2050326142","https://openalex.org/W2050890534","https://openalex.org/W2055666785","https://openalex.org/W2073536631","https://openalex.org/W2097628796","https://openalex.org/W2134452794","https://openalex.org/W2142290314","https://openalex.org/W2207779367","https://openalex.org/W2402808098","https://openalex.org/W2417593137","https://openalex.org/W2419268707","https://openalex.org/W3026787589"],"related_works":["https://openalex.org/W1603669210","https://openalex.org/W1619215150","https://openalex.org/W2084353496","https://openalex.org/W3026787589","https://openalex.org/W2417593137","https://openalex.org/W2082773738","https://openalex.org/W1999789083","https://openalex.org/W1513593008","https://openalex.org/W2078337604","https://openalex.org/W1552245412"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}