{"id":"https://openalex.org/W2012651444","doi":"https://doi.org/10.1016/j.bbrc.2006.10.032","title":"Mitogen-activated protein kinase kinase 1/extracellular signal-regulated kinase (MEK-1/ERK) inhibitors sensitize reduced glucocorticoid response mediated by TNF\u03b1 in human epidermal keratinocytes (HaCaT)","display_name":"Mitogen-activated protein kinase kinase 1/extracellular signal-regulated kinase (MEK-1/ERK) inhibitors sensitize reduced glucocorticoid response mediated by TNF\u03b1 in human epidermal keratinocytes (HaCaT)","publication_year":2006,"publication_date":"2006-10-20","ids":{"openalex":"https://openalex.org/W2012651444","doi":"https://doi.org/10.1016/j.bbrc.2006.10.032","mag":"2012651444","pmid":"https://pubmed.ncbi.nlm.nih.gov/17054908"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2006.10.032","doi":"https://doi.org/10.1016/j.bbrc.2006.10.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.10.032","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017611425","display_name":"Kenji Onda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kenji Onda","raw_affiliation_strings":["Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. knjond@ps.toyaku.ac.jp","Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. knjond@ps.toyaku.ac.jp","institution_ids":["https://openalex.org/I149964584"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan)","institution_ids":["https://openalex.org/I149964584"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masahiro Nagashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Nagashima","raw_affiliation_strings":["Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan","institution_ids":["https://openalex.org/I149964584"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yo Kawakubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yo Kawakubo","raw_affiliation_strings":["Department of Dermatology, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051093194","display_name":"Shota Inoue","orcid":"https://orcid.org/0000-0002-8754-0397","observed_orcids":["https://orcid.org/0000-0002-8754-0397"]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shota Inoue","raw_affiliation_strings":["Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan","institution_ids":["https://openalex.org/I149964584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040543323","display_name":"Toshihiko Hirano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiko Hirano","raw_affiliation_strings":["Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan","institution_ids":["https://openalex.org/I149964584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111867350","display_name":"Kitaro Oka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kitaro Oka","raw_affiliation_strings":["Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan","institution_ids":["https://openalex.org/I149964584"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017611425"],"corresponding_institution_ids":["https://openalex.org/I149964584"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.9233,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.67546655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"351","issue":"1","first_page":"266","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4779999852180481,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4779999852180481,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.14110000431537628,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0885000005364418,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-resistance","display_name":"glucocorticoid resistance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8059999942779541},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/epidermal-keratinocytes","display_name":"epidermal keratinocytes","score":0.8640000224113464},{"id":"https://openalex.org/keywords/gilz","display_name":"GILZ","score":0.7269999980926514},{"id":"https://openalex.org/keywords/mkp-1","display_name":"MKP-1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/fkbp51","display_name":"FKBP51","score":0.8859999775886536},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.9580000042915344},{"id":"https://openalex.org/keywords/topical-corticosteroids","display_name":"topical corticosteroids","score":0.7360000014305115},{"id":"https://openalex.org/keywords/pemphigus","display_name":"pemphigus","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.7870000004768372},{"id":"https://openalex.org/keywords/u0126","display_name":"U0126","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.7735207080841064},{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.679566502571106},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6789413690567017},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.6685658693313599},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.6135940551757812},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6030681133270264},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.5933156609535217},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5621457695960999},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5371933579444885},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.5309438705444336},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.522395133972168},{"id":"https://openalex.org/C99405784","wikidata":"https://www.wikidata.org/wiki/Q410434","display_name":"c-Raf","level":5,"score":0.5204493999481201},{"id":"https://openalex.org/C155985219","wikidata":"https://www.wikidata.org/wiki/Q409325","display_name":"Extracellular signal-regulated kinases","level":4,"score":0.4916430115699768},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.4425103962421417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43080902099609375},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.41120344400405884},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3517528176307678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2366364598274231},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2228204905986786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22217050194740295},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1992577612400055},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08701658248901367}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2006.10.032","doi":"https://doi.org/10.1016/j.bbrc.2006.10.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.10.032","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:17054908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17054908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310756","display_name":"Japan Research Foundation for Clinical Pharmacology","ror":"https://ror.org/02900by63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W124822819","https://openalex.org/W1586640515","https://openalex.org/W1604922500","https://openalex.org/W1689343528","https://openalex.org/W1745264954","https://openalex.org/W1953849107","https://openalex.org/W1966622565","https://openalex.org/W1966778168","https://openalex.org/W1968671826","https://openalex.org/W1974265619","https://openalex.org/W1974791065","https://openalex.org/W1992927495","https://openalex.org/W1996250489","https://openalex.org/W2005698033","https://openalex.org/W2010142538","https://openalex.org/W2022672527","https://openalex.org/W2031680195","https://openalex.org/W2049643877","https://openalex.org/W2053125671","https://openalex.org/W2061369078","https://openalex.org/W2063861465","https://openalex.org/W2066413131","https://openalex.org/W2083493178","https://openalex.org/W2084980112","https://openalex.org/W2087836842","https://openalex.org/W2099803817","https://openalex.org/W2119593016","https://openalex.org/W2128177613","https://openalex.org/W2145906341","https://openalex.org/W2147533486","https://openalex.org/W2159912211","https://openalex.org/W2336894893"],"related_works":["https://openalex.org/W1976617951","https://openalex.org/W1954477757","https://openalex.org/W2775831504","https://openalex.org/W2024625607","https://openalex.org/W2501777749","https://openalex.org/W1844293401","https://openalex.org/W2031822968","https://openalex.org/W2143704107","https://openalex.org/W2974222174","https://openalex.org/W2105324106"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
