{"id":"https://openalex.org/W2012628372","doi":"https://doi.org/10.1113/expphysiol.1995.sp003910","title":"Resistance to glomerular injury in the diabetic biobreeding rat","display_name":"Resistance to glomerular injury in the diabetic biobreeding rat","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W2012628372","doi":"https://doi.org/10.1113/expphysiol.1995.sp003910","mag":"2012628372","pmid":"https://pubmed.ncbi.nlm.nih.gov/8962713"},"language":"en","primary_location":{"id":"doi:10.1113/expphysiol.1995.sp003910","doi":"https://doi.org/10.1113/expphysiol.1995.sp003910","is_oa":false,"landing_page_url":"https://doi.org/10.1113/expphysiol.1995.sp003910","pdf_url":null,"source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113766321","display_name":"Feld Lg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LG Feld","raw_affiliation_strings":["Department of Pathology, State University of New York at Buffalo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, State University of New York at Buffalo, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076654097","display_name":"Steven Cachero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Cachero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041038523","display_name":"E N Ellis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EN Ellis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058503934","display_name":"\u00d6zen Dedeo\u011flu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Dedeoglu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Y Ueda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ueda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Leonard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Leonard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000293037","display_name":"R Letizia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Letizia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035159617","display_name":"V Mallon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Mallon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110109319","display_name":"Judith B. Van Liew","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JB Van Liew","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2940,"currency":"USD","value_usd":2940},"apc_paid":null,"fwci":1.7944,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83170901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"80","issue":"6","first_page":"991","last_page":"1000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/glomerular-hyperfiltration","display_name":"glomerular hyperfiltration","score":0.8289999961853027},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.8389999866485596},{"id":"https://openalex.org/keywords/nitric-oxide-metabolites","display_name":"nitric oxide metabolites","score":0.8840000033378601},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.8309999704360962},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.8640000224113464},{"id":"https://openalex.org/keywords/glomerular-basement-membrane-thickening","display_name":"glomerular basement membrane thickening","score":0.8050000071525574},{"id":"https://openalex.org/keywords/collagen-cross-links","display_name":"collagen cross-links","score":0.5249999761581421},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7643047571182251},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.76408851146698},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7468810677528381},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6323938965797424},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.6270562410354614},{"id":"https://openalex.org/C2776115139","wikidata":"https://www.wikidata.org/wiki/Q1753456","display_name":"Glomerular basement membrane","level":4,"score":0.6112960577011108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5855439901351929},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5585525035858154},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.5408461689949036},{"id":"https://openalex.org/C2776997535","wikidata":"https://www.wikidata.org/wiki/Q2556837","display_name":"Advanced glycation end-product","level":4,"score":0.5179733037948608},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.49505797028541565},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3266499638557434},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.25598737597465515},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.1541280746459961}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011913","descriptor_name":"Rats, Inbred BB","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1113/expphysiol.1995.sp003910","doi":"https://doi.org/10.1113/expphysiol.1995.sp003910","is_oa":false,"landing_page_url":"https://doi.org/10.1113/expphysiol.1995.sp003910","pdf_url":null,"source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},{"id":"pmid:8962713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8962713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066890099","https://openalex.org/W2392694406","https://openalex.org/W2181540743","https://openalex.org/W2322528414","https://openalex.org/W1809986544","https://openalex.org/W2161422560","https://openalex.org/W2016446757","https://openalex.org/W7096689185","https://openalex.org/W1986495348","https://openalex.org/W1519162988"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,59,118,174],"designed":[3],"to":[4,18,34,196,214,219],"determine":[5],"whether":[6],"the":[7,28,122,127,197,215,223,233],"diabetic":[8,63,92,123,149,163,191,204,225],"BioBreeding":[9,192,224],"rat":[10,226],"develops":[11],"significant":[12],"renal":[13,220],"injury":[14,221],"following":[15],"long-term":[16],"moderate":[17],"severe":[19],"hyperglycaemia.":[20],"Diabetic":[21],"and":[22,71,106,138,169,185,232],"control":[23,95,128],"rats":[24,64,124,150,193],"were":[25,43,88,142],"followed":[26],"from":[27],"onset":[29],"of":[30,37,74,84,99,132,157,179,183,236],"diabetes":[31],"(2-4":[32],"months)":[33],"18":[35,72,177],"months":[36,73,156,178],"age.":[38,75,158,180],"Frank":[39],"proteinuria":[40],"and/or":[41],"albuminuria":[42],"always":[44],"absent.":[45],"Glomerular":[46],"filtration":[47],"rate,":[48],"measured":[49],"by":[50,81],"inulin":[51],"clearance":[52],"(ml":[53],"min-1":[54],"(100":[55],"g":[56],"body":[57],"weight)-1),":[58],"significantly":[60,143],"higher":[61],"in":[62,66,91,103,107,121,126,148,152,190,200,222],"than":[65,125,151],"controls":[67,153],"at":[68,176],"10,":[69],"12":[70],"Advanced":[76],"glycosylation":[77,101,238],"end-product":[78],"cross-links":[79],"assessed":[80],"percentage":[82],"solubility":[83],"tail":[85],"tendon":[86],"collagen":[87],"moderately":[89],"increased":[90,166,228],"compared":[93],"with":[94],"animals.":[96],"Urinary":[97,130],"excretion":[98,131],"advanced":[100,237],"end-products":[102],"unfractionated":[104],"urine":[105,108],"fractionated":[109],"for":[110],"low":[111],"molecular":[112],"mass":[113],"peptides":[114],"(<":[115],"10":[116],"kDa)":[117],"11-fold":[119],"greater":[120,147],"group.":[129],"nitric":[133,229],"oxide":[134,230],"metabolites":[135],"(nmol":[136],"NO2-":[137],"NO3-":[139],"(24":[140],"h)-1)":[141],"(P":[144],"<":[145],"0.05)":[146],"after":[154],"8":[155],"Mild":[159],"histopathology":[160],"resembling":[161],"human":[162,203],"nephropathy,":[164],"including":[165],"mesangial":[167],"volume":[168],"glomerular":[170,187],"basement":[171],"membrane":[172],"thickness,":[173],"detected":[175],"The":[181],"findings":[182],"hyperfiltration":[184],"mild":[186],"morphological":[188],"changes":[189],"are":[194,227],"similar":[195],"abnormalities":[198],"seen":[199],"stage":[201],"2":[202],"nephropathy.":[205],"We":[206],"hypothesize":[207],"that":[208],"two":[209],"factors":[210],"which":[211],"may":[212],"contribute":[213],"resistance":[216],"or":[217],"tolerance":[218],"production":[231],"decreased":[234],"accumulation":[235],"end-products.":[239]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}