{"id":"https://openalex.org/W2012627874","doi":"https://doi.org/10.1097/00001813-200403000-00005","title":"Phase I trial of sequential raltitrexed followed by bolus 5-fluorouracil in patients with advanced colorectal cancer","display_name":"Phase I trial of sequential raltitrexed followed by bolus 5-fluorouracil in patients with advanced colorectal cancer","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W2012627874","doi":"https://doi.org/10.1097/00001813-200403000-00005","mag":"2012627874","pmid":"https://pubmed.ncbi.nlm.nih.gov/15014354"},"language":"en","primary_location":{"id":"doi:10.1097/00001813-200403000-00005","doi":"https://doi.org/10.1097/00001813-200403000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001813-200403000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S158028025","display_name":"Anti-Cancer Drugs","issn_l":"0959-4973","issn":["0959-4973","1473-5741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006913373","display_name":"Gary K. Schwartz","orcid":"https://orcid.org/0000-0003-1813-5061","observed_orcids":["https://orcid.org/0000-0003-1813-5061"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary K. Schwartz","raw_affiliation_strings":["Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY 10021, USA. Schwartg@mskcc.org","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY 10021, USA. Schwartg@mskcc.org","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012047866","display_name":"Joseph Bertino","orcid":"https://orcid.org/0000-0002-1743-7423","observed_orcids":["https://orcid.org/0000-0002-1743-7423"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Bertino","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, NY, USA","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069644669","display_name":"Nancy E. Kemeny","orcid":"https://orcid.org/0000-0002-0929-9542","observed_orcids":["https://orcid.org/0000-0002-0929-9542"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Kemeny","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, NY, USA","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037120205","display_name":"Leonard B. Saltz","orcid":"https://orcid.org/0000-0001-8353-4670","observed_orcids":["https://orcid.org/0000-0001-8353-4670"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Saltz","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, NY, USA","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103475477","display_name":"David K. Kelsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David K. Kelsen","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, NY, USA","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109233889","display_name":"William P. Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Tong","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, NY, USA","Cancer Systems Imaging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cancer Systems Imaging","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015328297","display_name":"Mary Roberta Welch","orcid":"https://orcid.org/0000-0001-7281-049X","observed_orcids":["https://orcid.org/0000-0001-7281-049X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Welch","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, NY, USA","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050122995","display_name":"Sandra Endres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Endres","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, NY, USA","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007514323","display_name":"Isaiah W. Dimery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Isaiah Dimery","raw_affiliation_strings":["AstraZeneca, Wilmington, DE, USA","AstraZeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Wilmington, DE, USA","institution_ids":["https://openalex.org/I4210150756"]},{"raw_affiliation_string":"AstraZeneca","institution_ids":["https://openalex.org/I105036370"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006913373"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":0.7353,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.72040733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"15","issue":"3","first_page":"219","last_page":"227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/raltitrexed","display_name":"raltitrexed","score":0.9879999756813049},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9940000176429749},{"id":"https://openalex.org/keywords/advanced-colorectal-cancer","display_name":"advanced colorectal cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/appendiceal-adenocarcinoma","display_name":"appendiceal adenocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/sequential-chemotherapy","display_name":"sequential chemotherapy","score":0.7059999704360962},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8489999771118164},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.5210000276565552},{"id":"https://openalex.org/keywords/antifolate-drugs","display_name":"antifolate","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2779268555","wikidata":"https://www.wikidata.org/wiki/Q15304877","display_name":"Raltitrexed","level":5,"score":0.998228907585144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8405598402023315},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.7219640016555786},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5220096707344055},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.5152854919433594},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4772079586982727},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.45008179545402527},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44930580258369446},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44524121284484863},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4263908863067627},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.37393566966056824},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3363751173019409},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3358299136161804}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00001813-200403000-00005","doi":"https://doi.org/10.1097/00001813-200403000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001813-200403000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S158028025","display_name":"Anti-Cancer Drugs","issn_l":"0959-4973","issn":["0959-4973","1473-5741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Drugs","raw_type":"journal-article"},{"id":"pmid:15014354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15014354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-cancer drugs","raw_type":"Clinical Trial"},{"id":"pmh:oai:alma.01RUT_INST:11664814040004646","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Phase-I-trial-of-sequential-raltitrexed/991031665035204646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1606031322","https://openalex.org/W1645370161","https://openalex.org/W1946289873","https://openalex.org/W1947562604","https://openalex.org/W1963503221","https://openalex.org/W1964540194","https://openalex.org/W1968737841","https://openalex.org/W1971325806","https://openalex.org/W2006824814","https://openalex.org/W2019049058","https://openalex.org/W2048433780","https://openalex.org/W2059228230","https://openalex.org/W2061951248","https://openalex.org/W2096122707","https://openalex.org/W2110519215","https://openalex.org/W2119270435","https://openalex.org/W2131508432","https://openalex.org/W2158436347","https://openalex.org/W2231459551"],"related_works":["https://openalex.org/W1964540194","https://openalex.org/W2230515726","https://openalex.org/W1991862947","https://openalex.org/W1986833841","https://openalex.org/W238137799","https://openalex.org/W2035925913","https://openalex.org/W2099938925","https://openalex.org/W1918961940","https://openalex.org/W2088915390","https://openalex.org/W2167690373"],"abstract_inverted_index":{"Our":[0],"objective":[1],"was":[2,38,117,126,133,141,199],"to":[3,54,119,135,193],"determine":[4],"the":[5,77,159,219,239],"maximum":[6],"tolerated":[7],"dose":[8,78,108,142,222],"(MTD)":[9],"of":[10,103,109,189,223],"sequential":[11],"raltitrexed":[12,50,58,82,110,132,205,213],"(Tomudex)":[13],"and":[14,30,72,131,154,172,234],"5-fluorouracil":[15],"(5-FU)":[16],"by":[17],"bolus":[18,210],"administration":[19],"every":[20],"3":[21],"weeks":[22],"in":[23,41,238],"patients":[24,90,161,180],"with":[25,91,209,226],"advanced":[26],"colorectal":[27],"cancer":[28],"(aCRC)":[29],"appendiceal":[31],"adenocarcinoma.":[32],"This":[33,229],"phase":[34],"I":[35],"dose-escalation":[36],"study":[37,149],"carried":[39],"out":[40],"three":[42],"stages:":[43],"(1)":[44],"5-FU":[45,63,74,116,125],"fixed":[46,59,75,107,127],"at":[47,60,76,128,212],"900":[48,66],"mg/m,":[49,56,62,112,225],"escalated":[51,64,83],"from":[52,65,84],"0.5":[53],"3.0":[55,61,85,111,224],"(2)":[57],"mg/m":[67,86,121,130,137,152,156],"until":[68,87],"dose-limiting":[69],"toxicity":[70],"(DLT)":[71],"(3)":[73],"level":[79],"below":[80],"DLT,":[81],"MTD.":[88],"Seventy-one":[89],"measurable":[92],"disease":[93,183],"were":[94,98],"enrolled.":[95],"No":[96],"DLTs":[97],"observed":[99],"during":[100],"stage":[101],"1":[102],"treatment.":[104],"At":[105],"a":[106,167],"DLT":[113,140],"developed":[114],"when":[115],"increased":[118,134],"1350":[120],"(stage":[122,138],"2).":[123],"When":[124],"1200":[129,155],"6.0":[136],"3),":[139],"limiting.":[143],"The":[144],"recommended":[145,220],"doses":[146,214],"for":[147,163,184],"further":[148],"are":[150,216,247],"5.5":[151],"ralitrexed":[153],"5-FU.":[157],"Of":[158],"69":[160],"evaluated":[162],"efficacy,":[164],"one":[165],"had":[166,174,181],"complete":[168],"response":[169],"(8.0":[170],"months)":[171],"five":[173],"partial":[175],"responses":[176],"(5.1-11.6":[177],"months).":[178,196],"Thirty":[179],"stable":[182],"5":[185],"or":[186],"more":[187],"cycles":[188],"therapy":[190],"(mean":[191],"time":[192],"progression:":[194],"3.6":[195],"Median":[197],"survival":[198,235],"11.7":[200],"months.":[201],"We":[202],"conclude":[203],"that":[204,215],"can":[206],"be":[207],"combined":[208],"5-FU,":[211],"higher":[217],"than":[218],"single-agent":[221],"manageable":[227],"toxicity.":[228],"combination":[230],"shows":[231],"encouraging":[232],"activity,":[233],"appears":[236],"promising":[237],"pre-treated":[240],"aCRC":[241],"patient":[242],"population.":[243],"Further":[244],"clinical":[245],"trials":[246],"warranted.":[248]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}