{"id":"https://openalex.org/W2012618825","doi":"https://doi.org/10.1139/y81-183","title":"On the suitability of Innovar, a neuroleptic analgesic, for cardiovascular experiments","display_name":"On the suitability of Innovar, a neuroleptic analgesic, for cardiovascular experiments","publication_year":1981,"publication_date":"1981-11-01","ids":{"openalex":"https://openalex.org/W2012618825","doi":"https://doi.org/10.1139/y81-183","mag":"2012618825","pmid":"https://pubmed.ncbi.nlm.nih.gov/7317842"},"language":"en","primary_location":{"id":"doi:10.1139/y81-183","doi":"https://doi.org/10.1139/y81-183","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y81-183","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031443407","display_name":"Richard W. Brill","orcid":"https://orcid.org/0000-0003-3087-6241","observed_orcids":["https://orcid.org/0000-0003-3087-6241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard W. Brill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064240414","display_name":"David Randolph Jones","orcid":"https://orcid.org/0000-0002-3318-0146","observed_orcids":["https://orcid.org/0000-0002-3318-0146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David R. Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.14352159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"59","issue":"11","first_page":"1184","last_page":"1189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/innovar","display_name":"Innovar","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cardiovascular-effects","display_name":"cardiovascular effects","score":0.8659999966621399},{"id":"https://openalex.org/keywords/arterial-pressure","display_name":"arterial pressure","score":0.9229999780654907},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/respiration-rate","display_name":"respiration rate","score":0.8450000286102295},{"id":"https://openalex.org/keywords/ventricular-contractility","display_name":"ventricular contractility","score":0.9789999723434448},{"id":"https://openalex.org/keywords/arterial-oxygen-tension","display_name":"arterial oxygen tension","score":0.9789999723434448},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.3619999885559082},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7579379081726074},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.7070125341415405},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6908235549926758},{"id":"https://openalex.org/C2910741262","wikidata":"https://www.wikidata.org/wiki/Q4927803","display_name":"Arterial oxygen tension","level":3,"score":0.6651395559310913},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6516183614730835},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.6264962553977966},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.6198937892913818},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6090853214263916},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.4859565496444702},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.45143160223960876},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2348596155643463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18893569707870483},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004329","descriptor_name":"Droperidol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009305","descriptor_name":"Nasopharynx","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1139/y81-183","doi":"https://doi.org/10.1139/y81-183","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y81-183","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:7317842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7317842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of physiology and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005678712","https://openalex.org/W2082654418","https://openalex.org/W1967897066","https://openalex.org/W2419307885","https://openalex.org/W2383795717","https://openalex.org/W2324322046","https://openalex.org/W1982743792","https://openalex.org/W2351519595","https://openalex.org/W2002287546","https://openalex.org/W2397560591"],"abstract_inverted_index":{"The":[0,113],"effects":[1,23,43,128,135],"of":[2,24,54,84,123,129],"0.2":[3,64],"and":[4,14,47,126,131,139],"0.5":[5,91],"mL/kg":[6,65,92],"Innovar":[7,25],"(a":[8],"neuroleptic":[9],"analgesic)":[10],"on":[11,26,44,136],"cardiovascular":[12,70,97,137,150],"functions":[13,138],"reflexes":[15],"in":[16,77],"rabbits":[17],"were":[18,101],"measured.":[19],"We":[20],"recorded":[21],"the":[22,41,45,55,82,85,124],"arterial":[27,35],"pressure,":[28],"heart":[29],"rate,":[30,32],"respiration":[31],"ventricular":[33],"contractility,":[34],"oxygen":[36],"tension,":[37],"as":[38,40,80],"well":[39],"drug's":[42],"bradycardia":[46],"vasoconstrictor":[48],"response":[49],"to":[50,74,108,117],"cigarette":[51],"smoke":[52],"stimulation":[53],"nose":[56],"(the":[57],"so-called":[58],"\"nasopharyngeal":[59],"reflex\").":[60],"In":[61,88],"animals":[62,89,159],"given":[63,90],"Innovar,":[66,93,130],"all":[67,94],"steady":[68,95],"state":[69,96],"variables":[71],"had":[72,81],"returned":[73,116],"pre-Innovar":[75],"levels":[76],"45":[78],"min,":[79],"efficacy":[83],"nasopharyngeal":[86,114],"reflex.":[87],"variables,":[98],"except":[99],"PaO2,":[100],"slightly":[102],"but":[103],"significantly":[104],"depressed":[105],"for":[106,149],"up":[107],"135":[109],"min":[110],"after":[111],"injection.":[112],"reflex":[115],"normal":[118],"within":[119],"90":[120],"min.":[121],"Because":[122],"calmative":[125],"analgesic":[127,147],"its":[132],"only":[133],"moderate":[134],"reflexes,":[140],"we":[141],"feel":[142],"it":[143],"is":[144],"a":[145],"suitable":[146],"agent":[148],"experiments":[151],"where":[152],"neither":[153],"fully":[154],"conscious":[155],"nor":[156],"surgically":[157],"anesthetized":[158],"can":[160],"be":[161],"used.":[162]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
