{"id":"https://openalex.org/W2012618006","doi":"https://doi.org/10.1182/blood-2008-12-196030","title":"Analysis of human \u03b1 globin gene mutations that impair binding to the \u03b1 hemoglobin stabilizing protein","display_name":"Analysis of human \u03b1 globin gene mutations that impair binding to the \u03b1 hemoglobin stabilizing protein","publication_year":2009,"publication_date":"2009-04-07","ids":{"openalex":"https://openalex.org/W2012618006","doi":"https://doi.org/10.1182/blood-2008-12-196030","mag":"2012618006","pmid":"https://pubmed.ncbi.nlm.nih.gov/19349619","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2700329"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2008-12-196030","doi":"https://doi.org/10.1182/blood-2008-12-196030","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2008-12-196030","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2700329","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100685654","display_name":"Xiang Yu","orcid":"https://orcid.org/0000-0002-5730-8802","observed_orcids":["https://orcid.org/0000-0002-5730-8802"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiang Yu","raw_affiliation_strings":["Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031181029","display_name":"Todd L. Mollan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd L. Mollan","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Rice University, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Rice University, Houston, TX;","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045049382","display_name":"Andrew D. Butler","orcid":"https://orcid.org/0000-0003-4963-9633","observed_orcids":["https://orcid.org/0000-0003-4963-9633"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Butler","raw_affiliation_strings":["Department of Pharmacology, Rutgers University, Piscataway, NJ; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Rutgers University, Piscataway, NJ; and","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021760409","display_name":"Andrew J. Gow","orcid":"https://orcid.org/0000-0003-0876-5158","observed_orcids":["https://orcid.org/0000-0003-0876-5158"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Gow","raw_affiliation_strings":["Department of Pharmacology, Rutgers University, Piscataway, NJ; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Rutgers University, Piscataway, NJ; and","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017318009","display_name":"John S. Olson","orcid":"https://orcid.org/0000-0002-0760-5403","observed_orcids":["https://orcid.org/0000-0002-0760-5403"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Olson","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Rice University, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Rice University, Houston, TX;","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056930601","display_name":"Mitchell J. Weiss","orcid":"https://orcid.org/0000-0003-2460-3036","observed_orcids":["https://orcid.org/0000-0003-2460-3036","https://orcid.org/0000-0002-6734-4858","https://orcid.org/0000-0002-1580-1332"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell J. Weiss","raw_affiliation_strings":["Division of Hematology, Children's Hospital of Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Children's Hospital of Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.3774,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.88165483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"113","issue":"23","first_page":"5961","last_page":"5969"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.07739999890327454,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-hemoglobin-stabilizing-protein","display_name":"AHSP","score":0.9190000295639038},{"id":"https://openalex.org/keywords/alpha-globin-variant","display_name":"alpha-globin variant","score":0.8100000023841858},{"id":"https://openalex.org/keywords/alpha-globin-gene-mutations","display_name":"alpha-globin gene mutations","score":0.8149999976158142},{"id":"https://openalex.org/keywords/protein-protein-binding","display_name":"protein-protein binding","score":0.5870000123977661},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.4410000145435333},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.7049999833106995},{"id":"https://openalex.org/keywords/microcytic-anemia","display_name":"microcytic anemia","score":0.7940000295639038},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6029103398323059},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5821558237075806},{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.5712465047836304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5304046869277954},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5019702911376953},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4931897521018982},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3562045097351074},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20669695734977722}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055542","descriptor_name":"alpha-Globins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D055542","descriptor_name":"alpha-Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055542","descriptor_name":"alpha-Globins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055542","descriptor_name":"alpha-Globins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055544","descriptor_name":"beta-Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055544","descriptor_name":"beta-Globins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood-2008-12-196030","doi":"https://doi.org/10.1182/blood-2008-12-196030","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2008-12-196030","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2043700","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2700329","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2700329","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2700329","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:19349619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19349619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2043700","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2700329","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2154546777","display_name":null,"funder_award_id":"HL47020","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3201808254","display_name":"Biotechnology Research Training Grant","funder_award_id":"T32GM008362","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3591803973","display_name":null,"funder_award_id":"GM35649","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4931488477","display_name":null,"funder_award_id":"DK061692","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6127818854","display_name":"Functional Properties of Hemoglobins and Myoglobins","funder_award_id":"R01GM035649","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6347589039","display_name":"The Role of Alpha Hemoglobin Stabilizing Protein in Human Beta Thalassemia","funder_award_id":"R01HL087427","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6453968972","display_name":"Trim58 and the Ubiquitin Proteasome System in Erythro-megakaryopoiesis","funder_award_id":"R01DK061692","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6472009606","display_name":"The function and regulation of alpha hemoglobin stabilizing protein (AHSP) in hem","funder_award_id":"R56DK061692","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7787175179","display_name":"Design of Heme Protein-Based Blood Substitutes","funder_award_id":"R01HL047020","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7792105565","display_name":null,"funder_award_id":"GM008362","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8209665308","display_name":null,"funder_award_id":"HL087427","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000908092","display_name":"Rutgers Center for Environmental Exposure and Disease (CEED)","funder_award_id":"P30ES005022","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W16313930","https://openalex.org/W1475771111","https://openalex.org/W1489407445","https://openalex.org/W1541751053","https://openalex.org/W1546673233","https://openalex.org/W1550663817","https://openalex.org/W1563029436","https://openalex.org/W1564607697","https://openalex.org/W1574800785","https://openalex.org/W1942083149","https://openalex.org/W1965872881","https://openalex.org/W1966416112","https://openalex.org/W1972719789","https://openalex.org/W1974269188","https://openalex.org/W1974702668","https://openalex.org/W1980212327","https://openalex.org/W1980670550","https://openalex.org/W1987929318","https://openalex.org/W1990927597","https://openalex.org/W1995756028","https://openalex.org/W1999522939","https://openalex.org/W2001043463","https://openalex.org/W2001185652","https://openalex.org/W2023384179","https://openalex.org/W2035982649","https://openalex.org/W2038597617","https://openalex.org/W2040223458","https://openalex.org/W2044223477","https://openalex.org/W2044364368","https://openalex.org/W2045690737","https://openalex.org/W2047936494","https://openalex.org/W2057565092","https://openalex.org/W2081115556","https://openalex.org/W2087523508","https://openalex.org/W2093935700","https://openalex.org/W2095520114","https://openalex.org/W2102138191","https://openalex.org/W2106021203","https://openalex.org/W2141667305","https://openalex.org/W2142895986","https://openalex.org/W2143272744","https://openalex.org/W2330684959"],"related_works":["https://openalex.org/W1965872881","https://openalex.org/W2019249506","https://openalex.org/W170618287","https://openalex.org/W2044223477","https://openalex.org/W2015568829","https://openalex.org/W2558629701","https://openalex.org/W1986219640","https://openalex.org/W2303714282","https://openalex.org/W1969425774","https://openalex.org/W1550663817"],"abstract_inverted_index":{"Alpha":[0,73],"hemoglobin":[1,20,49],"stabilizing":[2],"protein":[3,36,127],"(AHSP)":[4],"reversibly":[5],"binds":[6],"nascent":[7],"alpha":[8,30,65,112,147,177,187],"globin":[9,31,66,74,116,148,164,178,188],"to":[10,58,122,135,161],"maintain":[11],"its":[12,17,39],"native":[13],"structure":[14],"and":[15,81,88,98,103,110,129,133,144,180],"facilitate":[16],"incorporation":[18],"into":[19],"A.":[21],"Previous":[22],"studies":[23],"indicate":[24],"that":[25,184],"some":[26,176],"naturally":[27],"occurring":[28],"human":[29,64,192],"mutations":[32,45,92,125],"may":[33],"destabilize":[34],"the":[35,162,172,182],"by":[37],"inhibiting":[38],"interactions":[40,84],"with":[41,68,85,101,155],"AHSP.":[42,123],"However,":[43],"these":[44],"could":[46],"also":[47],"affect":[48],"A":[50],"production":[51],"through":[52],"AHSP-independent":[53],"effects,":[54],"including":[55],"reduced":[56],"binding":[57,121,160],"beta":[59,89,115],"globin.":[60,90],"We":[61],"analyzed":[62],"6":[63],"variants":[67,179],"altered":[69],"AHSP":[70,87,156,185],"contact":[71],"surfaces.":[72],"amino":[75],"acid":[76],"substitutions":[77],"H103Y,":[78],"H103R,":[79],"F117S,":[80],"P119S":[82],"impaired":[83],"both":[86],"These":[91,124],"are":[93,99],"destabilizing":[94,138],"in":[95,105,131,139,158],"biochemical":[96,173],"assays":[97],"associated":[100],"microcytosis":[102],"anemia":[104],"humans.":[106],"By":[107],"contrast,":[108],"K99E":[109,149],"K99N":[111],"globins":[113],"bind":[114],"normally":[117],"but":[118],"exhibit":[119],"attenuated":[120],"impair":[126],"folding":[128],"expression":[130],"vitro":[132],"appear":[134],"be":[136],"mildly":[137],"vivo.":[140],"In":[141],"Escherichia":[142],"coli":[143],"erythroid":[145],"cells,":[146],"stability":[150,190],"is":[151,166],"rescued":[152],"on":[153],"coexpression":[154],"mutants":[157],"which":[159],"abnormal":[163],"chain":[165,189],"restored.":[167],"Our":[168],"results":[169],"better":[170],"define":[171],"properties":[174],"of":[175],"support":[181],"hypothesis":[183],"promotes":[186],"during":[191],"erythropoiesis.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}