{"id":"https://openalex.org/W2012609490","doi":"https://doi.org/10.1515/cclm.2008.043","title":"Evaluation of the GEM\u00ae Premier\u2122 4000: a compact blood gas CO-Oximeter and electrolyte analyzer for point-of-care and laboratory testing","display_name":"Evaluation of the GEM\u00ae Premier\u2122 4000: a compact blood gas CO-Oximeter and electrolyte analyzer for point-of-care and laboratory testing","publication_year":2007,"publication_date":"2007-12-13","ids":{"openalex":"https://openalex.org/W2012609490","doi":"https://doi.org/10.1515/cclm.2008.043","mag":"2012609490","pmid":"https://pubmed.ncbi.nlm.nih.gov/18076351"},"language":"en","primary_location":{"id":"doi:10.1515/cclm.2008.043","doi":"https://doi.org/10.1515/cclm.2008.043","is_oa":false,"landing_page_url":"https://doi.org/10.1515/cclm.2008.043","pdf_url":null,"source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemical Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028459795","display_name":"B\u00e9n\u00e9dicte B\u00e9n\u00e9teau\u2010Burnat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B\u00e9n\u00e9dicte B\u00e9n\u00e9teau-Burnat","raw_affiliation_strings":["Service de Biochimie A, H\u00f4pital Saint-Antoine, Paris, France. benedicte.beneteau-burnat@sat.aphp.fr","Service de Biochimie A, H\u00f4pital Saint-Antoine, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Biochimie A, H\u00f4pital Saint-Antoine, Paris, France. benedicte.beneteau-burnat@sat.aphp.fr","institution_ids":["https://openalex.org/I4210102928"]},{"raw_affiliation_string":"Service de Biochimie A, H\u00f4pital Saint-Antoine, Paris, France","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070041272","display_name":"Pascal Pernet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pascal Pernet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038388507","display_name":"Antoine Pilon","orcid":"https://orcid.org/0000-0001-5125-9029","observed_orcids":["https://orcid.org/0000-0001-5125-9029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antoine Pilon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012747880","display_name":"Damien Latour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Damien Latour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082005073","display_name":"St\u00e9phanie Goujon","orcid":"https://orcid.org/0000-0002-4149-2246","observed_orcids":["https://orcid.org/0000-0002-4149-2246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Goujon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004134997","display_name":"Alain Feuillu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alain Feuillu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031693686","display_name":"Michel Vaubourdolle","orcid":"https://orcid.org/0000-0002-8343-030X","observed_orcids":["https://orcid.org/0000-0002-8343-030X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel Vaubourdolle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2400,"currency":"EUR","value_usd":2712},"apc_paid":null,"fwci":4.1835,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.92047872,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"46","issue":"2","first_page":"271","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11890","display_name":"Scientific Measurement and Uncertainty Evaluation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3105","display_name":"Instrumentation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13690","display_name":"Quality and Safety in Healthcare","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-gas-analyzer","display_name":"blood gas analyzer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/electrolyte-analyzer","display_name":"electrolyte analyzer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.9409999847412109},{"id":"https://openalex.org/keywords/analytical-performance","display_name":"analytical performance","score":0.6129999756813049},{"id":"https://openalex.org/keywords/method-comparison","display_name":"method comparison","score":0.7770000100135803},{"id":"https://openalex.org/keywords/carboxyhemoglobin","display_name":"carboxyhemoglobin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/automated-hematology-analyzer","display_name":"automated hematology analyzer","score":0.4560000002384186},{"id":"https://openalex.org/keywords/microhematocrit","display_name":"microhematocrit","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C158007255","wikidata":"https://www.wikidata.org/wiki/Q1055222","display_name":"Spectrum analyzer","level":2,"score":0.7379006743431091},{"id":"https://openalex.org/C68801617","wikidata":"https://www.wikidata.org/wiki/Q162908","display_name":"Electrolyte","level":3,"score":0.6711220741271973},{"id":"https://openalex.org/C64841741","wikidata":"https://www.wikidata.org/wiki/Q491983","display_name":"Point-of-care testing","level":2,"score":0.632142186164856},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.6156573295593262},{"id":"https://openalex.org/C51915194","wikidata":"https://www.wikidata.org/wiki/Q17075487","display_name":"Point of care","level":2,"score":0.5583269596099854},{"id":"https://openalex.org/C118530786","wikidata":"https://www.wikidata.org/wiki/Q1134732","display_name":"Instrumentation (computer programming)","level":2,"score":0.5367838740348816},{"id":"https://openalex.org/C34381374","wikidata":"https://www.wikidata.org/wiki/Q37144","display_name":"Cartridge","level":2,"score":0.5049510598182678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43225157260894775},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.37909889221191406},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3450619578361511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3329029679298401},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2735624313354492},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15688717365264893},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.15283289551734924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13809654116630554},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10150539875030518},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0738157331943512},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019095","descriptor_name":"Point-of-Care Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1515/cclm.2008.043","doi":"https://doi.org/10.1515/cclm.2008.043","is_oa":false,"landing_page_url":"https://doi.org/10.1515/cclm.2008.043","pdf_url":null,"source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemical Laboratory Medicine","raw_type":"journal-article"},{"id":"pmid:18076351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18076351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry and laboratory medicine","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1746656267","https://openalex.org/W1953733952","https://openalex.org/W2036545463","https://openalex.org/W2111648410","https://openalex.org/W2117894540","https://openalex.org/W2117925815","https://openalex.org/W2315233447","https://openalex.org/W2317481860"],"related_works":["https://openalex.org/W2036545463","https://openalex.org/W1910263056","https://openalex.org/W2783117615","https://openalex.org/W2909828402","https://openalex.org/W2775050124","https://openalex.org/W2084157967","https://openalex.org/W2944915795","https://openalex.org/W2027084684","https://openalex.org/W2886714431","https://openalex.org/W2783428389"],"abstract_inverted_index":{"BACKGROUND:":[0],"GEM":[1,159],"Premier":[2,21,160],"4000":[3,22,161],"(Instrumentation":[4],"Laboratory),":[5],"a":[6],"new":[7],"blood":[8,72,179],"gas/CO-Oximeter/hematocrit/electrolyte/glucose/lactate":[9],"analyzer":[10,181],"was":[11,36,104,148,164],"evaluated.":[12],"The":[13,34,158],"only":[14],"reagents":[15],"required":[16],"were":[17,65,132],"disposable":[18],"cartridges":[19],"(GEM":[20],"PAK":[23],"comprise":[24],"all":[25,101,167],"components":[26],"necessary":[27],"for":[28,100,166,187],"analysis,":[29],"including":[30],"quality":[31],"controls).":[32],"METHODS:":[33],"evaluation":[35],"performed":[37],"in":[38],"two":[39],"laboratories":[40],"according":[41],"to":[42],"the":[43,85,108,113,144,151,170,173,185],"Valtec":[44],"protocol":[45],"guidelines.":[46],"Analytical":[47],"performances":[48],"(imprecision":[49],"at":[50],"three":[51,68],"levels,":[52],"linearity,":[53],"inaccuracy":[54],"by":[55,112],"method":[56],"comparison":[57],"using":[58],"patient":[59],"samples,":[60],"interferences)":[61],"and":[62,77,84,91,106,130,172,190],"instrument":[63],"practicability":[64],"compared":[66],"with":[67,150,169],"routinely":[69],"used":[70],"laboratory":[71,191],"gas":[73,180],"analyzers":[74],"(ABL":[75],"835":[76],"725,":[78],"Radiometer;":[79],"OMNI":[80],"S,":[81],"Roche":[82],"Diagnostics)":[83],"centrifuged":[86],"microhematocrit":[87],"method.":[88],"RESULTS:":[89],"Within-run":[90],"between-run":[92],"imprecision":[93],"yielded":[94],"good":[95],"coefficients":[96,123],"of":[97,127,146,175,184],"variation":[98],"values":[99],"parameters.":[102,136],"Linearity":[103],"satisfactory":[105],"within":[107],"expected":[109],"ranges":[110],"provided":[111],"manufacturer.":[114],"Method":[115],"comparisons":[116],"demonstrated":[117],"close":[118],"agreement":[119],"(Deming's":[120],"regression":[121],"correlation":[122],"0.92-1.00).":[124],"No":[125],"interferences":[126],"lipemia,":[128],"hyperbilirubinemia":[129],"hemolysis":[131],"found":[133],"on":[134],"CO-Oximetry":[135],"Fetal":[137],"hemoglobin":[138,153],">35%":[139],"overestimated":[140],"carboxyhemoglobin":[141],"measurements,":[142],"but":[143],"magnitude":[145],"error":[147],"reduced":[149],"fetal":[152],"correction":[154],"analysis":[155],"mode.":[156],"CONCLUSION:":[157],"analytical":[162],"performance":[163],"validated":[165],"parameters":[168],"accuracy":[171],"reliability":[174],"traditional":[176],"systems.":[177],"This":[178],"fulfills":[182],"most":[183],"requirements":[186],"both":[188],"point-of-care":[189],"use.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}