{"id":"https://openalex.org/W2012594301","doi":"https://doi.org/10.1016/j.amjhyper.2005.05.015","title":"Effects of Different Classes of Antihypertensive Drugs on Cerebral Hemodynamics in Elderly Hypertensive Patients","display_name":"Effects of Different Classes of Antihypertensive Drugs on Cerebral Hemodynamics in Elderly Hypertensive Patients","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W2012594301","doi":"https://doi.org/10.1016/j.amjhyper.2005.05.015","mag":"2012594301","pmid":"https://pubmed.ncbi.nlm.nih.gov/16364836"},"language":"en","primary_location":{"id":"doi:10.1016/j.amjhyper.2005.05.015","doi":"https://doi.org/10.1016/j.amjhyper.2005.05.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.amjhyper.2005.05.015","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113569692","display_name":"Chen\u2010Chung Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189772984","display_name":"Tzu Chi University","ror":"https://ror.org/04ss1bw11","country_code":"TW","type":"education","lineage":["https://openalex.org/I189772984"]},{"id":"https://openalex.org/I4405279312","display_name":"Dalin Tzu Chi Hospital","ror":"https://ror.org/019t5b256","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4405279312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C FU","raw_affiliation_strings":["Department of Neurology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan","Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan","institution_ids":["https://openalex.org/I4405279312"]},{"raw_affiliation_string":"Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan","institution_ids":["https://openalex.org/I189772984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C YANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189772984","display_name":"Tzu Chi University","ror":"https://ror.org/04ss1bw11","country_code":"TW","type":"education","lineage":["https://openalex.org/I189772984"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C YANG","raw_affiliation_strings":["Department of Physiology, Tzu Chi University, Hualien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Tzu Chi University, Hualien, Taiwan","institution_ids":["https://openalex.org/I189772984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037416995","display_name":"Terry B. J. Kuo","orcid":"https://orcid.org/0000-0002-7107-3632","observed_orcids":["https://orcid.org/0000-0002-7107-3632"]},"institutions":[{"id":"https://openalex.org/I189772984","display_name":"Tzu Chi University","ror":"https://ror.org/04ss1bw11","country_code":"TW","type":"education","lineage":["https://openalex.org/I189772984"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"T KUO","raw_affiliation_strings":["Institute of Neuroscience, Tzu Chi University, Hualien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, Tzu Chi University, Hualien, Taiwan","institution_ids":["https://openalex.org/I189772984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037416995"],"corresponding_institution_ids":["https://openalex.org/I189772984"],"apc_list":{"value":4814,"currency":"USD","value_usd":4814},"apc_paid":null,"fwci":1.8239,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.86099824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"12","first_page":"1621","last_page":"1625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.6762999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.6762999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.11400000005960464,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.11159999668598175,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cerebral-hemodynamics","display_name":"cerebral hemodynamics","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6340000033378601},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.8669999837875366},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":0.9819999933242798},{"id":"https://openalex.org/keywords/valsartan","display_name":"valsartan","score":1.0},{"id":"https://openalex.org/keywords/middle-cerebral-artery-blood-flow-velocity","display_name":"middle cerebral artery blood flow velocity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/arterial-pressure-variability","display_name":"arterial pressure variability","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cerebral-autoregulation","display_name":"cerebral autoregulation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/transfer-function","display_name":"transfer function","score":0.5580000281333923},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8889999985694885},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9594807624816895},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.607617199420929},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5347456336021423},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5154772400856018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4623609185218811},{"id":"https://openalex.org/C2780192228","wikidata":"https://www.wikidata.org/wiki/Q575890","display_name":"Antihypertensive drug","level":3,"score":0.41272130608558655}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017585","descriptor_name":"Ultrasonography, Doppler, Transcranial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.amjhyper.2005.05.015","doi":"https://doi.org/10.1016/j.amjhyper.2005.05.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.amjhyper.2005.05.015","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:16364836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16364836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hypertension","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W153726898","https://openalex.org/W233000153","https://openalex.org/W1613038030","https://openalex.org/W1952072642","https://openalex.org/W1967831718","https://openalex.org/W1984539868","https://openalex.org/W1990161569","https://openalex.org/W2012637857","https://openalex.org/W2014257401","https://openalex.org/W2015101674","https://openalex.org/W2015338439","https://openalex.org/W2045574892","https://openalex.org/W2057748612","https://openalex.org/W2059075478","https://openalex.org/W2062450504","https://openalex.org/W2088277908","https://openalex.org/W2095552123","https://openalex.org/W2101077152","https://openalex.org/W2113554954","https://openalex.org/W2137567147","https://openalex.org/W2142898179","https://openalex.org/W2145127893","https://openalex.org/W2147292818","https://openalex.org/W2166686247","https://openalex.org/W2185616468","https://openalex.org/W2277948595","https://openalex.org/W2412537759","https://openalex.org/W2416841880"],"related_works":["https://openalex.org/W4311798710","https://openalex.org/W2373890026","https://openalex.org/W2330324228","https://openalex.org/W4404327566","https://openalex.org/W3144779016","https://openalex.org/W2065822046","https://openalex.org/W2137567147","https://openalex.org/W123061629","https://openalex.org/W2475297341","https://openalex.org/W1991175418"],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1],"study":[2],"was":[3,110,175,208],"designed":[4],"to":[5,90,97,105,225,237,245],"estimate":[6],"the":[7,113,148,161,169,186,204,235,239],"effect":[8,236],"of":[9,12,31,39,66,160],"different":[10,124,133,167],"classes":[11],"antihypertensive":[13],"drugs":[14],"on":[15],"cerebral":[16,73,191,195,205,230,242],"hemodynamics":[17,109],"in":[18,147,158,179,200,211,241,250],"elderly":[19],"stroke-free,":[20],"nondiabetic":[21],"hypertensive":[22,33,202],"patients":[23,34],"by":[24,79,112],"applying":[25],"frequency-domain":[26],"techniques.":[27],"METHODS:":[28],"A":[29],"total":[30],"60":[32],"divided":[35],"into":[36,85],"treatment":[37],"groups":[38,153],"15":[40,43,49,53,57],"unmedicated":[41,201],"(HT),":[42],"nifedepine":[44],"sustained":[45],"release":[46],"form":[47],"(CCB),":[48],"atenolol":[50],"(BB),":[51],"and":[52,56,71,100,120,127,138,144,151,171,181,194,213,218,228],"valsartan":[54,219],"(AIIA),":[55],"age-matched":[58,251],"healthy":[59,252],"volunteers":[60],"(CON)":[61],"were":[62,83,122,154],"studied":[63],"prospectively.":[64],"Variability":[65],"arterial":[67],"blood":[68,196,231],"pressure":[69],"(ABP)":[70],"middle":[72],"artery":[74],"flow":[75,197],"velocity":[76],"(MCAFV)":[77],"detected":[78],"transcranial":[80],"Doppler":[81],"sonography":[82],"diffracted":[84],"very-low":[86],"frequency":[87,94,102],"(VLF,":[88],"0.016":[89],"0.04":[91,96],"Hz),":[92,99],"low":[93],"(LF,":[95],"0.15":[98,104],"high":[101],"(HF,":[103],"0.4":[106],"Hz).":[107],"Cerebral":[108],"quantified":[111],"ABP-MCAFV":[114],"transfer":[115,183],"function.":[116],"RESULTS:":[117],"The":[118,141],"ABP":[119,227],"MCAFV":[121],"statistically":[123,166],"between":[125,168],"CON":[126,162,172],"HT":[128],"groups,":[129],"but":[130,164],"not":[131,165],"significantly":[132,155],"among":[134,185],"CON,":[135],"CCB,":[136,150],"BB,":[137],"AIIA":[139,170],"groups.":[140,173,188],"LF":[142,182],"phase":[143],"HF":[145],"magnitude":[146,184],"HT,":[149],"BB":[152],"attenuated":[156],"than":[157],"those":[159],"group,":[163],"There":[174],"no":[176],"statistical":[177],"difference":[178],"VLF":[180],"five":[187],"CONCLUSIONS:":[189],"Although":[190],"vasomotor":[192,243],"reserve":[193,244],"are":[198,220],"impaired":[199],"patients,":[203],"autoregulatory":[206],"response":[207],"preserved":[209],"both":[210],"controlled":[212],"uncontrolled":[214],"hypertension.":[215],"Nifedipine,":[216],"atenolol,":[217],"all":[221],"effective":[222],"as":[223,249],"monotherapy":[224],"control":[226],"restore":[229],"flow.":[232],"Valsartan":[233],"has":[234],"normalize":[238],"changes":[240],"a":[246],"level":[247],"similar":[248],"subjects.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
