{"id":"https://openalex.org/W2012581004","doi":"https://doi.org/10.1046/j.1440-1827.2000.01085.x","title":"Immunohistochemical adrenomedullin expression is decreased in the placenta from pregnancies with pre\u2010eclampsia","display_name":"Immunohistochemical adrenomedullin expression is decreased in the placenta from pregnancies with pre\u2010eclampsia","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2012581004","doi":"https://doi.org/10.1046/j.1440-1827.2000.01085.x","mag":"2012581004","pmid":"https://pubmed.ncbi.nlm.nih.gov/10886735"},"language":"en","primary_location":{"id":"doi:10.1046/j.1440-1827.2000.01085.x","doi":"https://doi.org/10.1046/j.1440-1827.2000.01085.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1440-1827.2000.01085.x","pdf_url":null,"source":{"id":"https://openalex.org/S70002872","display_name":"Pathology International","issn_l":"1320-5463","issn":["1320-5463","1440-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112354973","display_name":"Kenji Kanenishi","orcid":"https://orcid.org/0009-0003-0076-0501","observed_orcids":["https://orcid.org/0009-0003-0076-0501"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kenji Kanenishi","raw_affiliation_strings":["Department of Perinatology, Kagawa Medical University, Kagawa, Japan. kane@kms.ac.jp","Departments of      Perinatology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Perinatology, Kagawa Medical University, Kagawa, Japan. kane@kms.ac.jp","institution_ids":[]},{"raw_affiliation_string":"Departments of      Perinatology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082991847","display_name":"Hiroko Kuwabara","orcid":"https://orcid.org/0000-0002-7043-8820","observed_orcids":["https://orcid.org/0000-0002-7043-8820"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroko Kuwabara","raw_affiliation_strings":["Pathology, Kagawa Medical University, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Kagawa Medical University, Kagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069584678","display_name":"Masaki Ueno","orcid":"https://orcid.org/0000-0003-1484-9921","observed_orcids":["https://orcid.org/0000-0003-1484-9921"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaki Ueno","raw_affiliation_strings":["Pathology, Kagawa Medical University, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Kagawa Medical University, Kagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111780969","display_name":"Haruhiko Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haruhiko Sakamoto","raw_affiliation_strings":["Pathology, Kagawa Medical University, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Kagawa Medical University, Kagawa, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077964650","display_name":"Toshiyuki Hata","orcid":"https://orcid.org/0000-0002-8835-8554","observed_orcids":["https://orcid.org/0000-0002-8835-8554"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiyuki Hata","raw_affiliation_strings":["Departments of Perinatology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Perinatology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112354973"],"corresponding_institution_ids":[],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":3.2312,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.90446965,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"50","issue":"7","first_page":"536","last_page":"540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenomedullin","display_name":"adrenomedullin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.9990000128746033},{"id":"https://openalex.org/keywords/syncytiotrophoblast","display_name":"syncytiotrophoblast","score":0.9829999804496765},{"id":"https://openalex.org/keywords/extravillous-trophoblast","display_name":"extravillous trophoblast","score":0.8159999847412109},{"id":"https://openalex.org/keywords/amniotic-membrane","display_name":"amniotic membrane","score":0.968999981880188},{"id":"https://openalex.org/keywords/normotensive-pregnancy","display_name":"normotensive pregnancy","score":0.6790000200271606},{"id":"https://openalex.org/keywords/trophoblast-function","display_name":"trophoblast function","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2777152744","wikidata":"https://www.wikidata.org/wiki/Q366935","display_name":"Adrenomedullin","level":3,"score":0.9427756071090698},{"id":"https://openalex.org/C2908795334","wikidata":"https://www.wikidata.org/wiki/Q2745412","display_name":"Syncytiotrophoblasts","level":5,"score":0.932539165019989},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.7658601999282837},{"id":"https://openalex.org/C2781276381","wikidata":"https://www.wikidata.org/wiki/Q552348","display_name":"Eclampsia","level":3,"score":0.7053543329238892},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6912205815315247},{"id":"https://openalex.org/C2780646683","wikidata":"https://www.wikidata.org/wiki/Q473749","display_name":"Amnion","level":4,"score":0.6141095161437988},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5178397297859192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5175132751464844},{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.5150437355041504},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4597305357456207},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33403319120407104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28554433584213257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2667561173439026},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.21708068251609802},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0823681652545929},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000650","descriptor_name":"Amnion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001724","descriptor_name":"Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053607","descriptor_name":"Adrenomedullin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1440-1827.2000.01085.x","doi":"https://doi.org/10.1046/j.1440-1827.2000.01085.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1440-1827.2000.01085.x","pdf_url":null,"source":{"id":"https://openalex.org/S70002872","display_name":"Pathology International","issn_l":"1320-5463","issn":["1320-5463","1440-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology International","raw_type":"journal-article"},{"id":"pmid:10886735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10886735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology international","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1983429038","https://openalex.org/W1983687348","https://openalex.org/W1994134980","https://openalex.org/W2006038273","https://openalex.org/W2013651340","https://openalex.org/W2023873458","https://openalex.org/W2051734083","https://openalex.org/W2060000931","https://openalex.org/W2075303460","https://openalex.org/W2092419989","https://openalex.org/W2104709132","https://openalex.org/W2111310677","https://openalex.org/W2142726621","https://openalex.org/W2161842193","https://openalex.org/W2167075086"],"related_works":["https://openalex.org/W7101164539","https://openalex.org/W2112280049","https://openalex.org/W2142726621","https://openalex.org/W2091806615","https://openalex.org/W2167727364","https://openalex.org/W2049046562","https://openalex.org/W2089080596","https://openalex.org/W2113070064","https://openalex.org/W2149114840","https://openalex.org/W7056660335"],"abstract_inverted_index":{"The":[0,40,74,102],"purpose":[1],"of":[2,42,51,56,59,65,76,142],"the":[3,54,57,80,128,140,154],"present":[4],"study":[5],"was":[6,47,72,87,113,145],"to":[7,63],"investigate":[8],"whether":[9],"placental":[10],"immunohistochemical":[11],"adrenomedullin":[12,43,77,143,151],"expression":[13,78,92,144],"in":[14,22,45,79,93,106,118,134,153,159],"normal":[15,32,121],"normotensive":[16,33,97,122],"pregnancies":[17,23,34,37,84,98,110,123,160],"is":[18,157],"different":[19],"from":[20,30,83,95,109,120],"that":[21,64,117,150],"with":[24,38,85,91,111,161],"pre-eclampsia.":[25,39,162],"Placental":[26],"tissues":[27],"were":[28],"obtained":[29,82,108],"seven":[31],"and":[35,53,130],"12":[36],"intensity":[41,75,141],"staining":[44],"syncytiotrophoblasts":[46,156],"evaluated":[48],"by":[49],"means":[50],"immunohistochemistry":[52],"ratio":[55,105],"number":[58],"intact":[60],"tertiary":[61,67],"villi":[62,68,70,104],"total":[66],"(intact/total":[69],"ratio)":[71],"determined.":[73],"placenta":[81],"pre-eclampsia":[86,112],"significantly":[88,114],"decreased":[89,158],"compared":[90],"placentas":[94,107,119],"uncomplicated":[96],"(P":[99,124],"<":[100,125],"0.005).":[101],"intact/total":[103],"lower":[115],"than":[116],"0.0001).":[126],"In":[127],"amnion":[129],"extravillous":[131],"trophoblast":[132],"cells":[133],"both":[135],"groups,":[136],"no":[137],"difference":[138],"for":[139],"noted.":[146],"These":[147],"results":[148],"suggest":[149],"synthesis":[152],"villous":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}