{"id":"https://openalex.org/W2012575201","doi":"https://doi.org/10.1021/bi00386a038","title":"Locus of a histidine-based, stable trifunctional, helix to helix collagen cross-link: stereospecific collagen structure of type I skin fibrils","display_name":"Locus of a histidine-based, stable trifunctional, helix to helix collagen cross-link: stereospecific collagen structure of type I skin fibrils","publication_year":1987,"publication_date":"1987-06-16","ids":{"openalex":"https://openalex.org/W2012575201","doi":"https://doi.org/10.1021/bi00386a038","mag":"2012575201","pmid":"https://pubmed.ncbi.nlm.nih.gov/3651393"},"language":"en","primary_location":{"id":"doi:10.1021/bi00386a038","doi":"https://doi.org/10.1021/bi00386a038","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00386a038","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014587054","display_name":"Gerald L. Mechanic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald L. Mechanic","raw_affiliation_strings":["Dental Research Center, University of North Carolina at Chapel Hill 27514"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dental Research Center, University of North Carolina at Chapel Hill 27514","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110425026","display_name":"Elton P. Katz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elton P. Katz","raw_affiliation_strings":["University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masayuki Henmi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masayuki Henmi","raw_affiliation_strings":["University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109204479","display_name":"Claudia M. Noyes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia Noyes","raw_affiliation_strings":["University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111520627","display_name":"Mitsuo Yamauchi","orcid":"https://orcid.org/0000-0003-4212-3992","observed_orcids":["https://orcid.org/0000-0003-4212-3992"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitsuo Yamauchi","raw_affiliation_strings":["University of Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.7193,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.96869245,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"12","first_page":"3500","last_page":"3509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-cross-linking","display_name":"collagen cross-linking","score":0.753000020980835},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cross-linked-peptides","display_name":"cross-linked peptides","score":0.5109999775886536},{"id":"https://openalex.org/keywords/collagen-microstructure","display_name":"collagen microstructure","score":0.35100001096725464},{"id":"https://openalex.org/keywords/tryptic-peptides","display_name":"tryptic peptides","score":0.5450000166893005},{"id":"https://openalex.org/keywords/bovine-skin","display_name":"bovine skin","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7465598583221436},{"id":"https://openalex.org/C142708767","wikidata":"https://www.wikidata.org/wiki/Q898597","display_name":"Cross-link","level":3,"score":0.5583027601242065},{"id":"https://openalex.org/C2779463914","wikidata":"https://www.wikidata.org/wiki/Q183309","display_name":"Guanidine","level":2,"score":0.5437728762626648},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.49535977840423584},{"id":"https://openalex.org/C2776661909","wikidata":"https://www.wikidata.org/wiki/Q419226","display_name":"Hydroxylysine","level":4,"score":0.4781516492366791},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.458382785320282},{"id":"https://openalex.org/C10919887","wikidata":"https://www.wikidata.org/wiki/Q7843514","display_name":"Triple helix","level":2,"score":0.444879412651062},{"id":"https://openalex.org/C147259501","wikidata":"https://www.wikidata.org/wiki/Q14864949","display_name":"Fibrillogenesis","level":3,"score":0.4419093728065491},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.438493549823761},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.43741580843925476},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.4261947274208069},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41612082719802856},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.2165965735912323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08714109659194946},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0829649269580841},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006901","descriptor_name":"Hydroxylysine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006901","descriptor_name":"Hydroxylysine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006901","descriptor_name":"Hydroxylysine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009646","descriptor_name":"Norleucine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009646","descriptor_name":"Norleucine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009646","descriptor_name":"Norleucine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00386a038","doi":"https://doi.org/10.1021/bi00386a038","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00386a038","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:3651393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3651393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2801035210","display_name":null,"funder_award_id":"AM-37604","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8177678308","display_name":"BIOCHEMISTRY OF AGING OF TISSUE MATRICES","funder_award_id":"5r01am030587-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8232377812","display_name":"PHYSIOLOGY AND CHEMISTRY OF BONE: VITAMIN D NUTRITION","funder_award_id":"5r01am019969-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1030517862","https://openalex.org/W1244582110","https://openalex.org/W1412091299","https://openalex.org/W1577805473","https://openalex.org/W1590096305","https://openalex.org/W1592055267","https://openalex.org/W1973168752","https://openalex.org/W1978741400","https://openalex.org/W1997272982","https://openalex.org/W2001581598","https://openalex.org/W2007822059","https://openalex.org/W2010197729","https://openalex.org/W2022007125","https://openalex.org/W2025150768","https://openalex.org/W2034275429","https://openalex.org/W2044316638","https://openalex.org/W2050592185","https://openalex.org/W2053287668","https://openalex.org/W2058549879","https://openalex.org/W2066403803","https://openalex.org/W2068731367","https://openalex.org/W2080887130","https://openalex.org/W2086887929","https://openalex.org/W2088195766","https://openalex.org/W2092015861","https://openalex.org/W2318715497"],"related_works":["https://openalex.org/W2038029092","https://openalex.org/W1572824320","https://openalex.org/W2149666293","https://openalex.org/W1851071080","https://openalex.org/W2406556736","https://openalex.org/W2083512365","https://openalex.org/W2014066098","https://openalex.org/W2078467681","https://openalex.org/W1997211019","https://openalex.org/W2042247357"],"abstract_inverted_index":{"The":[0,80,184,197],"loci":[1],"of":[2,45,66,88,96,109,121,138,164,195,199,213],"the":[3,15,63,78,86,89,101,110,116,122,127,139,143,157,161,174,210],"three":[4,123,193],"amino":[5],"acid":[6,57],"residues":[7],"that":[8,62,156,190],"contribute":[9],"their":[10],"prosthetic":[11,64],"groups":[12,65],"to":[13,84],"form":[14],"stable,":[16,90],"nonreducible,":[17],"trifunctional":[18,92,151],"intermolecular":[19,175],"cross-link":[20],"histidinohydroxylysinonorleucine":[21,32,191],"in":[22,177,205],"skin":[23,54,165,178,202],"collagen":[24,203],"fibrils":[25,179],"were":[26,35,39,98],"identified.":[27],"Two":[28],"apparently":[29],"homogeneous":[30],"three-chained":[31,102],"cross-linked":[33,111],"peptides":[34,103,124],"chromatographically":[36],"isolated.":[37],"They":[38],"obtained":[40],"from":[41],"a":[42,136,214],"tryptic":[43,112],"digest":[44],"denatured":[46],"unreduced":[47],"6":[48],"M":[49],"guanidine":[50],"hydrochloride":[51],"insoluble":[52],"bovine":[53],"collagen.":[55,196],"Amino":[56],"and":[58,73,119,166,173,208],"sequence":[59],"analyses":[60,97],"demonstrated":[61],"alpha":[67,70,74,144,162],"1(I)-chain":[68,71],"Hyl-87,":[69],"Lys-16c,":[72],"2(I)-chain":[75],"His-92":[76],"formed":[77],"cross-link.":[79,128],"latter":[81],"results":[82],"served":[83],"define":[85],"locus":[87,154],"nonreducible":[91],"moiety.":[93],"Identical":[94],"types":[95],"performed":[99],"on":[100],"isolated":[104],"after":[105],"bacterial":[106],"collagenase":[107],"digestion":[108],"peptides.":[113],"This":[114],"confirmed":[115],"initial":[117],"identification":[118],"location":[120],"linked":[125],"by":[126],"In":[129],"addition,":[130],"data":[131],"reported":[132],"here":[133],"provide":[134],"for":[135,142,182,201,218],"correction":[137],"micromolecular":[140],"structure":[141],"2(I)":[145],"chain.":[146],"Stereochemical":[147],"considerations":[148],"concerning":[149],"this":[150,219],"cross-link's":[152],"specific":[153,181],"indicate":[155,189],"steric":[158],"relationships":[159,176,187],"between":[160],"chains":[163],"skeletal":[167],"tissue":[168,220],"collagens":[169],"are":[170,180],"fundamentally":[171],"different":[172],"skin.":[183],"same":[185],"molecular":[186],"also":[188],"links":[192],"molecules":[194],"stereochemistry":[198],"cross-linking":[200],"is":[204],"accordance":[206],"with":[207],"explains":[209],"X-ray":[211],"findings":[212],"65-nm":[215],"periodicity":[216],"found":[217],"[Stinson,":[221],"R.":[222,227],"H.,":[223],"&":[224,239],"Sweeny,":[225],"P.":[226],"(1980)":[228,242],"Biochim.":[229,243],"Biophys.":[230,244],"Acta":[231,245],"621,":[232,246],"158;":[233],"Brodsky,":[234],"B.,":[235],"Eikenberry,":[236],"E.":[237],"F.,":[238],"Cassidy,":[240],"K.":[241],"162].":[247]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
