{"id":"https://openalex.org/W2012555900","doi":"https://doi.org/10.1063/1.3473936","title":"Single-molecule binding experiments on long time scales","display_name":"Single-molecule binding experiments on long time scales","publication_year":2010,"publication_date":"2010-08-01","ids":{"openalex":"https://openalex.org/W2012555900","doi":"https://doi.org/10.1063/1.3473936","mag":"2012555900","pmid":"https://pubmed.ncbi.nlm.nih.gov/20815611"},"language":"en","primary_location":{"id":"doi:10.1063/1.3473936","doi":"https://doi.org/10.1063/1.3473936","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.3473936","pdf_url":"https://aip.scitation.org/doi/pdf/10.1063/1.3473936","source":{"id":"https://openalex.org/S31010182","display_name":"Review of Scientific Instruments","issn_l":"0034-6748","issn":["0034-6748","1089-7623","1527-2400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Review of Scientific Instruments","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://aip.scitation.org/doi/pdf/10.1063/1.3473936","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071850568","display_name":"Mark P. Elenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark P. Elenko","raw_affiliation_strings":["Harvard Medical School 1 Program in Biological and Biomedical Sciences, , Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School 1 Program in Biological and Biomedical Sciences, , Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023274897","display_name":"Jack W. Szostak","orcid":"https://orcid.org/0000-0003-4131-1203","observed_orcids":["https://orcid.org/0000-0003-4131-1203"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack W. Szostak","raw_affiliation_strings":["Massachusetts General Hospital 2 Howard Hughes Medical Institute and Center for Computational and Integrative Biology, , Boston, Massachusetts 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital 2 Howard Hughes Medical Institute and Center for Computational and Integrative Biology, , Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915","https://openalex.org/I4405271026"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075591359","display_name":"Antoine M. van Oijen","orcid":"https://orcid.org/0000-0002-1794-5161","observed_orcids":["https://orcid.org/0000-0002-1794-5161"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antoine M. van Oijen","raw_affiliation_strings":["Harvard Medical School 3 Department of Biological Chemistry and Molecular Pharmacology, , Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School 3 Department of Biological Chemistry and Molecular Pharmacology, , Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9118,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.70438842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"81","issue":"8","first_page":"083705","last_page":"083705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-molecule-binding","display_name":"single-molecule binding","score":0.9789999723434448},{"id":"https://openalex.org/keywords/long-time-scales","display_name":"long time scales","score":0.5720000267028809},{"id":"https://openalex.org/keywords/total-internal-reflection-fluorescence-microscopy","display_name":"total internal reflection fluorescence microscopy","score":0.875},{"id":"https://openalex.org/keywords/ligand-binding-kinetics","display_name":"ligand binding kinetics","score":0.7310000061988831},{"id":"https://openalex.org/keywords/flow-cell","display_name":"flow cell","score":0.6600000262260437},{"id":"https://openalex.org/keywords/photodamage","display_name":"photodamage","score":0.6290000081062317},{"id":"https://openalex.org/keywords/photobleaching","display_name":"photobleaching","score":0.9919999837875366},{"id":"https://openalex.org/keywords/autofocus","display_name":"autofocus","score":0.7250000238418579},{"id":"https://openalex.org/keywords/image-stability","display_name":"image stability","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C31332276","wikidata":"https://www.wikidata.org/wiki/Q899750","display_name":"Photobleaching","level":3,"score":0.9065251350402832},{"id":"https://openalex.org/C121381206","wikidata":"https://www.wikidata.org/wiki/Q902514","display_name":"Total internal reflection fluorescence microscope","level":3,"score":0.6924484372138977},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5968836545944214},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5310930013656616},{"id":"https://openalex.org/C26659971","wikidata":"https://www.wikidata.org/wiki/Q729923","display_name":"Fluorescence recovery after photobleaching","level":3,"score":0.525894820690155},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5201500058174133},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.4740920960903168},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.45234787464141846},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.44745370745658875},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4369966983795166},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.43665042519569397},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3211062550544739},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26347559690475464},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1864842176437378},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038761","descriptor_name":"Photobleaching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1063/1.3473936","doi":"https://doi.org/10.1063/1.3473936","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.3473936","pdf_url":"https://aip.scitation.org/doi/pdf/10.1063/1.3473936","source":{"id":"https://openalex.org/S31010182","display_name":"Review of Scientific Instruments","issn_l":"0034-6748","issn":["0034-6748","1089-7623","1527-2400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Review of Scientific Instruments","raw_type":"journal-article"},{"id":"pmid:20815611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20815611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Review of scientific instruments","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/5797f18b-96f2-4705-b5c4-18599ad7da4c","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/5797f18b-96f2-4705-b5c4-18599ad7da4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Elenko, M P, Szostak, J W & van Oijen, A M 2010, 'Single-molecule binding experiments on long time scales', Review of Scientific Instruments, vol. 81, no. 8, 083705, pp. 083705-1-083705-9. https://doi.org/10.1063/1.3473936","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ro.uow.edu.au:smhpapers-3214","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/smhpapers/2196","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Science, Medicine and Health - Papers: part A","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/27761370","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Single-molecule_binding_experiments_on_long_time_scales/27761370","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:rug:oai:pure.rug.nl:publications/5797f18b-96f2-4705-b5c4-18599ad7da4c","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/5797f18b-96f2-4705-b5c4-18599ad7da4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Review of Scientific Instruments, 81(8):083705. AMER INST PHYSICS","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1063/1.3473936","doi":"https://doi.org/10.1063/1.3473936","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.3473936","pdf_url":"https://aip.scitation.org/doi/pdf/10.1063/1.3473936","source":{"id":"https://openalex.org/S31010182","display_name":"Review of Scientific Instruments","issn_l":"0034-6748","issn":["0034-6748","1089-7623","1527-2400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Review of Scientific Instruments","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012555900.pdf","grobid_xml":"https://content.openalex.org/works/W2012555900.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1557714923","https://openalex.org/W1669383326","https://openalex.org/W1967501837","https://openalex.org/W1970611074","https://openalex.org/W1982538875","https://openalex.org/W1987864397","https://openalex.org/W1988503669","https://openalex.org/W1998645090","https://openalex.org/W2008101695","https://openalex.org/W2015404233","https://openalex.org/W2019309102","https://openalex.org/W2027836552","https://openalex.org/W2029146642","https://openalex.org/W2033788106","https://openalex.org/W2045058197","https://openalex.org/W2051489942","https://openalex.org/W2060177604","https://openalex.org/W2066997160","https://openalex.org/W2070234025","https://openalex.org/W2079991169","https://openalex.org/W2106395637","https://openalex.org/W2106769579","https://openalex.org/W2108167818","https://openalex.org/W2131448623","https://openalex.org/W2139304310","https://openalex.org/W2142337964","https://openalex.org/W2149005864","https://openalex.org/W2155748850","https://openalex.org/W4308665337"],"related_works":["https://openalex.org/W2746527005","https://openalex.org/W4285795606","https://openalex.org/W1991119712","https://openalex.org/W2074507206","https://openalex.org/W2002807517","https://openalex.org/W1997689148","https://openalex.org/W2347183264","https://openalex.org/W2298095968","https://openalex.org/W3184453886","https://openalex.org/W4297971198"],"abstract_inverted_index":{"We":[0],"describe":[1],"an":[2,53],"approach":[3],"for":[4,17,96],"performing":[5],"single-molecule":[6,29],"binding":[7,41],"experiments":[8,59],"on":[9],"time":[10],"scales":[11],"from":[12],"hours":[13],"to":[14,38,45,49,87,94],"days,":[15],"allowing":[16],"the":[18,40,50],"observation":[19],"of":[20,42,52,73,85],"slower":[21],"kinetics":[22],"than":[23],"have":[24],"been":[25],"previously":[26],"investigated":[27],"by":[28,62],"techniques.":[30],"Total":[31],"internal":[32],"reflection":[33],"fluorescence":[34],"microscopy":[35],"is":[36],"used":[37],"image":[39,69],"labeled":[43],"ligand":[44],"molecules":[46],"specifically":[47],"coupled":[48],"surface":[51],"optically":[54],"transparent":[55],"flow":[56],"cell.":[57],"Long-duration":[58],"are":[60],"enabled":[61],"ensuring":[63],"sufficient":[64],"positional,":[65],"chemical,":[66],"thermal,":[67],"and":[68,82,90,92],"stability.":[70],"Principal":[71],"components":[72],"this":[74],"experimental":[75],"stability":[76],"include":[77],"illumination":[78],"timing,":[79],"solution":[80,86],"replacement,":[81],"chemical":[83],"treatment":[84],"reduce":[88],"photodamage":[89],"photobleaching;":[91],"autofocusing":[93],"correct":[95],"spatial":[97],"drift.":[98]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
