{"id":"https://openalex.org/W2012543857","doi":"https://doi.org/10.1016/j.bpj.2011.11.372","title":"Crossing the Entropic Barrier to Coupled Folding and Binding","display_name":"Crossing the Entropic Barrier to Coupled Folding and Binding","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2012543857","doi":"https://doi.org/10.1016/j.bpj.2011.11.372","mag":"2012543857"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2011.11.372","doi":"https://doi.org/10.1016/j.bpj.2011.11.372","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2011.11.372","pdf_url":"http://www.cell.com/article/S0006349511017206/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349511017206/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012757416","display_name":"Wade M. Borcherds","orcid":"https://orcid.org/0000-0003-3459-4014","observed_orcids":["https://orcid.org/0000-0003-3459-4014"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wade M. Borcherds","raw_affiliation_strings":["University of South Florida, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061430976","display_name":"Gary W. Daughdrill","orcid":"https://orcid.org/0000-0001-5655-6559","observed_orcids":["https://orcid.org/0000-0001-5655-6559"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary W. Daughdrill","raw_affiliation_strings":["Center for Drug Design and Innovation, Tampa, FL, USA","University of South Florida, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Design and Innovation, Tampa, FL, USA","institution_ids":[]},{"raw_affiliation_string":"University of South Florida, Tampa, FL, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041459955","display_name":"Katie M. Mishall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katie Mishall","raw_affiliation_strings":["Center for Drug Design and Innovation, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Design and Innovation, Tampa, FL, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103039051","display_name":"Hongwei Wu","orcid":"https://orcid.org/0000-0002-8687-3843","observed_orcids":["https://orcid.org/0000-0002-8687-3843"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongwei Wu","raw_affiliation_strings":["Center for Drug Design and Innovation, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Design and Innovation, Tampa, FL, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0869687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"102","issue":"3","first_page":"62a","last_page":"63a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.9300000071525574},{"id":"https://openalex.org/keywords/coupled-folding-and-binding","display_name":"coupled folding and binding","score":0.9539999961853027},{"id":"https://openalex.org/keywords/conformational-entropy","display_name":"conformational entropy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/entropic-barrier","display_name":"entropic barrier","score":0.8500000238418579},{"id":"https://openalex.org/keywords/induced-folding","display_name":"induced folding","score":0.8539999723434448},{"id":"https://openalex.org/keywords/conformational-selection","display_name":"conformational selection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p53-transactivation-domain","display_name":"p53 transactivation domain","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mdmx","display_name":"MDMX","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8330000042915344},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C69308434","wikidata":"https://www.wikidata.org/wiki/Q5160266","display_name":"Conformational entropy","level":3,"score":0.7425586581230164},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.6444947719573975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6078743934631348},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5952733755111694},{"id":"https://openalex.org/C2777936996","wikidata":"https://www.wikidata.org/wiki/Q17148461","display_name":"Conformational ensembles","level":3,"score":0.5109354853630066},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.4931001365184784},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4813862144947052},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.46059879660606384},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4564597010612488},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.45367735624313354},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.4512060880661011},{"id":"https://openalex.org/C2777221213","wikidata":"https://www.wikidata.org/wiki/Q10322346","display_name":"MDMX","level":4,"score":0.4179019033908844},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4139559864997864},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3787267506122589},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3400711417198181},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27599823474884033},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.21779045462608337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19386041164398193},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.09502321481704712},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09018361568450928},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2011.11.372","doi":"https://doi.org/10.1016/j.bpj.2011.11.372","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2011.11.372","pdf_url":"http://www.cell.com/article/S0006349511017206/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2011.11.372","doi":"https://doi.org/10.1016/j.bpj.2011.11.372","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2011.11.372","pdf_url":"http://www.cell.com/article/S0006349511017206/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2012543857.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3006388201","https://openalex.org/W1993422461","https://openalex.org/W4211263644","https://openalex.org/W2058125583","https://openalex.org/W2904255358","https://openalex.org/W2912317068","https://openalex.org/W4234629063","https://openalex.org/W2912271084","https://openalex.org/W2461221920","https://openalex.org/W1490594935"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
