{"id":"https://openalex.org/W2012521937","doi":"https://doi.org/10.4103/2230-8598.153828","title":"Critical analysis of antimicrobial and respiratory fixed dose combinations available in Indian market","display_name":"Critical analysis of antimicrobial and respiratory fixed dose combinations available in Indian market","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2012521937","doi":"https://doi.org/10.4103/2230-8598.153828","mag":"2012521937"},"language":"en","primary_location":{"id":"doi:10.4103/2230-8598.153828","doi":"https://doi.org/10.4103/2230-8598.153828","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2230-8598.153828","pdf_url":"http://ijmedph.org/sites/default/files/IntJMedPublicHealth_2015_5_2_161_153828.pdf","source":{"id":"https://openalex.org/S2764905145","display_name":"International Journal of Medicine and Public Health","issn_l":"2230-8598","issn":["2230-8598","3033-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medicine and Public Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://ijmedph.org/sites/default/files/IntJMedPublicHealth_2015_5_2_161_153828.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112248129","display_name":"Samidh Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260799","display_name":"GCS Medical College","ror":"https://ror.org/049s68q83","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210089564","https://openalex.org/I4405260799"]},{"id":"https://openalex.org/I64157871","display_name":"B.J. Medical College","ror":"https://ror.org/0408b4j80","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I64157871"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Samidh Shah","raw_affiliation_strings":["GCS Medical College , Ahmedabad , Gujarat , India","Department of Pharmacology, B. J. Medical College, Ahmedabad Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GCS Medical College , Ahmedabad , Gujarat , India","institution_ids":["https://openalex.org/I4405260799"]},{"raw_affiliation_string":"Department of Pharmacology, B. J. Medical College, Ahmedabad Gujarat, India","institution_ids":["https://openalex.org/I64157871"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jignesh Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260799","display_name":"GCS Medical College","ror":"https://ror.org/049s68q83","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210089564","https://openalex.org/I4405260799"]},{"id":"https://openalex.org/I64157871","display_name":"B.J. Medical College","ror":"https://ror.org/0408b4j80","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I64157871"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jignesh Patel","raw_affiliation_strings":["GCS Medical College , Ahmedabad , Gujarat , India","Department of Pharmacology, B. J. Medical College, Ahmedabad Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GCS Medical College , Ahmedabad , Gujarat , India","institution_ids":["https://openalex.org/I4405260799"]},{"raw_affiliation_string":"Department of Pharmacology, B. J. Medical College, Ahmedabad Gujarat, India","institution_ids":["https://openalex.org/I64157871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048437237","display_name":"Mira K. Desai","orcid":"https://orcid.org/0000-0002-2337-5783","observed_orcids":["https://orcid.org/0000-0002-2337-5783"]},"institutions":[{"id":"https://openalex.org/I4405260799","display_name":"GCS Medical College","ror":"https://ror.org/049s68q83","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210089564","https://openalex.org/I4405260799"]},{"id":"https://openalex.org/I64157871","display_name":"B.J. Medical College","ror":"https://ror.org/0408b4j80","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I64157871"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mira Desai","raw_affiliation_strings":["GCS Medical College , Ahmedabad , Gujarat , India","Department of Pharmacology, B. J. Medical College, Ahmedabad Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GCS Medical College , Ahmedabad , Gujarat , India","institution_ids":["https://openalex.org/I4405260799"]},{"raw_affiliation_string":"Department of Pharmacology, B. J. Medical College, Ahmedabad Gujarat, India","institution_ids":["https://openalex.org/I64157871"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111564911","display_name":"RK Dikshit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260799","display_name":"GCS Medical College","ror":"https://ror.org/049s68q83","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210089564","https://openalex.org/I4405260799"]},{"id":"https://openalex.org/I64157871","display_name":"B.J. Medical College","ror":"https://ror.org/0408b4j80","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I64157871"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"RK Dikshit","raw_affiliation_strings":["Department of Pharmacology , B.J. Medical College , Ahmedabad - 380 016 , Gujarat , India","Department of Pharmacology , B.J. Medical College , Department of Pharmacology ,","Department of Pharmacology, GCS Medical College, Ahmedabad, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , B.J. Medical College , Ahmedabad - 380 016 , Gujarat , India","institution_ids":["https://openalex.org/I64157871"]},{"raw_affiliation_string":"Department of Pharmacology , B.J. Medical College , Department of Pharmacology ,","institution_ids":["https://openalex.org/I64157871"]},{"raw_affiliation_string":"Department of Pharmacology, GCS Medical College, Ahmedabad, Gujarat, India","institution_ids":["https://openalex.org/I4405260799"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.653,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78607969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"5","issue":"2","first_page":"161","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.04969999939203262,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":0.04450000077486038,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rational-drug-use","display_name":"rational drug use","score":0.7129999995231628},{"id":"https://openalex.org/keywords/who-model-list-of-essential-medicines","display_name":"WHO Model List of Essential Medicines","score":0.7760000228881836},{"id":"https://openalex.org/keywords/antiretroviral-drugs","display_name":"antiretroviral drugs","score":0.7540000081062317},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pharmacodynamic-interactions","display_name":"pharmacodynamic interactions","score":0.7089999914169312},{"id":"https://openalex.org/keywords/indian-pharmaceutical-market","display_name":"Indian pharmaceutical market","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7736837863922119},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4912497401237488},{"id":"https://openalex.org/C2777012970","wikidata":"https://www.wikidata.org/wiki/Q2659932","display_name":"Respiratory Medicine","level":2,"score":0.44662410020828247},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4379025995731354},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3222087323665619},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.14502087235450745},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4103/2230-8598.153828","doi":"https://doi.org/10.4103/2230-8598.153828","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2230-8598.153828","pdf_url":"http://ijmedph.org/sites/default/files/IntJMedPublicHealth_2015_5_2_161_153828.pdf","source":{"id":"https://openalex.org/S2764905145","display_name":"International Journal of Medicine and Public Health","issn_l":"2230-8598","issn":["2230-8598","3033-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medicine and Public Health","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4103/2230-8598.153828","doi":"https://doi.org/10.4103/2230-8598.153828","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2230-8598.153828","pdf_url":"http://ijmedph.org/sites/default/files/IntJMedPublicHealth_2015_5_2_161_153828.pdf","source":{"id":"https://openalex.org/S2764905145","display_name":"International Journal of Medicine and Public Health","issn_l":"2230-8598","issn":["2230-8598","3033-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medicine and Public Health","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012521937.pdf","grobid_xml":"https://content.openalex.org/works/W2012521937.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1563752259","https://openalex.org/W2006393942","https://openalex.org/W2092568595","https://openalex.org/W2108937333","https://openalex.org/W2118316408","https://openalex.org/W2339645792","https://openalex.org/W2418678983"],"related_works":["https://openalex.org/W4213414037","https://openalex.org/W3118142967","https://openalex.org/W4200624212","https://openalex.org/W2337857141","https://openalex.org/W7203975970","https://openalex.org/W4285206566","https://openalex.org/W1563752259","https://openalex.org/W2187349632","https://openalex.org/W2952588936","https://openalex.org/W2520013892"],"abstract_inverted_index":{"Critical":[0],"analysis":[1],"of":[2,17,62,83,95,152,164,172,185,205,225,243,253,266,285],"antimicrobial":[3,18],"and":[4,20,32,35,44,90,93,111,126,138,161,198,245,269,278,292],"respiratory":[5,21],"fixed":[6],"dose":[7,25],"combinations":[8,26],"available":[9,28],"in":[10,29,39,71,168,256],"Indian":[11,30,40,257],"marketObjective:":[12],"To":[13],"analyze":[14],"the":[15,122,206,286],"rationality":[16,143],"(AM)":[19],"(RP)":[22],"fi":[23],"xed":[24],"(FDCs)":[27],"market.Materials":[31],"Methods:":[33],"Antimicrobial":[34],"RP":[36,187,215,246],"FDCs":[37,153,209,216,227,247,255,268],"enlisted":[38],"Drug":[41],"Review":[42],"2010":[43],"2013":[45],"respectively":[46],"were":[47,98,136,140,154,159,166,178,183,191,196,210,217,228],"analyzed":[48,99],"by":[49,67,100],"a":[50,250,263,282],"pretested":[51],"validated":[52],"8":[53],"point":[54],"criteria":[55],"tool.Each":[56],"FDC":[57,97],"was":[58,106,124,129,145],"assessed":[59],"for":[60,109,114,121,219,262,289],"number":[61,252],"active":[63],"pharmacological":[64],"ingredients,":[65],"approval":[66],"regulatory":[68,287],"authority,":[69],"listing":[70],"World":[72],"Health":[73],"Organization":[74],"(WHO)":[75],"essential":[76],"medicine":[77],"list":[78],"(EML)":[79],"or":[80,116],"National":[81],"List":[82],"Essential":[84],"Medicine.While":[85],"effi":[86],"cacy,":[87],"safety,":[88],"pharmacokinetic":[89],"pharmacodynamic":[91,203],"interactions":[92],"advantages":[94],"each":[96],"evidence":[101],"based":[102],"literature":[103],"search.Each":[104],"criterion":[105],"scored":[107],"one":[108,113],"positive":[110],"minus":[112],"negative":[115],"unfavorable":[117,202],"observation.The":[118],"total":[119],"score":[120,127,144],"tool":[123],"12":[125,163],"\u22657":[128],"considered":[130],"rational.Results:":[131],"Of":[132],"209":[133],"FDCs,":[134,175,188],"108":[135,173],"AMs":[137],"101":[139,186],"RPs.The":[141],"mean":[142],"5.41":[146],"\u00b1":[147],"1.63":[148],"(95%":[149],"CI,":[150],"2.15-8.67).Majority":[151],"irrational":[155,197,226],"(174)":[156],"while":[157,180,193,214],"35":[158],"rational,":[160],"only":[162],"these":[165,254],"listed":[167],"WHO":[169],"EML":[170],"2013.Out":[171],"AM":[174,208,229,244],"21":[176],"(19%)":[177],"rational":[179,192,207],"87":[181,194],"(81%)":[182],"irrational.Out":[184],"14":[189],"(14%)":[190],"(86%)":[195],"24":[199],"(24%)":[200],"with":[201,275],"interactions.Majority":[204],"antiretroviral":[211],"(6)":[212],"agents":[213],"indicated":[218],"chronic":[220],"obstructive":[221],"pulmonary":[222],"diseases.While":[223],"majority":[224],"plus":[230,235],"steroids,":[231],"\u03b2":[232],"2":[233],"agonists":[234],"antihistaminics/expectorants/anticholinergics/mast":[236],"cell":[237],"stabilizers/leukotriene":[238],"receptor":[239],"antagonists.Conclusion:":[240],"Rationality":[241],"assessment":[242],"reveals":[248],"that":[249],"substantial":[251],"market":[258],"are":[259],"irrational.This":[260],"calls":[261],"close":[264],"scrutiny":[265],"marketed":[267],"educating":[270],"prescribers":[271],"to":[272],"use":[273],"them":[274],"great":[276],"care":[277],"caution.This":[279],"also":[280],"indicates":[281],"serious":[283],"review":[284],"framework":[288],"drug":[290],"manufacturing":[291],"marketing.":[293]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}