{"id":"https://openalex.org/W2012512419","doi":"https://doi.org/10.1002/ajh.2830280403","title":"Physiologic formation of intracellular vesicles in mature erythrocytes","display_name":"Physiologic formation of intracellular vesicles in mature erythrocytes","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W2012512419","doi":"https://doi.org/10.1002/ajh.2830280403","mag":"2012512419","pmid":"https://pubmed.ncbi.nlm.nih.gov/3414669"},"language":"en","primary_location":{"id":"doi:10.1002/ajh.2830280403","doi":"https://doi.org/10.1002/ajh.2830280403","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajh.2830280403","pdf_url":null,"source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062479670","display_name":"Richard H. Sills","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard H. Sills","raw_affiliation_strings":["Department of Pediatrics, School of Medicine, State University of New York, Children's Hospital of Buffalo 14222"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, State University of New York, Children's Hospital of Buffalo 14222","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010148608","display_name":"Judith H. Tamburlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith H. Tamburlin","raw_affiliation_strings":["Department of Anatomy, School of Medicine, State University of New York at Buffalo, Children's Hospital of Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Medicine, State University of New York at Buffalo, Children's Hospital of Buffalo","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003132037","display_name":"Nilka J. Barrios","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nilka J. Barrios","raw_affiliation_strings":["Department of Pediatrics, School of Medicine, State University of New York at Buffalo, Children's Hospital of Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, State University of New York at Buffalo, Children's Hospital of Buffalo","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049880042","display_name":"Philip L. Y\u00e8agle","orcid":"https://orcid.org/0000-0003-4157-8506","observed_orcids":["https://orcid.org/0000-0003-4157-8506"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip L. Yeagle","raw_affiliation_strings":["Department of Biochemistry, School of Medicine, State University of New York at Buffalo, Children's Hospital of Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, State University of New York at Buffalo, Children's Hospital of Buffalo","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006840231","display_name":"Chester A. Glomski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chester A. Glomski","raw_affiliation_strings":["Department of Anatomy, School of Medicine, State University of New York at Buffalo, Children's Hospital of Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Medicine, State University of New York at Buffalo, Children's Hospital of Buffalo","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062479670"],"corresponding_institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I63190737"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":0.6092,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71838341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"28","issue":"4","first_page":"219","last_page":"226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.053199999034404755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spontaneous-vesicle-formation","display_name":"spontaneous vesicle formation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/in-vitro-incubation","display_name":"in vitro incubation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/autologous-plasma","display_name":"autologous plasma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/erythrocyte-membrane","display_name":"erythrocyte membrane","score":0.5350000262260437},{"id":"https://openalex.org/keywords/erythrocyte-aging","display_name":"erythrocyte aging","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.9016985297203064},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.8867074251174927},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6634430289268494},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6623077392578125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4513890743255615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4321443736553192},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41368556022644043},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.41030097007751465},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4024590849876404},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39836233854293823},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.20099997520446777},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013156","descriptor_name":"Splenectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ajh.2830280403","doi":"https://doi.org/10.1002/ajh.2830280403","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajh.2830280403","pdf_url":null,"source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},{"id":"pmid:3414669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3414669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332641","display_name":"University at Buffalo","ror":"https://ror.org/01y64my43"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W129983935","https://openalex.org/W130553179","https://openalex.org/W182565305","https://openalex.org/W1542927610","https://openalex.org/W1608551040","https://openalex.org/W1975788090","https://openalex.org/W2002717668","https://openalex.org/W2004732678","https://openalex.org/W2016048209","https://openalex.org/W2018824043","https://openalex.org/W2019126938","https://openalex.org/W2022818138","https://openalex.org/W2026671832","https://openalex.org/W2027580829","https://openalex.org/W2029739196","https://openalex.org/W2030575274","https://openalex.org/W2043351401","https://openalex.org/W2049097722","https://openalex.org/W2061568699","https://openalex.org/W2067512827","https://openalex.org/W2070401635","https://openalex.org/W2077640216","https://openalex.org/W2091247709","https://openalex.org/W2094886333","https://openalex.org/W2109401564","https://openalex.org/W2126619595","https://openalex.org/W2318709867","https://openalex.org/W2409554838","https://openalex.org/W2410623295","https://openalex.org/W4230880527","https://openalex.org/W4245850932"],"related_works":["https://openalex.org/W1993925547","https://openalex.org/W7133204951","https://openalex.org/W2050532025","https://openalex.org/W2020067536","https://openalex.org/W1979526068","https://openalex.org/W1496092396","https://openalex.org/W2416336314","https://openalex.org/W2041420683","https://openalex.org/W3091128872","https://openalex.org/W2016294755"],"abstract_inverted_index":{"The":[0,98,117],"ability":[1,135],"of":[2,35,61,66,86,90,100,119,136],"mature":[3,31,137],"erythrocytes":[4,32,42,67,91,138],"to":[5,28,113,139],"spontaneously":[6,36,140],"form":[7,141],"intracellular":[8,38,69,84,142],"vesicles":[9,70,110,143],"has":[10,17],"been":[11,19],"implied":[12],"from":[13],"clinical":[14],"studies":[15,81],"but":[16],"not":[18],"examined":[20],"experimentally.":[21],"An":[22],"in":[23,45,54,92,103,122,125,130],"vitro":[24,46,126,131],"model":[25,132],"was":[26,105],"developed":[27,68],"demonstrate":[29],"whether":[30],"are":[33],"capable":[34],"forming":[37],"vesicles.":[39,88],"Normal":[40],"human":[41],"were":[43,72,127],"incubated":[44],"at":[47],"37":[48],"degrees":[49],"C":[50],"for":[51],"144":[52],"hr":[53],"a":[55,152],"synthetic":[56],"medium.":[57],"During":[58],"the":[59,83,134,147],"course":[60],"these":[62,87],"incubations,":[63],"approximately":[64],"4%":[65],"which":[71],"quantitated":[73],"by":[74,107],"using":[75],"interference":[76],"contrast":[77],"microscopy.":[78],"Electron":[79],"microscopic":[80],"confirmed":[82],"nature":[85],"Incubation":[89],"autologous":[93],"plasma":[94],"produced":[95],"similar":[96],"results.":[97],"rate":[99],"vesicle":[101,120],"acquisition":[102,121],"vivo":[104,123],"measured":[106],"quantitating":[108],"erythrocyte":[109],"immediately":[111],"prior":[112],"and":[114,124,144],"following":[115],"splenectomy.":[116],"rates":[118],"comparable.":[128],"This":[129],"confirms":[133],"strongly":[145],"supports":[146],"concept":[148],"that":[149],"this":[150],"is":[151],"physiologic":[153],"process.":[154]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}