{"id":"https://openalex.org/W2012509066","doi":"https://doi.org/10.1006/abbi.1999.1309","title":"Highly Efficient Inhibition of Human Chymase by \u03b1(2)-Macroglobulin","display_name":"Highly Efficient Inhibition of Human Chymase by \u03b1(2)-Macroglobulin","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2012509066","doi":"https://doi.org/10.1006/abbi.1999.1309","mag":"2012509066","pmid":"https://pubmed.ncbi.nlm.nih.gov/10441378"},"language":"en","primary_location":{"id":"doi:10.1006/abbi.1999.1309","doi":"https://doi.org/10.1006/abbi.1999.1309","is_oa":true,"landing_page_url":"https://doi.org/10.1006/abbi.1999.1309","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1006/abbi.1999.1309","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030896556","display_name":"Michele Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele Walter","raw_affiliation_strings":["Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA","Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085749423","display_name":"Renee M. Sutton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee M. Sutton","raw_affiliation_strings":["Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000644404","display_name":"Norman M. Schechter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Norman M. Schechter","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, 19104","Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000644404"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":{"value":3170,"currency":"USD","value_usd":3170},"fwci":0.6174,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.64172462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"368","issue":"2","first_page":"276","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-chymase","display_name":"human chymase","score":0.8370000123977661},{"id":"https://openalex.org/keywords/alpha-2-macroglobulin","display_name":"alpha2-macroglobulin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/protease-inhibition","display_name":"protease inhibition","score":0.8980000019073486},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.6880000233650208},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.628000020980835},{"id":"https://openalex.org/keywords/inhibition-kinetics","display_name":"inhibition kinetics","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2780614898","wikidata":"https://www.wikidata.org/wiki/Q5118578","display_name":"Chymase","level":3,"score":0.9078614711761475},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6854415535926819},{"id":"https://openalex.org/C52543561","wikidata":"https://www.wikidata.org/wiki/Q22680187","display_name":"alpha-2-Macroglobulin","level":3,"score":0.6775819063186646},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.5285709500312805},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.5157983303070068},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4664003252983093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45543181896209717},{"id":"https://openalex.org/C2781054842","wikidata":"https://www.wikidata.org/wiki/Q6725283","display_name":"Macroglobulin","level":2,"score":0.4370492696762085},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36734384298324585},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31699931621551514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20434266328811646},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000511","descriptor_name":"alpha-Macroglobulins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000511","descriptor_name":"alpha-Macroglobulins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000511","descriptor_name":"alpha-Macroglobulins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053818","descriptor_name":"Chymases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053818","descriptor_name":"Chymases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053818","descriptor_name":"Chymases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/abbi.1999.1309","doi":"https://doi.org/10.1006/abbi.1999.1309","is_oa":true,"landing_page_url":"https://doi.org/10.1006/abbi.1999.1309","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:10441378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10441378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1006/abbi.1999.1309","doi":"https://doi.org/10.1006/abbi.1999.1309","is_oa":true,"landing_page_url":"https://doi.org/10.1006/abbi.1999.1309","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.46000000834465027}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W626936574","https://openalex.org/W627627490","https://openalex.org/W1494869776","https://openalex.org/W1495275626","https://openalex.org/W1499789973","https://openalex.org/W1501230571","https://openalex.org/W1514143259","https://openalex.org/W1517709540","https://openalex.org/W1521804991","https://openalex.org/W1549183351","https://openalex.org/W1558266500","https://openalex.org/W1563535758","https://openalex.org/W1572914688","https://openalex.org/W1576487122","https://openalex.org/W1577742891","https://openalex.org/W1582826730","https://openalex.org/W1588568089","https://openalex.org/W1596543212","https://openalex.org/W1596762880","https://openalex.org/W1668617342","https://openalex.org/W1963801658","https://openalex.org/W1964861161","https://openalex.org/W1971379065","https://openalex.org/W1973909424","https://openalex.org/W1983562760","https://openalex.org/W1989119669","https://openalex.org/W1990383981","https://openalex.org/W1993585253","https://openalex.org/W1997944666","https://openalex.org/W2011345555","https://openalex.org/W2020553724","https://openalex.org/W2021535100","https://openalex.org/W2029481246","https://openalex.org/W2045937234","https://openalex.org/W2048012249","https://openalex.org/W2051988900","https://openalex.org/W2059412957","https://openalex.org/W2062110544","https://openalex.org/W2064137749","https://openalex.org/W2073283337","https://openalex.org/W2107873069","https://openalex.org/W2125748383","https://openalex.org/W2140861587","https://openalex.org/W2143658570","https://openalex.org/W2145210692","https://openalex.org/W2150403127","https://openalex.org/W2169218929","https://openalex.org/W2196966592","https://openalex.org/W2325551892","https://openalex.org/W2337972822","https://openalex.org/W2401278843","https://openalex.org/W2439236530"],"related_works":["https://openalex.org/W1549183351","https://openalex.org/W3039909536","https://openalex.org/W2164856097","https://openalex.org/W2081278774","https://openalex.org/W2946365635","https://openalex.org/W1980868518","https://openalex.org/W1790158792","https://openalex.org/W2418426864","https://openalex.org/W2073283337","https://openalex.org/W1552247526"],"abstract_inverted_index":{"The":[0,79,107],"inhibition":[1,85,111,138],"of":[2,14,26,32,39,46,53,63,73,102,118,137,158],"human":[3,159],"chymase":[4,15,103],"by":[5,116,123],"the":[6,40,64,95,135,156],"protease":[7,100],"inhibitor":[8,101,152],"alpha(2)-macroglobulin":[9],"(alpha2M)":[10],"was":[11,35,87,112],"investigated.":[12],"Titration":[13],"hydrolytic":[16],"activity":[17],"with":[18,37,69],"purified":[19],"alpha2M":[20,27,41,55,67,94,148],"showed":[21],"that":[22,126,147],"approximately":[23,114],"1":[24,30],"mol":[25,31],"tetramer":[28],"inhibits":[29],"chymase.":[33,78,129,160],"Inhibition":[34],"associated":[36],"cleavage":[38,57],"bait":[42,65],"region":[43],"and":[44,61],"formation":[45],"a":[47,120],"200-kDa":[48],"covalent":[49,141],"complex.":[50],"NH(2)-terminal":[51],"sequencing":[52],"chymase-treated":[54],"revealed":[56],"at":[58],"bonds":[59],"Phe684-Tyr685":[60],"Tyr685-Glu686":[62],"region.":[66],"pretreated":[68],"methylamine,":[70],"an":[71,150],"inactivator":[72],"alpha2M,":[74],"did":[75,131],"not":[76,132],"inhibit":[77],"apparent":[80],"second-order":[81],"rate":[82],"constant":[83],"for":[84,110],"(k(ass))":[86],"5":[88],"x":[89],"10(6)":[90],"M(-1)":[91],"s(-1),":[92],"making":[93],"most":[96],"efficient":[97],"natural":[98],"protein":[99],"so":[104],"far":[105],"described.":[106],"k(ass)":[108],"value":[109],"decreased":[113],"10-fold":[115],"addition":[117],"heparin,":[119],"glycosaminoglycan":[121],"produced":[122],"mast":[124],"cells":[125],"binds":[127],"to":[128,153],"Heparin":[130],"change":[133],"significantly":[134],"stoichiometry":[136],"or":[139],"block":[140],"complex":[142],"formation.":[143],"These":[144],"results":[145],"indicate":[146],"is":[149],"important":[151],"consider":[154],"in":[155],"regulation":[157]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}
