{"id":"https://openalex.org/W2012504794","doi":"https://doi.org/10.1097/00004872-199409000-00023","title":"6 Development of sudanophilic lesions along the renal preglomerular vasculature during prolonged NG-nitro-L-arginine methyl ester-induced hypertension in rats","display_name":"6 Development of sudanophilic lesions along the renal preglomerular vasculature during prolonged NG-nitro-L-arginine methyl ester-induced hypertension in rats","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W2012504794","doi":"https://doi.org/10.1097/00004872-199409000-00023","mag":"2012504794"},"language":"en","primary_location":{"id":"doi:10.1097/00004872-199409000-00023","doi":"https://doi.org/10.1097/00004872-199409000-00023","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-199409000-00023","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020669165","display_name":"Nathalie Bouriquet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152567","display_name":"H\u00f4pital Saint Charles","ror":"https://ror.org/01e4pq116","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210152567"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Bouriquet","raw_affiliation_strings":["Groupe Rein et Hypertension, H\u00f4pital Saint-Charles, 34295 Montpettier, France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe Rein et Hypertension, H\u00f4pital Saint-Charles, 34295 Montpettier, France)","institution_ids":["https://openalex.org/I4210152567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102965612","display_name":"Daniel Casellas","orcid":"https://orcid.org/0000-0002-6980-5793","observed_orcids":["https://orcid.org/0000-0002-6980-5793"]},"institutions":[{"id":"https://openalex.org/I4210152567","display_name":"H\u00f4pital Saint Charles","ror":"https://ror.org/01e4pq116","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210152567"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Casellas","raw_affiliation_strings":["Groupe Rein et Hypertension, H\u00f4pital Saint-Charles, 34295 Montpettier, France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe Rein et Hypertension, H\u00f4pital Saint-Charles, 34295 Montpettier, France)","institution_ids":["https://openalex.org/I4210152567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085118800","display_name":"Madeleine Dupont","orcid":"https://orcid.org/0000-0002-1120-8363","observed_orcids":["https://orcid.org/0000-0002-1120-8363"]},"institutions":[{"id":"https://openalex.org/I4210152567","display_name":"H\u00f4pital Saint Charles","ror":"https://ror.org/01e4pq116","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210152567"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Dupont","raw_affiliation_strings":["Groupe Rein et Hypertension, H\u00f4pital Saint-Charles, 34295 Montpettier, France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe Rein et Hypertension, H\u00f4pital Saint-Charles, 34295 Montpettier, France)","institution_ids":["https://openalex.org/I4210152567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070851068","display_name":"Albert Mimran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152567","display_name":"H\u00f4pital Saint Charles","ror":"https://ror.org/01e4pq116","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210152567"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Mimran","raw_affiliation_strings":["Groupe Rein et Hypertension, H\u00f4pital Saint-Charles, 34295 Montpettier, France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe Rein et Hypertension, H\u00f4pital Saint-Charles, 34295 Montpettier, France)","institution_ids":["https://openalex.org/I4210152567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210152567"],"apc_list":null,"apc_paid":null,"fwci":0.2047,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50683016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"9","first_page":"1115","last_page":"1115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.07900000363588333,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.03790000081062317,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-atherosclerosis","display_name":"renal atherosclerosis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/l-name-induced-hypertension","display_name":"L-NAME-induced hypertension","score":0.8199999928474426},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.984000027179718},{"id":"https://openalex.org/keywords/arcuate-arteries","display_name":"arcuate arteries","score":0.8529999852180481},{"id":"https://openalex.org/keywords/interlobular-arteries","display_name":"interlobular arteries","score":0.996999979019165},{"id":"https://openalex.org/keywords/afferent-arteriole","display_name":"afferent arteriole","score":0.9539999961853027},{"id":"https://openalex.org/keywords/granular-deposits","display_name":"granular deposits","score":0.746999979019165},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8262532353401184},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6564750671386719},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5394850969314575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5317913889884949},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48861199617385864},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.4672515392303467},{"id":"https://openalex.org/C2780636983","wikidata":"https://www.wikidata.org/wiki/Q2713567","display_name":"Afferent arterioles","level":4,"score":0.46421435475349426},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.43948161602020264},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.42404207587242126},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4189854562282562},{"id":"https://openalex.org/C171614378","wikidata":"https://www.wikidata.org/wiki/Q5064093","display_name":"Cerebral arteries","level":2,"score":0.4163222014904022},{"id":"https://openalex.org/C2776634560","wikidata":"https://www.wikidata.org/wiki/Q707540","display_name":"Renal artery","level":3,"score":0.41150572896003723},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3353389501571655},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.09077832102775574}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00004872-199409000-00023","doi":"https://doi.org/10.1097/00004872-199409000-00023","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-199409000-00023","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131751668","https://openalex.org/W1849981293","https://openalex.org/W2162858709","https://openalex.org/W1987542224","https://openalex.org/W2084797284","https://openalex.org/W2461792710","https://openalex.org/W2032010399","https://openalex.org/W2011500279","https://openalex.org/W2088790253","https://openalex.org/W7098380678"],"abstract_inverted_index":{"Methods:":[0],"The":[1,179],"morphology":[2],"of":[3,26,49,54,102,141,148,155,168,181,243],"renal":[4,143,253],"pregiomerular":[5,51],"vessels":[6,77,144,200],"was":[7,21,89],"studied":[8],"in":[9,16,18,131,185,201,212],"normotensive":[10],"male":[11],"Wistar":[12],"rats":[13,17],"(controls)":[14],"and":[15,42,60,83,95,99,120,157,172,240],"which":[19],"hypertension":[20,234],"induced":[22],"by":[23,91,111],"oral":[24],"administration":[25],"the":[27,50,66,136,146,153,213,227],"nitric":[28],"oxide":[29],"synthase":[30],"inhibitor":[31],"NG-nitro-L-arginine":[32],"methyl":[33],"ester":[34],"(L-NAME;":[35],"20mg/kg":[36],"per":[37],"day)":[38],"for":[39,221],"5,":[40,97],"10":[41,98],"25":[43,100,137],"days.":[44,138],"Large,":[45],"mostly":[46],"intact,":[47],"portions":[48],"vasculatures":[52],"consisting":[53],"arcuate":[55],"(ArcA),":[56],"interlobular":[57],"arteries":[58],"(ILA)":[59],"afferent":[61,195],"arterioles":[62],"were":[63,78,173,191,210,224],"isolated":[64,80],"from":[65,81],"kidneys":[67],"using":[68],"a":[69,162,186,238],"recently":[70],"developed":[71],"maceration-dissection":[72],"technique":[73],"[1].":[74],"For":[75],"comparison,":[76],"similarly":[79],"cardiac":[82,197,206],"cerebral":[84,199,208],"tissue.":[85],"Systolic":[86,105],"blood":[87,106,133],"pressure":[88,107,134],"measured":[90],"tail-cuff":[92],"manometry":[93],"before":[94],"after":[96],"days":[101],"treatment.":[103],"Results:":[104],"(mean\u00b1SEM)":[108],"significantly":[109],"increased":[110,176,184],"18\u00b12%":[112],"(n":[113,117,122],"=":[114,118,123],"5),":[115],"21\u00b12%":[116],"6)":[119],"49\u00b19%":[121],"7),":[124],"respectively.":[125],"Controls":[126],"showed":[127,161],"no":[128],"significant":[129],"variations":[130],"sys-tolic":[132],"over":[135],"Microscopic":[139],"observation":[140],"hypertensive":[142,202],"revealed":[145],"presence":[147],"focal,":[149],"granular":[150],"deposits":[151,160,183,190,209,216],"within":[152],"media":[154],"ArcA":[156],"ILA.":[158],"These":[159],"general":[163],"orientation":[164],"parallel":[165],"to":[166],"that":[167,252],"smooth":[169],"muscle":[170],"cells":[171],"associated":[174,236,256],"with":[175,226,237,257],"wall":[177],"thickness.":[178],"frequency":[180],"focal":[182],"time-dependent":[187],"manner.":[188],"Focal":[189],"never":[192],"observed":[193,211],"along":[194,246],"arterioles,":[196],"or":[198,207],"rats.":[203],"No":[204],"renal,":[205],"controls.":[214],"Granular":[215],"could":[217],"not":[218],"be":[219],"immunostained":[220],"renin":[222],"but":[223],"stained":[225],"lipophilic":[228],"dye":[229],"Sudan":[230],"black.":[231],"Conclusion:":[232],"L-NAME-induced":[233,258],"is":[235,255],"rapid":[239],"progressive":[241],"development":[242],"sudanophilic":[244],"lesions":[245],"pre-afferent":[247],"vessels.":[248],"Our":[249],"results":[250],"suggest":[251],"atherosclerosis":[254],"hypertension.":[259]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
