{"id":"https://openalex.org/W2012496837","doi":"https://doi.org/10.2298/mpns0506279n","title":"Comparative study of the efficacy of different regimens of intermittent subcutaneous dosing of erythropoietin \u03b2 in treatment of renal anemia in chronic dialysis patients","display_name":"Comparative study of the efficacy of different regimens of intermittent subcutaneous dosing of erythropoietin \u03b2 in treatment of renal anemia in chronic dialysis patients","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2012496837","doi":"https://doi.org/10.2298/mpns0506279n","mag":"2012496837","pmid":"https://pubmed.ncbi.nlm.nih.gov/16526235"},"language":"en","primary_location":{"id":"doi:10.2298/mpns0506279n","doi":"https://doi.org/10.2298/mpns0506279n","is_oa":true,"landing_page_url":"https://doi.org/10.2298/mpns0506279n","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0025-81050506279N","source":{"id":"https://openalex.org/S121341522","display_name":"Medicinski pregled","issn_l":"0025-8105","issn":["0025-8105","1820-7383"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinski pregled","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0025-81050506279N","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102140002","display_name":"Vidosava B. Nesic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Vidosava Nesic","raw_affiliation_strings":["Klini\u010dki centar Srbije, Institut za nefrologiju i urologiju, Beograd","Klinicki centar Srbije, Beograd--Institut za nefrologiju i urologiju"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klini\u010dki centar Srbije, Institut za nefrologiju i urologiju, Beograd","institution_ids":["https://openalex.org/I4210113171"]},{"raw_affiliation_string":"Klinicki centar Srbije, Beograd--Institut za nefrologiju i urologiju","institution_ids":["https://openalex.org/I4210113171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022026109","display_name":"Vladimir O\u0161tri\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Vladimir Ostric","raw_affiliation_strings":["Klini\u010dki centar Srbije, Institut za nefrologiju i urologiju, Beograd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klini\u010dki centar Srbije, Institut za nefrologiju i urologiju, Beograd","institution_ids":["https://openalex.org/I4210113171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103645352","display_name":"Zoran Kova\u010devi\u0107","orcid":"https://orcid.org/0009-0008-8637-1692","observed_orcids":["https://orcid.org/0009-0008-8637-1692"]},"institutions":[{"id":"https://openalex.org/I1304155728","display_name":"Military Medical Academy","ror":"https://ror.org/04dt6a039","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I1304155728"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Zoran Kovacevic","raw_affiliation_strings":["Vojnomedicinska akademija, Klinika za nefrologiju, Beograd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vojnomedicinska akademija, Klinika za nefrologiju, Beograd","institution_ids":["https://openalex.org/I1304155728"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053350696","display_name":"Nada B. Dimkovic","orcid":"https://orcid.org/0000-0002-9553-777X","observed_orcids":["https://orcid.org/0000-0002-9553-777X"]},"institutions":[{"id":"https://openalex.org/I4210098583","display_name":"Klini\u010dko Bolni\u010dki Centar Zvezdara","ror":"https://ror.org/00rrer658","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210098583"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Nada Dimkovic","raw_affiliation_strings":["KBC 'Zvezdara', Institut za bubre\u017ene bolesti i metaboli\u010dke poreme\u0107aje, Beograd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KBC 'Zvezdara', Institut za bubre\u017ene bolesti i metaboli\u010dke poreme\u0107aje, Beograd","institution_ids":["https://openalex.org/I4210098583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081485617","display_name":"Slobodan Curi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Slobodan Curic","raw_affiliation_strings":["Klini\u010dki centar 'Novi Sad', Institut za interne bolesti, Novi Sad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klini\u010dki centar 'Novi Sad', Institut za interne bolesti, Novi Sad","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marina Lazarevic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154797","display_name":"Clinical Centre of Kragujevac","ror":"https://ror.org/054nax084","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210154797"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Marina Lazarevic","raw_affiliation_strings":["Klini\u010dki centar 'Kragujevac' - Klinika za internu medicinu, Kragujevac"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klini\u010dki centar 'Kragujevac' - Klinika za internu medicinu, Kragujevac","institution_ids":["https://openalex.org/I4210154797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112430682","display_name":"Marina Ratkovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106873","display_name":"Klini\u010dki Centar Crne Gore","ror":"https://ror.org/01teshw58","country_code":"ME","type":"healthcare","lineage":["https://openalex.org/I4210106873"]}],"countries":["ME"],"is_corresponding":false,"raw_author_name":"Marina Ratkovic","raw_affiliation_strings":["Klini\u010dki centar Crne Gore, Klinika za urologiju i nefrologiju, Podgorica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klini\u010dki centar Crne Gore, Klinika za urologiju i nefrologiju, Podgorica","institution_ids":["https://openalex.org/I4210106873"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jasmina Bogdanovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jasmina Bogdanovic","raw_affiliation_strings":["Zdravstveni centar Valjevo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zdravstveni centar Valjevo","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005678133","display_name":"Rosa Jela\u010di\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosa Jelacic","raw_affiliation_strings":["Op\u0161ta bolnica, Zrenjanin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Op\u0161ta bolnica, Zrenjanin","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1969,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57497761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"58","issue":"5-6","first_page":"279","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anemia-of-chronic-kidney-disease","display_name":"anemia of chronic kidney disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/maintenance-hemodialysis","display_name":"maintenance hemodialysis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/dosing-frequency","display_name":"dosing frequency","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hemoglobin-maintenance","display_name":"hemoglobin maintenance","score":0.675000011920929},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.9729999899864197},{"id":"https://openalex.org/keywords/iron-status","display_name":"iron status","score":0.43299999833106995},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.6240000128746033},{"id":"https://openalex.org/keywords/transferrin-saturation","display_name":"transferrin saturation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/anemia-treatment-efficacy","display_name":"anemia treatment efficacy","score":0.5419999957084656},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.31299999356269836},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9787988066673279},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.8348044157028198},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.6808050274848938},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6630822420120239},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.5620232224464417},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.5211896300315857},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5194827318191528},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5136491656303406},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.49987268447875977},{"id":"https://openalex.org/C153852466","wikidata":"https://www.wikidata.org/wiki/Q907072","display_name":"Transferrin saturation","level":4,"score":0.4953269064426422},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48189812898635864},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4434834420681},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4215199649333954},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33202439546585083},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.1746523678302765}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2298/mpns0506279n","doi":"https://doi.org/10.2298/mpns0506279n","is_oa":true,"landing_page_url":"https://doi.org/10.2298/mpns0506279n","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0025-81050506279N","source":{"id":"https://openalex.org/S121341522","display_name":"Medicinski pregled","issn_l":"0025-8105","issn":["0025-8105","1820-7383"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinski pregled","raw_type":"journal-article"},{"id":"pmid:16526235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16526235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinski pregled","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.2298/mpns0506279n","doi":"https://doi.org/10.2298/mpns0506279n","is_oa":true,"landing_page_url":"https://doi.org/10.2298/mpns0506279n","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0025-81050506279N","source":{"id":"https://openalex.org/S121341522","display_name":"Medicinski pregled","issn_l":"0025-8105","issn":["0025-8105","1820-7383"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinski pregled","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2012496837.pdf"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2009838803","https://openalex.org/W2015448181","https://openalex.org/W2033601942","https://openalex.org/W2059698794","https://openalex.org/W2112657209"],"related_works":["https://openalex.org/W2065750129","https://openalex.org/W2519611779","https://openalex.org/W214813968","https://openalex.org/W2463176973","https://openalex.org/W7208476828","https://openalex.org/W2265775174","https://openalex.org/W1990072478","https://openalex.org/W4416428347","https://openalex.org/W2429913857","https://openalex.org/W2086599987"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,46,197,347,363],"use":[2],"of":[3,9,19,48,56,59,66,88,109,166,192,204,396,406,428],"erythropoietin":[4,27],"(EPO)":[5],"in":[6,62,72,274,296,306,329,388,413],"the":[7,54,124,131,153,157,190,193,202,227,251,263,321,334,399],"treatment":[8,443],"renal":[10],"anemia":[11],"is":[12],"justified":[13],"by":[14],"more":[15],"than":[16],"15":[17],"years":[18],"experience.":[20],"Clinical":[21],"trials":[22],"have":[23],"shown":[24],"that":[25,383],"subcutaneous":[26,407],"beta":[28,409,430],"(Recormon":[29],"-":[30],"F.":[31],"Hoffmann-La":[32],"Roche)":[33],"therapy":[34,61,276],"once":[35,39,145,172,176,186,423],"weekly,":[36,146,173],"or":[37,359,390,394,422],"even":[38],"every":[40,177,424,445],"two":[41,178,425],"weeks":[42,127,139,179,426],"has":[43],"proven":[44],"successful.":[45],"aim":[47],"this":[49],"study":[50,82,159,228,322],"was":[51,83,201,244,248],"to":[52,189,255,269,278,434,441,451],"evaluate":[53],"efficacy":[55,199],"different":[57,355],"regimes":[58],"Recormon":[60],"maintaining":[63,206,414],"stable":[64,98,107,293,327],"levels":[65,212,291,308,325],"hemoglobin":[67],"(Hb)":[68],"and":[69,90,111,119,210,215,219,237,343,370,417,437,448],"hematocrit":[70],"(HCT)":[71],"hemodialysis":[73],"patients.":[74],"MATERIAL":[75],"AND":[76],"METHODS:":[77],"An":[78],"open,":[79],"comparative,":[80],"multicenter":[81],"divided":[84],"into":[85],"three":[86,298,331,403],"arms":[87],"patients":[89,96,142,149,169,184,205,224,397],"lasted":[91],"for":[92,156,217,444],"24":[93],"weeks.":[94],"98":[95],"with":[97,105,280],"Hb":[99,209,290,307,416],"level":[100,115],"(>100":[101,213,294],"g/l),":[102],"were":[103,129,266,302,313,351,375,385,410],"treated":[104],"a":[106,113],"dose":[108,435],"Recormon,":[110],"had":[112],"ferritin":[114],">":[116],"200":[117],"microg/l":[118],"transferrin":[120],"saturation":[121],">20%.":[122],"During":[123],"first":[125],"8":[126,138,163],"all":[128,261,297,330,378],"on":[130],"usual":[132],"2-3":[133],"times":[134],"weekly":[135,187,421],"epo":[136,144,171,275,281,349,408,429],"dosage.":[137],"later,":[140],"70":[141,168],"received":[143,174],"while":[147,182,258],"28":[148],"(group":[150,180,195],"1)":[151],"maintained":[152],"same":[154,264],"regimen":[155,188],"entire":[158],"period.":[160],"After":[161],"another":[162],"weeks,":[164],"21":[165],"those":[167],"receiving":[170],"it":[175],"3),":[181],"49":[183],"continued":[185],"end":[191],"trial":[194],"2).":[196],"primary":[198],"parameter":[200],"percentage":[203],"their":[207],"target":[208,415],"HCT":[211,220,324,418],"g/l":[214],">30%":[216],"HB":[218],"respectively).":[221],"RESULTS:":[222],"86":[223],"(87.75%)":[225],"completed":[226],"(25":[229],"from":[230,234,239,262],"group":[231,235,240],"1,":[232],"42":[233],"2":[236],"19":[238],"3).":[241],"One":[242],"patient":[243,447],"excluded":[245,267],"because":[246],"he":[247],"transplated":[249],"during":[250],"study,":[252,335],"one":[253],"due":[254,268,277],"uncontrolled":[256],"hypertension,":[257],"10":[259],"patients,":[260],"center,":[265],"protocol":[270],"violation":[271],"(4-week":[272],"gap":[273],"problems":[279],"supply).":[282],"Efficacy":[283],"analysis":[284,381],"included":[285],"per-protocol":[286],"population":[287],"(86":[288],"patients).":[289],"remained":[292,326],"g/l)":[295],"groups.":[299],"Although":[300],"there":[301,312,384],"statistically":[303,315,337,353,411],"significant":[304,316,338],"differences":[305,317,339,387],"between":[309,318,340,344,356,360,392],"visits":[310,341,357,393],"(p=0,026),":[311],"no":[314,386],"groups":[319,332,345,361,395],"throughout":[320,333,398],"(p=0,439).":[323],"(>30%)":[328],"without":[336],"(p=0,053)":[342],"(p=0,155).":[346],"average":[348],"doses":[350],"not":[352,432],"significantly":[354],"(p=0,676)":[358],"(p=0,512).":[362],"main":[364],"tolerability":[365],"parameters:":[366],"sitting":[367],"systolic":[368],"(SSBP)":[369],"diastolic":[371],"(SDBP)":[372],"blood":[373],"pressures":[374],"monitored":[376],"at":[377],"visits.":[379],"Statistical":[380],"showed":[382],"SSBP":[389],"SDBP":[391],"study.":[400],"CONCLUSION:":[401],"All":[402],"dosing":[404],"regimens":[405],"equivalent":[412],"levels.":[419],"Once":[420],"administration":[427],"does":[431],"lead":[433,450],"increase,":[436],"provides":[438],"greater":[439],"opportunities":[440],"individualize":[442],"single":[446],"may":[449],"better":[452],"compliance.":[453]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}