{"id":"https://openalex.org/W2012485636","doi":"https://doi.org/10.1210/jc.2003-030934","title":"The Hormonal Phenotype of Nonclassic 3\u03b2-Hydroxysteroid Dehydrogenase (HSD3B) Deficiency in Hyperandrogenic Females Is Associated with Insulin-Resistant Polycystic Ovary Syndrome and Is Not a Variant of Inherited HSD3B2 Deficiency","display_name":"The Hormonal Phenotype of Nonclassic 3\u03b2-Hydroxysteroid Dehydrogenase (HSD3B) Deficiency in Hyperandrogenic Females Is Associated with Insulin-Resistant Polycystic Ovary Syndrome and Is Not a Variant of Inherited HSD3B2 Deficiency","publication_year":2004,"publication_date":"2004-02-01","ids":{"openalex":"https://openalex.org/W2012485636","doi":"https://doi.org/10.1210/jc.2003-030934","mag":"2012485636","pmid":"https://pubmed.ncbi.nlm.nih.gov/14764797"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2003-030934","doi":"https://doi.org/10.1210/jc.2003-030934","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-030934","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083011754","display_name":"Goldy Carbunaru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Goldy Carbunaru","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Endocrinology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Endocrinology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pallavi Prasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pallavi Prasad","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009754654","display_name":"Bert Scoccia","orcid":"https://orcid.org/0000-0002-9970-9890","observed_orcids":["https://orcid.org/0000-0002-9970-9890"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bert Scoccia","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","University of Illinois at Chicago, Chicago, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago, Chicago, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Patrick Shea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Shea","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110255139","display_name":"Nancy J. Hopwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Hopwood","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan (N.H.), Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan (N.H.), Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061183321","display_name":"Fuad Ziai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fuad Ziai","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102996198","display_name":"Ying Chang","orcid":"https://orcid.org/0009-0008-9146-8122","observed_orcids":["https://orcid.org/0009-0008-9146-8122"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Tai Chang","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108775625","display_name":"Susan E. Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan E. Myers","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Endocrinology, St. Louis University (S.E.M.), St. Louis, Missouri 63104",", Saint Louis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Endocrinology, St. Louis University (S.E.M.), St. Louis, Missouri 63104","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":", Saint Louis University","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063152677","display_name":"J. Ian Mason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Ian Mason","raw_affiliation_strings":["Division of Reproductive and Developmental Sciences (Clinical Biochemistry), University of Edinburgh (J.I.M.), Edinburgh, Scotland EH16 4SB","University of Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive and Developmental Sciences (Clinical Biochemistry), University of Edinburgh (J.I.M.), Edinburgh, Scotland EH16 4SB","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"University of Edinburgh","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110179021","display_name":"Songya Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Songya Pang","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Endocrinology, and Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Illinois College of Medicine (G.C., P.P., B.S., P.S., F.Z., Y.T.C., S.P.), Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":6.1686,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.95924264,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"89","issue":"2","first_page":"783","last_page":"794"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsd3b2","display_name":"HSD3B2","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.7540000081062317},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9769999980926514},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9890000224113464},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.8529999852180481},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lh-fsh-ratio","display_name":"LH/FSH ratio","score":0.8389999866485596},{"id":"https://openalex.org/keywords/adrenal-steroidogenesis","display_name":"adrenal steroidogenesis","score":0.7350000143051147},{"id":"https://openalex.org/keywords/acth-stimulation-test","display_name":"ACTH stimulation test","score":0.6499999761581421},{"id":"https://openalex.org/keywords/premature-pubarche","display_name":"premature pubarche","score":0.7929999828338623},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.34700000286102295},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9048886299133301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8894115686416626},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.858939528465271},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.48215243220329285},{"id":"https://openalex.org/C2780186808","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Hyperandrogenism","level":5,"score":0.4349801540374756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3802317976951599},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.33324867486953735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32223203778266907}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006062","descriptor_name":"Gonadotropins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015096","descriptor_name":"3-Hydroxysteroid Dehydrogenases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D017588","descriptor_name":"Hyperandrogenism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017588","descriptor_name":"Hyperandrogenism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017588","descriptor_name":"Hyperandrogenism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jc.2003-030934","doi":"https://doi.org/10.1210/jc.2003-030934","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-030934","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:14764797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14764797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5670057312","display_name":null,"funder_award_id":"R01 HD 36399","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6135510409","display_name":"ETIOLOGY, HORMONAL CRITERIA OF 3 BETA HSD DEFICIENCY","funder_award_id":"5r01hd036399-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W107679361","https://openalex.org/W1503163311","https://openalex.org/W1725142614","https://openalex.org/W1976662653","https://openalex.org/W1980035206","https://openalex.org/W1991795681","https://openalex.org/W2000250636","https://openalex.org/W2009295157","https://openalex.org/W2012047091","https://openalex.org/W2014761945","https://openalex.org/W2016251482","https://openalex.org/W2018135774","https://openalex.org/W2018255105","https://openalex.org/W2023473391","https://openalex.org/W2026675220","https://openalex.org/W2028242557","https://openalex.org/W2033275614","https://openalex.org/W2033307020","https://openalex.org/W2035956286","https://openalex.org/W2044970382","https://openalex.org/W2049948770","https://openalex.org/W2052836193","https://openalex.org/W2053664000","https://openalex.org/W2054403993","https://openalex.org/W2060930388","https://openalex.org/W2062778218","https://openalex.org/W2063009554","https://openalex.org/W2071297057","https://openalex.org/W2075667097","https://openalex.org/W2075987903","https://openalex.org/W2078646048","https://openalex.org/W2087414764","https://openalex.org/W2093801820","https://openalex.org/W2096892296","https://openalex.org/W2106378688","https://openalex.org/W2110661248","https://openalex.org/W2120215340","https://openalex.org/W2142894568","https://openalex.org/W2148636250","https://openalex.org/W2155995048","https://openalex.org/W2156262209","https://openalex.org/W2158949625","https://openalex.org/W2170855066","https://openalex.org/W2171217985","https://openalex.org/W2412999436","https://openalex.org/W2616354190","https://openalex.org/W4302050492"],"related_works":["https://openalex.org/W51609634","https://openalex.org/W4413154235","https://openalex.org/W2042514771","https://openalex.org/W2084291909","https://openalex.org/W2018930069","https://openalex.org/W2441789302","https://openalex.org/W2006578229","https://openalex.org/W2008489567","https://openalex.org/W7101001471","https://openalex.org/W2075987903"],"abstract_inverted_index":{"To":[0],"test":[1,144,208],"our":[2],"hypothesis":[3],"that":[4,287,318,375],"the":[5,81,139,186,189,254,261,277,311,328,341,357,376,396,403],"hormonal":[6,131],"phenotype":[7,43,84,91,152,280,314,331,360,379,406,416],"of":[8,61,161,273,306,325,347,387,399],"mild":[9],"3beta-hydroxysteroid":[10],"dehydrogenase":[11],"(HSD3B)":[12],"deficiency":[13],"in":[14,33,53,70,108,146,154,169,209,220,234,245,253,270,288,304,319,353,371,380,395],"hyperandrogenic":[15],"females":[16,110,222],"(HF)":[17],"is":[18,382],"related":[19],"to":[20,51,101,286,301,337,413],"insulin-resistant":[21,388],"polycystic":[22],"ovary":[23],"syndrome":[24],"(PCOS),":[25],"we":[26],"compared":[27],"insulin":[28,134,182,200,255,267,302,338,348,366,392,420],"sensitivity":[29,135,256,268,349,393],"and":[30,79,99,128,153,174,193,195,231,257,350,361,368],"gonadotropin":[31,258,351],"secretion":[32],"HF":[34,54,123,148,156,211,236,355,381],"with":[35,55,75,149,157,223,276,292,310,327,356,384,402,418],"compromised":[36],"(":[37],"downward":[38],"arrow":[39],")":[40],"adrenal":[41],"HSD3B":[42,83,90,151,279,313,330,359,378,405],"despite":[44],"normal":[45,109,129,172,178,221,224,246],"HSD3B2":[46],"genes":[47],"(n":[48,58,76,85,111],"=":[49,59,77,86,112,117],"6)":[50],"those":[52,107,219,244],"classic":[56,158,362],"PCOS":[57,122,363],"9)":[60],"similar":[62,285,294],"ages":[63],"(14-36":[64],"yr).":[65],"The":[66,88,133,266,298,345,390],"same":[67],"was":[68,92,166,281,315],"examined":[69],"premature":[71],"pubarche":[72],"(PP)":[73],"girls":[74,275,291,309,401],"4)":[78],"without":[80],"descending":[82,89,150,278,312,329,358,377,404],"5).":[87],"defined":[93],"by":[94,138,184,203],"ACTH-stimulated":[95,130],"Delta(5)-precursor":[96],"steroid":[97,103],"levels":[98,127,201,230],"Delta(5)-precursors":[100],"Delta(4)-product":[102],"ratios":[104,233],"higher":[105,214,239,334],"than":[106,168,218,243,283,317,340],"30":[113],"for":[114,119,191],"adult,":[115],"n":[116],"12":[118],"pubertal).":[120],"Classic":[121],"had":[124,332],"elevated":[125],"testosterone":[126],"profiles.":[132],"index":[136,164,269],"determined":[137,183,202],"frequently":[140],"sampled":[141],"iv":[142],"glucose-tolbutamide":[143],"(FSIVGTT)":[145],"all":[147,155,170],"PCOS,":[159],"regardless":[160],"body":[162],"mass":[163],"(BMI),":[165],"lower":[167,282,316],"eight":[171],"BMI":[173,177],"five":[175],"high":[176,226],"females.":[179,247],"Integrated":[180],"incremental":[181],"FSIVGTT,":[185],"area":[187],"under":[188],"curve":[190],"insulin,":[192],"fasting":[194,299,335],"2":[196],"h":[197],"glucose":[198,206,300,336],"load":[199],"an":[204],"oral":[205],"tolerance":[207],"both":[210,235,354],"groups":[212,237],"were":[213,238,251],"(P":[215,240],"<":[216,241],"0.01-0.0001)":[217],"or":[225,284],"BMI.":[227],"LHRH-stimulated":[228],"LH":[229,369],"LH/FSH":[232],"0.01)":[242],"No":[248],"statistical":[249],"differences":[250],"found":[252],"parameter":[259,394],"between":[260],"two":[262],"PP":[263,274,290,308,321,343,400],"girl":[264],"groups.":[265],"each":[271],"half":[272],"control":[289,320,342],"a":[293,333,385,408],"weight":[295],"length":[296],"index.":[297],"ratio":[303,339],"three":[305],"four":[307,326],"girls,":[322],"but":[323],"one":[324],"girls.":[344],"findings":[346],"data":[352],"indicate":[364],"significant":[365],"resistance":[367],"hypersecretion":[370],"both.":[372],"These":[373],"suggest":[374],"associated":[383],"variant":[386],"PCOS.":[389],"variable":[391],"small":[397],"number":[398],"warrants":[407],"further":[409],"large":[410],"scale":[411],"study":[412],"examine":[414],"this":[415],"association":[417],"childhood":[419],"resistance.":[421]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}