{"id":"https://openalex.org/W2012473548","doi":"https://doi.org/10.1016/j.jconrel.2015.01.029","title":"Infiltration of plasma rich in growth factors enhances in vivo angiogenesis and improves reperfusion and tissue remodeling after severe hind limb ischemia","display_name":"Infiltration of plasma rich in growth factors enhances in vivo angiogenesis and improves reperfusion and tissue remodeling after severe hind limb ischemia","publication_year":2015,"publication_date":"2015-01-24","ids":{"openalex":"https://openalex.org/W2012473548","doi":"https://doi.org/10.1016/j.jconrel.2015.01.029","mag":"2012473548","pmid":"https://pubmed.ncbi.nlm.nih.gov/25626084"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2015.01.029","doi":"https://doi.org/10.1016/j.jconrel.2015.01.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2015.01.029","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003483976","display_name":"Eduardo Anitua","orcid":"https://orcid.org/0000-0002-8386-5303","observed_orcids":["https://orcid.org/0000-0002-8386-5303"]},"institutions":[{"id":"https://openalex.org/I4405267055","display_name":"Fundaci\u00f3n Eduardo Anitua para la investigaci\u00f3n biom\u00e9dica","ror":"https://ror.org/010bet687","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405267055"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo Anitua","raw_affiliation_strings":["Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain","institution_ids":["https://openalex.org/I4405267055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059491868","display_name":"Beatriz Pelacho","orcid":"https://orcid.org/0000-0002-0411-7164","observed_orcids":["https://orcid.org/0000-0002-0411-7164"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Pelacho","raw_affiliation_strings":["Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002411741","display_name":"Roberto C\u00e9sar Pereira do Prado","orcid":"https://orcid.org/0000-0003-4767-7206","observed_orcids":["https://orcid.org/0000-0003-4767-7206"]},"institutions":[{"id":"https://openalex.org/I4210105825","display_name":"BTI Biotechnology Institute","ror":"https://ror.org/01me5n293","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210105825"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Roberto Prado","raw_affiliation_strings":["BTI - Biotechnology Institute, Vitoria, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BTI - Biotechnology Institute, Vitoria, Spain","institution_ids":["https://openalex.org/I4210105825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102955896","display_name":"Jos\u00e9 Javier Aguirre","orcid":"https://orcid.org/0000-0001-9946-7521","observed_orcids":["https://orcid.org/0000-0001-9946-7521"]},"institutions":[{"id":"https://openalex.org/I4210105825","display_name":"BTI Biotechnology Institute","ror":"https://ror.org/01me5n293","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210105825"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Javier Aguirre","raw_affiliation_strings":["BTI - Biotechnology Institute, Vitoria, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BTI - Biotechnology Institute, Vitoria, Spain","institution_ids":["https://openalex.org/I4210105825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075666258","display_name":"Mikel S\u00e1nchez","orcid":"https://orcid.org/0000-0001-9992-6927","observed_orcids":["https://orcid.org/0000-0001-9992-6927"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikel S\u00e1nchez","raw_affiliation_strings":["Arthroscopic Surgery Unit, Hospital Vithas San Jose, Vitoria, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthroscopic Surgery Unit, Hospital Vithas San Jose, Vitoria, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072085187","display_name":"Sabino Padilla","orcid":"https://orcid.org/0000-0001-9672-2881","observed_orcids":["https://orcid.org/0000-0001-9672-2881"]},"institutions":[{"id":"https://openalex.org/I4210105825","display_name":"BTI Biotechnology Institute","ror":"https://ror.org/01me5n293","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210105825"]},{"id":"https://openalex.org/I4405267055","display_name":"Fundaci\u00f3n Eduardo Anitua para la investigaci\u00f3n biom\u00e9dica","ror":"https://ror.org/010bet687","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405267055"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sabino Padilla","raw_affiliation_strings":["Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain; BTI - Biotechnology Institute, Vitoria, Spain","Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain; BTI - Biotechnology Institute, Vitoria, Spain","institution_ids":["https://openalex.org/I4210105825","https://openalex.org/I4405267055"]},{"raw_affiliation_string":"Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain","institution_ids":["https://openalex.org/I4405267055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039553666","display_name":"Xabier L. Aranguren","orcid":"https://orcid.org/0000-0002-1834-603X","observed_orcids":["https://orcid.org/0000-0002-1834-603X"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Xabier L. Aranguren","raw_affiliation_strings":["Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023348035","display_name":"Gloria Abizanda","orcid":"https://orcid.org/0000-0002-2504-5163","observed_orcids":["https://orcid.org/0000-0002-2504-5163"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gloria Abizanda","raw_affiliation_strings":["Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007339532","display_name":"Mar\u00eda Collantes","orcid":"https://orcid.org/0000-0003-1162-1470","observed_orcids":["https://orcid.org/0000-0003-1162-1470"]},"institutions":[{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Collantes","raw_affiliation_strings":["Department of Nuclear Medicine, MicroPET Research Unit CIMA-CUN, Cl\u00ednica Universitaria, University of Navarra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, MicroPET Research Unit CIMA-CUN, Cl\u00ednica Universitaria, University of Navarra, Spain","institution_ids":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110906490","display_name":"Milagros Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Milagros Hernandez","raw_affiliation_strings":["Hematology and Cell Therapy Department, Cl\u00ednica Universidad de Navarra, University of Navarra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Cell Therapy Department, Cl\u00ednica Universidad de Navarra, University of Navarra, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017479030","display_name":"Ana P\u00e9rez Ruiz","orcid":"https://orcid.org/0000-0002-9901-057X","observed_orcids":["https://orcid.org/0000-0002-9901-057X","https://orcid.org/0000-0002-5159-0122"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Perez-Ruiz","raw_affiliation_strings":["Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013934560","display_name":"Iv\u00e1n Pe\u00f1uelas","orcid":"https://orcid.org/0000-0001-8008-976X","observed_orcids":["https://orcid.org/0000-0001-8008-976X"]},"institutions":[{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ivan Pe\u00f1uelas","raw_affiliation_strings":["Department of Nuclear Medicine, MicroPET Research Unit CIMA-CUN, Cl\u00ednica Universitaria, University of Navarra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, MicroPET Research Unit CIMA-CUN, Cl\u00ednica Universitaria, University of Navarra, Spain","institution_ids":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031536814","display_name":"Gorka Orive","orcid":"https://orcid.org/0000-0002-0773-300X","observed_orcids":["https://orcid.org/0000-0002-0773-300X","https://orcid.org/0009-0003-7478-8857"]},"institutions":[{"id":"https://openalex.org/I4405267055","display_name":"Fundaci\u00f3n Eduardo Anitua para la investigaci\u00f3n biom\u00e9dica","ror":"https://ror.org/010bet687","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405267055"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Gorka Orive","raw_affiliation_strings":["Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain. Electronic address: gorka.orive@ehu.es","Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain. Electronic address: gorka.orive@ehu.es","institution_ids":["https://openalex.org/I4405267055"]},{"raw_affiliation_string":"Eduardo Anitua Foundation for Biomedical Research, Vitoria, Spain","institution_ids":["https://openalex.org/I4405267055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016030888","display_name":"Felipe Pr\u00f3sper","orcid":"https://orcid.org/0000-0001-6115-8790","observed_orcids":["https://orcid.org/0000-0001-6115-8790","https://orcid.org/0000-0002-3274-2450"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Felipe Prosper","raw_affiliation_strings":["Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain; Hematology and Cell Therapy Department, Cl\u00ednica Universidad de Navarra, University of Navarra, Spain. Electronic address: fprosper@unav.es","Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain","Hematology and Cell Therapy Department, Cl\u00ednica Universidad de Navarra, University of Navarra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain; Hematology and Cell Therapy Department, Cl\u00ednica Universidad de Navarra, University of Navarra, Spain. Electronic address: fprosper@unav.es","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I88155538"]},{"raw_affiliation_string":"Cell Therapy Program, Foundation for Applied Medical Research, University of Navarra, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Hematology and Cell Therapy Department, Cl\u00ednica Universidad de Navarra, University of Navarra, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I88155538"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5016030888","https://openalex.org/A5031536814"],"corresponding_institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4405267055","https://openalex.org/I88155538"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":7.7431,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.98168308,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"202","issue":null,"first_page":"31","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-rich-in-growth-factors","display_name":"plasma rich in growth factors","score":0.921999990940094},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hindlimb-ischemia","display_name":"hindlimb ischemia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.953000009059906},{"id":"https://openalex.org/keywords/tissue-remodeling","display_name":"tissue remodeling","score":0.902999997138977},{"id":"https://openalex.org/keywords/skeletal-muscle-regeneration","display_name":"skeletal muscle regeneration","score":0.5270000100135803},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.722000002861023},{"id":"https://openalex.org/keywords/skeletal-myoblasts","display_name":"skeletal myoblasts","score":0.8619999885559082},{"id":"https://openalex.org/keywords/matrigel-plug-assay","display_name":"Matrigel plug assay","score":0.8199999928474426},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.6949999928474426},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7515685558319092},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.6960952877998352},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6349793076515198},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4490054249763489},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.42496681213378906},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4148527979850769},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38276582956314087},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3579797148704529},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.344257652759552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.284965455532074},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.23476815223693848},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015424","descriptor_name":"Reperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jconrel.2015.01.029","doi":"https://doi.org/10.1016/j.jconrel.2015.01.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2015.01.029","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:25626084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25626084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W66003617","https://openalex.org/W1591505787","https://openalex.org/W1875609998","https://openalex.org/W1964217387","https://openalex.org/W1966149993","https://openalex.org/W1967791041","https://openalex.org/W1969393655","https://openalex.org/W1978429709","https://openalex.org/W1987012866","https://openalex.org/W1994129658","https://openalex.org/W1994850462","https://openalex.org/W1996660997","https://openalex.org/W2005909933","https://openalex.org/W2011468880","https://openalex.org/W2011544428","https://openalex.org/W2013051575","https://openalex.org/W2018297853","https://openalex.org/W2020450503","https://openalex.org/W2025957803","https://openalex.org/W2032059477","https://openalex.org/W2047470479","https://openalex.org/W2050709789","https://openalex.org/W2053404797","https://openalex.org/W2064902846","https://openalex.org/W2067115133","https://openalex.org/W2084671501","https://openalex.org/W2087122544","https://openalex.org/W2088755431","https://openalex.org/W2092315508","https://openalex.org/W2096005052","https://openalex.org/W2099204150","https://openalex.org/W2122366747","https://openalex.org/W2125931106","https://openalex.org/W2127461936","https://openalex.org/W2132525312","https://openalex.org/W2137521329","https://openalex.org/W2143110295","https://openalex.org/W2147807311","https://openalex.org/W2151231918","https://openalex.org/W2156497704","https://openalex.org/W2157364879","https://openalex.org/W2165611865","https://openalex.org/W2166725324","https://openalex.org/W2168140872","https://openalex.org/W2170450076","https://openalex.org/W3163818508"],"related_works":["https://openalex.org/W7128610529","https://openalex.org/W7172500481","https://openalex.org/W3198591589","https://openalex.org/W2081193100","https://openalex.org/W2011468880","https://openalex.org/W1797899103","https://openalex.org/W2892518447","https://openalex.org/W2181015864","https://openalex.org/W4238844346","https://openalex.org/W2061149882"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}