{"id":"https://openalex.org/W2012442465","doi":"https://doi.org/10.1128/aac.19.2.306","title":"Effects of vancomycin on renal function in rats","display_name":"Effects of vancomycin on renal function in rats","publication_year":1981,"publication_date":"1981-02-01","ids":{"openalex":"https://openalex.org/W2012442465","doi":"https://doi.org/10.1128/aac.19.2.306","mag":"2012442465","pmid":"https://pubmed.ncbi.nlm.nih.gov/7347562","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/181415"},"language":"en","primary_location":{"id":"doi:10.1128/aac.19.2.306","doi":"https://doi.org/10.1128/aac.19.2.306","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.19.2.306","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC181415","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110136372","display_name":"George R. Aronoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G R Aronoff","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana 46223","Departments of Medicine' and Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana 46223","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Departments of Medicine' and Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114003522","display_name":"Rebecca S. Sloan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R S Sloan","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana 46223","Departments of Medicine' and Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana 46223","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Departments of Medicine' and Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073830207","display_name":"C B Dinwiddie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C B Dinwiddie","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana 46223","Departments of Medicine' and Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana 46223","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Departments of Medicine' and Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109073045","display_name":"Michael D. Glant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M D Glant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103430976","display_name":"Naomi S. Fineberg","orcid":"https://orcid.org/0000-0003-1158-6900","observed_orcids":["https://orcid.org/0000-0003-1158-6900"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N S Fineberg","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana 46223","Departments of Medicine' and Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana 46223","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Departments of Medicine' and Pathology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056794023","display_name":"Friedrich Cameron Luft","orcid":"https://orcid.org/0000-0002-8635-1199","observed_orcids":["https://orcid.org/0000-0002-8635-1199"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F C Luft","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana 46223","Departments of Medicine' and Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana 46223","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Departments of Medicine' and Pathology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3626,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.58037112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"2","first_page":"306","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.40549999475479126,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.8109999895095825},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.8180000185966492},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.9710000157356262},{"id":"https://openalex.org/keywords/urinary-protein-excretion","display_name":"urinary protein excretion","score":0.8140000104904175},{"id":"https://openalex.org/keywords/urine-osmolality","display_name":"urine osmolality","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5879999995231628},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.8114854097366333},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7821660041809082},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.7262508273124695},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6544438600540161},{"id":"https://openalex.org/C2778534349","wikidata":"https://www.wikidata.org/wiki/Q7900633","display_name":"Urine osmolality","level":3,"score":0.6292574405670166},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5607885122299194},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5560824871063232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5511429905891418},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4486801028251648},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4377918243408203},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3225991427898407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24290597438812256},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.09069886803627014},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07111608982086182},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.19.2.306","doi":"https://doi.org/10.1128/aac.19.2.306","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.19.2.306","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:211078","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC181415","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:181415","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/181415","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:7347562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7347562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:211078","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC181415","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1997833735","https://openalex.org/W2017411172","https://openalex.org/W2128635872","https://openalex.org/W2274635712","https://openalex.org/W2342347321","https://openalex.org/W7118090196"],"related_works":["https://openalex.org/W2127042249","https://openalex.org/W2064342523","https://openalex.org/W2360874890","https://openalex.org/W4316814948","https://openalex.org/W4366084255","https://openalex.org/W2492686798","https://openalex.org/W2036129782","https://openalex.org/W2326444415","https://openalex.org/W1973795734","https://openalex.org/W2137967400"],"abstract_inverted_index":{"To":[0],"assess":[1],"the":[2,7,34,48],"effects":[3],"of":[4,13],"vancomycin":[5,61],"on":[6],"kidney,":[8],"we":[9],"gave":[10],"rats":[11,46],"doses":[12],"10,":[14],"50,":[15],"100,":[16],"200,":[17],"and":[18,25],"400":[19],"mg/kg":[20],"per":[21],"day.":[22],"Creatinine":[23],"clearance":[24],"urine":[26],"protein":[27],"excretion":[28],"did":[29],"not":[30,63],"differ":[31],"significantly":[32],"from":[33],"control":[35],"values.":[36],"Urine":[37],"osmolality":[38],"was":[39],"unchanged.":[40],"Mild":[41],"histological":[42],"changes":[43,56],"occurred":[44,57],"in":[45,67],"given":[47],"highest":[49],"dose.":[50],"We":[51],"conclude":[52],"that":[53],"although":[54],"histopathological":[55],"at":[58],"high":[59],"doses,":[60],"does":[62],"alter":[64],"renal":[65],"function":[66],"rats.":[68]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}