{"id":"https://openalex.org/W2012397548","doi":"https://doi.org/10.1016/j.ejps.2008.11.003","title":"The effect of chemical heterogeneity of HPMC on polymer release from matrix tablets","display_name":"The effect of chemical heterogeneity of HPMC on polymer release from matrix tablets","publication_year":2008,"publication_date":"2008-11-14","ids":{"openalex":"https://openalex.org/W2012397548","doi":"https://doi.org/10.1016/j.ejps.2008.11.003","mag":"2012397548","pmid":"https://pubmed.ncbi.nlm.nih.gov/19049865"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejps.2008.11.003","doi":"https://doi.org/10.1016/j.ejps.2008.11.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejps.2008.11.003","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083582254","display_name":"Anna Virid\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anna Virid\u00e9n","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031945237","display_name":"Bengt Wittgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bengt Wittgren","raw_affiliation_strings":["AstraZeneca R&D, SE\u2010431 83, M\u00f6lndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D, SE\u2010431 83, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080821830","display_name":"Thomas Andersson","orcid":"https://orcid.org/0000-0002-7777-5870","observed_orcids":["https://orcid.org/0000-0002-7777-5870"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Thomas Andersson","raw_affiliation_strings":["AstraZeneca R&D, SE\u2010431 83, M\u00f6lndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D, SE\u2010431 83, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055902694","display_name":"Anette Larsson","orcid":"https://orcid.org/0000-0002-6119-8423","observed_orcids":["https://orcid.org/0000-0002-6119-8423"]},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anette Larsson","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083582254"],"corresponding_institution_ids":["https://openalex.org/I66862912"],"apc_list":{"value":3070,"currency":"USD","value_usd":3070},"apc_paid":null,"fwci":3.575,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.92682417,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"36","issue":"4-5","first_page":"392","last_page":"400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.25540000200271606,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.12020000070333481,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hydrophilic-matrix-tablets","display_name":"hydrophilic matrix tablets","score":0.8759999871253967},{"id":"https://openalex.org/keywords/compositional-heterogeneity","display_name":"compositional heterogeneity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/substituent-distribution","display_name":"substituent distribution","score":0.8259999752044678},{"id":"https://openalex.org/keywords/polymer-chain-interactions","display_name":"polymer chain interactions","score":0.6570000052452087},{"id":"https://openalex.org/keywords/polymer-size","display_name":"polymer size","score":0.3230000138282776},{"id":"https://openalex.org/keywords/dissolution-time","display_name":"dissolution time","score":0.3269999921321869},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.8681178092956543},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.7051628232002258},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6398070454597473},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5469215512275696},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.49395400285720825},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.49328774213790894},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.4601943790912628},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.3748193085193634},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.35714003443717957},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24888095259666443},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008747","descriptor_name":"Methylcellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008747","descriptor_name":"Methylcellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065347","descriptor_name":"Hypromellose Derivatives","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ejps.2008.11.003","doi":"https://doi.org/10.1016/j.ejps.2008.11.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejps.2008.11.003","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:19049865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19049865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences","raw_type":"Journal Article"},{"id":"pmh:oai:publications.lib.chalmers.se:106748","doi":null,"is_oa":false,"landing_page_url":"http://publications.lib.chalmers.se/publication/106748-the-effect-of-chemical-heterogeneity-of-hpmc-on-polymer-release-from-matrix-tablets","pdf_url":null,"source":{"id":"https://openalex.org/S4377196470","display_name":"Chalmers Publication Library (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text.Article.Journal.PeerReviewed"},{"id":"pmh:oai:research.chalmers.se:106748","doi":null,"is_oa":false,"landing_page_url":"https://research.chalmers.se/en/publication/106748","pdf_url":null,"source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W65523500","https://openalex.org/W86403101","https://openalex.org/W130887233","https://openalex.org/W858838767","https://openalex.org/W1012619711","https://openalex.org/W1488723840","https://openalex.org/W1757841377","https://openalex.org/W1821751113","https://openalex.org/W1963889257","https://openalex.org/W1986292147","https://openalex.org/W1989601471","https://openalex.org/W2003086220","https://openalex.org/W2003480886","https://openalex.org/W2004105737","https://openalex.org/W2007049342","https://openalex.org/W2009539533","https://openalex.org/W2009818079","https://openalex.org/W2011732960","https://openalex.org/W2013205865","https://openalex.org/W2018542845","https://openalex.org/W2024929982","https://openalex.org/W2030593590","https://openalex.org/W2032115485","https://openalex.org/W2040880880","https://openalex.org/W2041337043","https://openalex.org/W2050346481","https://openalex.org/W2052682310","https://openalex.org/W2058394431","https://openalex.org/W2060320802","https://openalex.org/W2068313125","https://openalex.org/W2076134714","https://openalex.org/W2079383095","https://openalex.org/W2086179443","https://openalex.org/W2090027874","https://openalex.org/W2108042514","https://openalex.org/W2110680433","https://openalex.org/W2111421969","https://openalex.org/W2158075824","https://openalex.org/W2298484406","https://openalex.org/W2483521448","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2025192848","https://openalex.org/W2073560709","https://openalex.org/W2068280589","https://openalex.org/W345919931","https://openalex.org/W2017781159","https://openalex.org/W2063849265","https://openalex.org/W2009539533","https://openalex.org/W3196014795","https://openalex.org/W2039187916","https://openalex.org/W2082996010"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
