{"id":"https://openalex.org/W2012394330","doi":"https://doi.org/10.1159/000330410","title":"Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 Cotreatment versus Insulin-Like Growth Factor-I Alone in Two Brothers with Growth Hormone Insensitivity Syndrome: Effects on Insulin Sensitivity, Body Composition and Linear Growth","display_name":"Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 Cotreatment versus Insulin-Like Growth Factor-I Alone in Two Brothers with Growth Hormone Insensitivity Syndrome: Effects on Insulin Sensitivity, Body Composition and Linear Growth","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2012394330","doi":"https://doi.org/10.1159/000330410","mag":"2012394330","pmid":"https://pubmed.ncbi.nlm.nih.gov/21968387"},"language":"en","primary_location":{"id":"doi:10.1159/000330410","doi":"https://doi.org/10.1159/000330410","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000330410","pdf_url":null,"source":{"id":"https://openalex.org/S159506102","display_name":"Hormone Research in Paediatrics","issn_l":"1663-2818","issn":["1663-2818","1663-2826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone Research in Paediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111572282","display_name":"Klas Ekstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Klas Ekstr\u00f6m","raw_affiliation_strings":["Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institute and Hospital, Stockholm, Sweden. klas.ekstrom@karolinska.se","Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institute and Hospital, Stockholm,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institute and Hospital, Stockholm, Sweden. klas.ekstrom@karolinska.se","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institute and Hospital, Stockholm,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110243516","display_name":"Christine Carlsson\u2010Skwirut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christine Carlsson-Skwirut","raw_affiliation_strings":["Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institute and Hospital, Stockholm,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institute and Hospital, Stockholm,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022847398","display_name":"E. Martin Ritz\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"E. Martin Ritz\u00e9n","raw_affiliation_strings":["Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institute and Hospital, Stockholm,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institute and Hospital, Stockholm,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042402725","display_name":"Peter Bang","orcid":"https://orcid.org/0000-0001-6579-1710","observed_orcids":["https://orcid.org/0000-0001-6579-1710"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Peter Bang","raw_affiliation_strings":["Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2324,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.78464112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"76","issue":"5","first_page":"355","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-insensitivity-syndrome","display_name":"growth hormone insensitivity syndrome","score":0.9879999756813049},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8949999809265137},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-protein-3","display_name":"insulin-like growth factor binding protein-3","score":0.9089999794960022},{"id":"https://openalex.org/keywords/growth-hormone-receptor-deficiency","display_name":"growth hormone receptor deficiency","score":0.7279999852180481},{"id":"https://openalex.org/keywords/short-stature","display_name":"short stature","score":0.7419999837875366},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hepatic-insulin-sensitivity","display_name":"hepatic insulin sensitivity","score":0.871999979019165},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.7649999856948853},{"id":"https://openalex.org/keywords/lean-body-mass","display_name":"lean body mass","score":0.9269999861717224},{"id":"https://openalex.org/keywords/abdominal-adiposity","display_name":"abdominal fat","score":0.8619999885559082},{"id":"https://openalex.org/keywords/linear-growth-velocity","display_name":"linear growth velocity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.8679999709129333},{"id":"https://openalex.org/keywords/igfbp-1","display_name":"IGFBP-1","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9131577014923096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.909472644329071},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.728946328163147},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.6154934763908386},{"id":"https://openalex.org/C113675107","wikidata":"https://www.wikidata.org/wiki/Q2299608","display_name":"Growth hormone receptor","level":4,"score":0.5941999554634094},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5581145882606506},{"id":"https://openalex.org/C2778808658","wikidata":"https://www.wikidata.org/wiki/Q2975183","display_name":"Glucose clamp technique","level":5,"score":0.5372915267944336},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4296303391456604},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.41279828548431396},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.39745575189590454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39075028896331787},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.3644055128097534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3528480529785156},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34032589197158813},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.26055973768234253}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002657","descriptor_name":"Child Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018972","descriptor_name":"Insulin-Like Growth Factor Binding Protein 3","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D035781","descriptor_name":"Siblings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046150","descriptor_name":"Laron Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D046150","descriptor_name":"Laron Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046150","descriptor_name":"Laron Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000330410","doi":"https://doi.org/10.1159/000330410","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000330410","pdf_url":null,"source":{"id":"https://openalex.org/S159506102","display_name":"Hormone Research in Paediatrics","issn_l":"1663-2818","issn":["1663-2818","1663-2826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone Research in Paediatrics","raw_type":"journal-article"},{"id":"pmid:21968387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21968387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone research in paediatrics","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1574487823","https://openalex.org/W1966025734","https://openalex.org/W1977873280","https://openalex.org/W1985594739","https://openalex.org/W1987587625","https://openalex.org/W2000975185","https://openalex.org/W2007210480","https://openalex.org/W2017026416","https://openalex.org/W2026475737","https://openalex.org/W2026792808","https://openalex.org/W2032472474","https://openalex.org/W2034960978","https://openalex.org/W2035648138","https://openalex.org/W2052588649","https://openalex.org/W2054121324","https://openalex.org/W2060033992","https://openalex.org/W2061776732","https://openalex.org/W2064072059","https://openalex.org/W2077327282","https://openalex.org/W2088127887","https://openalex.org/W2089583049","https://openalex.org/W2092014129","https://openalex.org/W2093424366","https://openalex.org/W2096935527","https://openalex.org/W2104259296","https://openalex.org/W2105912552","https://openalex.org/W2111911379","https://openalex.org/W2117430507","https://openalex.org/W2123317466","https://openalex.org/W2130333682","https://openalex.org/W2132555220","https://openalex.org/W2133538229","https://openalex.org/W2137814422","https://openalex.org/W2139019858","https://openalex.org/W2140338031","https://openalex.org/W2149250249","https://openalex.org/W2153868160","https://openalex.org/W2414424074","https://openalex.org/W4236757670"],"related_works":["https://openalex.org/W2052588649","https://openalex.org/W2091981096","https://openalex.org/W2123317466","https://openalex.org/W2240211161","https://openalex.org/W1969008045","https://openalex.org/W2419855199","https://openalex.org/W2025337792","https://openalex.org/W2043507058","https://openalex.org/W2076638439","https://openalex.org/W2053418734"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Growth":[1],"hormone":[2,12],"insensitivity":[3],"syndrome":[4],"(GHIS)":[5],"is":[6,16],"caused":[7],"by":[8,101,107,141],"a":[9,44,67,123],"defective":[10],"growth":[11,20,197],"receptor":[13],"(GHR)":[14],"and":[15,32,58,82,111,121,151,178,195],"associated":[17],"with":[18,40,48,52],"insulin-like":[19],"factor-I":[21],"(IGF-I)":[22],"deficiency,":[23],"severely":[24],"short":[25],"stature":[26],"and,":[27,87],"from":[28],"adolescence,":[29],"fasting":[30],"hyperglycemia":[31],"obesity.":[33],"We":[34],"studied":[35],"the":[36,80,162],"effects":[37,84],"of":[38,85,94,118,125,185,189],"treatment":[39],"IGF-I":[41,53,186,200],"in":[42,156],"either":[43],"1:1":[45],"molar":[46],"complex":[47],"IGFBP-3":[49],"(IGF-I/BP-3-Tx)":[50],"or":[51],"alone":[54,201],"(IGF-I-Tx)":[55],"on":[56,90,130,137,159,176,180],"metabolism":[57],"linear":[59,112,196],"growth.":[60,113],"METHODS:":[61],"Two":[62],"brothers,":[63],"compound":[64],"heterozygous":[65],"for":[66],"GHR":[68],"gene":[69],"defect,":[70],"were":[71,164],"studied.":[72],"After":[73],"8":[74],"months":[75],"without":[76,172],"treatment,":[77,173],"we":[78],"examined":[79],"short-":[81],"long-term":[83],"IGF-I/BP-3-Tx":[86,177],"subsequently,":[88],"IGF-I-Tx":[89],"12-hour":[91],"overnight":[92,116],"levels":[93,117],"IGF-I,":[95],"GH,":[96],"insulin,":[97],"IGFBP-1,":[98,122],"insulin":[99,119,127,191],"sensitivity":[100,140],"hyperinsulinemic":[102],"euglycemic":[103],"clamp,":[104],"body":[105,148,193],"composition":[106,194],"dual-energy":[108],"X-ray":[109],"absorptiometry":[110],"RESULTS:":[114],"Mean":[115],"decreased":[120,155],"measure":[124],"hepatic":[126,190],"sensitivity,":[128,192],"increased":[129,150,174],"both":[131,157],"regimens,":[132],"but":[133],"was":[134,170],"more":[135,205],"pronounced":[136],"IGF-I-Tx.":[138,160,181],"Insulin":[139],"clamp":[142],"showed":[143],"no":[144],"consistent":[145],"changes.":[146],"Lean":[147],"mass":[149,154],"abdominal":[152],"fat":[153],"subjects":[158],"However,":[161],"changes":[163],"inconsistent":[165],"during":[166],"IGF-I/BP-3-Tx.":[167],"Height":[168],"velocity":[169],"low":[171],"slightly":[175],"doubled":[179],"CONCLUSION:":[182],"Both":[183],"modalities":[184],"improved":[187],"determinants":[188],"rate;":[198],"however,":[199],"seemed":[202],"to":[203],"be":[204],"efficient.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}