{"id":"https://openalex.org/W2012384932","doi":"https://doi.org/10.1097/00003246-199710000-00027","title":"Effect of nitric oxide in meconium aspiration syndrome after treatment with surfactant","display_name":"Effect of nitric oxide in meconium aspiration syndrome after treatment with surfactant","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W2012384932","doi":"https://doi.org/10.1097/00003246-199710000-00027","mag":"2012384932","pmid":"https://pubmed.ncbi.nlm.nih.gov/9377892"},"language":"en","primary_location":{"id":"doi:10.1097/00003246-199710000-00027","doi":"https://doi.org/10.1097/00003246-199710000-00027","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-199710000-00027","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110018650","display_name":"Khodayar Rais\u2010Bahrami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I4210153900","display_name":"Ross Laboratories (United States)","ror":"https://ror.org/04462nt90","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153900"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khodayar Rais-Bahrami","raw_affiliation_strings":["George Washington University School of Medicine, Washington, DC, USA","Address requests for reprints to: K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","From The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","Presented, in part, at the annual meeting of the Society of Pediatric Research, Washington, DC, May 1996","Supported, in part, through a grant from the Eppley Foundation. Survanta[registered sign] was supplied by Ross Laboratories at no cost"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University School of Medicine, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Address requests for reprints to: K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"From The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Presented, in part, at the annual meeting of the Society of Pediatric Research, Washington, DC, May 1996","institution_ids":[]},{"raw_affiliation_string":"Supported, in part, through a grant from the Eppley Foundation. Survanta[registered sign] was supplied by Ross Laboratories at no cost","institution_ids":["https://openalex.org/I4210153900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041149010","display_name":"Oswaldo Rivera","orcid":"https://orcid.org/0000-0003-1751-3016","observed_orcids":["https://orcid.org/0000-0003-1751-3016"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I4210153900","display_name":"Ross Laboratories (United States)","ror":"https://ror.org/04462nt90","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153900"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oswaldo Rivera","raw_affiliation_strings":["K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","Address requests for reprints to: K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","From The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","Presented, in part, at the annual meeting of the Society of Pediatric Research, Washington, DC, May 1996","Supported, in part, through a grant from the Eppley Foundation. Survanta[registered sign] was supplied by Ross Laboratories at no cost"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Address requests for reprints to: K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"From The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Presented, in part, at the annual meeting of the Society of Pediatric Research, Washington, DC, May 1996","institution_ids":[]},{"raw_affiliation_string":"Supported, in part, through a grant from the Eppley Foundation. Survanta[registered sign] was supplied by Ross Laboratories at no cost","institution_ids":["https://openalex.org/I4210153900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061095664","display_name":"Winslow R. Seale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I4210153900","display_name":"Ross Laboratories (United States)","ror":"https://ror.org/04462nt90","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153900"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Winslow R. Seale","raw_affiliation_strings":["K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","Address requests for reprints to: K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","From The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","Presented, in part, at the annual meeting of the Society of Pediatric Research, Washington, DC, May 1996","Supported, in part, through a grant from the Eppley Foundation. Survanta[registered sign] was supplied by Ross Laboratories at no cost"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Address requests for reprints to: K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"From The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Presented, in part, at the annual meeting of the Society of Pediatric Research, Washington, DC, May 1996","institution_ids":[]},{"raw_affiliation_string":"Supported, in part, through a grant from the Eppley Foundation. Survanta[registered sign] was supplied by Ross Laboratories at no cost","institution_ids":["https://openalex.org/I4210153900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070712701","display_name":"Billie Lou Short","orcid":"https://orcid.org/0000-0002-6785-9069","observed_orcids":["https://orcid.org/0000-0002-6785-9069"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I4210153900","display_name":"Ross Laboratories (United States)","ror":"https://ror.org/04462nt90","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153900"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Billie L. Short","raw_affiliation_strings":["K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","Address requests for reprints to: K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","From The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","Presented, in part, at the annual meeting of the Society of Pediatric Research, Washington, DC, May 1996","Supported, in part, through a grant from the Eppley Foundation. Survanta[registered sign] was supplied by Ross Laboratories at no cost"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Address requests for reprints to: K. Rais-Bahrami, MD, Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"From The George Washington University School of Medicine (Drs. Rais-Bahrami and Short), Department of Neonatology (Drs. Rais-Bahrami and Short and Mr. Seale), and the Department of Biomedical Engineering (Dr. Rivera), The Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1336742384","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Presented, in part, at the annual meeting of the Society of Pediatric Research, Washington, DC, May 1996","institution_ids":[]},{"raw_affiliation_string":"Supported, in part, through a grant from the Eppley Foundation. Survanta[registered sign] was supplied by Ross Laboratories at no cost","institution_ids":["https://openalex.org/I4210153900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.041,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.93089404,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"25","issue":"10","first_page":"1744","last_page":"1747"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11586","display_name":"Congenital Diaphragmatic Hernia Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhaled-nitric-oxide","display_name":"inhaled nitric oxide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pulmonary-surfactant","display_name":"pulmonary surfactant","score":0.8259999752044678},{"id":"https://openalex.org/keywords/beractant","display_name":"beractant","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oxygenation","display_name":"oxygenation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/neonatal-respiratory-distress","display_name":"neonatal respiratory distress","score":0.6060000061988831},{"id":"https://openalex.org/keywords/pulmonary-vasoconstriction","display_name":"pulmonary vasoconstriction","score":0.6019999980926514},{"id":"https://openalex.org/keywords/methemoglobin","display_name":"methemoglobin","score":0.7429999709129333},{"id":"https://openalex.org/keywords/pulmonary-artery-pressure","display_name":"pulmonary artery pressure","score":0.45500001311302185},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.45100000500679016},{"id":"https://openalex.org/keywords/meconium","display_name":"meconium","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9300227761268616},{"id":"https://openalex.org/C2780745319","wikidata":"https://www.wikidata.org/wiki/Q1918881","display_name":"Meconium aspiration syndrome","level":5,"score":0.8556364178657532},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7167234420776367},{"id":"https://openalex.org/C2780985857","wikidata":"https://www.wikidata.org/wiki/Q937557","display_name":"Meconium","level":4,"score":0.6700630784034729},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.5046781301498413},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5013222694396973},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.4651288688182831},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.45428207516670227},{"id":"https://openalex.org/C2779537118","wikidata":"https://www.wikidata.org/wiki/Q618362","display_name":"Arterial blood","level":2,"score":0.4108430743217468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14905643463134766},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.10796371102333069},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.06991568207740784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008471","descriptor_name":"Meconium Aspiration Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008471","descriptor_name":"Meconium Aspiration Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008471","descriptor_name":"Meconium Aspiration Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019141","descriptor_name":"Respiratory System Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00003246-199710000-00027","doi":"https://doi.org/10.1097/00003246-199710000-00027","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-199710000-00027","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:9377892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9377892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1540754314","https://openalex.org/W1594412732","https://openalex.org/W1987761704","https://openalex.org/W2001345635","https://openalex.org/W2007650499","https://openalex.org/W2018190349","https://openalex.org/W2030743643","https://openalex.org/W2036869521","https://openalex.org/W2037128630","https://openalex.org/W2044434481","https://openalex.org/W2057564817","https://openalex.org/W2116339746","https://openalex.org/W2128139551","https://openalex.org/W2140036859","https://openalex.org/W2157030563","https://openalex.org/W2413687683","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2004010146","https://openalex.org/W1978863837","https://openalex.org/W2119374986","https://openalex.org/W2082628631","https://openalex.org/W2028476550","https://openalex.org/W2413411239","https://openalex.org/W2068296557","https://openalex.org/W2052348454","https://openalex.org/W2093122640","https://openalex.org/W1995353489"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1,229],"test":[2],"the":[3,59,74,81,101,149,193,368],"hypothesis":[4],"that":[5,231],"inhaled":[6,213,238,285,314,338,352],"nitric":[7,214,239,286,315,339,353],"oxide":[8,215,287,316,340],"may":[9,20,359,376],"be":[10,360,377],"an":[11,363],"effective":[12],"therapeutic":[13],"agent":[14],"in":[15,73,80,94,111,323,357,373],"meconium":[16,93,301,332],"aspiration":[17,302,333],"syndrome":[18],"and":[19,67,77,79,131,165,222,270,288,295,384],"improve":[21],"oxygenation":[22,318,346,358],"after":[23,281,289,300,341],"pretreatment":[24],"with":[25,305,310,343],"surfactant.":[26],"DESIGN:":[27],"Prospective,":[28],"interventional":[29],"study.":[30,60],"SETTING:":[31],"The":[32,37,355],"animal":[33],"research":[34],"laboratory":[35],"at":[36,254,274],"Children's":[38],"National":[39],"Medical":[40],"Center.":[41],"SUBJECTS:":[42],"Eight":[43],"newborn":[44],"pigs,":[45],"1":[46,85],"to":[47,106,119,124,128,135,139,187,284,337,348,362],"2":[48,173],"wks":[49],"of":[50,87,91,117,122,133,156,161,169,175,180,199,208,219,237,313,331,351,371,380],"age,":[51],"4.1":[52],"+/-":[53],"0.4":[54],"kg,":[55],"were":[56,63,71,104,144,153,227,272,279,297],"used":[57],"for":[58,245],"INTERVENTIONS:":[61],"Animals":[62,103],"anesthetized,":[64],"paralyzed,":[65],"intubated,":[66],"mechanically":[68],"ventilated.":[69],"Catheters":[70],"placed":[72],"femoral":[75],"vein":[76],"artery,":[78],"pulmonary":[82,324,385],"artery.":[83],"After":[84,172,204,308],"hr":[86],"recovery,":[88],"10":[89,223],"mL/kg":[90,198],"20%":[92],"normal":[95,113],"saline":[96],"solution":[97],"was":[98,201,216,233,243],"insufflated":[99],"into":[100],"lungs.":[102],"ventilated":[105],"maintain":[107,188],"arterial":[108,267,325],"blood":[109,190,268],"gases":[110,191],"a":[112,205,250,320,378],"range":[114],"(i.e.,":[115],"pH":[116],"7.35":[118],"7.45,":[120],"Paco2":[121],"40":[123,162],"45":[125],"torr":[126,137],"[5.3":[127],"6.0":[129],"kPa],":[130],"Pao2":[132,296],"70":[134],"90":[136],"[9.3":[138],"12.0":[140],"kPa]).":[141],"Ventilatory":[142],"settings":[143,152],"increased,":[145],"as":[146],"needed,":[147],"until":[148],"following":[150,210],"maximum":[151,194],"reached:":[154],"FIO2":[155],"1.0;":[157],"peak":[158],"inspiratory":[159],"pressure":[160],"cm":[163],"H2O;":[164],"intermittent":[166],"mandatory":[167],"ventilation":[168,177],"60":[170],"breaths/min.":[171],"hrs":[174],"conventional":[176],"or":[178],"demonstration":[179],"clinically":[181],"important":[182],"lung":[183,382],"disease":[184,383],"by":[185,249],"failure":[186],"desired":[189],"on":[192],"ventilatory":[195,265],"settings,":[196,266],"4":[197],"beractant":[200],"given":[202,244],"intratracheally.":[203],"short":[206],"period":[207,253],"stabilization":[209],"surfactant":[211,344],"therapy,":[212],"administered.":[217],"Concentrations":[218],"40,":[220],"20,":[221],"parts":[224,256],"per":[225,257],"million":[226],"given.":[228],"assure":[230],"there":[232],"no":[234],"additive":[235],"effect":[236],"oxide,":[240],"each":[241,275,282],"dose":[242],"20":[246],"mins,":[247],"followed":[248],"15-min":[251],"normalization":[252],"0":[255],"million.":[258],"MEASUREMENTS":[259],"AND":[260],"MAIN":[261],"RESULTS:":[262],"Physiologic":[263],"measurements,":[264],"gases,":[269],"methemoglobin":[271],"recorded":[273],"study":[276],"period.":[277],"Measurements":[278],"taken":[280],"exposure":[283,336],"its":[290],"discontinuation.":[291],"Arterial":[292],"oxygen":[293],"saturation":[294],"significantly":[298],"lower":[299],"when":[303],"compared":[304],"baseline":[306],"values.":[307],"treatment":[309,342],"surfactant,":[311],"administration":[312],"improved":[317,345,364],"without":[319],"significant":[321],"decrease":[322],"pressure.":[326],"CONCLUSIONS:":[327],"In":[328],"this":[329,374],"model":[330,375],"syndrome,":[334],"short-term":[335],"secondary":[347,361],"better":[349],"distribution":[350],"oxide.":[354],"increase":[356],"ventilation/perfusion":[365],"mismatch,":[366],"since":[367],"primary":[369],"etiology":[370],"hypoxia":[372],"combination":[379],"parenchymal":[381],"hypertension.":[386]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
