{"id":"https://openalex.org/W2012384166","doi":"https://doi.org/10.1016/j.toxlet.2008.12.006","title":"Ethanol-induced expression of glutamate\u2013cysteine ligase catalytic subunit gene is mediated by NF-\u03baB","display_name":"Ethanol-induced expression of glutamate\u2013cysteine ligase catalytic subunit gene is mediated by NF-\u03baB","publication_year":2008,"publication_date":"2008-12-16","ids":{"openalex":"https://openalex.org/W2012384166","doi":"https://doi.org/10.1016/j.toxlet.2008.12.006","mag":"2012384166","pmid":"https://pubmed.ncbi.nlm.nih.gov/19133322"},"language":"en","primary_location":{"id":"doi:10.1016/j.toxlet.2008.12.006","doi":"https://doi.org/10.1016/j.toxlet.2008.12.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2008.12.006","pdf_url":null,"source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055653919","display_name":"Tomoki Kimura","orcid":"https://orcid.org/0000-0002-5138-5882","observed_orcids":["https://orcid.org/0000-0002-5138-5882"]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tomoki Kimura","raw_affiliation_strings":["Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. tomoki@pharm.setsunan.ac.jp","Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45\u20101 Nagaotoge\u2010cho, Hirakata, Osaka 573\u20100101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. tomoki@pharm.setsunan.ac.jp","institution_ids":["https://openalex.org/I102826571"]},{"raw_affiliation_string":"Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45\u20101 Nagaotoge\u2010cho, Hirakata, Osaka 573\u20100101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yukiko Kawasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiko Kawasaki","raw_affiliation_strings":["Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071224968","display_name":"Fumika Okumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumika Okumura","raw_affiliation_strings":["Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012477292","display_name":"Tomomichi Sone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomichi Sone","raw_affiliation_strings":["Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053934556","display_name":"REIKO NATSUKI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Natsuki","raw_affiliation_strings":["Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111369432","display_name":"Masakazu Isobe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakazu Isobe","raw_affiliation_strings":["Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055653919"],"corresponding_institution_ids":["https://openalex.org/I102826571"],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":null,"fwci":1.232,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.76048099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"185","issue":"2","first_page":"110","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gclc","display_name":"GCLC","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8820000290870667},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":0.7950000166893005},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/dna-binding-activity","display_name":"DNA-binding activity","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2779881523","wikidata":"https://www.wikidata.org/wiki/Q18026129","display_name":"GCLC","level":4,"score":0.9966154098510742},{"id":"https://openalex.org/C2781173740","wikidata":"https://www.wikidata.org/wiki/Q18026132","display_name":"GCLM","level":5,"score":0.7474973797798157},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.7261765003204346},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.657121479511261},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5756723284721375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5635714530944824},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.535300076007843},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5041061639785767},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4896910488605499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4528048038482666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31755030155181885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2530338168144226},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22613510489463806}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005721","descriptor_name":"Glutamate-Cysteine Ligase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.toxlet.2008.12.006","doi":"https://doi.org/10.1016/j.toxlet.2008.12.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2008.12.006","pdf_url":null,"source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},{"id":"pmid:19133322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19133322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1480984787","https://openalex.org/W1490395456","https://openalex.org/W1491137382","https://openalex.org/W1531100917","https://openalex.org/W1589430668","https://openalex.org/W1963874550","https://openalex.org/W1970957929","https://openalex.org/W1971090593","https://openalex.org/W1985623783","https://openalex.org/W1986619037","https://openalex.org/W1990541549","https://openalex.org/W1991423707","https://openalex.org/W1991631628","https://openalex.org/W1992813824","https://openalex.org/W1993243592","https://openalex.org/W2001051081","https://openalex.org/W2006152006","https://openalex.org/W2010377711","https://openalex.org/W2014355861","https://openalex.org/W2041453347","https://openalex.org/W2045111144","https://openalex.org/W2046639766","https://openalex.org/W2051988120","https://openalex.org/W2063810460","https://openalex.org/W2065079479","https://openalex.org/W2065369881","https://openalex.org/W2068370659","https://openalex.org/W2068520436","https://openalex.org/W2082105991","https://openalex.org/W2082438874","https://openalex.org/W2091906087","https://openalex.org/W2110598362","https://openalex.org/W2123107291","https://openalex.org/W2133833958","https://openalex.org/W2142952749","https://openalex.org/W2155399571","https://openalex.org/W2155917817","https://openalex.org/W2190096001","https://openalex.org/W2257536788","https://openalex.org/W2415612865","https://openalex.org/W6692419478"],"related_works":["https://openalex.org/W2104138299","https://openalex.org/W1560220156","https://openalex.org/W2039261294","https://openalex.org/W2046639766","https://openalex.org/W2005674193","https://openalex.org/W2155399571","https://openalex.org/W2065369881","https://openalex.org/W1995573353","https://openalex.org/W2016919451","https://openalex.org/W2021372143"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}