{"id":"https://openalex.org/W2012358397","doi":"https://doi.org/10.1210/en.2012-1066","title":"The Human Gonadotropin-Inhibitory Hormone Ortholog RFamide-Related Peptide-3 Suppresses Gonadotropin-Induced Progesterone Production in Human Granulosa Cells","display_name":"The Human Gonadotropin-Inhibitory Hormone Ortholog RFamide-Related Peptide-3 Suppresses Gonadotropin-Induced Progesterone Production in Human Granulosa Cells","publication_year":2012,"publication_date":"2012-06-12","ids":{"openalex":"https://openalex.org/W2012358397","doi":"https://doi.org/10.1210/en.2012-1066","mag":"2012358397","pmid":"https://pubmed.ncbi.nlm.nih.gov/22691551"},"language":"en","primary_location":{"id":"doi:10.1210/en.2012-1066","doi":"https://doi.org/10.1210/en.2012-1066","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2012-1066","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068674987","display_name":"Hajime Oishi","orcid":"https://orcid.org/0000-0002-0265-7263","observed_orcids":["https://orcid.org/0000-0002-0265-7263"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210162161","display_name":"Child and Family Research Institute","ror":"https://ror.org/04yqm9y25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210162161"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Hajime Oishi","raw_affiliation_strings":["Department of Obstetrics and Gynaecology (H.O., C.K., P.C.K.L.), Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5","Department of Obstetrics and Gynecology (H.O., T.Y.), Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology (H.O., C.K., P.C.K.L.), Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210162161"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology (H.O., T.Y.), Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010089421","display_name":"Christian Klausen","orcid":"https://orcid.org/0000-0002-0485-0366","observed_orcids":["https://orcid.org/0000-0002-0485-0366"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210162161","display_name":"Child and Family Research Institute","ror":"https://ror.org/04yqm9y25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210162161"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christian Klausen","raw_affiliation_strings":["Department of Obstetrics and Gynaecology (H.O., C.K., P.C.K.L.), Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology (H.O., C.K., P.C.K.L.), Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210162161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113721475","display_name":"George E. Bentley","orcid":"https://orcid.org/0000-0003-0202-7277","observed_orcids":["https://orcid.org/0000-0003-0202-7277"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George E. Bentley","raw_affiliation_strings":["Department of Integrative Biology and Helen Wills Neuroscience Institute (G.E.B.), University of California at Berkeley, Berkeley, California 94720-3140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Helen Wills Neuroscience Institute (G.E.B.), University of California at Berkeley, Berkeley, California 94720-3140","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016118872","display_name":"Tomohiro Osugi","orcid":"https://orcid.org/0000-0001-6987-9576","observed_orcids":["https://orcid.org/0000-0001-6987-9576"]},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Osugi","raw_affiliation_strings":["Department of Biology (T.O., K.T.), Waseda University, and Center for Medical Life Science of Waseda University, Tokyo 162-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology (T.O., K.T.), Waseda University, and Center for Medical Life Science of Waseda University, Tokyo 162-8480, Japan","institution_ids":["https://openalex.org/I150744194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074471026","display_name":"Kazuyoshi Tsutsui","orcid":"https://orcid.org/0000-0002-6261-3035","observed_orcids":["https://orcid.org/0000-0002-6261-3035"]},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyoshi Tsutsui","raw_affiliation_strings":["Department of Biology (T.O., K.T.), Waseda University, and Center for Medical Life Science of Waseda University, Tokyo 162-8480, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology (T.O., K.T.), Waseda University, and Center for Medical Life Science of Waseda University, Tokyo 162-8480, Japan","institution_ids":["https://openalex.org/I150744194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032474916","display_name":"C. Blake Gilks","orcid":"https://orcid.org/0000-0001-7889-8250","observed_orcids":["https://orcid.org/0000-0001-7889-8250"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2802832906","display_name":"Vancouver General Hospital","ror":"https://ror.org/02zg69r60","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I141074466","https://openalex.org/I2799475292","https://openalex.org/I2802832906"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C. Blake Gilks","raw_affiliation_strings":["Department of Pathology (C.B.G.) Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada V6H 3Z6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology (C.B.G.) Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada V6H 3Z6","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2802832906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108226924","display_name":"Tetsu Yano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsu Yano","raw_affiliation_strings":["Department of Obstetrics and Gynecology (H.O., T.Y.), Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (H.O., T.Y.), Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083611772","display_name":"Peter C. K. Leung","orcid":"https://orcid.org/0000-0003-3152-3800","observed_orcids":["https://orcid.org/0000-0003-3152-3800"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210162161","display_name":"Child and Family Research Institute","ror":"https://ror.org/04yqm9y25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210162161"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Peter C. K. Leung","raw_affiliation_strings":["Department of Obstetrics and Gynaecology (H.O., C.K., P.C.K.L.), Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology (H.O., C.K., P.C.K.L.), Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210162161"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5083611772"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210162161"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":5.7226,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.96219783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"153","issue":"7","first_page":"3435","last_page":"3445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.07180000096559525,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0714000016450882,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonadotropin-inhibitory-hormone","display_name":"gonadotropin-inhibitory hormone","score":0.9279999732971191},{"id":"https://openalex.org/keywords/gpr147","display_name":"GPR147","score":0.9929999709129333},{"id":"https://openalex.org/keywords/granulosa-lutein-cells","display_name":"granulosa-lutein cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/progesterone-synthesis","display_name":"progesterone secretion","score":0.878000020980835},{"id":"https://openalex.org/keywords/gonadotropin-signaling","display_name":"gonadotropin signaling","score":0.9229999780654907},{"id":"https://openalex.org/keywords/camp-accumulation","display_name":"cAMP accumulation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.6690000295639038},{"id":"https://openalex.org/keywords/steroidogenic-acute-regulatory-protein","display_name":"steroidogenic acute regulatory protein","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.6290000081062317},{"id":"https://openalex.org/keywords/ovarian-function","display_name":"ovarian function","score":0.6140000224113464},{"id":"https://openalex.org/keywords/corpus-luteum","display_name":"corpus luteum","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7950363755226135},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7645025849342346},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.7388567924499512},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.5142540335655212},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49967479705810547},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.47250187397003174},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.44424569606781006},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.42079785466194153},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.16145381331443787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13868355751037598}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006062","descriptor_name":"Gonadotropins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017697","descriptor_name":"Premenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018013","descriptor_name":"Receptors, Neuropeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037342","descriptor_name":"Pertussis Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/en.2012-1066","doi":"https://doi.org/10.1210/en.2012-1066","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2012-1066","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:22691551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22691551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2447924384","display_name":"Demonstration of Novel Brain Molecular Mechanisms Regulating Reproduction","funder_award_id":"22227002","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6475938636","display_name":"The analysis of physiological function of FOXL2 in human ovary.","funder_award_id":"23791815","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320323180","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1540547666","https://openalex.org/W1577822051","https://openalex.org/W1966384215","https://openalex.org/W1967547663","https://openalex.org/W1982573687","https://openalex.org/W1983198743","https://openalex.org/W1984553637","https://openalex.org/W1987816139","https://openalex.org/W1996417927","https://openalex.org/W2003432885","https://openalex.org/W2008482532","https://openalex.org/W2012382894","https://openalex.org/W2014371484","https://openalex.org/W2022852585","https://openalex.org/W2033011212","https://openalex.org/W2045750579","https://openalex.org/W2046494491","https://openalex.org/W2051702632","https://openalex.org/W2055660125","https://openalex.org/W2074830088","https://openalex.org/W2077412978","https://openalex.org/W2081134805","https://openalex.org/W2081993111","https://openalex.org/W2098874094","https://openalex.org/W2100733933","https://openalex.org/W2114711950","https://openalex.org/W2116285899","https://openalex.org/W2127199761","https://openalex.org/W2134876608","https://openalex.org/W2142793823","https://openalex.org/W2144993213","https://openalex.org/W2154775029","https://openalex.org/W2166025044","https://openalex.org/W4248350370"],"related_works":["https://openalex.org/W4389502868","https://openalex.org/W1963842388","https://openalex.org/W4234871524","https://openalex.org/W2166025044","https://openalex.org/W2055660125","https://openalex.org/W6987002233","https://openalex.org/W2782606838","https://openalex.org/W2706706961","https://openalex.org/W2944506192","https://openalex.org/W2127199761"],"abstract_inverted_index":{"RFamide-related":[0],"peptide-3":[1],"(RFRP-3),":[2],"a":[3,17,216],"mammalian":[4],"ortholog":[5],"of":[6,19,47,57,63,83,95,145,154,210,215],"avian":[7],"gonadotropin-inhibitory":[8],"hormone,":[9],"has":[10],"pronounced":[11],"inhibitory":[12,146],"effects":[13,137,153],"on":[14,156],"reproduction":[15],"in":[16,54,78,90,191,195],"number":[18],"species.":[20],"RFRP-3":[21,100,127,155,188],"suppresses":[22],"gonadotropin":[23,205],"release":[24],"at":[25,207],"the":[26,39,45,79,91,152,171,208],"hypothalamic":[27],"and/or":[28],"pituitary":[29],"levels;":[30],"however,":[31],"increasing":[32],"evidence":[33],"also":[34],"suggests":[35],"putative":[36],"functions":[37],"within":[38],"ovary.":[40],"We":[41],"have":[42],"now":[43],"demonstrated":[44],"expression":[46,113],"both":[48],"RFRP":[49],"and":[50,73,104,108,130,135,159,162,228],"its":[51,200],"receptor":[52],"(GPR147)":[53],"primary":[55],"cultures":[56],"human":[58,65,96,192],"granulosa-lutein":[59,97],"cells.":[60],"Immunohistochemical":[61],"analysis":[62],"normal":[64,246],"ovaries":[66],"from":[67],"premenopausal":[68],"women":[69],"showed":[70],"that":[71,187],"RFRPs":[72],"GPR147":[74,180],"were":[75,138,165],"primarily":[76],"localized":[77],"granulosa":[80,193],"cell":[81],"layer":[82],"large":[84],"preovulatory":[85],"follicles":[86],"as":[87,89],"well":[88],"corpus":[92],"luteum.":[93],"Treatment":[94],"cells":[98,194],"with":[99,142,170,179],"reduced":[101,224,233],"FSH-,":[102,157],"LH-":[103],"forskolin-stimulated":[105],"progesterone":[106,163,229],"production":[107],"steroidogenic":[109,234],"acute":[110,235],"regulatory":[111,236],"protein":[112,237],"but":[114],"did":[115],"not":[116],"affect":[117],"basal":[118],"or":[119,176],"8-bromoadenosine":[120],"3'5'-cyclic":[121],"monophosphate":[122],"stimulated":[123],"levels.":[124],"In":[125],"addition,":[126],"inhibited":[128],"gonadotropin-":[129],"forskolin-induced":[131,160],"intracellular":[132],"cAMP":[133,161,226],"accumulation,":[134],"these":[136],"abolished":[139],"by":[140,168,177],"pretreatment":[141,178],"an":[143],"inhibitor":[144],"G(i/o)":[147],"proteins":[148],"(pertussis":[149],"toxin).":[150],"Importantly,":[151],"LH-,":[158],"accumulation":[164,227],"completely":[166],"eliminated":[167],"cotreatment":[169],"bifunctional":[172],"GPR147/GPR74":[173],"antagonist":[174],"RF9":[175],"small":[181],"interfering":[182],"RNA.":[183],"These":[184],"results":[185],"suggest":[186],"is":[189],"expressed":[190],"which":[196],"it":[197],"acts":[198],"via":[199,213,232],"receptor,":[201],"GPR147,":[202],"to":[203,223,245],"inhibit":[204],"signaling":[206,242],"level":[209],"adenylyl":[211],"cyclase":[212],"activation":[214],"pertussis":[217],"toxin-sensitive":[218],"G\u03b1(i/o)":[219],"protein.":[220],"This":[221],"leads":[222],"gonadotropin-stimulated":[225],"synthesis,":[230],"likely":[231],"expression.":[238],"Thus,":[239],"ovarian":[240,247],"RFRP-3/GPR147":[241],"could":[243],"contribute":[244],"function.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}