{"id":"https://openalex.org/W2012350344","doi":"https://doi.org/10.1053/he.2000.5720","title":"Human liver class I alcohol dehydrogenase \u03b3\u03b3 isozyme: the sole cytosolic 3\u03b2-hydroxysteroid dehydrogenase of iso bile acids","display_name":"Human liver class I alcohol dehydrogenase \u03b3\u03b3 isozyme: the sole cytosolic 3\u03b2-hydroxysteroid dehydrogenase of iso bile acids","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W2012350344","doi":"https://doi.org/10.1053/he.2000.5720","mag":"2012350344","pmid":"https://pubmed.ncbi.nlm.nih.gov/10733557"},"language":"en","primary_location":{"id":"doi:10.1053/he.2000.5720","doi":"https://doi.org/10.1053/he.2000.5720","is_oa":true,"landing_page_url":"https://doi.org/10.1053/he.2000.5720","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/he.2000.5720","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/he.2000.5720","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078832883","display_name":"Hanns\u2013Ulrich Marschall","orcid":"https://orcid.org/0000-0001-7347-3085","observed_orcids":["https://orcid.org/0000-0001-7347-3085"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Hanns-Ulrich Marschall","raw_affiliation_strings":["Karolinska Institutet, Division of Gastroenterology and Hepatology, Huddinge University Hospital, SE-141 86 Huddinge, Sweden. hannsulrich.marschall@mbb.ki.se","Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden","Department of Medicine, Division of Gastroenterology and Hepatology, Huddinge University Hospital, SE-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institutet, Division of Gastroenterology and Hepatology, Huddinge University Hospital, SE-141 86 Huddinge, Sweden. hannsulrich.marschall@mbb.ki.se","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology and Hepatology, Huddinge University Hospital, SE-141 86 Huddinge, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103438701","display_name":"Udo C.I. Oppermann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Udo C.I. Oppermann","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109847263","display_name":"Stefan Svensson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Svensson","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021715811","display_name":"Erik Nordling","orcid":"https://orcid.org/0000-0001-9310-7947","observed_orcids":["https://orcid.org/0000-0001-9310-7947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik Nordling","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bengt Persson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bengt Persson","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108609335","display_name":"Jan\u2010Olov H\u00f6\u00f6g","orcid":"https://orcid.org/0000-0002-2923-8261","observed_orcids":["https://orcid.org/0000-0002-2923-8261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan-Olov H\u00f6\u00f6g","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113570579","display_name":"Hans J\u00f6rnvall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans J\u00f6rnvall","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, SE-171 77 Stockholm, Sweden","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078832883"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":1.7962,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.83090379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"31","issue":"4","first_page":"990","last_page":"996"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.3537999987602234,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.3537999987602234,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.27489998936653137,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.19519999623298645,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3beta-hydroxysteroid-dehydrogenase","display_name":"3\u03b2-hydroxysteroid dehydrogenase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/class-i-alcohol-dehydrogenase","display_name":"class I alcohol dehydrogenase","score":0.8500000238418579},{"id":"https://openalex.org/keywords/enterohepatic-circulation","display_name":"enterohepatic circulation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/nad-cofactor","display_name":"NAD+ cofactor","score":0.8180000185966492},{"id":"https://openalex.org/keywords/substrate-docking","display_name":"substrate docking","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.8212220072746277},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.7635644674301147},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6119410395622253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5931499600410461},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.5648506283760071},{"id":"https://openalex.org/C96722902","wikidata":"https://www.wikidata.org/wiki/Q17710244","display_name":"ADH1B","level":5,"score":0.5300284028053284},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.494021475315094},{"id":"https://openalex.org/C151325109","wikidata":"https://www.wikidata.org/wiki/Q22327132","display_name":"Branched-chain alpha-keto acid dehydrogenase complex","level":4,"score":0.41367584466934204},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4082493484020233}],"mesh":[{"descriptor_ui":"D000426","descriptor_name":"Alcohol Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000426","descriptor_name":"Alcohol Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014580","descriptor_name":"Ursodeoxycholic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014580","descriptor_name":"Ursodeoxycholic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015096","descriptor_name":"3-Hydroxysteroid Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1053/he.2000.5720","doi":"https://doi.org/10.1053/he.2000.5720","is_oa":true,"landing_page_url":"https://doi.org/10.1053/he.2000.5720","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/he.2000.5720","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:10733557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10733557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1053/he.2000.5720","doi":"https://doi.org/10.1053/he.2000.5720","is_oa":true,"landing_page_url":"https://doi.org/10.1053/he.2000.5720","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/he.2000.5720","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012350344.pdf"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1508197436","https://openalex.org/W1525724539","https://openalex.org/W1567974272","https://openalex.org/W1570817778","https://openalex.org/W1578943887","https://openalex.org/W1585301053","https://openalex.org/W1862249829","https://openalex.org/W1932604376","https://openalex.org/W1966916675","https://openalex.org/W1976507106","https://openalex.org/W1997491900","https://openalex.org/W2004446599","https://openalex.org/W2026495389","https://openalex.org/W2033893741","https://openalex.org/W2034344440","https://openalex.org/W2035440265","https://openalex.org/W2037644387","https://openalex.org/W2048730019","https://openalex.org/W2053916731","https://openalex.org/W2058400202","https://openalex.org/W2071394537","https://openalex.org/W2079935897","https://openalex.org/W2089224327","https://openalex.org/W2092544712","https://openalex.org/W2099810178","https://openalex.org/W2123846998","https://openalex.org/W2128324003","https://openalex.org/W2128635872","https://openalex.org/W2138982626","https://openalex.org/W2141929879","https://openalex.org/W2158022532","https://openalex.org/W2167648459","https://openalex.org/W2177377868","https://openalex.org/W4211248395","https://openalex.org/W4293201222"],"related_works":["https://openalex.org/W2107811305","https://openalex.org/W1986437312","https://openalex.org/W7145378603","https://openalex.org/W2138982626","https://openalex.org/W2345350034","https://openalex.org/W4225389396","https://openalex.org/W2019306408","https://openalex.org/W493680676","https://openalex.org/W2037644387","https://openalex.org/W2034344440"],"abstract_inverted_index":{"3beta-Hydroxy":[0],"(iso)":[1],"bile":[2,11,80,126,177,241,259,271],"acids":[3,12,127],"are":[4,20,250],"formed":[5],"during":[6],"enterohepatic":[7],"circulation":[8],"from":[9],"3alpha-hydroxy":[10,60,258],"and":[13,67,86,92,103,123,141,205,212,255,274],"constitute":[14],"normal":[15],"compounds":[16],"in":[17,23,51,181,194,244,269],"plasma":[18],"but":[19],"virtually":[21],"absent":[22],"bile.":[24,52],"Isoursodeoxycholic":[25],"acid":[26,50,81,178,199,202,207,242,272],"(isoUDCA)":[27],"is":[28,267],"a":[29,35,59,158,188],"major":[30,49],"metabolite":[31],"of":[32,44,55,151,157,161,227,230,257],"UDCA.":[33],"In":[34],"recent":[36],"study":[37,73],"it":[38],"was":[39,130,167,172,236],"found":[40],"that":[41,263],"after":[42],"administration":[43],"isoUDCA,":[45,204],"UDCA":[46],"became":[47],"the":[48,56,77,154,175,195,224,228,239,253],"Thus,":[53],"epimerization":[54],"3beta-hydroxy":[57],"to":[58,75,97,132,153,223],"group,":[61],"catalyzed":[62],"by":[63,143],"3beta-hydroxysteroid":[64],"dehydrogenases":[65,249],"(HSD)":[66],"3-oxo-reductases":[68],"must":[69],"occur.":[70],"The":[71],"present":[72,180],"aims":[74],"characterize":[76],"human":[78,162,182,245],"liver":[79,84,183,246],"3beta-HSD.":[82],"Human":[83],"cytosol":[85],"recombinant":[87],"alcohol":[88],"dehydrogenase":[89],"(ADH)":[90],"betabeta":[91],"gammagamma":[93,165,170,234,265],"isozymes":[94],"were":[95,139,193],"subjected":[96],"native":[98],"polyacrylamide":[99],"gel":[100],"electrophoresis":[101],"(PAGE)":[102],"isoelectric":[104],"focusing.":[105],"Activity":[106],"staining":[107],"with":[108,185],"oxidized":[109,115],"nicotinamide":[110,116],"adenine":[111,117],"dinucleotide":[112,118],"(NAD(+))":[113],"or":[114],"phosphate":[119],"(NADP(+))":[120],"as":[121,128,174,187,221,238,277],"cofactors":[122],"various":[124],"iso":[125,176],"substrates":[129],"used":[131],"screen":[133],"for":[134,191,252],"3beta-HSD":[135,179,243],"activity.":[136],"Reaction":[137],"products":[138],"identified":[140,173],"quantified":[142],"gas":[144],"chromotography/mass":[145],"spectrometry":[146],"(GC/MS).":[147],"Computer-assisted":[148],"substrate":[149,222],"docking":[150],"isoUDCA":[152],"active":[155],"site":[156],"3-dimensional":[159,225],"model":[160,226],"class":[163],"I":[164],"ADH":[166,169,231,233,264],"performed.":[168],"isozyme":[171,235,266],"cytosol,":[184],"NAD(+)":[186],"cofactor.":[189],"Values":[190],"k(cat)/K(m)":[192],"rank":[196],"order":[197],"isodeoxycholic":[198],"(isoDCA),":[200],"isochenodeoxycholic":[201],"(isoCDCA),":[203],"isolithocholic":[206],"(isoLCA)":[208],"(0.10,":[209],"0.09,":[210],"0.08,":[211],"0.":[213],"05":[214],"min(-1)":[215],"x":[216],"micromol/L(-1),":[217],"respectively).":[218],"IsoUDCA":[219],"fits":[220],"active-site":[229],"gammagamma.":[232],"defined":[237],"only":[240],"cytosol.":[247],"Hydroxysteroid":[248],"candidates":[251],"binding":[254,273],"transport":[256,275],"acids.":[260],"We":[261],"assume":[262],"involved":[268],"cytosolic":[270],"processes":[276],"well.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
