{"id":"https://openalex.org/W2012337686","doi":"https://doi.org/10.1111/j.1365-2559.1989.tb02143.x","title":"Portal tract macrophages are increased in alcoholic liver disease","display_name":"Portal tract macrophages are increased in alcoholic liver disease","publication_year":1989,"publication_date":"1989-03-01","ids":{"openalex":"https://openalex.org/W2012337686","doi":"https://doi.org/10.1111/j.1365-2559.1989.tb02143.x","mag":"2012337686","pmid":"https://pubmed.ncbi.nlm.nih.gov/2785081"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2559.1989.tb02143.x","doi":"https://doi.org/10.1111/j.1365-2559.1989.tb02143.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2559.1989.tb02143.x","pdf_url":null,"source":{"id":"https://openalex.org/S14376486","display_name":"Histopathology","issn_l":"0309-0167","issn":["0309-0167","1365-2559"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023383754","display_name":"\u0130nci Karak\u00fc\u00e7\u00fck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1310053265","display_name":"St George's Hospital","ror":"https://ror.org/0001ke483","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1310053265","https://openalex.org/I2801196673"]},{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. KARAKUCUK","raw_affiliation_strings":["Department of Histopathology, St. George\u2019s Hospital Medical School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, St. George\u2019s Hospital Medical School, London, UK","institution_ids":["https://openalex.org/I1310053265","https://openalex.org/I165862685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110257595","display_name":"Susan A. Dilly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1310053265","display_name":"St George's Hospital","ror":"https://ror.org/0001ke483","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1310053265","https://openalex.org/I2801196673"]},{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"S. A. DILLY","raw_affiliation_strings":["Department of Histopathology, St. George\u2019s Hospital Medical School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, St. George\u2019s Hospital Medical School, London, UK","institution_ids":["https://openalex.org/I1310053265","https://openalex.org/I165862685"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113172629","display_name":"J. Douglas Maxwell","orcid":"https://orcid.org/0009-0004-1044-8236","observed_orcids":["https://orcid.org/0009-0004-1044-8236"]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. D. MAXWELL","raw_affiliation_strings":["Department of Medicine, St. George\u2019s Hospital Medical School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, St. George\u2019s Hospital Medical School, London, UK","institution_ids":["https://openalex.org/I165862685"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110257595"],"corresponding_institution_ids":["https://openalex.org/I1310053265","https://openalex.org/I165862685"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":3.4386,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.91806331,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"245","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.11550000309944153,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"alcoholic liver disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/liver-macrophages","display_name":"hepatic macrophages","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mac387","display_name":"MAC387","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.972000002861023},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/macrophage-heterogeneity","display_name":"macrophage heterogeneity","score":0.800000011920929},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.7291923761367798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5378197431564331},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46059784293174744},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4485241770744324},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3992446959018707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3647289574146271},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.0655059814453125}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2559.1989.tb02143.x","doi":"https://doi.org/10.1111/j.1365-2559.1989.tb02143.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2559.1989.tb02143.x","pdf_url":null,"source":{"id":"https://openalex.org/S14376486","display_name":"Histopathology","issn_l":"0309-0167","issn":["0309-0167","1365-2559"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"journal-article"},{"id":"pmid:2785081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2785081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histopathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W131502452","https://openalex.org/W196899815","https://openalex.org/W1445009497","https://openalex.org/W1966875515","https://openalex.org/W1967034103","https://openalex.org/W1976822990","https://openalex.org/W1981325787","https://openalex.org/W1986300628","https://openalex.org/W2010874939","https://openalex.org/W2018895320","https://openalex.org/W2028278792","https://openalex.org/W2057797562","https://openalex.org/W2073180142","https://openalex.org/W2074281064","https://openalex.org/W2074673544","https://openalex.org/W2090915006","https://openalex.org/W2121449692","https://openalex.org/W2138954731","https://openalex.org/W2140358693","https://openalex.org/W4237139158"],"related_works":["https://openalex.org/W2010874939","https://openalex.org/W2029157606","https://openalex.org/W4229046459","https://openalex.org/W2312733964","https://openalex.org/W4386885556","https://openalex.org/W4403481737","https://openalex.org/W2921077929","https://openalex.org/W2088296072","https://openalex.org/W434163288","https://openalex.org/W4283814264"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"indicated":[2],"decreased":[3,115],"numbers":[4,80],"and":[5,35,53,62,71,97,130,161,174,191],"depressed":[6],"clearance":[7],"function":[8],"of":[9,33,65,148,154,193,199,204],"hepatic":[10,19,68,111,155,167,185],"macrophages":[11,20,58,70,74,113,133,156,169,180,186],"in":[12,24,87,100,116,136,208,220],"alcoholic":[13],"liver":[14,26],"disease":[15],"(ALD).":[16],"We":[17],"examined":[18],"by":[21],"immunohistochemical":[22],"techniques":[23],"45":[25],"biopsies":[27,42,88],"from":[28,43],"patients":[29],"with":[30,38,83,98,106,138,157],"a":[31,54],"spectrum":[32],"ALD":[34,102,118],"compared":[36],"them":[37],"20":[39],"histologically":[40],"normal":[41],"non-alcoholic":[44],"patients.":[45],"Antisera":[46],"against":[47],"lysozyme,":[48],"alpha":[49,162],"1-antitrypsin":[50],"(alpha":[51],"1AT)":[52],"cytoplasmic":[55],"molecule":[56],"on":[57],"(MAC-387)":[59],"were":[60,81,114,134],"used":[61],"the":[63,121,197,202,216,228],"number":[64],"positively":[66],"staining":[67,165,176],"sinusoidal":[69,112,168],"portal":[72,178],"tract":[73,78,179],"assessed":[75],"separately.":[76],"Portal":[77],"macrophage":[79],"increased":[82,135,205,217],"all":[84,101,117],"three":[85,149],"markers":[86,123,150],"exhibiting":[89],"only":[90],"fatty":[91],"change":[92],"(P":[93,142],"less":[94,143],"than":[95,144,170,181],"0.05)":[96],"MAC-387":[99,131,173],"groups.":[103,119],"In":[104],"agreement":[105],"previous":[107],"studies,":[108],"lysozyme":[109,160],"positive":[110,132],"However,":[120],"other":[122],"did":[124],"not":[125],"show":[126],"any":[127],"significant":[128],"decrease":[129],"livers":[137],"cirrhosis":[139],"plus":[140],"hepatitis":[141],"0.01).":[145],"The":[146],"use":[147],"revealed":[151],"phenotypic":[152],"heterogeneity":[153],"antibodies":[158],"to":[159,188,215,227],"1":[163],"AT":[164],"more":[166,177],"MAC-387,":[171],"but":[172],"anti-lysozyme":[175],"anti-alpha":[182],"1AT.":[183],"Since":[184],"appear":[187],"be":[189],"heterogeneous":[190],"capable":[192],"diverse":[194],"functions":[195],"including":[196],"release":[198],"cytotoxic":[200],"mediators,":[201],"finding":[203],"numbers,":[206,218],"even":[207,219],"early":[209,221],"ALD,":[210,222],"suggests":[211,223],"they":[212,224],"may":[213,225],"contribute":[214,226],"tissue":[229],"damage.":[230]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
