{"id":"https://openalex.org/W2012334457","doi":"https://doi.org/10.1074/jbc.m501080200","title":"Wnt Signaling Inhibits Adipogenesis through \u03b2-Catenin-dependent and -independent Mechanisms","display_name":"Wnt Signaling Inhibits Adipogenesis through \u03b2-Catenin-dependent and -independent Mechanisms","publication_year":2005,"publication_date":"2005-04-24","ids":{"openalex":"https://openalex.org/W2012334457","doi":"https://doi.org/10.1074/jbc.m501080200","mag":"2012334457","pmid":"https://pubmed.ncbi.nlm.nih.gov/15849360"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m501080200","doi":"https://doi.org/10.1074/jbc.m501080200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m501080200","pdf_url":"http://www.jbc.org/article/S0021925820674579/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820674579/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032662565","display_name":"Jennifer A. Kennell","orcid":"https://orcid.org/0000-0001-9793-6259","observed_orcids":["https://orcid.org/0000-0001-9793-6259"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Kennell","raw_affiliation_strings":["Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0622, USA","Program in Cellular and Molecular Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0622, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Program in Cellular and Molecular Biology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077260684","display_name":"Ormond A. MacDougald","orcid":"https://orcid.org/0000-0001-6907-7960","observed_orcids":["https://orcid.org/0000-0001-6907-7960"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ormond A. MacDougald","raw_affiliation_strings":["Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0622","Program in Cellular and Molecular Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0622","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Program in Cellular and Molecular Biology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077260684"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.233,"has_fulltext":true,"cited_by_count":250,"citation_normalized_percentile":{"value":0.95626173,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"280","issue":"25","first_page":"24004","last_page":"24010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":1.0},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/frizzled-1","display_name":"Frizzled-1","score":0.8190000057220459},{"id":"https://openalex.org/keywords/frizzled-2","display_name":"Frizzled-2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.777999997138977},{"id":"https://openalex.org/keywords/preadipocytes","display_name":"preadipocytes","score":0.7860000133514404},{"id":"https://openalex.org/keywords/mesenchymal-progenitor-cells","display_name":"mesenchymal progenitor cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/osteoblastogenesis","display_name":"osteoblastogenesis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/wnt8","display_name":"Wnt8","score":0.6790000200271606},{"id":"https://openalex.org/keywords/wnt3a","display_name":"Wnt3a","score":0.8349999785423279},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.8951741456985474},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8674931526184082},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.694391131401062},{"id":"https://openalex.org/C2779131293","wikidata":"https://www.wikidata.org/wiki/Q18048098","display_name":"WNT3A","level":4,"score":0.6939811706542969},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5850939750671387},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.5426419973373413},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5056242942810059},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.47918665409088135},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.4600522220134735},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4572148323059082},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4506969749927521},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.40733063220977783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4067782163619995}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060509","descriptor_name":"Wnt3A Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m501080200","doi":"https://doi.org/10.1074/jbc.m501080200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m501080200","pdf_url":"http://www.jbc.org/article/S0021925820674579/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15849360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15849360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m501080200","doi":"https://doi.org/10.1074/jbc.m501080200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m501080200","pdf_url":"http://www.jbc.org/article/S0021925820674579/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5445575128","display_name":"Systems and Integrative Biology Training Program","funder_award_id":"T32GM008322","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7991074845","display_name":"Regulation of adipocyte differentiation and metabolism","funder_award_id":"R01DK051563","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012334457.pdf","grobid_xml":"https://content.openalex.org/works/W2012334457.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1508739164","https://openalex.org/W1549691444","https://openalex.org/W1554815317","https://openalex.org/W1556721384","https://openalex.org/W1968366612","https://openalex.org/W1974319293","https://openalex.org/W1984900499","https://openalex.org/W1988277042","https://openalex.org/W1989168385","https://openalex.org/W1994922837","https://openalex.org/W1999126906","https://openalex.org/W1999411923","https://openalex.org/W2000352591","https://openalex.org/W2002156733","https://openalex.org/W2015974087","https://openalex.org/W2021747430","https://openalex.org/W2022083755","https://openalex.org/W2029187758","https://openalex.org/W2032381707","https://openalex.org/W2036883820","https://openalex.org/W2037615799","https://openalex.org/W2043096216","https://openalex.org/W2043129312","https://openalex.org/W2053083708","https://openalex.org/W2053617341","https://openalex.org/W2054094827","https://openalex.org/W2055557491","https://openalex.org/W2068118215","https://openalex.org/W2073998126","https://openalex.org/W2075124840","https://openalex.org/W2088942336","https://openalex.org/W2090851532","https://openalex.org/W2097899015","https://openalex.org/W2103450164","https://openalex.org/W2105054202","https://openalex.org/W2109069210","https://openalex.org/W2109767902","https://openalex.org/W2112197118","https://openalex.org/W2119284420","https://openalex.org/W2120983879","https://openalex.org/W2124578454","https://openalex.org/W2131270588","https://openalex.org/W2133172561","https://openalex.org/W2150589615","https://openalex.org/W2158963518","https://openalex.org/W2164964874","https://openalex.org/W2166298779","https://openalex.org/W2169000920","https://openalex.org/W2170136499","https://openalex.org/W2173681478","https://openalex.org/W2176176727","https://openalex.org/W7095734969"],"related_works":["https://openalex.org/W2073998126","https://openalex.org/W2008069108","https://openalex.org/W2349337608","https://openalex.org/W2043129312","https://openalex.org/W2094254575","https://openalex.org/W2731454723","https://openalex.org/W7074191480","https://openalex.org/W2616746443","https://openalex.org/W3128961813","https://openalex.org/W2102987465"],"abstract_inverted_index":{"Wnt":[0,28,42,145],"signaling":[1,146],"has":[2],"been":[3],"reported":[4],"to":[5,117,130],"block":[6,129],"apoptosis":[7,97],"and":[8,21,48,64,70,88,152],"regulate":[9],"differentiation":[10],"of":[11,16,23,27,54,82,107,112,122],"mesenchymal":[12,71],"progenitors":[13],"through":[14,34,103,149],"inhibition":[15],"glycogen":[17],"synthase":[18],"kinase":[19],"3":[20],"stabilization":[22],"beta-catenin.":[24,108],"The":[25],"effects":[26],"in":[29,46,68,143],"preadipocytes":[30,47,69],"may":[31],"be":[32,118],"mediated":[33],"Frizzled":[35],"(Fz)":[36],"1":[37],"and/or":[38],"Fz2":[39,67,93],"as":[40],"these":[41],"receptors":[43],"are":[44],"expressed":[45,58],"their":[49],"expression":[50],"declines":[51],"upon":[52],"induction":[53],"differentiation.":[55],"We":[56],"ectopically":[57],"constitutively":[59],"active":[60],"chimeras":[61],"between":[62],"Wnt8":[63],"Fz1":[65,79],"or":[66,98,135],"precursor":[72],"cells.":[73],"Our":[74],"results":[75],"indicated":[76],"that":[77],"activated":[78,92,136],"increases":[80],"stability":[81],"beta-catenin,":[83],"inhibits":[84,89,101,147],"apoptosis,":[85],"induces":[86],"osteoblastogenesis,":[87,99],"adipogenesis.":[90],"Although":[91],"does":[94],"not":[95],"influence":[96],"it":[100],"adipogenesis":[102,131,148],"a":[104,141],"mechanism":[105],"independent":[106],"An":[109],"important":[110],"mediator":[111],"the":[113,128],"beta-catenin-independent":[114,153],"pathway":[115],"appears":[116],"calcineurin":[119],"because":[120],"inhibitors":[121],"this":[123],"serine/threonine":[124],"phosphatase":[125],"partially":[126],"rescue":[127],"caused":[132],"by":[133],"Wnt3a":[134],"Fz2.":[137],"These":[138],"data":[139],"supported":[140],"model":[142],"which":[144],"both":[150],"beta-catenin-dependent":[151],"mechanisms.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}