{"id":"https://openalex.org/W2012330784","doi":"https://doi.org/10.3109/02841869309092448","title":"Combined Bleomycin and Irradiation in Preoperative Treatment of Advanced Squamous Cell Carcinoma of the Vulva","display_name":"Combined Bleomycin and Irradiation in Preoperative Treatment of Advanced Squamous Cell Carcinoma of the Vulva","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2012330784","doi":"https://doi.org/10.3109/02841869309092448","mag":"2012330784","pmid":"https://pubmed.ncbi.nlm.nih.gov/7505091"},"language":"en","primary_location":{"id":"doi:10.3109/02841869309092448","doi":"https://doi.org/10.3109/02841869309092448","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02841869309092448","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841869309092448?needAccess=true","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841869309092448?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029237342","display_name":"Marit Scheistr\u00f8en","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marit Scheistr\u00f6en","raw_affiliation_strings":["Norwegian Radium Hospital, Oslo","Norwegian Radium Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwegian Radium Hospital, Oslo","institution_ids":[]},{"raw_affiliation_string":"Norwegian Radium Hospital, Oslo, Norway","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041434650","display_name":"Claes Goran Trope","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claes Trop\u00e9","raw_affiliation_strings":["Norwegian Radium Hospital, Oslo, Norway","Gynecological Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwegian Radium Hospital, Oslo, Norway","institution_ids":[]},{"raw_affiliation_string":"Gynecological Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5675,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.62087671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"32","issue":"6","first_page":"657","last_page":"661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vulvar-squamous-cell-carcinoma","display_name":"vulvar squamous cell carcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/advanced-vulvar-cancer","display_name":"advanced vulvar cancer","score":0.8349999785423279},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.906000018119812},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.5680000185966492},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.6669999957084656},{"id":"https://openalex.org/keywords/recurrent-vulvar-cancer","display_name":"recurrent vulvar cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6010000109672546},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8619999885559082},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.965605616569519},{"id":"https://openalex.org/C2776316342","wikidata":"https://www.wikidata.org/wiki/Q2192288","display_name":"Vulva","level":2,"score":0.8333638906478882},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6362593173980713},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6305951476097107},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.6290140151977539},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6104298830032349},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5427461266517639},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.4836200773715973},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.41497108340263367},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4007995128631592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2658484876155853}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014846","descriptor_name":"Vulvar Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014846","descriptor_name":"Vulvar Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D014846","descriptor_name":"Vulvar Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D014846","descriptor_name":"Vulvar Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/02841869309092448","doi":"https://doi.org/10.3109/02841869309092448","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02841869309092448","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841869309092448?needAccess=true","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},{"id":"pmid:7505091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7505091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oncologica (Stockholm, Sweden)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3109/02841869309092448","doi":"https://doi.org/10.3109/02841869309092448","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02841869309092448","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841869309092448?needAccess=true","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012330784.pdf","grobid_xml":"https://content.openalex.org/works/W2012330784.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1979300931","https://openalex.org/W1979445325","https://openalex.org/W1984066460","https://openalex.org/W1992082172","https://openalex.org/W2013226893","https://openalex.org/W2020640284","https://openalex.org/W2027124062","https://openalex.org/W2057621991","https://openalex.org/W2066308837","https://openalex.org/W2067720048","https://openalex.org/W2074666136","https://openalex.org/W2081860389","https://openalex.org/W2127905814","https://openalex.org/W2409380676","https://openalex.org/W2409598265","https://openalex.org/W2417165571","https://openalex.org/W2420177867","https://openalex.org/W3041047318"],"related_works":["https://openalex.org/W2127905814","https://openalex.org/W2425590207","https://openalex.org/W2095148478","https://openalex.org/W2012385586","https://openalex.org/W1993577287","https://openalex.org/W1974466781","https://openalex.org/W2056411928","https://openalex.org/W2401245675","https://openalex.org/W2052368503","https://openalex.org/W1995064390"],"abstract_inverted_index":{"Forty-two":[0],"patients":[1,26,32,40,91,103,121,148],"with":[2,12,41,64],"advanced":[3,151],"squamous":[4],"cell":[5],"carcinoma":[6,84,124],"of":[7,16,38,67,72,77,83,85,101,123,125,159,166],"the":[8,39,86,126,153,160,164,177],"vulva":[9],"were":[10,138],"treated":[11,92,104],"a":[13],"combination":[14],"regimen":[15],"bleomycin":[17],"180":[18],"mg":[19],"and":[20,30,49,81,112,136,170],"external":[21],"irradiation":[22],"30-45":[23],"Gy.":[24],"Twenty":[25],"had":[27,33,149],"primary":[28,42,94],"lesions,":[29],"22":[31,102],"recurrent":[34],"disease.":[35,68],"Fifteen":[36],"(75%)":[37],"disease":[43,95],"showed":[44,107],"objective":[45,108],"response":[46,109],"(five":[47],"complete":[48,111],"ten":[50],"partial":[51,114],"response).":[52],"Four":[53],"underwent":[54,117],"surgery.":[55,118],"Of":[56],"these,":[57],"one":[58],"is":[59],"alive":[60],"after":[61],"60":[62],"months":[63],"no":[65,139],"evidence":[66],"Two":[69],"have":[70,175],"died":[71,82,122],"unrelated":[73],"causes":[74],"without":[75],"signs":[76],"recurrence.":[78],"Seventeen":[79],"relapsed":[80],"vulva.":[87,127],"Median":[88,128],"survival":[89,129],"for":[90,93,105],"was":[96,130,134],"8.0":[97],"months.":[98,132],"Thirteen":[99],"(59%)":[100],"recurrence":[106],"(two":[110],"eleven":[113],"responses).":[115],"None":[116],"All":[119],"these":[120],"6.4":[131],"Toxicity":[133],"acceptable,":[135],"there":[137],"treatment-related":[140],"deaths.":[141],"Even":[142],"taking":[143],"into":[144],"account":[145],"that":[146],"our":[147],"very":[150],"disease,":[152],"results":[154],"are":[155],"disappointing.":[156],"An":[157],"increase":[158],"radiation":[161],"dose":[162],"beyond":[163],"maximum":[165],"45":[167],"Gy":[168],"given,":[169],"more":[171],"aggressive":[172],"surgery,":[173],"might":[174],"improved":[176],"results.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}