{"id":"https://openalex.org/W2012328023","doi":"https://doi.org/10.1074/jbc.m107899200","title":"Changes in Phospholipid Extractability and Composition Accompany Mineralization of Chicken Growth Plate Cartilage Matrix Vesicles","display_name":"Changes in Phospholipid Extractability and Composition Accompany Mineralization of Chicken Growth Plate Cartilage Matrix Vesicles","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2012328023","doi":"https://doi.org/10.1074/jbc.m107899200","mag":"2012328023","pmid":"https://pubmed.ncbi.nlm.nih.gov/11714705"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m107899200","doi":"https://doi.org/10.1074/jbc.m107899200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m107899200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m107899200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111685519","display_name":"Licia N.Y. Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Licia N.Y. Wu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA","From the Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA","institution_ids":["https://openalex.org/I155781252"]},{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208 and the","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060346248","display_name":"Brian R. Genge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian R. Genge","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208 and the","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Min W. Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min W. Kang","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208 and the","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012974017","display_name":"A. Larry Arsenault","orcid":"https://orcid.org/0000-0003-2758-9495","observed_orcids":["https://orcid.org/0000-0003-2758-9495"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. Larry Arsenault","raw_affiliation_strings":["Department of Pathology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109997080","display_name":"Roy E. Wuthier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roy E. Wuthier","raw_affiliation_strings":["From the Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208 and the","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109997080"],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.0352,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.87563481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"277","issue":"7","first_page":"5126","last_page":"5133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11278","display_name":"Calcium Carbonate Crystallization and Inhibition","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-vesicles","display_name":"matrix vesicles","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cartilage-mineralization","display_name":"cartilage calcification","score":0.718999981880188},{"id":"https://openalex.org/keywords/phospholipid-composition","display_name":"phospholipid composition","score":0.7789999842643738},{"id":"https://openalex.org/keywords/phosphatidylserine","display_name":"phosphatidylserine","score":0.968999981880188},{"id":"https://openalex.org/keywords/phosphatidylinositol","display_name":"phosphatidylinositol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/phosphatidylethanolamine","display_name":"phosphatidylethanolamine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-degradation","display_name":"lipid degradation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2781170229","wikidata":"https://www.wikidata.org/wiki/Q426095","display_name":"Phosphatidylethanolamine","level":5,"score":0.8291473984718323},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.8268479704856873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7228502035140991},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.7130395174026489},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5657666921615601},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5245257019996643},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.5046645402908325},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.48708558082580566},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.47669264674186707},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4687032401561737},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3438878655433655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14931190013885498},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010714","descriptor_name":"Phosphatidylethanolamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013109","descriptor_name":"Sphingomyelins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m107899200","doi":"https://doi.org/10.1074/jbc.m107899200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m107899200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11714705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11714705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m107899200","doi":"https://doi.org/10.1074/jbc.m107899200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m107899200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G495542304","display_name":"ROLE OF MATRIX VESICLES IN CALCIFICATION","funder_award_id":"R01AR018983","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1544995067","https://openalex.org/W1550929510","https://openalex.org/W1561676733","https://openalex.org/W1582367462","https://openalex.org/W1775749144","https://openalex.org/W1967182443","https://openalex.org/W1968581435","https://openalex.org/W1970577860","https://openalex.org/W1976404758","https://openalex.org/W1981528794","https://openalex.org/W1985394791","https://openalex.org/W1986204633","https://openalex.org/W1986262918","https://openalex.org/W1991508565","https://openalex.org/W1994558789","https://openalex.org/W2008753199","https://openalex.org/W2009460052","https://openalex.org/W2012228965","https://openalex.org/W2014111851","https://openalex.org/W2028787115","https://openalex.org/W2043776346","https://openalex.org/W2060782752","https://openalex.org/W2064182974","https://openalex.org/W2074953517","https://openalex.org/W2076670735","https://openalex.org/W2084404464","https://openalex.org/W2090148718","https://openalex.org/W2107582286","https://openalex.org/W2112705642","https://openalex.org/W2127748297","https://openalex.org/W2143430115","https://openalex.org/W2144846481","https://openalex.org/W2309351454","https://openalex.org/W2323529181"],"related_works":["https://openalex.org/W2072604466","https://openalex.org/W111276579","https://openalex.org/W2410503957","https://openalex.org/W2479948845","https://openalex.org/W2061538966","https://openalex.org/W2422492391","https://openalex.org/W3081152444","https://openalex.org/W2412886004","https://openalex.org/W1582367462","https://openalex.org/W2314088527"],"abstract_inverted_index":{"Matrix":[0],"vesicles":[1,63],"are":[2],"lipid":[3,24,54],"bilayer-enclosed":[4],"structures":[5],"that":[6,115,171,175],"initiate":[7],"extracellular":[8],"mineral":[9,20,41,72,177,190],"formation.":[10,73],"Little":[11],"attention":[12],"has":[13],"been":[14],"given":[15],"to":[16,38,70,91],"how":[17],"newly":[18,121],"formed":[19],"interacts":[21],"with":[22,120,132,137],"the":[23,30,39,46,79,138,192],"constituents":[25],"and":[26,42,56,88,96,147],"then":[27],"emerges":[28],"from":[29,101,191],"lumen.":[31,194],"To":[32],"explore":[33],"whether":[34],"specific":[35],"lipids":[36,80],"bind":[37],"incipient":[40],"if":[43],"breakdown":[44],"of":[45,78,164,181,188],"membrane":[47,183],"is":[48],"involved,":[49],"we":[50],"analyzed":[51],"changes":[52],"in":[53,66],"composition":[55],"extractability":[57],"during":[58],"vesicle-induced":[59],"calcification.":[60],"Isolated":[61],"matrix":[62],"were":[64,81],"incubated":[65],"synthetic":[67],"cartilage":[68],"lymph":[69],"induce":[71],"At":[74],"various":[75],"times,":[76],"samples":[77],"taken":[82],"for":[83],"analysis,":[84],"extracted":[85],"both":[86,98],"before":[87,104],"after":[89,112],"demineralization":[90,113],"remove":[92],"deposited":[93],"mineral.":[94,123],"Phosphatidylserine":[95],"phosphatidylinositol":[97,140],"rapidly":[99,143],"disappeared":[100],"extracts":[102,110],"made":[103,111],"decalcification,":[105],"indicating":[106],"rapid":[107,151],"degradation.":[108],"However,":[109],"revealed":[114],"phosphatidylserine":[116,172],"had":[117],"become":[118],"complexed":[119,136],"forming":[122],"Concomitantly,":[124],"its":[125],"levels":[126],"actually":[127],"increased,":[128],"apparently":[129,185],"by":[130,161],"base-exchange":[131],"phosphatidylethanolamine.":[133],"Though":[134],"partially":[135],"mineral,":[139],"was":[141,155],"nevertheless":[142],"broken":[144],"down.":[145],"Sphingomyelin":[146],"phosphatidylethanolamine":[148],"also":[149],"underwent":[150],"breakdown,":[152],"but":[153],"phosphatidylcholine":[154],"degraded":[156],"more":[157],"slowly,":[158],"all":[159],"accompanied":[160],"a":[162],"buildup":[163],"free":[165],"fatty":[166],"acids.":[167],"The":[168],"data":[169],"indicate":[170],"forms":[173],"complexes":[174],"accompany":[176],"formation,":[178],"while":[179],"degradation":[180],"other":[182],"phospholipids":[184],"enables":[186],"egress":[187],"crystalline":[189],"vesicle":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
