{"id":"https://openalex.org/W2012321301","doi":"https://doi.org/10.1096/fj.09-144295","title":"The death effector domain protein PEA\u201015 negatively regulates T\u2010cell receptor signaling","display_name":"The death effector domain protein PEA\u201015 negatively regulates T\u2010cell receptor signaling","publication_year":2010,"publication_date":"2010-03-30","ids":{"openalex":"https://openalex.org/W2012321301","doi":"https://doi.org/10.1096/fj.09-144295","mag":"2012321301","pmid":"https://pubmed.ncbi.nlm.nih.gov/20354143","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2909277"},"language":"en","primary_location":{"id":"doi:10.1096/fj.09-144295","doi":"https://doi.org/10.1096/fj.09-144295","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.09-144295","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2909277","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062184701","display_name":"Sandra Pastorino","orcid":"https://orcid.org/0000-0002-4559-1065","observed_orcids":["https://orcid.org/0000-0002-4559-1065"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Pastorino","raw_affiliation_strings":["Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024644082","display_name":"Hemamalini Renganathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hemamalini Renganathan","raw_affiliation_strings":["Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063487985","display_name":"Maisel J. Caliva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maisel J. Caliva","raw_affiliation_strings":["Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062448287","display_name":"Erin L. Filbert","orcid":"https://orcid.org/0000-0001-5077-9030","observed_orcids":["https://orcid.org/0000-0001-5077-9030"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin L. Filbert","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081191243","display_name":"John Opoku\u2010Ansah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Opoku\u2010Ansah","raw_affiliation_strings":["Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089337746","display_name":"Florian J. Sulzmaier","orcid":"https://orcid.org/0000-0003-1352-2556","observed_orcids":["https://orcid.org/0000-0003-1352-2556"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florian J. Sulzmaier","raw_affiliation_strings":["Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111916642","display_name":"Joanna E. Gawecka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna E. Gawecka","raw_affiliation_strings":["Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001485563","display_name":"Guy Werlen","orcid":"https://orcid.org/0000-0002-1148-0906","observed_orcids":["https://orcid.org/0000-0002-1148-0906"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy Werlen","raw_affiliation_strings":["Department of Cell Biology and Neuroscience, The Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Neuroscience, The Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090663440","display_name":"Andr\u00e9y S. Shaw","orcid":"https://orcid.org/0000-0001-5685-0272","observed_orcids":["https://orcid.org/0000-0001-5685-0272"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrey S. Shaw","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA","Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059446232","display_name":"Joe William Ramos","orcid":"https://orcid.org/0000-0002-9708-2115","observed_orcids":["https://orcid.org/0000-0002-9708-2115"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joe W. Ramos","raw_affiliation_strings":["Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5059446232"],"corresponding_institution_ids":["https://openalex.org/I117965899"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.7711,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.68734351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"8","first_page":"2818","last_page":"2828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pea-15","display_name":"PEA-15","score":0.9959999918937683},{"id":"https://openalex.org/keywords/death-effector-domain","display_name":"death effector domain","score":0.8949999809265137},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/erk-nuclear-translocation","display_name":"ERK nuclear translocation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/il-2-transcription","display_name":"IL-2 transcription","score":0.9359999895095825},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/t-cell-homeostasis","display_name":"T cell homeostasis","score":0.847000002861023},{"id":"https://openalex.org/keywords/fadd","display_name":"FADD","score":0.7149999737739563},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6934940218925476},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6411753296852112},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5425392389297485},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5266915559768677},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.4836758077144623},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48146548867225647},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4555552899837494},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43369102478027344},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4164336621761322},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37300869822502136},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27747148275375366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16958537697792053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08859586715698242}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1096/fj.09-144295","doi":"https://doi.org/10.1096/fj.09-144295","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.09-144295","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2909277","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2909277","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB J","raw_type":"Text"},{"id":"pmid:20354143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20354143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2909277","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2909277","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB J","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2025720102","display_name":null,"funder_award_id":"08\u20101089\u2010CCR\u2010EO","funder_id":"https://openalex.org/F4320308304","funder_display_name":"New Jersey Commission on Spinal Cord Research"},{"id":"https://openalex.org/G3355429260","display_name":"Bioscience Research Infrastructure Development for Grant Enhancement and Success","funder_award_id":"G12RR003061","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3770754435","display_name":"Regulation of Cell Signaling and Adhesion","funder_award_id":"R01CA093849","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4638874981","display_name":"Pacific Center for Emerging Infectious Diseases Research","funder_award_id":"P20RR018727","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5788460938","display_name":null,"funder_award_id":"CA03849","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7614142558","display_name":null,"funder_award_id":"CA03849","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320308304","display_name":"New Jersey Commission on Spinal Cord Research","ror":"https://ror.org/03kmrjq19"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1507379897","https://openalex.org/W1515152372","https://openalex.org/W1516476750","https://openalex.org/W1549711458","https://openalex.org/W1883645593","https://openalex.org/W1899552864","https://openalex.org/W1965712069","https://openalex.org/W1967400782","https://openalex.org/W1971692004","https://openalex.org/W1983952740","https://openalex.org/W1987163073","https://openalex.org/W1993031309","https://openalex.org/W1995819749","https://openalex.org/W1997546191","https://openalex.org/W2002440150","https://openalex.org/W2004232796","https://openalex.org/W2009548555","https://openalex.org/W2021911222","https://openalex.org/W2025531843","https://openalex.org/W2026900959","https://openalex.org/W2031133522","https://openalex.org/W2031547967","https://openalex.org/W2055059373","https://openalex.org/W2057694016","https://openalex.org/W2066274736","https://openalex.org/W2072638221","https://openalex.org/W2086783008","https://openalex.org/W2093902610","https://openalex.org/W2095405582","https://openalex.org/W2114325422","https://openalex.org/W2114569569","https://openalex.org/W2122075091","https://openalex.org/W2132346729","https://openalex.org/W2135868454","https://openalex.org/W2137830314","https://openalex.org/W2145661576","https://openalex.org/W2147438402","https://openalex.org/W2158175056","https://openalex.org/W2158488680","https://openalex.org/W2158617540","https://openalex.org/W2158969445","https://openalex.org/W2413195530"],"related_works":["https://openalex.org/W7097253958","https://openalex.org/W1845469332","https://openalex.org/W7097356242","https://openalex.org/W2138012930","https://openalex.org/W4255128792","https://openalex.org/W3175865596","https://openalex.org/W2108394389","https://openalex.org/W2135868454","https://openalex.org/W3174962886","https://openalex.org/W2158617540"],"abstract_inverted_index":{"ABSTRACT":[0],"PEA\u201015":[1,17,33,54,65,74,92,127,135,170,225],"is":[2,34,171,193],"a":[3,172],"death":[4,28,221],"effector":[5,222],"domain\u2010containing":[6],"phosphoprotein":[7],"that":[8,73],"binds":[9,19],"ERK":[10,102,144],"and":[11,22,40,103,109,145],"restricts":[12],"it":[13],"to":[14,20,113,165],"the":[15,51,64,120,190],"cytoplasm.":[16],"also":[18],"FADD":[21],"thereby":[23,71],"blocks":[24],"apoptosis":[25,166],"induced":[26],"by":[27],"receptors.":[29],"Abnormal":[30],"expression":[31],"of":[32,53,101,106,119,129,134,143],"associated":[35],"with":[36],"type":[37],"II":[38],"diabetes":[39],"some":[41],"cancers;":[42],"however,":[43],"its":[44],"physiological":[45],"function":[46,52],"remains":[47],"unclear.":[48],"To":[49],"determine":[50],"in":[55,62,111,123,136,161,175,187],"vivo":[56],",":[57],"we":[58],"used":[59],"C57BL/6":[60],"mice":[61,79,125],"which":[63],"coding":[66],"region":[67],"was":[68],"deleted.":[69],"We":[70],"found":[72],"regulates":[75,227],"T\u2010cell":[76,121,176,228],"proliferation.":[77],"PEA\u201015\u2010null":[78,149],"did":[80],"not":[81],"have":[82,183],"altered":[83],"thymic":[84],"or":[85,89],"splenic":[86],"lymphocyte":[87],"cellularity":[88],"differentiation.":[90],"However,":[91],"deficient":[93],"T":[94,138,150,162],"cells":[95,139,151],"had":[96],"increased":[97,104,153],"CD3/CD28\u2010induced":[98],"nuclear":[99,141],"translocation":[100,142],"activation":[105,118],"IL\u20102":[107,146,154],"transcription":[108],"secretion":[110],"comparison":[112],"control":[114],"wild\u2010type":[115,124],"littermates.":[116],"Indeed,":[117],"receptor":[122,229],"caused":[126],"release":[128],"ERK.":[130],"In":[131],"contrast,":[132],"overexpression":[133],"Jurkat":[137],"blocked":[140],"transcription.":[147],"Finally,":[148],"showed":[152],"dependent":[155],"proliferation":[156],"on":[157],"stimulation.":[158],"No":[159],"differences":[160],"cell":[163],"susceptibility":[164],"were":[167],"found.":[168],"Thus,":[169],"novel":[173],"player":[174],"homeostasis.":[177],"As":[178],"such":[179],"this":[180],"work":[181],"may":[182],"far":[184],"reaching":[185],"implications":[186],"understanding":[188],"how":[189],"immune":[191],"response":[192],"controlled.\u2014Pastorino,":[194],"S.,":[195,216],"Renganathan,":[196],"H.,":[197],"Caliva,":[198],"M.":[199],"J.,":[200,205,208],"Filbert,":[201],"E.":[202],"L.,":[203],"Opoku\u2010Ansah,":[204],"Sulzmaier,":[206],"F.":[207],"Gawecka,":[209],"J.":[210,218],"E.,":[211],"Werlen,":[212],"G.,":[213],"Shaw,":[214],"A.":[215],"Ramos,":[217],"W.":[219],"The":[220],"domain":[223],"protein":[224],"negatively":[226],"signaling.":[230],"FASEB":[231],"J":[232],".":[233],"24,":[234],"2818\u20132828":[235],"(2010).":[236],"www.fasebj.org":[237]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
