{"id":"https://openalex.org/W2012319129","doi":"https://doi.org/10.1002/eji.1830210318","title":"Molecular basis of IgG Fc receptor III defect in a patient with systemic lupus erythematosus","display_name":"Molecular basis of IgG Fc receptor III defect in a patient with systemic lupus erythematosus","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W2012319129","doi":"https://doi.org/10.1002/eji.1830210318","mag":"2012319129","pmid":"https://pubmed.ncbi.nlm.nih.gov/1826262"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830210318","doi":"https://doi.org/10.1002/eji.1830210318","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830210318","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050089436","display_name":"Barbara Enenkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Barbara Enenkel","raw_affiliation_strings":["Universit\u00e4t Bielefeld, Fakult\u00e4t f\u00fcr Chemie, Biochemie, Bielefeld"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4t Bielefeld, Fakult\u00e4t f\u00fcr Chemie, Biochemie, Bielefeld","institution_ids":["https://openalex.org/I20121455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087765652","display_name":"Dirk Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Jung","raw_affiliation_strings":["Universita\u0308t Bielefeld, Fakulta\u0308t fu\u0308r Chemie, Biochemie, Bielefeld","Universit\u00e4t Bielefeld, Fakult\u00e4t f\u00fcr Chemie, Biochemie, Bielefeld"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0308t Bielefeld, Fakulta\u0308t fu\u0308r Chemie, Biochemie, Bielefeld","institution_ids":["https://openalex.org/I20121455"]},{"raw_affiliation_string":"Universit\u00e4t Bielefeld, Fakult\u00e4t f\u00fcr Chemie, Biochemie, Bielefeld","institution_ids":["https://openalex.org/I20121455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113695089","display_name":"J\u00fcrgen Frey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J\u00fcrgen Frey","raw_affiliation_strings":["Universita\u0308t Bielefeld, Fakulta\u0308t fu\u0308r Chemie, Biochemie, Bielefeld","Universit\u00e4t Bielefeld, Fakult\u00e4t f\u00fcr Chemie, Biochemie, Universit\u00e4tsstr. 25, D\u20104800 Bielefeld 1, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0308t Bielefeld, Fakulta\u0308t fu\u0308r Chemie, Biochemie, Bielefeld","institution_ids":["https://openalex.org/I20121455"]},{"raw_affiliation_string":"Universit\u00e4t Bielefeld, Fakult\u00e4t f\u00fcr Chemie, Biochemie, Universit\u00e4tsstr. 25, D\u20104800 Bielefeld 1, FRG","institution_ids":["https://openalex.org/I20121455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113695089"],"corresponding_institution_ids":["https://openalex.org/I20121455"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":1.3158,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.78936292,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"3","first_page":"659","last_page":"663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fc-gamma-receptor-iii","display_name":"Fc gamma receptor III","score":0.9129999876022339},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9629999995231628},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7302333116531372},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6626862287521362},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49455544352531433},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.444282203912735},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21870100498199463}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/eji.1830210318","doi":"https://doi.org/10.1002/eji.1830210318","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830210318","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:1826262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1826262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Case Reports"},{"id":"pmh:oai:pub.librecat.org:1650139","doi":null,"is_oa":false,"landing_page_url":"https://pub.uni-bielefeld.de/record/1650139","pdf_url":null,"source":{"id":"https://openalex.org/S4306401671","display_name":"PUB \u2013 Publications at Bielefeld University (Bielefeld University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ENENKEL B, JUNG D, Frey J. MOLECULAR-BASIS OF IGG FC RECEPTOR-III DEFECT IN A PATIENT WITH SYSTEMIC LUPUS-ERYTHEMATOSUS. &lt;em&gt;EUROPEAN JOURNAL OF IMMUNOLOGY&lt;/em&gt;. 1991;21(3):659-663.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pub.uni-bielefeld.de:1650139","doi":null,"is_oa":false,"landing_page_url":"https://pub.uni-bielefeld.de/record/1650139","pdf_url":null,"source":{"id":"https://openalex.org/S4306401624","display_name":"Publikationen an der Universit\u00e4t Bielefeld (Universit\u00e4t Bielefeld)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ENENKEL B, JUNG D, Frey J. MOLECULAR-BASIS OF IGG FC RECEPTOR-III DEFECT IN A PATIENT WITH SYSTEMIC LUPUS-ERYTHEMATOSUS. &lt;em&gt;EUROPEAN JOURNAL OF IMMUNOLOGY&lt;/em&gt;. 1991;21(3):659-663.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W171398818","https://openalex.org/W1486578103","https://openalex.org/W1489541744","https://openalex.org/W1510592856","https://openalex.org/W1516752435","https://openalex.org/W1606776565","https://openalex.org/W1773790949","https://openalex.org/W1965051773","https://openalex.org/W1965372133","https://openalex.org/W1989237539","https://openalex.org/W1991028538","https://openalex.org/W2006203423","https://openalex.org/W2009598751","https://openalex.org/W2009811622","https://openalex.org/W2012045532","https://openalex.org/W2031013105","https://openalex.org/W2042096080","https://openalex.org/W2053630011","https://openalex.org/W2058088729","https://openalex.org/W2059300566","https://openalex.org/W2062703426","https://openalex.org/W2067823440","https://openalex.org/W2070814047","https://openalex.org/W2084106813","https://openalex.org/W2084263070","https://openalex.org/W2092562610","https://openalex.org/W2095308764","https://openalex.org/W2102162360","https://openalex.org/W2107164544","https://openalex.org/W2130672995","https://openalex.org/W2138270253","https://openalex.org/W2138879032","https://openalex.org/W2140810411","https://openalex.org/W2141168306","https://openalex.org/W2182452189","https://openalex.org/W2315955202"],"related_works":["https://openalex.org/W2107164544","https://openalex.org/W2047029262","https://openalex.org/W96520922","https://openalex.org/W2012793867","https://openalex.org/W2071128401","https://openalex.org/W2151368570","https://openalex.org/W2353921640","https://openalex.org/W2068894829","https://openalex.org/W2080092004","https://openalex.org/W2394048904"],"abstract_inverted_index":{"By":[0],"flow":[1,165],"cytometry":[2,166],"analysis":[3],"we":[4,30,57,205],"could":[5,131],"show":[6],"a":[7,22,32,90],"decreased":[8,209],"expression":[9,130,138,177,210],"of":[10,21,42,128,139,158,178,184,188,211,217,227,229],"Fc":[11,52,60,81,99,195,212],"gamma":[12,17,53,61,82,100,196,213],"receptor":[13,180,231],"type":[14],"III":[15],"(Fc":[16],"RIII)":[18],"on":[19,46,215],"granulocytes":[20,216],"patient":[23,38,77,220],"with":[24,39],"systemic":[25],"lupus":[26],"erythematosus":[27],"(SLE).":[28],"Therefore,":[29,204],"constructed":[31],"leukocyte":[33],"cDNA":[34,55,63,92,141,147,186],"library":[35],"from":[36],"this":[37,44,140,179,218],"the":[40,47,76,97,102,108,116,126,154,159,164,168,175,185,193,201,208,224,230],"aim":[41],"investigating":[43],"defect":[45,123,226],"molecular":[48],"level.":[49],"Using":[50],"an":[51],"RIII":[54,62,83,101,197,214],"probe":[56],"isolated":[58,190],"15":[59],"clones,":[64],"which":[65],"were":[66],"all":[67,189],"characterized":[68],"by":[69,134],"sequencing.":[70],"Our":[71],"sequence":[72,104,170,187],"data":[73,167],"revealed":[74],"that":[75,207],"was":[78,89],"heterozygous":[79],"for":[80,112],"(NA-1/NA-2).":[84],"Only":[85],"clone":[86,142],"5":[87],"(NA-2)":[88],"full-length":[91],"clone.":[93],"In":[94],"contrast":[95],"to":[96,125,200,223],"wild-type":[98,202],"signal":[103,160,169],"is":[105,198,221],"mutated,":[106],"lacking":[107],"hydrophobic":[109],"region":[110],"essential":[111],"co-translational":[113],"transport":[114,122,225],"across":[115],"endoplasmic":[117],"reticulum":[118],"membrane.":[119],"The":[120,146,182],"predicted":[121],"leading":[124],"lack":[127,153],"membrane":[129,176],"be":[132,172],"confirmed":[133],"immunofluorescence":[135],"staining":[136],"after":[137],"in":[143],"BHK":[144],"cells.":[145],"clones":[148,191],"6":[149],"and":[150],"8":[151],"(NA-1)":[152],"first":[155],"45":[156],"bp":[157],"sequence,":[161],"but":[162],"considering":[163],"must":[171],"functional":[173],"allowing":[174],"allele.":[181],"part":[183],"coding":[192],"mature":[194],"identical":[199],"sequence.":[203],"conclude":[206],"SLE":[219],"due":[222],"one":[228],"alleles.":[232]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
