{"id":"https://openalex.org/W2012316183","doi":"https://doi.org/10.1007/s10858-009-9349-4","title":"Mapping the dynamics of ligand reorganization via 13CH3 and 13CH2 relaxation dispersion at natural abundance","display_name":"Mapping the dynamics of ligand reorganization via 13CH3 and 13CH2 relaxation dispersion at natural abundance","publication_year":2009,"publication_date":"2009-07-28","ids":{"openalex":"https://openalex.org/W2012316183","doi":"https://doi.org/10.1007/s10858-009-9349-4","mag":"2012316183","pmid":"https://pubmed.ncbi.nlm.nih.gov/19639385","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2846628"},"language":"en","primary_location":{"id":"doi:10.1007/s10858-009-9349-4","doi":"https://doi.org/10.1007/s10858-009-9349-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10858-009-9349-4","pdf_url":null,"source":{"id":"https://openalex.org/S181390377","display_name":"Journal of Biomolecular NMR","issn_l":"0925-2738","issn":["0925-2738","1573-5001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular NMR","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2846628","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085781283","display_name":"Jeffrey W. Peng","orcid":"https://orcid.org/0000-0002-1226-3815","observed_orcids":["https://orcid.org/0000-0002-1226-3815"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey W. Peng","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. jpeng@nd.edu","University of Notre Dame"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. jpeng@nd.edu","institution_ids":["https://openalex.org/I107639228"]},{"raw_affiliation_string":"University of Notre Dame","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108949083","display_name":"Brian D. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D. Wilson","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA","University of Notre Dame"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA","institution_ids":["https://openalex.org/I107639228"]},{"raw_affiliation_string":"University of Notre Dame","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034464729","display_name":"Andrew T. Namanja","orcid":"https://orcid.org/0000-0001-8950-8860","observed_orcids":["https://orcid.org/0000-0001-8950-8860"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew T. Namanja","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA","University of Notre Dame"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA","institution_ids":["https://openalex.org/I107639228"]},{"raw_affiliation_string":"University of Notre Dame","institution_ids":["https://openalex.org/I107639228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085781283"],"corresponding_institution_ids":["https://openalex.org/I107639228"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.8583,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.67043453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"1-2","first_page":"171","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-abundance-13c","display_name":"13C natural abundance","score":0.7630000114440918},{"id":"https://openalex.org/keywords/methyl-group-exchange","display_name":"methyl group exchange","score":0.5220000147819519},{"id":"https://openalex.org/keywords/flexible-ligands","display_name":"flexible ligands","score":0.6859999895095825},{"id":"https://openalex.org/keywords/protein-ligand-binding","display_name":"protein-ligand binding","score":0.8640000224113464},{"id":"https://openalex.org/keywords/peptidyl-prolyl-cis-trans-isomerase","display_name":"peptidyl-prolyl isomerase","score":0.878000020980835},{"id":"https://openalex.org/keywords/pin1","display_name":"Pin1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6299999952316284},{"id":"https://openalex.org/keywords/ligand-optimization","display_name":"ligand optimization","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8109335899353027},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.7736295461654663},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5563494563102722},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.5350673198699951},{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.44342413544654846},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.42909783124923706},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4255269169807434},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.39411717653274536},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3793974816799164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09788352251052856},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08915147185325623},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08259731531143188},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072340","descriptor_name":"NIMA-Interacting Peptidylprolyl Isomerase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010748","descriptor_name":"Phosphopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019696","descriptor_name":"Peptidylprolyl Isomerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10858-009-9349-4","doi":"https://doi.org/10.1007/s10858-009-9349-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10858-009-9349-4","pdf_url":null,"source":{"id":"https://openalex.org/S181390377","display_name":"Journal of Biomolecular NMR","issn_l":"0925-2738","issn":["0925-2738","1573-5001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular NMR","raw_type":"journal-article"},{"id":"pmid:19639385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19639385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomolecular NMR","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2846628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2846628","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biomol NMR","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2846628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2846628","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biomol NMR","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3887975497","display_name":null,"funder_award_id":"NIH-R01 GM 083081","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8142400571","display_name":"Functional Motions of Modular Signaling Proteins","funder_award_id":"R01GM083081","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W167277884","https://openalex.org/W1563420247","https://openalex.org/W1589295940","https://openalex.org/W1966565782","https://openalex.org/W1971557089","https://openalex.org/W1974491895","https://openalex.org/W1978545297","https://openalex.org/W1981342080","https://openalex.org/W1981596913","https://openalex.org/W1987528091","https://openalex.org/W1990721255","https://openalex.org/W1992933392","https://openalex.org/W1994681621","https://openalex.org/W1995412269","https://openalex.org/W2003932717","https://openalex.org/W2004252276","https://openalex.org/W2011148270","https://openalex.org/W2016367377","https://openalex.org/W2017387272","https://openalex.org/W2031292508","https://openalex.org/W2033269344","https://openalex.org/W2040180879","https://openalex.org/W2043035995","https://openalex.org/W2045295833","https://openalex.org/W2048338648","https://openalex.org/W2052626801","https://openalex.org/W2056229694","https://openalex.org/W2060531713","https://openalex.org/W2061720107","https://openalex.org/W2062371417","https://openalex.org/W2062801508","https://openalex.org/W2064019856","https://openalex.org/W2067722023","https://openalex.org/W2068056075","https://openalex.org/W2076283593","https://openalex.org/W2077467665","https://openalex.org/W2084825358","https://openalex.org/W2087295915","https://openalex.org/W2105649494","https://openalex.org/W2139056820","https://openalex.org/W2139936160","https://openalex.org/W2148521301","https://openalex.org/W2165849976","https://openalex.org/W2168696636","https://openalex.org/W2173710522","https://openalex.org/W2298618286","https://openalex.org/W2322398337","https://openalex.org/W6733947138"],"related_works":["https://openalex.org/W2016367377","https://openalex.org/W2105776901","https://openalex.org/W7097067168","https://openalex.org/W2068213938","https://openalex.org/W1963659157","https://openalex.org/W1974491895","https://openalex.org/W2890268513","https://openalex.org/W2147106126","https://openalex.org/W7135562769","https://openalex.org/W2020695579"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}