{"id":"https://openalex.org/W2012309077","doi":"https://doi.org/10.1186/1471-2121-12-12","title":"Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status","display_name":"Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status","publication_year":2011,"publication_date":"2011-03-30","ids":{"openalex":"https://openalex.org/W2012309077","doi":"https://doi.org/10.1186/1471-2121-12-12","mag":"2012309077","pmid":"https://pubmed.ncbi.nlm.nih.gov/21450070"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2121-12-12","doi":"https://doi.org/10.1186/1471-2121-12-12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2121-12-12","pdf_url":"https://bmcmolcellbiol.biomedcentral.com/counter/pdf/10.1186/1471-2121-12-12","source":{"id":"https://openalex.org/S43757101","display_name":"BMC Cell Biology","issn_l":"1471-2121","issn":["1471-2121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmolcellbiol.biomedcentral.com/counter/pdf/10.1186/1471-2121-12-12","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025800003","display_name":"Leticia Basciano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leticia Basciano","raw_affiliation_strings":["Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500 Vand\u0153uvre-l\u00e8s-Nancy, France","Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500 Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]},{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053580457","display_name":"Christophe N\u00e9mos","orcid":"https://orcid.org/0000-0001-8828-5407","observed_orcids":["https://orcid.org/0000-0001-8828-5407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christophe Nemos","raw_affiliation_strings":["Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]},{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014560661","display_name":"B. Foliguet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard Foliguet","raw_affiliation_strings":["Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]},{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014547000","display_name":"N. de Isla","orcid":"https://orcid.org/0000-0002-6701-3485","observed_orcids":["https://orcid.org/0000-0002-6701-3485"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia de Isla","raw_affiliation_strings":["Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]},{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015344865","display_name":"Marcelo De Carvalho Bittencourt","orcid":"https://orcid.org/0000-0002-2698-2458","observed_orcids":["https://orcid.org/0000-0002-2698-2458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcelo de Carvalho","raw_affiliation_strings":["Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]},{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064522649","display_name":"Nguyen Tran","orcid":"https://orcid.org/0000-0002-7037-8936","observed_orcids":["https://orcid.org/0000-0002-7037-8936"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nguyen Tran","raw_affiliation_strings":["Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]},{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111652687","display_name":"Ali H. Dalloul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ali Dalloul","raw_affiliation_strings":["Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), 54500, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]},{"raw_affiliation_string":"Nancy University Medical School (EA 4369) and School of Surgery (NT), Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111652687"],"corresponding_institution_ids":[],"apc_list":{"value":2170,"currency":"USD","value_usd":2170},"apc_paid":{"value":2170,"currency":"USD","value_usd":2170},"fwci":9.5274,"has_fulltext":true,"cited_by_count":249,"citation_normalized_percentile":{"value":0.98525052,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":1.0},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/long-term-culture","display_name":"long-term culture","score":0.8190000057220459},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.7630000114440918},{"id":"https://openalex.org/keywords/multipotency","display_name":"multipotency","score":0.9190000295639038},{"id":"https://openalex.org/keywords/undifferentiated-state","display_name":"undifferentiated state","score":0.8169999718666077},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.5099999904632568},{"id":"https://openalex.org/keywords/extracellular-matrix-genes","display_name":"extracellular matrix genes","score":0.7350000143051147},{"id":"https://openalex.org/keywords/stem-cell-plasticity","display_name":"stem cell plasticity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.7789999842643738},{"id":"https://openalex.org/keywords/oxygen-partial-pressure","display_name":"oxygen partial pressure","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7794864177703857},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7083709836006165},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7015987038612366},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5789013504981995},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5764639377593994},{"id":"https://openalex.org/C2993207723","wikidata":"https://www.wikidata.org/wiki/Q4927803","display_name":"Oxygen tension","level":3,"score":0.5518956780433655},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.47028449177742004},{"id":"https://openalex.org/C2910776680","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Multipotent Stem Cell","level":4,"score":0.46007639169692993},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4493183195590973},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2591695785522461},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22100898623466492},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.19809263944625854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1146349310874939},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.06824955344200134},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057905","descriptor_name":"Stem Cell Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057905","descriptor_name":"Stem Cell Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057905","descriptor_name":"Stem Cell Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2121-12-12","doi":"https://doi.org/10.1186/1471-2121-12-12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2121-12-12","pdf_url":"https://bmcmolcellbiol.biomedcentral.com/counter/pdf/10.1186/1471-2121-12-12","source":{"id":"https://openalex.org/S43757101","display_name":"BMC Cell Biology","issn_l":"1471-2121","issn":["1471-2121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cell Biology","raw_type":"journal-article"},{"id":"pmid:21450070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21450070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2084767","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3073900","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3073900","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3073900","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cell Biol","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02973723v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.univ-lorraine.fr/hal-02973723","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cell Biology, 2011, 12 (1), pp.12. &#x27E8;10.1186/1471-2121-12-12&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:2dff663c74ee4867ae474641c5ea1f2c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2dff663c74ee4867ae474641c5ea1f2c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cell Biology, Vol 12, Iss 1, p 12 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2121-12-12","doi":"https://doi.org/10.1186/1471-2121-12-12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2121-12-12","pdf_url":"https://bmcmolcellbiol.biomedcentral.com/counter/pdf/10.1186/1471-2121-12-12","source":{"id":"https://openalex.org/S43757101","display_name":"BMC Cell Biology","issn_l":"1471-2121","issn":["1471-2121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012309077.pdf","grobid_xml":"https://content.openalex.org/works/W2012309077.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1484043356","https://openalex.org/W1555330200","https://openalex.org/W1578652965","https://openalex.org/W1861988602","https://openalex.org/W1967168354","https://openalex.org/W1968442155","https://openalex.org/W1968628080","https://openalex.org/W1971964553","https://openalex.org/W1973994630","https://openalex.org/W1974207011","https://openalex.org/W1979828992","https://openalex.org/W1992714486","https://openalex.org/W1993925802","https://openalex.org/W1996803044","https://openalex.org/W1999070656","https://openalex.org/W2000503805","https://openalex.org/W2009948917","https://openalex.org/W2015884402","https://openalex.org/W2017554160","https://openalex.org/W2028420398","https://openalex.org/W2039748263","https://openalex.org/W2041552691","https://openalex.org/W2043814008","https://openalex.org/W2051471390","https://openalex.org/W2055521188","https://openalex.org/W2057597564","https://openalex.org/W2057932705","https://openalex.org/W2064277958","https://openalex.org/W2070773381","https://openalex.org/W2074121232","https://openalex.org/W2075683471","https://openalex.org/W2089951947","https://openalex.org/W2091698674","https://openalex.org/W2094260447","https://openalex.org/W2103893610","https://openalex.org/W2111727066","https://openalex.org/W2129986646","https://openalex.org/W2133230064","https://openalex.org/W2147673404","https://openalex.org/W2163059752","https://openalex.org/W2167298048","https://openalex.org/W2167628367","https://openalex.org/W2171846115","https://openalex.org/W2183280890"],"related_works":["https://openalex.org/W3183465125","https://openalex.org/W3029486551","https://openalex.org/W4301868323","https://openalex.org/W2564474899","https://openalex.org/W2138305086","https://openalex.org/W2296384277","https://openalex.org/W2074259847","https://openalex.org/W2089975035","https://openalex.org/W2093922799","https://openalex.org/W1990153575"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,112],"the":[2,16,40,57,171,208,214,230,247,257],"bone":[3],"marrow,":[4],"hematopietic":[5],"and":[6,33,65,91,97,106,128,136,156,176,192,199,250],"mesenchymal":[7],"stem":[8,28],"cells":[9,152,164,172,248],"form":[10],"a":[11,24,226,242],"unique":[12],"niche":[13],"in":[14,26,44,74,102,110,122,134,168,174,186,229,236,258,267],"which":[15],"oxygen":[17],"tension":[18],"is":[19,225],"low.":[20],"Hypoxia":[21],"may":[22,254],"have":[23],"role":[25],"maintaining":[27],"cell":[29,125],"fate,":[30],"self":[31],"renewal":[32],"multipotency.":[34],"However,":[35],"whereas":[36,131],"most":[37],"studies":[38],"addressed":[39],"effect":[41],"of":[42,47,119,181,223,233,262],"transient":[43],"vitro":[45],"exposure":[46],"MSC":[48,72,114],"to":[49,84,148,218],"hypoxia,":[50],"permanent":[51],"culture":[52],"under":[53],"hypoxia":[54,79,103,169,240],"should":[55],"reflect":[56,256],"better":[58,255],"physiological":[59],"conditions.":[60],"RESULTS:":[61],"Morphologic":[62],"studies,":[63],"differentiation":[64,231],"transcriptional":[66],"profiling":[67],"experiments":[68],"were":[69,95,145,153],"performed":[70],"on":[71],"cultured":[73,173],"normoxia":[75,175],"(21%":[76],"O2)":[77,81],"versus":[78],"(5%":[80],"for":[82,207],"up":[83],"passage":[85,89,93,100,166],"2.":[86],"Cells":[87],"at":[88,92,99,165],"0":[90,101],"2":[94,167],"compared,":[96],"those":[98],"generated":[104],"fewer":[105],"smaller":[107],"colonies":[108],"than":[109],"normoxia.":[111],"parallel,":[113],"displayed":[115,177],"(>4":[116],"fold)":[117,184],"inhibition":[118],"genes":[120,182],"involved":[121,133,185],"DNA":[123],"metabolism,":[124],"cycle":[126],"progression":[127],"chromosome":[129],"cohesion":[130],"transcripts":[132],"adhesion":[135],"metabolism":[137],"(CD93,":[138],"ESAM,":[139],"VWF,":[140],"PLVAP,":[141],"ANGPT2,":[142],"LEP,":[143],"TCF1)":[144],"stimulated.":[146],"Compared":[147],"normoxic":[149],"cells,":[150],"hypoxic":[151],"morphologically":[154],"undifferentiated":[155,249],"contained":[157],"less":[158],"mitochondrias.":[159],"After":[160],"this":[161],"lag":[162],"phase,":[163],"outgrew":[170],"an":[178],"enhanced":[179,241],"expression":[180],"(4-60":[183],"extracellular":[187],"matrix":[188],"assembly":[189],"(SMOC2),":[190],"neural":[191],"muscle":[193],"development":[194,201],"(NOG,":[195],"GPR56,":[196],"SNTG2,":[197],"LAMA)":[198],"epithelial":[200],"(DMKN).":[202],"This":[203,252],"group":[204],"described":[205],"herein":[206],"first":[209],"time":[210],"was":[211],"assigned":[212],"by":[213],"Gene":[215],"Ontology":[216],"program":[217,244],"\"plasticity\".":[219],"CONCLUSION:":[220],"The":[221],"duration":[222],"hypoxemia":[224],"critical":[227],"parameter":[228],"capacity":[232],"MSC.":[234],"Even":[235],"growth":[237],"promoting":[238],"conditions,":[239],"genetic":[243],"that":[245],"maintained":[246],"multipotent.":[251],"condition":[253],"vivo":[259],"gene":[260],"signature":[261],"MSC,":[263],"with":[264],"potential":[265],"implications":[266],"regenerative":[268],"medicine.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":16}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
