{"id":"https://openalex.org/W2012305341","doi":"https://doi.org/10.1073/pnas.77.1.604","title":"Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human plasma low density (beta) lipoproteins].","display_name":"Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human plasma low density (beta) lipoproteins].","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W2012305341","doi":"https://doi.org/10.1073/pnas.77.1.604","mag":"2012305341","pmid":"https://pubmed.ncbi.nlm.nih.gov/6928647","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/348323"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.77.1.604","doi":"https://doi.org/10.1073/pnas.77.1.604","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.77.1.604","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC348323","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108571370","display_name":"Allan D. Sniderman","orcid":"https://orcid.org/0000-0002-3540-3956","observed_orcids":["https://orcid.org/0000-0002-3540-3956"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A Sniderman","raw_affiliation_strings":["McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018641462","display_name":"Stan Shapiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S Shapiro","raw_affiliation_strings":["McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071522599","display_name":"Derek G. F. Marpole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D Marpole","raw_affiliation_strings":["McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B Skinner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Skinner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070740000","display_name":"Ba\u2010Bie Teng","orcid":"https://orcid.org/0000-0002-6652-5382","observed_orcids":["https://orcid.org/0000-0002-6652-5382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Teng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110177982","display_name":"Peter O. Kwiterovich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P O Kwiterovich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":26.6321,"has_fulltext":false,"cited_by_count":632,"citation_normalized_percentile":{"value":0.99738313,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"77","issue":"1","first_page":"604","last_page":"608"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hyperapobetalipoproteinemia","display_name":"hyperapobetalipoproteinemia","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7639999985694885},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/type-ii-hyperlipoproteinemia","display_name":"type II hyperlipoproteinemia","score":0.824999988079071},{"id":"https://openalex.org/keywords/plasma-lipids","display_name":"plasma lipids","score":0.5929999947547913},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ischemic-heart-disease","display_name":"ischemic heart disease","score":0.6679999828338623},{"id":"https://openalex.org/keywords/discriminant-analysis","display_name":"discriminant analysis","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7619897127151489},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6947754621505737},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5904312133789062},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5886161923408508},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.5619666576385498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5534508228302002},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5361506938934326},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.47546762228012085},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4627056419849396},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45474785566329956},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.44832247495651245},{"id":"https://openalex.org/C2777785397","wikidata":"https://www.wikidata.org/wiki/Q492194","display_name":"Group B","level":2,"score":0.42938005924224854},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.41327735781669617}],"mesh":[{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.77.1.604","doi":"https://doi.org/10.1073/pnas.77.1.604","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.77.1.604","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:240067","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC348323","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:348323","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/348323","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6928647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6928647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:240067","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC348323","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W5864664","https://openalex.org/W1484275600","https://openalex.org/W1505532345","https://openalex.org/W1513741126","https://openalex.org/W1523513367","https://openalex.org/W1572539022","https://openalex.org/W1979722563","https://openalex.org/W1981388632","https://openalex.org/W1990816837","https://openalex.org/W2010868465","https://openalex.org/W2017602185","https://openalex.org/W2025726242","https://openalex.org/W2029746534","https://openalex.org/W2034842825","https://openalex.org/W2040164369","https://openalex.org/W2040718956","https://openalex.org/W2051291943","https://openalex.org/W2059516204","https://openalex.org/W2076831553","https://openalex.org/W2078765414","https://openalex.org/W2081096617","https://openalex.org/W2091118505","https://openalex.org/W2094768566","https://openalex.org/W2095160367","https://openalex.org/W2112698709","https://openalex.org/W2116404316","https://openalex.org/W2133294177","https://openalex.org/W2135503869","https://openalex.org/W2142802148","https://openalex.org/W2158385780","https://openalex.org/W2189103032","https://openalex.org/W2240155433","https://openalex.org/W2337433739","https://openalex.org/W2409024158"],"related_works":["https://openalex.org/W2135291489","https://openalex.org/W2092287196","https://openalex.org/W2038890063","https://openalex.org/W2467008181","https://openalex.org/W2405203409","https://openalex.org/W2119026555","https://openalex.org/W2079699089","https://openalex.org/W2341310987","https://openalex.org/W2605382825","https://openalex.org/W1966374305"],"abstract_inverted_index":{"Most":[0],"patients":[1,50,61,70,76],"with":[2,77,190,198,203],"coronary":[3,58,79,177,191],"artery":[4,80,192],"disease":[5],"do":[6],"not":[7,170],"have":[8],"elevated":[9],"plasma":[10,37],"or":[11],"low":[12],"density":[13],"lipoprotein":[14],"(LDL)":[15],"cholesterol.":[16],"To":[17],"test":[18],"whether":[19],"the":[20,36,55,106,220],"protein":[21,135,208],"moiety":[22],"of":[23,57,205],"LDL,":[24],"LDL":[25,40,43,86,100,113,125,173,200,206,222],"B,":[26],"might":[27],"be":[28,230],"a":[29,196],"parameter":[30],"to":[31,142,210,229],"identify":[32],"ischemic":[33],"heart":[34],"disease,":[35,193],"cholesterol,":[38,41,83],"triglyceride,":[39,84],"and":[42,72,85,178],"B":[44,101,114,126,134,174,207],"were":[45,62,89],"measured":[46],"in":[47,93,122,137,213,225],"100":[48],"consecutive":[49],"undergoing":[51],"cardiac":[52],"catheterization.":[53],"On":[54],"basis":[56],"angiography,":[59],"these":[60],"divided":[63],"into":[64],"two":[65,107],"groups:":[66],"group":[67,73,94,110,123,138,197,227],"I,":[68],"31":[69],"without,":[71],"II,":[74,95,124],"59":[75],"significant":[78],"disease.":[81],"Although":[82],"cholesterol":[87,201],"levels":[88,204],"all":[90],"significantly":[91],"higher":[92],"discriminant":[96],"analysis":[97],"indicated":[98],"that":[99,169],"concentrations":[102],"most":[103],"clearly":[104],"separated":[105],"groups.":[108],"In":[109],"I":[111,139],"(noncoronary),":[112],"was":[115,127,140],"82":[116],"+/-":[117,129,152,161],"22":[118,130],"mg/100":[119,131,154,163],"ml,":[120],"whereas":[121],"118":[128],"ml.":[132],"The":[133,165,217],"level":[136],"similar":[141,209],"other":[143,182],"normal":[144,199],"groups":[145,180],"studied":[146],"(35":[147],"asymptomatic":[148],"male":[149],"physicians,":[150],"83":[151],"11":[153],"ml;":[155],"90":[156],"normolipidemic":[157],"medical":[158],"students,":[159],"72":[160],"17":[162],"ml).":[164],"results":[166],"therefore":[167],"indicate":[168],"only":[171],"does":[172],"better":[175],"separate":[176],"noncoronary":[179],"than":[181],"lipid":[183],"parameters":[184],"studied,":[185],"but":[186,202],"also,":[187],"among":[188],"those":[189,211],"there":[194],"exists":[195],"observed":[212,224],"type":[214],"II":[215],"hyperlipoproteinemia.":[216],"explanation":[218],"for":[219],"altered":[221],"composition":[223],"this":[226],"remains":[228],"elucidated.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}