{"id":"https://openalex.org/W2012271071","doi":"https://doi.org/10.1111/j.1530-0277.2009.01029.x","title":"Schedule of Passive Ethanol Exposure Affects Subsequent Intragastric Ethanol Self\u2010Infusion","display_name":"Schedule of Passive Ethanol Exposure Affects Subsequent Intragastric Ethanol Self\u2010Infusion","publication_year":2009,"publication_date":"2009-08-10","ids":{"openalex":"https://openalex.org/W2012271071","doi":"https://doi.org/10.1111/j.1530-0277.2009.01029.x","mag":"2012271071","pmid":"https://pubmed.ncbi.nlm.nih.gov/19673748","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2883445"},"language":"en","primary_location":{"id":"doi:10.1111/j.1530-0277.2009.01029.x","doi":"https://doi.org/10.1111/j.1530-0277.2009.01029.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.2009.01029.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2883445","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026466902","display_name":"Tara L. Fidler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tara L. Fidler","raw_affiliation_strings":["Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, OR 97239-3098, USA. fidlert@ohsu.edu","Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239\u20133098, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, OR 97239-3098, USA. fidlert@ohsu.edu","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239\u20133098, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091709005","display_name":"Brandon G. Oberlin","orcid":"https://orcid.org/0000-0002-8948-4800","observed_orcids":["https://orcid.org/0000-0002-8948-4800"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon G. Oberlin","raw_affiliation_strings":["From the Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035870195","display_name":"Amanda M. Struthers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda M. Struthers","raw_affiliation_strings":["From the Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085790973","display_name":"Christopher L. Cunningham","orcid":"https://orcid.org/0000-0002-9619-4190","observed_orcids":["https://orcid.org/0000-0002-9619-4190"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Cunningham","raw_affiliation_strings":["From the Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026466902"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":0.5529,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.60732677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"33","issue":"11","first_page":"1909","last_page":"1923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.22290000319480896,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol-dependence","display_name":"ethanol dependence","score":0.6159999966621399},{"id":"https://openalex.org/keywords/withdrawal","display_name":"withdrawal","score":0.4230000078678131},{"id":"https://openalex.org/keywords/negative-reinforcement","display_name":"negative reinforcement","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ethanol-aversion","display_name":"ethanol aversion","score":0.7080000042915344},{"id":"https://openalex.org/keywords/ethanol-tolerance","display_name":"ethanol tolerance","score":0.6819999814033508},{"id":"https://openalex.org/keywords/alcohol-self-administration","display_name":"alcohol self-administration","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2780723003","wikidata":"https://www.wikidata.org/wiki/Q2917928","display_name":"Licking","level":2,"score":0.7954437732696533},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.767603874206543},{"id":"https://openalex.org/C2778555786","wikidata":"https://www.wikidata.org/wiki/Q7448011","display_name":"Self-administration","level":2,"score":0.7344433069229126},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.661695122718811},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43081697821617126},{"id":"https://openalex.org/C2778349201","wikidata":"https://www.wikidata.org/wiki/Q4117015","display_name":"Liquid diet","level":3,"score":0.4278843402862549},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41114020347595215},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.37609779834747314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26179343461990356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11654984951019287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0803256630897522}],"mesh":[{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000435","descriptor_name":"Alcoholic Intoxication","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002492","descriptor_name":"Central Nervous System Depressants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002492","descriptor_name":"Central Nervous System Depressants","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002492","descriptor_name":"Central Nervous System Depressants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003213","descriptor_name":"Conditioning, Psychological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007441","descriptor_name":"Intubation, Gastrointestinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012646","descriptor_name":"Self Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1530-0277.2009.01029.x","doi":"https://doi.org/10.1111/j.1530-0277.2009.01029.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.2009.01029.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"pmid:19673748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19673748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2883445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2883445","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Alcohol Clin Exp Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2883445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2883445","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Alcohol Clin Exp Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.7200000286102295}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5664556956","display_name":"Dependence Driven Alterations in Ethanol Reinforcement","funder_award_id":"U01AA013479","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000911509","display_name":"Behavioral Genomics of Alcohol Neuroadaptation","funder_award_id":"P60AA010760","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W831138826","https://openalex.org/W1940656453","https://openalex.org/W1963557453","https://openalex.org/W1971831953","https://openalex.org/W1978013837","https://openalex.org/W1981997565","https://openalex.org/W1984109440","https://openalex.org/W1984112365","https://openalex.org/W1987256529","https://openalex.org/W1988544635","https://openalex.org/W1990114427","https://openalex.org/W1991839015","https://openalex.org/W1993860337","https://openalex.org/W1996299401","https://openalex.org/W1996783861","https://openalex.org/W2008944623","https://openalex.org/W2014003202","https://openalex.org/W2019699133","https://openalex.org/W2026984303","https://openalex.org/W2034490236","https://openalex.org/W2036138175","https://openalex.org/W2057302757","https://openalex.org/W2057596402","https://openalex.org/W2064282880","https://openalex.org/W2065955598","https://openalex.org/W2068127155","https://openalex.org/W2068300068","https://openalex.org/W2078382471","https://openalex.org/W2084605594","https://openalex.org/W2084664557","https://openalex.org/W2084706252","https://openalex.org/W2086092458","https://openalex.org/W2089140744","https://openalex.org/W2093636190","https://openalex.org/W2102250963","https://openalex.org/W2116882701","https://openalex.org/W2126344484","https://openalex.org/W2163550364","https://openalex.org/W2345663481","https://openalex.org/W4322703284"],"related_works":["https://openalex.org/W2084706252","https://openalex.org/W2030829586","https://openalex.org/W1972697738","https://openalex.org/W2084664557","https://openalex.org/W2126344484","https://openalex.org/W2074587495","https://openalex.org/W2028292251","https://openalex.org/W2067610077","https://openalex.org/W2011421981","https://openalex.org/W2026984303"],"abstract_inverted_index":{"BACKGROUND:":[0],"Many":[1],"studies":[2,19,29],"have":[3,20],"shown":[4],"that":[5,222,234],"chronic":[6,36],"ethanol":[7,37,57,68,139,149,172,185,236],"exposure":[8,38,140,166,186,208,225],"can":[9],"enhance":[10],"later":[11],"self-administration":[12],"of":[13,35,44,92,116,128,148,158,164,189,218,285],"ethanol,":[14],"but":[15],"only":[16],"a":[17,72,265],"few":[18,206],"identified":[21],"critical":[22],"parameters":[23,34],"for":[24,58,247,268],"such":[25],"exposure.":[26],"The":[27,178],"present":[28],"examined":[30,85],"temporal":[31],"and":[32,63,114,187],"other":[33],"on":[39,141,194],"subsequent":[40],"intragastric":[41],"(IG)":[42],"self-infusion":[43,117,130,150,173,190,195,201,213,237],"ethanol.":[45,252],"METHODS:":[46],"Sprague-Dawley":[47],"rats":[48],"implanted":[49],"with":[50,56],"IG":[51],"catheters":[52],"were":[53,77],"passively":[54],"infused":[55],"5":[59],"to":[60,66,152,167,288],"6":[61],"days":[62,131,143,202,209],"then":[64],"allowed":[65],"self-infuse":[67],"or":[69],"water":[70],"using":[71],"procedure":[73],"in":[74,238,293],"which":[75],"infusions":[76],"contingent":[78],"upon":[79],"licking":[80],"fruit-flavored":[81],"solutions.":[82],"Experiment":[83,104,123],"1":[84],"the":[86,107,110,126,133,156,159,182,204,245,261,269,273,283,294],"time":[87,179],"interval":[88,108,161],"between":[89,109,162,181,203],"consecutive":[90,142],"periods":[91,163],"passive":[93,112,134,165,184,207,224,231],"infusion":[94,113,135],"(Massed":[95],"Group:":[96,101],"12":[97],"hours":[98,169],"vs.":[99,119],"Spaced":[100,230,274],"36":[102,120,168],"hours).":[103,121],"2":[105],"studied":[106],"final":[111],"onset":[115,188],"(12":[118],"Finally,":[122],"3":[124],"tested":[125],"effect":[127,193],"inserting":[129,199],"within":[132],"phase.":[136],"RESULTS:":[137],"Passive":[138],"induced":[144],"relatively":[145],"large":[146],"amounts":[147],"(4.1":[151],"7.9":[153],"g/kg/d).":[154],"Increasing":[155],"duration":[157],"ethanol-free":[160],"significantly":[170],"reduced":[171],"(2.2":[174],"g/kg/d;":[175],"Exp.":[176],"1).":[177],"delay":[180],"last":[183,205],"had":[191],"no":[192],"(Exp.":[196,214],"2).":[197],"Moreover,":[198],"no-choice":[200],"did":[210],"not":[211],"increase":[212],"3).":[215],"CONCLUSIONS:":[216],"Measurement":[217],"withdrawal":[219],"signs":[220],"indicated":[221],"Massed":[223,239,262,295],"produced":[226],"stronger":[227],"dependence":[228],"than":[229,272],"exposure,":[232],"suggesting":[233],"enhanced":[235,254],"Groups":[240],"might":[241,257],"be":[242,280],"explained":[243,281],"by":[244,251,282],"opportunity":[246],"greater":[248,286],"negative":[249,255],"reinforcement":[250,256],"Although":[253],"also":[258,279],"explain":[259],"why":[260],"Group":[263],"showed":[264],"weaker":[266],"aversion":[267],"ethanol-paired":[270],"flavor":[271],"Group,":[275],"this":[276],"observation":[277],"could":[278],"development":[284],"tolerance":[287],"ethanol's":[289],"aversive":[290],"pharmacological":[291],"effects":[292],"Group.":[296]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}