{"id":"https://openalex.org/W2012268660","doi":"https://doi.org/10.1210/me.2006-0480","title":"ETV1 Is a Novel Androgen Receptor-Regulated Gene that Mediates Prostate Cancer Cell Invasion","display_name":"ETV1 Is a Novel Androgen Receptor-Regulated Gene that Mediates Prostate Cancer Cell Invasion","publication_year":2007,"publication_date":"2007-05-16","ids":{"openalex":"https://openalex.org/W2012268660","doi":"https://doi.org/10.1210/me.2006-0480","mag":"2012268660","pmid":"https://pubmed.ncbi.nlm.nih.gov/17505060"},"language":"en","primary_location":{"id":"doi:10.1210/me.2006-0480","doi":"https://doi.org/10.1210/me.2006-0480","is_oa":false,"landing_page_url":"https://doi.org/10.1210/me.2006-0480","pdf_url":null,"source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050848129","display_name":"Changmeng Cai","orcid":"https://orcid.org/0000-0002-8701-2586","observed_orcids":["https://orcid.org/0000-0002-8701-2586"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Changmeng Cai","raw_affiliation_strings":["Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2800921988","https://openalex.org/I4210163910","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029002402","display_name":"Chen-Lin Hsieh","orcid":"https://orcid.org/0000-0003-0686-8794","observed_orcids":["https://orcid.org/0000-0003-0686-8794","https://orcid.org/0009-0000-9239-8711"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Chen-Lin Hsieh","raw_affiliation_strings":["Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2800921988","https://openalex.org/I4210163910","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001573563","display_name":"Josephat Omwancha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Josephat Omwancha","raw_affiliation_strings":["Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2800921988","https://openalex.org/I4210163910","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072473852","display_name":"Zhe Zheng","orcid":"https://orcid.org/0000-0003-0055-2940","observed_orcids":["https://orcid.org/0000-0003-0055-2940"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Zhe Zheng","raw_affiliation_strings":["Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2800921988","https://openalex.org/I4210163910","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066896225","display_name":"Shaoyong Chen","orcid":"https://orcid.org/0000-0003-0809-8383","observed_orcids":["https://orcid.org/0000-0003-0809-8383"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Shao-Yong Chen","raw_affiliation_strings":["Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2800921988","https://openalex.org/I4210163910","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111853487","display_name":"Jean\u2010Luc Baert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Jean-Luc Baert","raw_affiliation_strings":["Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2800921988","https://openalex.org/I4210163910","https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020260630","display_name":"Lirim Shemshedini","orcid":"https://orcid.org/0000-0002-0210-8061","observed_orcids":["https://orcid.org/0000-0002-0210-8061"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210163910","display_name":"Institut de Biologie de Lille","ror":"https://ror.org/05gd4yq49","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210163910"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Lirim Shemshedini","raw_affiliation_strings":["Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606; Unite\u0301 Mixte de Recherche 8161, Institut de Biologie de Lille, Centre National de la Recherche Scientifique, Universities of Lille 1 and Lille 2, Pasteur Institute of Lille, Institut Fe\u0301de\u0301ratif de Recherche 142, 59021 Lille Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2800921988","https://openalex.org/I4210163910","https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1212,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.93193041,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"21","issue":"8","first_page":"1835","last_page":"1846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etv1","display_name":"ETV1","score":1.0},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9300000071525574},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.734000027179718},{"id":"https://openalex.org/keywords/androgen-regulated-gene-expression","display_name":"androgen-regulated gene expression","score":0.7870000004768372},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.7559999823570251},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9240000247955322},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.550000011920929},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.8105905055999756},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7754561901092529},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6819861531257629},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.66412752866745},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6324466466903687},{"id":"https://openalex.org/C2778042024","wikidata":"https://www.wikidata.org/wiki/Q18032025","display_name":"TMPRSS2","level":5,"score":0.6176653504371643},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5821517109870911},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.41008591651916504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40616574883461},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39695385098457336},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.30767911672592163},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22503340244293213},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14108353853225708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13364827632904053},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10062861442565918},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05231645703315735},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013196","descriptor_name":"Dihydrotestosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/me.2006-0480","doi":"https://doi.org/10.1210/me.2006-0480","is_oa":false,"landing_page_url":"https://doi.org/10.1210/me.2006-0480","pdf_url":null,"source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmid:17505060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17505060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W147591239","https://openalex.org/W1209284060","https://openalex.org/W1604588411","https://openalex.org/W1614690294","https://openalex.org/W1965283193","https://openalex.org/W1978643290","https://openalex.org/W1985550922","https://openalex.org/W1985781201","https://openalex.org/W1986718029","https://openalex.org/W1990287298","https://openalex.org/W1990725971","https://openalex.org/W1992885568","https://openalex.org/W1995477681","https://openalex.org/W1996487270","https://openalex.org/W1999653164","https://openalex.org/W2001778920","https://openalex.org/W2003955264","https://openalex.org/W2006502722","https://openalex.org/W2007672389","https://openalex.org/W2014351671","https://openalex.org/W2017136310","https://openalex.org/W2019020763","https://openalex.org/W2025631499","https://openalex.org/W2045075062","https://openalex.org/W2054801411","https://openalex.org/W2057477877","https://openalex.org/W2062393124","https://openalex.org/W2062440930","https://openalex.org/W2080709087","https://openalex.org/W2081558968","https://openalex.org/W2093519703","https://openalex.org/W2101581671","https://openalex.org/W2103555733","https://openalex.org/W2118390821","https://openalex.org/W2121158863","https://openalex.org/W2123230966","https://openalex.org/W2129583552","https://openalex.org/W2130358475","https://openalex.org/W2160427174","https://openalex.org/W2166599679","https://openalex.org/W2172256092","https://openalex.org/W2320752200","https://openalex.org/W2325780118","https://openalex.org/W2328599562","https://openalex.org/W6636094848","https://openalex.org/W6636523765","https://openalex.org/W6655460415"],"related_works":["https://openalex.org/W7112879309","https://openalex.org/W1982956833","https://openalex.org/W2109445770","https://openalex.org/W3015471106","https://openalex.org/W1984164815","https://openalex.org/W2323356867","https://openalex.org/W2012364920","https://openalex.org/W2082848009","https://openalex.org/W2009975002","https://openalex.org/W1995536040"],"abstract_inverted_index":{"Androgens":[0],"and":[1,36,67,105,145,189],"the":[2,69,72,90,115,135,152,200,223,226],"androgen":[3],"receptor":[4],"(AR)":[5],"act":[6],"in":[7,40,45,56,71,93,99,121,130,142,164,196,206],"cells":[8,102,149,183],"by":[9,65,84],"modulating":[10],"gene":[11,14,220],"expression.":[12],"Through":[13],"microarray":[15],"studies,":[16],"we":[17],"have":[18],"identified":[19],"Ets":[20],"Variant":[21],"Gene":[22],"1":[23],"(ETV1)":[24],"as":[25,180],"a":[26],"novel":[27],"androgen-regulated":[28],"gene.":[29],"Our":[30],"data":[31,211],"demonstrate":[32,171],"that":[33,172,191],"ETV1":[34,54,61,97,111,127,140,163,173,204],"mRNA":[35],"protein":[37],"are":[38],"up-regulated":[39],"response":[41],"to":[42,89,107,178,187],"ligand-activated":[43,85],"AR":[44,70,217],"androgen-dependent":[46,94,144],"LNCaP":[47,95,101],"cells,":[48,96,157],"but":[49],"there":[50],"is":[51,63,103,128],"no":[52],"detectable":[53],"expression":[55,92,98,112,117,141,174],"normal":[57],"prostate":[58,124,131,147,165,181,207],"cells.":[59,126],"The":[60],"promoter":[62],"induced":[64,83],"androgens":[66],"recruits":[68],"context":[73],"of":[74,134,139,155,203,216,219,225],"chromatin.":[75],"ETV1-regulated":[76],"endogenous":[77],"matrix":[78],"metalloproteinase":[79],"genes":[80],"can":[81],"be":[82,195],"AR.":[86],"In":[87],"contrast":[88],"hormone-induced":[91],"androgen-independent":[100,110,123,146,179],"high":[104],"unresponsive":[106],"androgen.":[108],"This":[109],"contrasts":[113],"with":[114],"hormone-dependent":[116,186],"observed":[118,205],"for":[119,162,199],"TMPRSS2":[120],"these":[122,156,169],"cancer":[125,132,148,166,182],"overexpressed":[129],"independent":[133],"TMPRSS2:ETV1":[136],"translocation.":[137],"Disruption":[138],"both":[143],"significantly":[150],"compromises":[151],"invasion":[153],"capacity":[154],"suggesting":[158],"an":[159,213],"important":[160],"role":[161],"metastasis.":[167],"Collectively,":[168],"results":[170],"transitions":[175],"from":[176,185],"androgen-induced":[177],"switch":[184],"hormone-refractory":[188],"suggest":[190],"this":[192],"transition":[193],"may":[194],"part":[197],"responsible":[198],"elevated":[201],"levels":[202],"tumors.":[208],"Additionally,":[209],"our":[210],"provide":[212],"indirect":[214],"mechanism":[215],"regulation":[218],"expression,":[221],"via":[222],"transactivation":[224],"transcription":[227],"factor":[228],"ETV1.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}