{"id":"https://openalex.org/W2012266747","doi":"https://doi.org/10.2337/dc13-2312","title":"Elevated Levels of hs-CRP Are Associated With High Prevalence of Depression in Japanese Patients With Type 2 Diabetes: The Diabetes Distress and Care Registry at Tenri (DDCRT 6)","display_name":"Elevated Levels of hs-CRP Are Associated With High Prevalence of Depression in Japanese Patients With Type 2 Diabetes: The Diabetes Distress and Care Registry at Tenri (DDCRT 6)","publication_year":2014,"publication_date":"2014-06-27","ids":{"openalex":"https://openalex.org/W2012266747","doi":"https://doi.org/10.2337/dc13-2312","mag":"2012266747","pmid":"https://pubmed.ncbi.nlm.nih.gov/24969579"},"language":"en","primary_location":{"id":"doi:10.2337/dc13-2312","doi":"https://doi.org/10.2337/dc13-2312","is_oa":false,"landing_page_url":"https://doi.org/10.2337/dc13-2312","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085532693","display_name":"Yasuaki Hayashino","orcid":"https://orcid.org/0000-0002-2932-8478","observed_orcids":["https://orcid.org/0000-0002-2932-8478"]},"institutions":[{"id":"https://openalex.org/I2802367119","display_name":"Tenri Hospital","ror":"https://ror.org/05g2axc67","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802367119"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasuaki Hayashino","raw_affiliation_strings":["Department of Endocrinology, Tenri Hospital, Tenri, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2932-8478","affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Tenri Hospital, Tenri, Japan","institution_ids":["https://openalex.org/I2802367119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055409975","display_name":"Tsuyoshi Mashitani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802367119","display_name":"Tenri Hospital","ror":"https://ror.org/05g2axc67","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802367119"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Mashitani","raw_affiliation_strings":["Department of Endocrinology, Tenri Hospital, Tenri, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Tenri Hospital, Tenri, Japan","institution_ids":["https://openalex.org/I2802367119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046418717","display_name":"Satoru Tsujii","orcid":"https://orcid.org/0000-0002-1834-6515","observed_orcids":["https://orcid.org/0000-0002-1834-6515"]},"institutions":[{"id":"https://openalex.org/I2802367119","display_name":"Tenri Hospital","ror":"https://ror.org/05g2axc67","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802367119"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Tsujii","raw_affiliation_strings":["Department of Endocrinology, Tenri Hospital, Tenri, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Tenri Hospital, Tenri, Japan","institution_ids":["https://openalex.org/I2802367119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053080474","display_name":"Hitoshi Ishii","orcid":"https://orcid.org/0000-0002-6214-0557","observed_orcids":["https://orcid.org/0000-0002-6214-0557"]},"institutions":[{"id":"https://openalex.org/I2802367119","display_name":"Tenri Hospital","ror":"https://ror.org/05g2axc67","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802367119"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Ishii","raw_affiliation_strings":["Department of Endocrinology, Tenri Hospital, Tenri, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Tenri Hospital, Tenri, Japan","institution_ids":["https://openalex.org/I2802367119"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the Diabetes Distress and Care Registry at Tenri Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the Diabetes Distress and Care Registry at Tenri Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085532693"],"corresponding_institution_ids":["https://openalex.org/I2802367119"],"apc_list":null,"apc_paid":null,"fwci":3.8337,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.93538366,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"37","issue":"9","first_page":"2459","last_page":"2465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.210099995136261,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0737999975681305,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.9449999928474426},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8119999766349792},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8029999732971191},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6439999938011169},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.5950000286102295},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.6539999842643738},{"id":"https://openalex.org/keywords/diabetes-registry","display_name":"diabetes registry","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9131805896759033},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7576392292976379},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7129011154174805},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.7125568985939026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.701850950717926},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6064868569374084},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6021826863288879},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.49717429280281067},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.41601240634918213},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20421448349952698},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.052052080631256104},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2337/dc13-2312","doi":"https://doi.org/10.2337/dc13-2312","is_oa":false,"landing_page_url":"https://doi.org/10.2337/dc13-2312","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:24969579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24969579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.990.2789","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.990.2789","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://care.diabetesjournals.org/content/diacare/37/9/2459.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.995.7552","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.995.7552","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://care.diabetesjournals.org/content/diacare/early/2014/06/19/dc13-2312.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6254162978","display_name":"Evaluation of psycho-socio-economic aspect of diabetes care","funder_award_id":"25460641","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1554276420","https://openalex.org/W1964249945","https://openalex.org/W1966460145","https://openalex.org/W1978180139","https://openalex.org/W1981294971","https://openalex.org/W1981962083","https://openalex.org/W1986031269","https://openalex.org/W1994825856","https://openalex.org/W2002039072","https://openalex.org/W2004713138","https://openalex.org/W2007116949","https://openalex.org/W2010664010","https://openalex.org/W2016367071","https://openalex.org/W2018135697","https://openalex.org/W2021654823","https://openalex.org/W2026633588","https://openalex.org/W2026703925","https://openalex.org/W2031507962","https://openalex.org/W2046667801","https://openalex.org/W2058667229","https://openalex.org/W2058717577","https://openalex.org/W2080312294","https://openalex.org/W2091367129","https://openalex.org/W2091975706","https://openalex.org/W2097395605","https://openalex.org/W2097740790","https://openalex.org/W2108453323","https://openalex.org/W2108682642","https://openalex.org/W2113635822","https://openalex.org/W2114429616","https://openalex.org/W2121827707","https://openalex.org/W2129316761","https://openalex.org/W2132061072","https://openalex.org/W2132322340","https://openalex.org/W2136759091","https://openalex.org/W2141393362","https://openalex.org/W2143812909","https://openalex.org/W2146597578","https://openalex.org/W2161097799","https://openalex.org/W2167238703","https://openalex.org/W2167314970","https://openalex.org/W2171129594","https://openalex.org/W2171308227","https://openalex.org/W2172502596","https://openalex.org/W2411826498"],"related_works":["https://openalex.org/W3111493307","https://openalex.org/W4307382762","https://openalex.org/W2080647566","https://openalex.org/W7043144151","https://openalex.org/W1977295539","https://openalex.org/W2231398417","https://openalex.org/W2029070645","https://openalex.org/W2965689518"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Because":[1],"of":[2,5,30,170],"the":[3,8,21,27,84,114,119,135,143,179],"absence":[4],"data":[6,44],"on":[7],"direct":[9],"association":[10,22,149,175,201],"between":[11,23,75,178,202],"inflammation":[12],"and":[13,26,78,92,100,105,116,183,206],"depression":[14,31,125,185,207],"in":[15,32,134,142,208],"patients":[16,34,49,107,166,209],"with":[17,35,50,140,167,210],"diabetes,":[18],"we":[19],"examined":[20],"hs-CRP":[24,76,181,204],"levels":[25,77,94,205],"high":[28,203,215],"prevalence":[29],"adult":[33],"type":[36,51],"2":[37,52],"diabetes.":[38],"RESEARCH":[39],"DESIGN":[40],"AND":[41],"METHODS:":[42],"Cross-sectional":[43],"were":[45,95],"obtained":[46],"from":[47,55,110],"3,573":[48],"diabetes":[53,58,211],"recruited":[54],"a":[56,168,173,198,214],"Japanese":[57],"registry.":[59],"A":[60],"multiple":[61],"logistic":[62],"regression":[63],"analysis":[64],"adjusted":[65],"for":[66,123,153],"potential":[67],"confounders":[68,156],"was":[69,126,176],"used":[70],"to":[71],"assess":[72],"independent":[73],"associations":[74],"major":[79,111,124,184],"depression,":[80],"as":[81],"defined":[82],"by":[83],"Patient":[85],"Health":[86],"Questionnaire-9.":[87],"RESULTS:":[88],"Mean":[89],"age,":[90],"BMI,":[91],"HbA1c":[93],"66.0":[96],"years,":[97],"24.6":[98],"kg/m(2),":[99,172],"7.4%":[101],"(57.8":[102],"mmol/mol),":[103],"respectively,":[104],"122":[106],"(3.4%)":[108],"suffered":[109],"depression.":[112],"In":[113],"age-":[115],"sex-adjusted":[117],"model,":[118],"odds":[120],"ratio":[121],"(OR)":[122],"1.86":[127],"(95%":[128],"CI":[129,160,190],"1.01-3.42;":[130],"P":[131,162,192],"=":[132,163,193],"0.045)":[133],"highest":[136,180],"CRP":[137,145],"quintile":[138,182],"compared":[139],"that":[141],"3rd":[144],"quintile;":[146],"however,":[147],"this":[148],"disappeared":[150],"after":[151],"adjustment":[152],"other":[154],"possible":[155],"(OR":[157],"1.58":[158],"[95%":[159,189],"0.85-2.94];":[161],"0.148).":[164],"Among":[165],"BMI":[169],"\u226525":[171],"significant":[174,199],"observed":[177,197],"(multivariable-adjusted":[186],"OR":[187],"2.69":[188],"1.09-7.08];":[191],"0.032).":[194],"CONCLUSIONS:":[195],"We":[196],"positive":[200],"who":[212],"had":[213],"BMI.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
