{"id":"https://openalex.org/W2012264968","doi":"https://doi.org/10.1038/sj.bjc.6600465","title":"Darbepoetin alfa given every 1 or 2 weeks alleviates anaemia associated with cancer chemotherapy","display_name":"Darbepoetin alfa given every 1 or 2 weeks alleviates anaemia associated with cancer chemotherapy","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2012264968","doi":"https://doi.org/10.1038/sj.bjc.6600465","mag":"2012264968","pmid":"https://pubmed.ncbi.nlm.nih.gov/12177793"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6600465","doi":"https://doi.org/10.1038/sj.bjc.6600465","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6600465","pdf_url":"https://www.nature.com/articles/6600465.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6600465.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080006341","display_name":"John A. Glaspy","orcid":"https://orcid.org/0000-0002-1800-9076","observed_orcids":["https://orcid.org/0000-0002-1800-9076"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J A Glaspy","raw_affiliation_strings":["jglaspy@mednet.ucla.edu","200 UCLA Medical Plaza, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"jglaspy@mednet.ucla.edu","institution_ids":[]},{"raw_affiliation_string":"200 UCLA Medical Plaza, California, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027016729","display_name":"J. Jadeja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145631","display_name":"Hematology Oncology Associates","ror":"https://ror.org/04w3zd882","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210145631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J S Jadeja","raw_affiliation_strings":["Hematology-Oncology Associates of Jacksonville, 5742 Booth Road, Jacksonville, Florida, USA","Hematology-Oncology Associates of Jacksonville, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology Associates of Jacksonville, 5742 Booth Road, Jacksonville, Florida, USA","institution_ids":[]},{"raw_affiliation_string":"Hematology-Oncology Associates of Jacksonville, Jacksonville, USA","institution_ids":["https://openalex.org/I4210145631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015136036","display_name":"Glen R. Justice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Justice","raw_affiliation_strings":["Pacific Coast Hematology Oncology Medical Group, 11190 Warner Avenue, Suite 300, Fountain Valley, California, USA","Pacific Coast Hematology Oncology Medical Group, Fountain Valley, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Coast Hematology Oncology Medical Group, 11190 Warner Avenue, Suite 300, Fountain Valley, California, USA","institution_ids":[]},{"raw_affiliation_string":"Pacific Coast Hematology Oncology Medical Group, Fountain Valley, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Kessler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088931","display_name":"Virginia Oncology Associates","ror":"https://ror.org/009yyqs39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210088931"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Kessler","raw_affiliation_strings":["Virginia Oncology Associates, 895 Middle Ground Boulevard, Newport News, Virginia, USA","Virginia Oncology Associates, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Oncology Associates, 895 Middle Ground Boulevard, Newport News, Virginia, USA","institution_ids":["https://openalex.org/I4210088931"]},{"raw_affiliation_string":"Virginia Oncology Associates, Virginia, USA","institution_ids":["https://openalex.org/I4210088931"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Richards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Richards","raw_affiliation_strings":["Tyler Cancer Center, 910 E Houston, Tyler, Texas, USA","Tyler Cancer Center, Tyler, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tyler Cancer Center, 910 E Houston, Tyler, Texas, USA","institution_ids":[]},{"raw_affiliation_string":"Tyler Cancer Center, Tyler, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072563567","display_name":"Lee Steven Schwartzberg","orcid":"https://orcid.org/0000-0002-7433-3428","observed_orcids":["https://orcid.org/0000-0002-7433-3428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Schwartzberg","raw_affiliation_strings":["The West Clinic, 100 N Humphries Blvd, Suite 100, Memphis, Tennessee, USA","The West Clinic, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The West Clinic, 100 N Humphries Blvd, Suite 100, Memphis, Tennessee, USA","institution_ids":[]},{"raw_affiliation_string":"The West Clinic, Memphis, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022403155","display_name":"Nerses Simon Tchekmedyian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N S Tchekmedyian","raw_affiliation_strings":["Pacific Shores Medical Group, 1043 Elm Avenue, Suite 104, Long Beach, California, USA","Pacific Shores Medical Group, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Shores Medical Group, 1043 Elm Avenue, Suite 104, Long Beach, California, USA","institution_ids":[]},{"raw_affiliation_string":"Pacific Shores Medical Group, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Armstrong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Armstrong","raw_affiliation_strings":["Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91320, CA, USA","Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91320, CA, USA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043655365","display_name":"J O\u2019Byrne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J O'Byrne","raw_affiliation_strings":["Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91320, CA, USA","Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91320, CA, USA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101631020","display_name":"Giuseppe Rossi","orcid":"https://orcid.org/0000-0001-8377-2898","observed_orcids":["https://orcid.org/0000-0001-8377-2898"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Rossi","raw_affiliation_strings":["Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91320, CA, USA","Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91320, CA, USA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078487911","display_name":"Alan B. Colowick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A B Colowick","raw_affiliation_strings":["Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91320, CA, USA","Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91320, CA, USA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, USA","institution_ids":["https://openalex.org/I1320553840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080006341"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":12.7157,"has_fulltext":true,"cited_by_count":171,"citation_normalized_percentile":{"value":0.99162715,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"87","issue":"3","first_page":"268","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/darbepoetin-alfa","display_name":"darbepoetin alfa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epoetin-alfa","display_name":"epoetin alfa","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chemotherapy-induced-anemia","display_name":"chemotherapy-induced anemia","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cancer-chemotherapy","display_name":"cancer chemotherapy","score":0.5979999899864197},{"id":"https://openalex.org/keywords/hemoglobin-response","display_name":"hemoglobin response","score":0.8109999895095825},{"id":"https://openalex.org/keywords/dosing-interval","display_name":"dosing interval","score":0.9380000233650208},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6320000290870667},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7269999980926514},{"id":"https://openalex.org/keywords/anti-drug-antibodies","display_name":"anti-drug antibodies","score":0.7049999833106995},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6499999761581421},{"id":"https://openalex.org/keywords/erythropoiesis-stimulating-agents","display_name":"erythropoiesis-stimulating agents","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2781404941","wikidata":"https://www.wikidata.org/wiki/Q2178381","display_name":"Darbepoetin alfa","level":3,"score":0.975806474685669},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.851193904876709},{"id":"https://openalex.org/C2776164570","wikidata":"https://www.wikidata.org/wiki/Q5383794","display_name":"Epoetin alfa","level":3,"score":0.7942854166030884},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7398677468299866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5737859010696411},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5593831539154053},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5360880494117737},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4748547375202179},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.4665014147758484},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40073883533477783},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37232911586761475}],"mesh":[{"descriptor_ui":"D000068256","descriptor_name":"Darbepoetin alfa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068256","descriptor_name":"Darbepoetin alfa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068256","descriptor_name":"Darbepoetin alfa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/sj.bjc.6600465","doi":"https://doi.org/10.1038/sj.bjc.6600465","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6600465","pdf_url":"https://www.nature.com/articles/6600465.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:12177793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12177793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:2364226","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2364226","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt03j7d1rf","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/03j7d1rf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British journal of cancer, vol 87, iss 3","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt03j7d1rf","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/03j7d1rf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Cancer, vol 87, iss 3","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6600465","doi":"https://doi.org/10.1038/sj.bjc.6600465","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6600465","pdf_url":"https://www.nature.com/articles/6600465.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012264968.pdf","grobid_xml":"https://content.openalex.org/works/W2012264968.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W281780641","https://openalex.org/W1821554592","https://openalex.org/W1867073577","https://openalex.org/W1884165293","https://openalex.org/W1885881044","https://openalex.org/W1957959321","https://openalex.org/W2007313133","https://openalex.org/W2056251445","https://openalex.org/W2074742749","https://openalex.org/W2086437884","https://openalex.org/W2108511043","https://openalex.org/W2113785887","https://openalex.org/W2131447863","https://openalex.org/W2135819931","https://openalex.org/W2145908121","https://openalex.org/W2220352889","https://openalex.org/W2340124568"],"related_works":["https://openalex.org/W2113406202","https://openalex.org/W2061049097","https://openalex.org/W4230542217","https://openalex.org/W2121864589","https://openalex.org/W4243838391","https://openalex.org/W2139586631","https://openalex.org/W2034827321","https://openalex.org/W2003674296","https://openalex.org/W4236565616","https://openalex.org/W2039615128"],"abstract_inverted_index":{"In":[0,45],"part":[1,46],"A":[2],"of":[3,16,37,84,106,113,121,139,145,161],"this":[4],"study,":[5],"patients":[6,146,203],"were":[7,50,135],"randomised":[8],"to":[9,18,26,54,86,111,132,156,165,183],"cohorts":[10,49],"receiving":[11,30,206],"darbepoetin":[12,51,87,107,133,140,162,188],"alfa":[13,32,52,108,134,141,163,189],"at":[14,33],"doses":[15,138],"0.5":[17],"8.0":[19],"m.c.g":[20,56],"x":[21,23,40,57,70],"kg(-1)":[22,41,58],"wk(-1)":[24],"or":[25,62],"a":[27,148,167,196],"control":[28],"group":[29],"epoetin":[31,63,114],"an":[34],"initial":[35,65],"dose":[36,66,160],"150":[38],"U":[39,69],"three":[42],"times":[43],"weekly.":[44],"B,":[47],"the":[48,119,143,153,176],"3.0":[53],"9.0":[55],"every":[59],"2":[60,184],"weeks":[61],"alfa,":[64],"40":[67],"000":[68],"wk(-1).":[71],"Safety":[72],"was":[73,90,109,128],"assessed":[74,91],"by":[75,92],"adverse":[76,103,126],"events,":[77],"changes":[78],"in":[79,98,170,194,199,202],"blood":[80],"pressure,":[81],"and":[82,124,151,192],"formation":[83],"antibodies":[85,131],"alfa.":[88,115],"Efficacy":[89],"several":[93],"haematologic":[94],"endpoints,":[95],"including":[96],"change":[97],"haemoglobin":[99,122,149,171,200],"from":[100,181],"baseline.":[101],"The":[102,158],"event":[104,127],"profile":[105],"similar":[110],"that":[112],"No":[116,130],"relationship":[117],"between":[118],"rapidity":[120],"response":[123,150],"any":[125],"observed.":[129],"detected.":[136],"Higher":[137],"increased":[142,180],"proportion":[144],"with":[147,187,204],"decreased":[152],"median":[154],"time":[155],"response.":[157],"overall":[159],"required":[164],"produce":[166],"mean":[168],"increase":[169,174,198],"does":[172],"not":[173],"when":[175],"dosing":[177],"interval":[178],"is":[179,190],"1":[182],"weeks.":[185],"Therapy":[186],"safe":[191],"effective":[193],"producing":[195],"dose-related":[197],"levels":[201],"cancer":[205],"chemotherapy.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}