{"id":"https://openalex.org/W2012258115","doi":"https://doi.org/10.1038/cddis.2013.391","title":"Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration","display_name":"Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration","publication_year":2013,"publication_date":"2013-10-17","ids":{"openalex":"https://openalex.org/W2012258115","doi":"https://doi.org/10.1038/cddis.2013.391","mag":"2012258115","pmid":"https://pubmed.ncbi.nlm.nih.gov/24136224"},"language":"en","primary_location":{"id":"doi:10.1038/cddis.2013.391","doi":"https://doi.org/10.1038/cddis.2013.391","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2013.391","pdf_url":"https://www.nature.com/articles/cddis2013391.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/cddis2013391.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026652978","display_name":"Yasushi Kitaoka","orcid":"https://orcid.org/0000-0001-9422-7983","observed_orcids":["https://orcid.org/0000-0001-9422-7983"]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Y Kitaoka","raw_affiliation_strings":["Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","Department of Ophthalmology; St. Marianna University School of Medicine; Kawasaki Kanagawa Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","institution_ids":["https://openalex.org/I163917720"]},{"raw_affiliation_string":"Department of Ophthalmology; St. Marianna University School of Medicine; Kawasaki Kanagawa Japan","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033682056","display_name":"Yasunari Munemasa","orcid":"https://orcid.org/0009-0007-6892-2326","observed_orcids":["https://orcid.org/0009-0007-6892-2326"]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Munemasa","raw_affiliation_strings":["Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","institution_ids":["https://openalex.org/I163917720"]},{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110564312","display_name":"Kaori Kojima","orcid":"https://orcid.org/0009-0002-1675-0722","observed_orcids":["https://orcid.org/0009-0002-1675-0722"]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kojima","raw_affiliation_strings":["Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","institution_ids":["https://openalex.org/I163917720"]},{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043202885","display_name":"Ayano Hirano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Hirano","raw_affiliation_strings":["Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","institution_ids":["https://openalex.org/I163917720"]},{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060125365","display_name":"Satoki Ueno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Ueno","raw_affiliation_strings":["Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","institution_ids":["https://openalex.org/I163917720"]},{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101960460","display_name":"Hitoshi Takagi","orcid":"https://orcid.org/0000-0002-7940-9030","observed_orcids":["https://orcid.org/0000-0002-7940-9030"]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Takagi","raw_affiliation_strings":["Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan","institution_ids":["https://openalex.org/I163917720"]},{"raw_affiliation_string":"Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan","institution_ids":["https://openalex.org/I163917720"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026652978"],"corresponding_institution_ids":["https://openalex.org/I163917720"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":7.2173,"has_fulltext":true,"cited_by_count":107,"citation_normalized_percentile":{"value":0.97081243,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"4","issue":"10","first_page":"e860","last_page":"e860"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.1088000014424324,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmnat3","display_name":"NMNAT3","score":0.996999979019165},{"id":"https://openalex.org/keywords/nmnat","display_name":"nicotinamide mononucleotide adenylyltransferase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/axonal-protection","display_name":"axonal protection","score":0.8370000123977661},{"id":"https://openalex.org/keywords/optic-nerve-degeneration","display_name":"optic nerve degeneration","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9039999842643738},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.8949999809265137},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.6620000004768372},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/3-methyladenine","display_name":"3-methyladenine","score":0.8999999761581421},{"id":"https://openalex.org/keywords/axon-degeneration","display_name":"axonal degeneration","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.7798064947128296},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.6364495158195496},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.505645751953125},{"id":"https://openalex.org/C2779683492","wikidata":"https://www.wikidata.org/wiki/Q792615","display_name":"Axotomy","level":3,"score":0.4969654381275177},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.4559089243412018},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4520948529243469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4466102123260498},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4340517520904541},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3535411059856415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25765925645828247},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.24760881066322327},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2185879349708557},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.11376982927322388},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07372429966926575},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071456","descriptor_name":"Sequestosome-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071456","descriptor_name":"Sequestosome-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071456","descriptor_name":"Sequestosome-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009612","descriptor_name":"Nicotinamide-Nucleotide Adenylyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009612","descriptor_name":"Nicotinamide-Nucleotide Adenylyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009612","descriptor_name":"Nicotinamide-Nucleotide Adenylyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/cddis.2013.391","doi":"https://doi.org/10.1038/cddis.2013.391","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2013.391","pdf_url":"https://www.nature.com/articles/cddis2013391.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},{"id":"pmid:24136224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24136224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2906857","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3920931","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3920931","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3920931","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/cddis.2013.391","doi":"https://doi.org/10.1038/cddis.2013.391","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2013.391","pdf_url":"https://www.nature.com/articles/cddis2013391.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4955349939","display_name":"Modulation of gamma-secretase and autophagy in optic nerve axonal degeneration","funder_award_id":"24592683","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5414866143","display_name":"Regulation of Nell2 in the senescence-accelerated mouse andelucidation of axonal extension.","funder_award_id":"23792016","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G816278012","display_name":"Clinical evidence-based investigation of developmental mechanism in diabetic retinopathy","funder_award_id":"23592594","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320324720","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012258115.pdf","grobid_xml":"https://content.openalex.org/works/W2012258115.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W60487933","https://openalex.org/W1528196156","https://openalex.org/W1593937083","https://openalex.org/W1624269173","https://openalex.org/W1801924460","https://openalex.org/W1975774056","https://openalex.org/W1976244696","https://openalex.org/W1981591235","https://openalex.org/W1992532731","https://openalex.org/W1994823455","https://openalex.org/W2002022907","https://openalex.org/W2002030019","https://openalex.org/W2002483881","https://openalex.org/W2011349933","https://openalex.org/W2011931872","https://openalex.org/W2015875096","https://openalex.org/W2017085357","https://openalex.org/W2019132331","https://openalex.org/W2024184215","https://openalex.org/W2025665129","https://openalex.org/W2028348496","https://openalex.org/W2029754794","https://openalex.org/W2033382767","https://openalex.org/W2033394446","https://openalex.org/W2037726118","https://openalex.org/W2038084692","https://openalex.org/W2038542010","https://openalex.org/W2041033949","https://openalex.org/W2046359526","https://openalex.org/W2055335620","https://openalex.org/W2055600586","https://openalex.org/W2055878329","https://openalex.org/W2068128334","https://openalex.org/W2072679909","https://openalex.org/W2073988218","https://openalex.org/W2074301486","https://openalex.org/W2078013685","https://openalex.org/W2091506036","https://openalex.org/W2091533593","https://openalex.org/W2116511131","https://openalex.org/W2119399459","https://openalex.org/W2124427604","https://openalex.org/W2134769368","https://openalex.org/W2138132658","https://openalex.org/W2144997370","https://openalex.org/W2161555979","https://openalex.org/W2165444724","https://openalex.org/W2168693839","https://openalex.org/W4295065557","https://openalex.org/W6635439109"],"related_works":["https://openalex.org/W2350871020","https://openalex.org/W4388182358","https://openalex.org/W2004695476","https://openalex.org/W2091299313","https://openalex.org/W1976244696","https://openalex.org/W2010247968","https://openalex.org/W2374328717","https://openalex.org/W4386476165","https://openalex.org/W4321499284","https://openalex.org/W2061427111"],"abstract_inverted_index":{"Axonal":[0],"degeneration":[1],"often":[2],"leads":[3],"to":[4,211],"the":[5,14,39,76,90,102,112,128,158,191],"death":[6],"of":[7,17,43,104,137,164,194,205],"neuronal":[8],"cell":[9,173],"bodies.":[10],"Previous":[11],"studies":[12],"demonstrated":[13],"crucial":[15],"role":[16],"nicotinamide":[18],"mononucleotide":[19],"adenylyltransferase":[20],"(Nmnat)":[21],"1,":[22],"2,":[23],"and":[24,52,66,86,95,116,122,131,160,167,180,202,207],"3":[25,71],"in":[26,38,75,89,107,111,127,157,169,184,199],"axonal":[27,46,146],"protection.":[28],"In":[29],"this":[30],"study,":[31],"Nmnat3":[32,44,82,138,166,176,195,206],"immunoreactivity":[33],"was":[34,139,155],"observed":[35],"inside":[36],"axons":[37,110],"optic":[40,57,77,91,108,216],"nerve.":[41],"Overexpression":[42],"exerts":[45],"protection":[47,147],"against":[48,214],"tumor":[49],"necrosis":[50],"factor-induced":[51],"intraocular":[53],"pressure":[54],"(IOP)":[55],"elevation-induced":[56],"nerve":[58,78,92,109,217],"degeneration.":[59],"Immunoblot":[60],"analysis":[61],"showed":[62,101],"that":[63,153,190,203],"both":[64,93],"p62":[65,85,154,168,179],"microtubule-associated":[67],"protein":[68],"light":[69],"chain":[70],"(LC3)-II":[72],"were":[73,125],"upregulated":[74],"after":[79,148],"IOP":[80,149],"elevation.":[81,150],"transfection":[83,130,177],"decreased":[84,178],"increased":[87,181],"LC3-II":[88],"with":[94],"without":[96],"experimental":[97],"glaucoma.":[98],"Electron":[99],"microscopy":[100],"existence":[103],"autophagic":[105,182],"vacuoles":[106],"glaucoma,":[113],"glaucoma+Nmnat3":[114,129],"transfection,":[115],"glaucoma+rapamycin":[117,132],"groups,":[118],"although":[119],"preserved":[120],"myelin":[121],"microtubule":[123],"structures":[124],"noted":[126],"groups.":[133],"The":[134],"axonal-protective":[135,192],"effect":[136,193],"inhibited":[140],"by":[141],"3-methyladenine,":[142],"whereas":[143],"rapamycin":[144],"exerted":[145],"We":[151],"found":[152],"present":[156],"mitochondria":[159],"confirmed":[161],"substantial":[162],"colocalization":[163],"mitochondrial":[165],"starved":[170],"retinal":[171],"ganglion":[172],"(RGC)-5":[174],"cells.":[175,186],"flux":[183],"RGC-5":[185],"These":[187],"results":[188],"suggest":[189],"may":[196,209],"be":[197],"involved":[198],"autophagy":[200,208],"machinery,":[201],"modulation":[204],"lead":[210],"potential":[212],"strategies":[213],"degenerative":[215],"disease.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}