{"id":"https://openalex.org/W2012257510","doi":"https://doi.org/10.1097/qad.0000000000000294","title":"Physiologic doses of depot-medroxyprogesterone acetate do not increase acute plasma simian HIV viremia or mucosal virus shedding in pigtail macaques","display_name":"Physiologic doses of depot-medroxyprogesterone acetate do not increase acute plasma simian HIV viremia or mucosal virus shedding in pigtail macaques","publication_year":2014,"publication_date":"2014-04-22","ids":{"openalex":"https://openalex.org/W2012257510","doi":"https://doi.org/10.1097/qad.0000000000000294","mag":"2012257510","pmid":"https://pubmed.ncbi.nlm.nih.gov/24759208"},"language":"en","primary_location":{"id":"doi:10.1097/qad.0000000000000294","doi":"https://doi.org/10.1097/qad.0000000000000294","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qad.0000000000000294","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110089258","display_name":"Jessica Radzio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Radzio","raw_affiliation_strings":["aLaboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention bDepartment of Pathology, Emory University, Atlanta, Georgia, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","e-mail: [email\u00a0protected]","fax: +1 404 639 1174","to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention bDepartment of Pathology, Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I150468666","https://openalex.org/I4210113904"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 404 639 1174","institution_ids":[]},{"raw_affiliation_string":"to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038852703","display_name":"Krisztina Z. Hanley","orcid":"https://orcid.org/0000-0002-7841-4700","observed_orcids":["https://orcid.org/0000-0002-7841-4700"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krisztina Hanley","raw_affiliation_strings":["Department of Pathology, Emory University, Atlanta, Georgia, USA","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","e-mail: [email\u00a0protected]","fax: +1 404 639 1174","to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 404 639 1174","institution_ids":[]},{"raw_affiliation_string":"to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101897624","display_name":"James Michael Mitchell","orcid":"https://orcid.org/0000-0002-5987-113X","observed_orcids":["https://orcid.org/0000-0002-5987-113X","https://orcid.org/0000-0001-6785-9352"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210102376","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/00qzjvm58","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210102376"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","UG","US"],"is_corresponding":false,"raw_author_name":"James Mitchell","raw_affiliation_strings":["Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","e-mail: [email\u00a0protected]","fax: +1 404 639 1174","to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210102376","https://openalex.org/I4210113904","https://openalex.org/I4210145675"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 404 639 1174","institution_ids":[]},{"raw_affiliation_string":"to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012237881","display_name":"Shanon Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210102376","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/00qzjvm58","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210102376"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","UG","US"],"is_corresponding":false,"raw_author_name":"Shanon Ellis","raw_affiliation_strings":["Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","e-mail: [email\u00a0protected]","fax: +1 404 639 1174","to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210102376","https://openalex.org/I4210113904","https://openalex.org/I4210145675"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 404 639 1174","institution_ids":[]},{"raw_affiliation_string":"to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008019835","display_name":"Frank Deyounks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210102376","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/00qzjvm58","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210102376"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","UG","US"],"is_corresponding":false,"raw_author_name":"Frank Deyounks","raw_affiliation_strings":["Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","e-mail: [email\u00a0protected]","fax: +1 404 639 1174","to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210102376","https://openalex.org/I4210113904","https://openalex.org/I4210145675"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 404 639 1174","institution_ids":[]},{"raw_affiliation_string":"to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086768143","display_name":"Leecresia T. Jenkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210102376","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/00qzjvm58","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210102376"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","UG","US"],"is_corresponding":false,"raw_author_name":"Leecresia T. Jenkins","raw_affiliation_strings":["Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","e-mail: [email\u00a0protected]","fax: +1 404 639 1174","to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210102376","https://openalex.org/I4210113904","https://openalex.org/I4210145675"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 404 639 1174","institution_ids":[]},{"raw_affiliation_string":"to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072275302","display_name":"Debra L. Hanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210102376","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/00qzjvm58","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210102376"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","UG","US"],"is_corresponding":false,"raw_author_name":"Debra Hanson","raw_affiliation_strings":["Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","e-mail: [email\u00a0protected]","fax: +1 404 639 1174","to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210102376","https://openalex.org/I4210113904","https://openalex.org/I4210145675"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 404 639 1174","institution_ids":[]},{"raw_affiliation_string":"to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031077639","display_name":"Walid Heneine","orcid":"https://orcid.org/0000-0003-3119-3565","observed_orcids":["https://orcid.org/0000-0003-3119-3565"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210102376","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/00qzjvm58","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210102376"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","UG","US"],"is_corresponding":false,"raw_author_name":"Walid Heneine","raw_affiliation_strings":["Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","e-mail: [email\u00a0protected]","fax: +1 404 639 1174","to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210102376","https://openalex.org/I4210113904","https://openalex.org/I4210145675"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 404 639 1174","institution_ids":[]},{"raw_affiliation_string":"to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019037088","display_name":"Jose Gerardo Garcia-Lerma","orcid":"https://orcid.org/0000-0001-6437-7745","observed_orcids":["https://orcid.org/0000-0001-6437-7745"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210102376","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/00qzjvm58","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210102376"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","UG","US"],"is_corresponding":false,"raw_author_name":"J. Gerardo Garc\u00eda-Lerma","raw_affiliation_strings":["Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","e-mail: [email\u00a0protected]","fax: +1 404 639 1174","to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210102376","https://openalex.org/I4210113904","https://openalex.org/I4210145675"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com)","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 404 639 1174","institution_ids":[]},{"raw_affiliation_string":"to J. Gerardo Garcia-Lerma, Laboratory Branch, Division of HIV/AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA. Tel: +1 404 639 4987","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.0471,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.95945999,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":"10","first_page":"1431","last_page":"1439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.5985999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.5985999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depot-medroxyprogesterone-acetate","display_name":"depot medroxyprogesterone acetate","score":0.9909999966621399},{"id":"https://openalex.org/keywords/injectable-contraceptives","display_name":"injectable contraceptives","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hiv-transmission","display_name":"HIV transmission","score":0.5950000286102295},{"id":"https://openalex.org/keywords/vaginal-epithelium","display_name":"vaginal epithelium","score":0.6309999823570251},{"id":"https://openalex.org/keywords/shiv","display_name":"SHIV","score":0.6990000009536743},{"id":"https://openalex.org/keywords/pig-tailed-macaque","display_name":"Macaca nemestrina","score":0.8659999966621399},{"id":"https://openalex.org/keywords/plasma-viremia","display_name":"plasma viremia","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.7727245092391968},{"id":"https://openalex.org/C2776306185","wikidata":"https://www.wikidata.org/wiki/Q2823834","display_name":"Medroxyprogesterone acetate","level":3,"score":0.7462504506111145},{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.6376012563705444},{"id":"https://openalex.org/C2775934596","wikidata":"https://www.wikidata.org/wiki/Q416667","display_name":"Medroxyprogesterone","level":4,"score":0.5874014496803284},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46682876348495483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45150458812713623},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.42654716968536377},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.411127507686615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38487333059310913},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32318314909935},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.3145475387573242},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003271","descriptor_name":"Contraceptive Agents, Female","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003271","descriptor_name":"Contraceptive Agents, Female","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008254","descriptor_name":"Macaca nemestrina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D017201","descriptor_name":"Virus Shedding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017258","descriptor_name":"Medroxyprogesterone Acetate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017258","descriptor_name":"Medroxyprogesterone Acetate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/qad.0000000000000294","doi":"https://doi.org/10.1097/qad.0000000000000294","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qad.0000000000000294","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},{"id":"pmid:24759208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24759208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G209864319","display_name":null,"funder_award_id":"Y1-AI-0681-02","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6873332610","display_name":"ANALYSIS OF THE GENETIC BASIS OF DENGUE VIRUS NEUROVIRULENCE IN MICE","funder_award_id":"Z01AI000681","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1963960283","https://openalex.org/W1967020365","https://openalex.org/W1977325647","https://openalex.org/W1993650351","https://openalex.org/W2001213681","https://openalex.org/W2004059008","https://openalex.org/W2009856015","https://openalex.org/W2015632747","https://openalex.org/W2034503047","https://openalex.org/W2037478116","https://openalex.org/W2055941221","https://openalex.org/W2069164737","https://openalex.org/W2069603904","https://openalex.org/W2070503161","https://openalex.org/W2071227044","https://openalex.org/W2089912966","https://openalex.org/W2097057569","https://openalex.org/W2110714233","https://openalex.org/W2112589439","https://openalex.org/W2116219734","https://openalex.org/W2116605213","https://openalex.org/W2117239545","https://openalex.org/W2119524073","https://openalex.org/W2135795769","https://openalex.org/W2140554379","https://openalex.org/W2141655588","https://openalex.org/W2144023036","https://openalex.org/W2154491542","https://openalex.org/W2161348345","https://openalex.org/W2161496228","https://openalex.org/W2277571592","https://openalex.org/W2419469447"],"related_works":["https://openalex.org/W2326622385","https://openalex.org/W1567344392","https://openalex.org/W2740824381","https://openalex.org/W2741196123","https://openalex.org/W2332061686","https://openalex.org/W3132726492","https://openalex.org/W3036421532","https://openalex.org/W2061767699","https://openalex.org/W2889942007","https://openalex.org/W2165823914"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Epidemiologic":[1],"studies":[2],"remain":[3],"inconclusive":[4],"on":[5,30,50,93,248],"whether":[6],"the":[7,26,46,180],"injectable":[8],"contraceptive":[9],"depot-medroxyprogesterone":[10],"acetate":[11,72],"(DMPA)":[12],"increases":[13],"mucosal":[14,252,269],"HIV":[15,32,53,270],"shedding":[16,99,212,254],"and":[17,44,70,81,96,137,158,168,176,209,217,223,236,251],"transmissibility.":[18],"Nonhuman":[19],"primate":[20],"models":[21],"may":[22],"help":[23],"to":[24],"determine":[25],"effects":[27],"of":[28,40,48,62,68,78,83,91,139,195,234,246,265],"DMPA":[29,41,49,63,92,152,235,247,266],"acute":[31,51,256],"replication.":[33,55],"DESIGN:":[34],"We":[35],"defined":[36],"a":[37,263],"physiologic":[38],"dose":[39,153],"in":[42,102,128,160,165,200,267],"macaques":[43,58,105,117,170,191,219],"assessed":[45],"impact":[47],"simian":[52],"(SHIV)":[54],"METHODS:":[56],"Pigtail":[57],"received":[59],"1-30":[60],"mg":[61,113,151],"intramuscularly":[64],"followed":[65],"by":[66],"measurements":[67],"progesterone":[69],"medroxyprogesterone":[71],"(MPA).":[73],"Vaginal":[74],"epithelial":[75,129,162],"thickness,":[76],"number":[77],"cell":[79],"layers":[80],"density":[82,138],"intraepithelial":[84,140],"CD3":[85,141],"cells":[86,142],"were":[87,118],"measured.":[88],"The":[89],"effect":[90,245],"SHIV":[94,238],"viremia":[95,175,250],"genital":[97],"virus":[98,197,211,253],"was":[100,213],"investigated":[101],"six":[103],"pigtail":[104,231],"infected":[106],"during":[107,255],"monthly":[108],"treatment":[109],"cycles":[110],"with":[111,126],"3":[112,150],"DMPA.":[114],"Six":[115],"DMPA-untreated":[116],"controls.":[119],"RESULTS:":[120],"Plasma":[121],"MPA":[122,156],"concentrations":[123,157],"directly":[124],"correlated":[125],"changes":[127,159],"thickness":[130,163],"(correlation":[131,143],"=":[132,144,147,187,206,221,225],"0.84;":[133],"P":[134,146,205,224],"<":[135],"0.001)":[136],"0.41;":[145],"0.02).":[148,207],"A":[149],"recapitulated":[154],"plasma":[155,174,201,249],"vaginal":[161,210,237],"seen":[164],"women.":[166],"DMPA-treated":[167],"untreated":[169,218],"showed":[171],"similar":[172,214],"peak":[173],"RNA":[177],"area":[178],"under":[179],"curve":[181],"values":[182],"over":[183],"12":[184],"weeks":[185],"(P":[186,220],"0.94),":[188],"although":[189],"treated":[190,216],"had":[192],"higher":[193],"odds":[194],"having":[196],"being":[198],"detected":[199],"(odds":[202],"ratio":[203],"6.6,":[204],"Rectal":[208],"between":[215],"0.72":[222],"0.53,":[226],"respectively).":[227],"CONCLUSION:":[228],"In":[229],"this":[230],"macaque":[232],"model":[233],"infection,":[239],"we":[240],"found":[241],"little":[242],"or":[243],"no":[244],"infection.":[257],"These":[258],"results":[259],"do":[260],"not":[261],"support":[262],"role":[264],"increasing":[268],"shedding.":[271]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}