{"id":"https://openalex.org/W2012254883","doi":"https://doi.org/10.1002/uog.8890","title":"Early first\u2010trimester maternal serum placental growth factor in trisomy 21 pregnancies","display_name":"Early first\u2010trimester maternal serum placental growth factor in trisomy 21 pregnancies","publication_year":2010,"publication_date":"2010-11-23","ids":{"openalex":"https://openalex.org/W2012254883","doi":"https://doi.org/10.1002/uog.8890","mag":"2012254883","pmid":"https://pubmed.ncbi.nlm.nih.gov/21105022"},"language":"en","primary_location":{"id":"doi:10.1002/uog.8890","doi":"https://doi.org/10.1002/uog.8890","is_oa":true,"landing_page_url":"https://doi.org/10.1002/uog.8890","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/uog.8890","source":{"id":"https://openalex.org/S22881060","display_name":"Ultrasound in Obstetrics and Gynecology","issn_l":"0960-7692","issn":["0960-7692","1469-0705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasound in Obstetrics &amp; Gynecology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/uog.8890","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004860323","display_name":"Nicholas J. Cowans","orcid":"https://orcid.org/0000-0003-4681-6980","observed_orcids":["https://orcid.org/0000-0003-4681-6980"]},"institutions":[{"id":"https://openalex.org/I4210094392","display_name":"King George Hospital","ror":"https://ror.org/00qp1n828","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1293052470","https://openalex.org/I4210094392"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. J. Cowans","raw_affiliation_strings":["Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Goodmayes, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Goodmayes, UK","institution_ids":["https://openalex.org/I4210094392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050101176","display_name":"Anastasia Stamatopoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094392","display_name":"King George Hospital","ror":"https://ror.org/00qp1n828","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1293052470","https://openalex.org/I4210094392"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Stamatopoulou","raw_affiliation_strings":["Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Goodmayes, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Goodmayes, UK","institution_ids":["https://openalex.org/I4210094392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052296435","display_name":"Niels T\u00f8rring","orcid":"https://orcid.org/0000-0001-8450-8052","observed_orcids":["https://orcid.org/0000-0001-8450-8052"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"N. T\u00f8rring","raw_affiliation_strings":["Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075229954","display_name":"Kevin Spencer","orcid":"https://orcid.org/0000-0002-5500-7627","observed_orcids":["https://orcid.org/0000-0002-5500-7627"]},"institutions":[{"id":"https://openalex.org/I4210094392","display_name":"King George Hospital","ror":"https://ror.org/00qp1n828","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1293052470","https://openalex.org/I4210094392"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"K. Spencer","raw_affiliation_strings":["Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Goodmayes, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Goodmayes, UK","institution_ids":["https://openalex.org/I4210094392"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075229954"],"corresponding_institution_ids":["https://openalex.org/I4210094392"],"apc_list":{"value":4940,"currency":"USD","value_usd":4940},"apc_paid":null,"fwci":1.7491,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.84647417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"37","issue":"5","first_page":"515","last_page":"519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placental-growth-factor","display_name":"placental growth factor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9739999771118164},{"id":"https://openalex.org/keywords/prenatal-screening","display_name":"prenatal screening","score":0.675000011920929},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.7979999780654907},{"id":"https://openalex.org/keywords/multiple-of-the-median","display_name":"multiple of the median","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2776229224","wikidata":"https://www.wikidata.org/wiki/Q844903","display_name":"Trisomy","level":2,"score":0.7540541887283325},{"id":"https://openalex.org/C2776871010","wikidata":"https://www.wikidata.org/wiki/Q18030500","display_name":"Placental growth factor","level":4,"score":0.6636201739311218},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.6072579026222229},{"id":"https://openalex.org/C3019714739","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"First trimester","level":4,"score":0.5318453311920166},{"id":"https://openalex.org/C3019108941","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Second trimester","level":4,"score":0.5169355273246765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4744231104850769},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.4453587532043457},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4166506230831146},{"id":"https://openalex.org/C2779954681","wikidata":"https://www.wikidata.org/wiki/Q47715","display_name":"Down syndrome","level":2,"score":0.41334718465805054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23432281613349915},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.20123866200447083},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1619502305984497},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.12805339694023132},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.08712917566299438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.050332725048065186},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.043906331062316895}],"mesh":[{"descriptor_ui":"D000072483","descriptor_name":"Placenta Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072483","descriptor_name":"Placenta Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072483","descriptor_name":"Placenta Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003718","descriptor_name":"Denmark","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003718","descriptor_name":"Denmark","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003718","descriptor_name":"Denmark","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008423","descriptor_name":"Maternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008423","descriptor_name":"Maternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008423","descriptor_name":"Maternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011266","descriptor_name":"Pregnancy-Associated Plasma Protein-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011266","descriptor_name":"Pregnancy-Associated Plasma Protein-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011266","descriptor_name":"Pregnancy-Associated Plasma Protein-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018997","descriptor_name":"Chorionic Gonadotropin, beta Subunit, Human","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018997","descriptor_name":"Chorionic Gonadotropin, beta Subunit, Human","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018997","descriptor_name":"Chorionic Gonadotropin, beta Subunit, Human","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D048208","descriptor_name":"Nuchal Translucency Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048208","descriptor_name":"Nuchal Translucency Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048208","descriptor_name":"Nuchal Translucency Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/uog.8890","doi":"https://doi.org/10.1002/uog.8890","is_oa":true,"landing_page_url":"https://doi.org/10.1002/uog.8890","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/uog.8890","source":{"id":"https://openalex.org/S22881060","display_name":"Ultrasound in Obstetrics and Gynecology","issn_l":"0960-7692","issn":["0960-7692","1469-0705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasound in Obstetrics &amp; Gynecology","raw_type":"journal-article"},{"id":"pmid:21105022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21105022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/89306f30-01eb-11e0-83f5-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/89306f30-01eb-11e0-83f5-000ea68e967b","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nj, C, A, S, T\u00f8rring, N & K, S 2011, 'Early first-trimester maternal serum placental growth factor (PlGF) in trisomy 21 pregnancies', Ultrasound in Obstetrics & Gynecology. https://doi.org/10.1002/uog.8890","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1002/uog.8890","doi":"https://doi.org/10.1002/uog.8890","is_oa":true,"landing_page_url":"https://doi.org/10.1002/uog.8890","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/uog.8890","source":{"id":"https://openalex.org/S22881060","display_name":"Ultrasound in Obstetrics and Gynecology","issn_l":"0960-7692","issn":["0960-7692","1469-0705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasound in Obstetrics &amp; Gynecology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6700000166893005}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012254883.pdf","grobid_xml":"https://content.openalex.org/works/W2012254883.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W45761779","https://openalex.org/W1963628301","https://openalex.org/W1968530430","https://openalex.org/W1992338344","https://openalex.org/W1993545701","https://openalex.org/W2010876692","https://openalex.org/W2011722454","https://openalex.org/W2013062981","https://openalex.org/W2019525370","https://openalex.org/W2026038921","https://openalex.org/W2028417117","https://openalex.org/W2029763523","https://openalex.org/W2037730388","https://openalex.org/W2042292710","https://openalex.org/W2060804947","https://openalex.org/W2068866375","https://openalex.org/W2078531184","https://openalex.org/W2084033092","https://openalex.org/W2093318355","https://openalex.org/W2096439989","https://openalex.org/W2096476475","https://openalex.org/W2097871919","https://openalex.org/W2101536802","https://openalex.org/W2119141626","https://openalex.org/W2152695196","https://openalex.org/W2160479984","https://openalex.org/W2165705031","https://openalex.org/W2468207994"],"related_works":["https://openalex.org/W1599138788","https://openalex.org/W2010876692","https://openalex.org/W7020348975","https://openalex.org/W2165705031","https://openalex.org/W3199046775","https://openalex.org/W1987629835","https://openalex.org/W2335313269","https://openalex.org/W2027362635","https://openalex.org/W2019525370","https://openalex.org/W1944280125"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"measure":[2],"maternal":[3,26,94,154],"serum":[4,27,95,155],"placental":[5],"growth":[6],"factor":[7],"(PlGF)":[8],"levels":[9,66,88,152,172],"in":[10,16,92,101,153,156,176,182],"trisomy":[11,42,76,97,113,143,157,177],"21":[12,43,77,98,114,144,158,178],"cases":[13,44,99,159],"and":[14,34,45,54,75,78,86,132,145,173,179,193],"controls":[15,48,102],"samples":[17],"drawn":[18,29],"before":[19],"11":[20],"weeks'":[21,38],"gestation.":[22],"METHODS:":[23],"Early":[24,150],"first-trimester":[25],"samples,":[28],"between":[30,142,170],"8":[31,122],"+":[32,36],"0":[33],"10":[35,134],"6":[37],"gestation,":[39],"for":[40],"37":[41],"244":[46],"unaffected":[47,79,146,165,180],"were":[49,67,81,89],"retrieved":[50],"from":[51],"frozen":[52],"storage,":[53],"PlGF":[55,65,85,147,151,171],"was":[56,129,138],"retrospectively":[57],"measured":[58],"using":[59],"a":[60],"DELFIA":[61],"Xpress":[62],"immunoassay":[63],"platform.":[64],"converted":[68],"to":[69,164,190],"multiples":[70],"of":[71,96,125,187],"the":[72,93,104,127,168,183],"median":[73],"(MoM),":[74],"groups":[80],"compared.":[82],"RESULTS:":[83],"Raw":[84],"MoM":[87,110,116],"significantly":[90],"higher":[91],"than":[100],"over":[103],"3-week":[105],"gestational":[106,174],"window":[107],"(unaffected":[108],"1.0":[109],"compared":[111],"with":[112],"1.3":[115],"(P":[117],"<":[118],"0.0001)).":[119],"However":[120],"at":[121,133],"completed":[123,135],"weeks":[124,136],"gestation":[126],"increase":[128],"most":[130],"significant":[131,140],"there":[137],"no":[139],"difference":[141],"levels.":[148],"CONCLUSIONS:":[149],"may":[160],"be":[161,191],"increased":[162],"relative":[163],"controls,":[166],"however,":[167],"relationship":[169],"age":[175],"pregnancies":[181],"first":[184],"two":[185],"trimesters":[186],"pregnancy":[188],"appears":[189],"complex":[192],"requires":[194],"further":[195],"study.":[196]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
