{"id":"https://openalex.org/W2012251502","doi":"https://doi.org/10.1158/1538-7445.am2012-22","title":"Abstract 22: Differential IGF-II response of AA and CA normal breast cell lines to prolactin treatment","display_name":"Abstract 22: Differential IGF-II response of AA and CA normal breast cell lines to prolactin treatment","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2012251502","doi":"https://doi.org/10.1158/1538-7445.am2012-22","mag":"2012251502"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-22","doi":"https://doi.org/10.1158/1538-7445.am2012-22","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-22","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011827445","display_name":"Teleka C. Calderon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teleka Calderon","raw_affiliation_strings":["1Loma Linda University, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Loma Linda University, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022663291","display_name":"Marino A. De Leo\u0301n","orcid":"https://orcid.org/0000-0001-6576-785X","observed_orcids":["https://orcid.org/0000-0001-6576-785X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marino De Leo\u0301n","raw_affiliation_strings":["1Loma Linda University, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Loma Linda University, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055248077","display_name":"Daisy De Le\u00f3n","orcid":"https://orcid.org/0000-0002-2693-0957","observed_orcids":["https://orcid.org/0000-0002-2693-0957"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daisy D. De Leo\u0301n","raw_affiliation_strings":["1Loma Linda University, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Loma Linda University, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I26347476"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"22","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.8410000205039978},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/fatty-acid-binding-protein-3","display_name":"fatty acid binding protein 3","score":0.8500000238418579},{"id":"https://openalex.org/keywords/fabp5","display_name":"FABP5","score":0.9769999980926514},{"id":"https://openalex.org/keywords/african-american-women","display_name":"African American women","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mcf-10a-cells","display_name":"MCF10A cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/breast-cancer-prevention","display_name":"breast cancer prevention","score":0.6179999709129333},{"id":"https://openalex.org/keywords/breast-cancer-incidence","display_name":"breast cancer incidence","score":0.44999998807907104},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6039999723434448},{"id":"https://openalex.org/keywords/tumor-suppressor-proteins","display_name":"tumor suppressor proteins","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.8272702693939209},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.7139045596122742},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6181536912918091},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6001569628715515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5853909850120544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4118686318397522},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40772324800491333},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3968908190727234},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.355629563331604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32647186517715454},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.24773496389389038},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-22","doi":"https://doi.org/10.1158/1538-7445.am2012-22","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-22","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2211441072","https://openalex.org/W2313299870","https://openalex.org/W2033050971","https://openalex.org/W2334330921","https://openalex.org/W2050233824","https://openalex.org/W2567647183","https://openalex.org/W1970535435","https://openalex.org/W1969803665","https://openalex.org/W2216793629","https://openalex.org/W4282976557"],"abstract_inverted_index":{"Abstract":[0],"African-American":[1],"(AA)":[2,155],"breast":[3,26,33,61,110,124,157,373],"cancer":[4,27,34],"patients":[5],"have":[6,65,74],"lower":[7,23,75],"survival":[8,15],"compared":[9,79],"with":[10,37,141,161,212,242],"Caucasian-American":[11],"(CA)":[12,152],"patients.":[13],"This":[14],"disparity":[16],"is":[17,35,47,87,139],"significant":[18],"in":[19,41,98,191,200,269,294,301,333,375],"view":[20],"of":[21,25,32,60,121,179,194,203,208,238,329,362,396,401],"the":[22,101,109,281,351,397,402],"incidence":[24,31],"among":[28],"AA.":[29],"Lower":[30],"associated":[36,140],"parity":[38],"and":[39,96,135,143,153,176,182,197,224,229,248,259,287,320,331,343,378],"lactation":[40,102],"young":[42],"women.":[43],"Lactation's":[44],"protective":[45,89,292],"effect":[46],"mediated":[48,112],"by":[49,113],"fatty-acid":[50],"binding":[51],"protein":[52,56,175,192,201,236,270],"3":[53],"(FABP3),":[54],"a":[55,88,198,356],"that":[57,67,92,118,338],"promotes":[58],"differentiation":[59],"epithelial":[62,123,158],"cells.":[63,297,325],"We":[64,149],"demonstrated":[66],"AA":[68,376],"normal":[69,122,156,295],"women":[70,82],"below":[71],"50":[72,223],"years":[73],"FABP3":[76,86,147,209,239,298,319,332],"levels":[77,178,193,202,207,219,237,251,299,328],"as":[78],"to":[80,100,130,277,312,323,350,354,366,382],"CA":[81],"(p":[83],"=":[84],"0.030).":[85],"tumor":[90],"suppressor":[91],"increases":[93],"during":[94],"pregnancy":[95],"lactation,":[97],"response":[99],"hormone":[103],"prolactin":[104],"(PRL).":[105],"PRL":[106,119,164,187,214,227,244,257,278,306,330,347,367],"effects":[107],"on":[108],"are":[111,291,340],"IGF-II.":[114],"Thus,":[115],"we":[116],"propose":[117],"treatment":[120],"cell":[125,159,274,364],"lines":[126,160,275,365],"would":[127],"increase":[128,133,190],"IGF-II":[129,195,217,247,286],"promote":[131],"differentiation,":[132],"FABP3,":[134,181],"decrease":[136,199],"FABP5.":[137,183],"FABP5":[138,204,249],"metastasis":[142],"may":[144,309,368,379],"compensate":[145],"for":[146,167,174,405],"decrease.":[148],"treated":[150],"MCF10A":[151,185,282,302,314,335],"AG11132":[154,234,324,352],"recombinant":[162],"human":[163],"(0-200":[165],"ng/ml)":[166],"24":[168],"hours.":[169],"Cell":[170],"lysates":[171],"were":[172,267],"examined":[173],"mRNA":[177,218,250],"IGF-II,":[180],"In":[184,233],"cells,":[186,235,353],"stimulated":[188],"an":[189],"(p=0.044),":[196],"(p=0.044).":[205],"Protein":[206],"significantly":[210,240,253,317],"decreased":[211,288,300,370],"increasing":[213,243],"concentration":[215,245],"(p=0.030).":[216],"also":[220],"increased":[221,241,252,285],"at":[222,254,304],"200":[225],"ng/ml":[226,256],"(2.59":[228],"2.58":[230],"fold,":[231,261],"respectively).":[232],"(p=0.016).":[246],"10":[255],"(49.91":[258],"2.13":[260],"respectively);":[262],"however,":[263],"no":[264],"corresponding":[265],"changes":[266,293],"seen":[268],"levels.":[271],"Though":[272],"both":[273],"respond":[276],"treatment,":[279],"only":[280],"line":[283],"displays":[284],"FABP5,":[289],"which":[290],"mammary":[296],"cells":[303,315,336],"higher":[305,327],"concentrations;":[307],"this":[308,385],"be":[310],"due":[311],"untreated":[313,334],"expressing":[316],"more":[318,341],"prolactin,":[321],"relative":[322,349],"The":[326,359],"indicate":[337],"they":[339],"differentiated":[342,357],"thus":[344],"require":[345],"less":[346],"stimulation,":[348],"achieve":[355],"state.":[358],"dissimilar":[360],"responsiveness":[361],"these":[363],"suggest":[369],"protection":[371],"against":[372],"carcinogenesis":[374],"patients,":[377],"help":[380],"us":[381],"further":[383],"understand":[384],"health":[386],"disparity.":[387],"Citation":[388],"Format:":[389],"{Authors}.":[390],"{Abstract":[391],"title}":[392],"[abstract].":[393],"In:":[394],"Proceedings":[395],"103rd":[398],"Annual":[399],"Meeting":[400],"American":[403],"Association":[404],"Cancer":[406,417],"Research;":[407],"2012":[408],"Mar":[409],"31-Apr":[410],"4;":[411],"Chicago,":[412],"IL.":[413],"Philadelphia":[414],"(PA):":[415],"AACR;":[416],"Res":[418],"2012;72(8":[419],"Suppl):Abstract":[420],"nr":[421],"22.":[422],"doi:1538-7445.AM2012-22":[423]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
