{"id":"https://openalex.org/W2012249507","doi":"https://doi.org/10.1258/acb.2010.010176","title":"Development and validation of a quantitative assay based on tandem mass spectrometry","display_name":"Development and validation of a quantitative assay based on tandem mass spectrometry","publication_year":2011,"publication_date":"2011-02-08","ids":{"openalex":"https://openalex.org/W2012249507","doi":"https://doi.org/10.1258/acb.2010.010176","mag":"2012249507","pmid":"https://pubmed.ncbi.nlm.nih.gov/21303874"},"language":"en","primary_location":{"id":"doi:10.1258/acb.2010.010176","doi":"https://doi.org/10.1258/acb.2010.010176","is_oa":false,"landing_page_url":"https://doi.org/10.1258/acb.2010.010176","pdf_url":null,"source":{"id":"https://openalex.org/S175011280","display_name":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","issn_l":"0004-5632","issn":["0004-5632","1758-1001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063195969","display_name":"John William Honour","orcid":"https://orcid.org/0000-0002-9035-0543","observed_orcids":["https://orcid.org/0000-0002-9035-0543"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John W Honour","raw_affiliation_strings":["Department of Clinical Biochemistry, University College London Hospitals, 60 Whitfield Street, London W1T 4EU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, University College London Hospitals, 60 Whitfield Street, London W1T 4EU, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063195969"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":10.567,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.98990395,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"48","issue":"2","first_page":"97","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.15800000727176666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.07169999927282333,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/assay-validation","display_name":"assay validation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.9369999766349792},{"id":"https://openalex.org/keywords/lc-ms-ms","display_name":"LC-MS/MS","score":0.8730000257492065},{"id":"https://openalex.org/keywords/clinical-laboratory-techniques","display_name":"clinical laboratory methods","score":0.6019999980926514},{"id":"https://openalex.org/keywords/immunoassay-comparison","display_name":"immunoassay comparison","score":0.6420000195503235},{"id":"https://openalex.org/keywords/method-accuracy-and-precision","display_name":"method accuracy and precision","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6498264670372009},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.5363577008247375},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.47496744990348816},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4746426045894623},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4393453896045685},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.42218053340911865},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3256374001502991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.270391047000885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2402586042881012},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007755","descriptor_name":"Laboratories, Hospital","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D007755","descriptor_name":"Laboratories, Hospital","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D007755","descriptor_name":"Laboratories, Hospital","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053000","descriptor_name":"Analytic Sample Preparation Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053000","descriptor_name":"Analytic Sample Preparation Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053000","descriptor_name":"Analytic Sample Preparation Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1258/acb.2010.010176","doi":"https://doi.org/10.1258/acb.2010.010176","is_oa":false,"landing_page_url":"https://doi.org/10.1258/acb.2010.010176","pdf_url":null,"source":{"id":"https://openalex.org/S175011280","display_name":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","issn_l":"0004-5632","issn":["0004-5632","1758-1001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","raw_type":"journal-article"},{"id":"pmid:21303874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21303874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1130352","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1130352/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ANNALS OF CLINICAL BIOCHEMISTRY , 48 pp. 97-111. (2011)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1522508179","https://openalex.org/W1557141846","https://openalex.org/W1879099940","https://openalex.org/W1964198697","https://openalex.org/W1973875012","https://openalex.org/W1976497681","https://openalex.org/W1977431049","https://openalex.org/W1978815453","https://openalex.org/W1978946416","https://openalex.org/W1980103804","https://openalex.org/W1980648884","https://openalex.org/W1986204659","https://openalex.org/W1988996905","https://openalex.org/W1990499995","https://openalex.org/W1992073724","https://openalex.org/W1996507019","https://openalex.org/W1996832147","https://openalex.org/W1999365897","https://openalex.org/W2003500175","https://openalex.org/W2007460251","https://openalex.org/W2009389492","https://openalex.org/W2011720547","https://openalex.org/W2016821887","https://openalex.org/W2016968987","https://openalex.org/W2019140910","https://openalex.org/W2020844936","https://openalex.org/W2027313122","https://openalex.org/W2029629076","https://openalex.org/W2030172737","https://openalex.org/W2030253332","https://openalex.org/W2030353836","https://openalex.org/W2030652657","https://openalex.org/W2031748687","https://openalex.org/W2034751460","https://openalex.org/W2050226999","https://openalex.org/W2056944801","https://openalex.org/W2066322883","https://openalex.org/W2066323347","https://openalex.org/W2070698734","https://openalex.org/W2072808610","https://openalex.org/W2078674857","https://openalex.org/W2081230960","https://openalex.org/W2082303677","https://openalex.org/W2088285579","https://openalex.org/W2095229779","https://openalex.org/W2097781250","https://openalex.org/W2102192892","https://openalex.org/W2109442511","https://openalex.org/W2109844142","https://openalex.org/W2110828355","https://openalex.org/W2111673931","https://openalex.org/W2114726465","https://openalex.org/W2119233368","https://openalex.org/W2121129723","https://openalex.org/W2132076248","https://openalex.org/W2133597621","https://openalex.org/W2134472266","https://openalex.org/W2134571812","https://openalex.org/W2140695271","https://openalex.org/W2141387425","https://openalex.org/W2142839710","https://openalex.org/W2151182366","https://openalex.org/W2160769763","https://openalex.org/W2168015482","https://openalex.org/W2169494016","https://openalex.org/W2328728152","https://openalex.org/W2496690265","https://openalex.org/W2796745860","https://openalex.org/W3217804244","https://openalex.org/W4211180812"],"related_works":["https://openalex.org/W1944150046","https://openalex.org/W2082761856","https://openalex.org/W1991280445","https://openalex.org/W1995472698","https://openalex.org/W2501505803","https://openalex.org/W2153421357","https://openalex.org/W3160812369","https://openalex.org/W2089625500","https://openalex.org/W2103021125","https://openalex.org/W2051901836"],"abstract_inverted_index":{"Many":[0],"routine":[1,230],"hospital":[2,104,231],"and":[3,34,92,122,139,185,191,206,241,258],"clinical":[4,173,295],"research":[5],"assays":[6,126,132],"have":[7,26,37,193],"relied":[8],"upon":[9],"immunoassay":[10],"procedures":[11],"to":[12,63,79,151,200,209,238,245,288],"achieve":[13],"sensitive":[14],"measurements":[15],"of":[16,19,23,42,68,73,82,103,110,113,124,154,172,181,189,219,235,253,262,283],"a":[17,56,101,111,220,229,247,263,281,290,298,301],"range":[18],"important":[20,278],"analytes.":[21],"Some":[22],"the":[24,61,69,80,83,107,143,162,170,182,214,306],"methods":[25,44,138,150],"been":[27,194],"developed":[28],"in-house":[29,137],"but":[30,118],"increasingly":[31],"commercial":[32],"kits":[33,176],"automated":[35],"analysers":[36],"become":[38],"commonplace.":[39],"The":[40,260],"accuracies":[41],"these":[43],"are":[45,127,166,198,202],"under":[46],"question":[47],"in":[48,100,243,251,286],"health":[49],"care.":[50],"Mass":[51],"spectrometry":[52,95],"(MS)":[53],"is":[54,97,309],"potentially":[55],"more":[57],"accurate":[58],"technique":[59],"with":[60,90,175],"ability":[62],"demonstrate":[64],"specificity.":[65],"An":[66],"introduction":[67,218,261],"basic":[70],"analytical":[71],"aspects":[72],"liquid":[74],"chromatography":[75],"(LC)-MS/MS":[76],"leads":[77],"on":[78,168,267],"validation":[81,123,292,308],"method":[84,250,265],"before":[85],"general":[86],"use.":[87],"LC":[88],"coupled":[89],"MS":[91,269],"tandem":[93,221,268],"mass":[94,148,222],"(MS(n))":[96],"being":[98],"adopted":[99],"number":[102,112,188,234,282],"laboratories":[105,157,174],"for":[106,120,147,158,217,225,294,304],"quantitative":[108,249,264],"analysis":[109],"analytes":[114],"from":[115,280],"physiological":[116],"matrices,":[117],"standards":[119],"development":[121],"such":[125],"not":[128,207],"easily":[129],"available.":[130],"Most":[131],"can":[133],"be":[134,239],"regarded":[135],"as":[136],"herein":[140],"may":[141],"lay":[142],"failure":[144],"so":[145],"far":[146],"spectrometric":[149,223],"improve":[152],"quality":[153],"results":[155],"between":[156],"an":[159],"analyte":[160],"using":[161],"same":[163],"technology.":[164],"Manufacturers":[165],"taking":[167],"board":[169],"experience":[171],"containing":[177],"all":[178],"or":[179],"most":[180],"disposable":[183],"items":[184],"reagents.":[186],"A":[187,233],"documents":[190,197,285],"guidelines":[192],"consulted.":[195],"These":[196],"expensive":[199],"purchase,":[201],"often":[203],"very":[204],"long":[205],"easy":[208],"read.":[210],"This":[211,273],"review":[212,274],"highlights":[213],"specific":[215],"requirements":[216],"test":[224],"small":[226],"molecules":[227],"into":[228],"laboratory.":[232],"experiments":[236],"need":[237],"planned":[240],"executed":[242],"order":[244,287],"describe":[246],"new":[248],"terms":[252],"selectivity,":[254],"accuracy,":[255],"imprecision,":[256],"sensitivity":[257],"stability.":[259],"based":[266],"requires":[270],"careful":[271],"validation.":[272],"has":[275],"distilled":[276],"out":[277],"points":[279],"key":[284],"provide":[289],"working":[291,302],"guideline":[293],"laboratories.":[296],"In":[297],"supplementary":[299],"file":[300],"document":[303],"assembling":[305],"assay":[307],"proposed.":[310]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
